PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24200065-0 2013 [Effect of acetazolamide on AQP1 and AQP3 expressions in fibroblast-like synoviocytes of rheumatoid arthritis]. Acetazolamide 11-24 aquaporin 1 (Colton blood group) Homo sapiens 28-32 32947166-4 2020 Moreover, the effect of acetazolamide and cisplatin on the expression of aquaporin-1 was detected by RT-qPCR. Acetazolamide 24-37 aquaporin 1 (Colton blood group) Homo sapiens 73-84 32947166-5 2020 Loss-of-function assays was performed to assess whether the effect of acetazolamide and cisplatin on TU868 cells was mediated by aquaporin-1. Acetazolamide 70-83 aquaporin 1 (Colton blood group) Homo sapiens 129-140 24200065-1 2013 OBJECTIVE: To observe the effect of acetazolamide (AZ) on the expressions of aquaporin 1 (AQP1) and AQP3 in fibroblast-like synoviocytes of rheumatoid arthritis (RAFLSs) and explore the roles of AQP1 and AQP3 in the development of rheumatoid arthritis (RA). Acetazolamide 36-49 aquaporin 1 (Colton blood group) Homo sapiens 77-88 24200065-1 2013 OBJECTIVE: To observe the effect of acetazolamide (AZ) on the expressions of aquaporin 1 (AQP1) and AQP3 in fibroblast-like synoviocytes of rheumatoid arthritis (RAFLSs) and explore the roles of AQP1 and AQP3 in the development of rheumatoid arthritis (RA). Acetazolamide 36-49 aquaporin 1 (Colton blood group) Homo sapiens 90-94 24200065-1 2013 OBJECTIVE: To observe the effect of acetazolamide (AZ) on the expressions of aquaporin 1 (AQP1) and AQP3 in fibroblast-like synoviocytes of rheumatoid arthritis (RAFLSs) and explore the roles of AQP1 and AQP3 in the development of rheumatoid arthritis (RA). Acetazolamide 36-49 aquaporin 1 (Colton blood group) Homo sapiens 195-199 24200065-1 2013 OBJECTIVE: To observe the effect of acetazolamide (AZ) on the expressions of aquaporin 1 (AQP1) and AQP3 in fibroblast-like synoviocytes of rheumatoid arthritis (RAFLSs) and explore the roles of AQP1 and AQP3 in the development of rheumatoid arthritis (RA). Acetazolamide 51-53 aquaporin 1 (Colton blood group) Homo sapiens 77-88 24200065-1 2013 OBJECTIVE: To observe the effect of acetazolamide (AZ) on the expressions of aquaporin 1 (AQP1) and AQP3 in fibroblast-like synoviocytes of rheumatoid arthritis (RAFLSs) and explore the roles of AQP1 and AQP3 in the development of rheumatoid arthritis (RA). Acetazolamide 51-53 aquaporin 1 (Colton blood group) Homo sapiens 90-94 24200065-1 2013 OBJECTIVE: To observe the effect of acetazolamide (AZ) on the expressions of aquaporin 1 (AQP1) and AQP3 in fibroblast-like synoviocytes of rheumatoid arthritis (RAFLSs) and explore the roles of AQP1 and AQP3 in the development of rheumatoid arthritis (RA). Acetazolamide 51-53 aquaporin 1 (Colton blood group) Homo sapiens 195-199 24200065-5 2013 The expressions of AQP1 mRNA and AQP3 mRNA in RAFLSs and OAFLSs were measured by RT-PCR; the expression of AQP1 protein was detected by immunofluorescence in RAFLSs and OAFLSs treated with the same concentration of acetazolamide (10(-4) mol/L) for different time (24, 48, 72 hours). Acetazolamide 215-228 aquaporin 1 (Colton blood group) Homo sapiens 107-111 24200065-8 2013 Different concentrations of acetazolamide (10(-4), 10(-6), 10(-8) mol/L) were able to significantly decrease the expression level of AQP1 mRNA in RAFLSs (P<0.05) in a time- and dose-dependent manner. Acetazolamide 28-41 aquaporin 1 (Colton blood group) Homo sapiens 133-137 24200065-12 2013 Acetazolamide can reduce the expression of AQP1 rather than AQP3 in RAFLSs. Acetazolamide 0-13 aquaporin 1 (Colton blood group) Homo sapiens 43-47 17126329-0 2006 Comparative efficacy of HgCl2 with candidate aquaporin-1 inhibitors DMSO, gold, TEA+ and acetazolamide. Acetazolamide 89-102 aquaporin 1 (Colton blood group) Homo sapiens 45-56 16480680-0 2006 Acetazolamide inhibits osmotic water permeability by interaction with aquaporin-1. Acetazolamide 0-13 aquaporin 1 (Colton blood group) Homo sapiens 70-81 16480680-6 2006 Acetazolamide, at concentrations of 1 and 10muM, inhibited the osmotic water permeability in HEK293 cells transfected with pEGFP/AQP1. Acetazolamide 0-13 aquaporin 1 (Colton blood group) Homo sapiens 129-133 16480680-7 2006 The direct binding between acetazolamide and AQP1 was detected by surface plasmon resonance. Acetazolamide 27-40 aquaporin 1 (Colton blood group) Homo sapiens 45-49 16480680-9 2006 The binding assay showed that acetazolamide could directly interact with AQP1. Acetazolamide 30-43 aquaporin 1 (Colton blood group) Homo sapiens 73-77 16480680-10 2006 This study demonstrated that acetazolamide inhibited osmotic water permeability through interaction with AQP1. Acetazolamide 29-42 aquaporin 1 (Colton blood group) Homo sapiens 105-109 23123479-2 2012 So, using this method we reinvestigated the functions as AQP1 inhibitors of drugs and chemicals such as acetazolamide, sodium nitroprusside, tetraethylammonium ions (TEA(+)), and dimethylsulfoxide (DMSO). Acetazolamide 104-117 aquaporin 1 (Colton blood group) Homo sapiens 57-61 17219999-4 2006 RESULT: The expression of AQP-1 is mainly found on membrane of Hep-2 cell and the expression is significantly reduced when the concentration of acetazolamide is 5 x 10(-5) mol/L. Acetazolamide 144-157 aquaporin 1 (Colton blood group) Homo sapiens 26-31 17219999-5 2006 Noteworthily, inhibiting AQP-1 by acetazolamide, the rate of cell growth and cell apoptosis significantly increases with the time prolong. Acetazolamide 34-47 aquaporin 1 (Colton blood group) Homo sapiens 25-30 17219999-8 2006 CONCLUSION: The inhibiting AQP-1 with acetazolamide may significantly induce apoptosis of Hep-2 cell. Acetazolamide 38-51 aquaporin 1 (Colton blood group) Homo sapiens 27-32