PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21166739-8 2011 Compared with radiation alone, 3-MA combined with radiation significantly decreased cell viability, as well as autophagic ratio, beclin-1, and LC3-II protein level. 3-methyladenine 31-35 microtubule associated protein 1 light chain 3 alpha Homo sapiens 143-146 22745580-12 2012 Autophagy inhibitor 3-methyladenine (3-MA) reduced AVOs formation and inhibited LC3-I to LC3-II conversion. 3-methyladenine 20-35 microtubule associated protein 1 light chain 3 alpha Homo sapiens 80-83 22745580-12 2012 Autophagy inhibitor 3-methyladenine (3-MA) reduced AVOs formation and inhibited LC3-I to LC3-II conversion. 3-methyladenine 20-35 microtubule associated protein 1 light chain 3 alpha Homo sapiens 89-92 22745580-12 2012 Autophagy inhibitor 3-methyladenine (3-MA) reduced AVOs formation and inhibited LC3-I to LC3-II conversion. 3-methyladenine 37-41 microtubule associated protein 1 light chain 3 alpha Homo sapiens 80-83 22745580-12 2012 Autophagy inhibitor 3-methyladenine (3-MA) reduced AVOs formation and inhibited LC3-I to LC3-II conversion. 3-methyladenine 37-41 microtubule associated protein 1 light chain 3 alpha Homo sapiens 89-92 21453691-6 2011 Application of IR with 3-MA to inhibit autophagy simultaneously suppressed the expression of LC3 and enhanced cell death. 3-methyladenine 23-27 microtubule associated protein 1 light chain 3 alpha Homo sapiens 93-96 20350574-6 2010 Treatment of cells with an inhibitor of autophagosome formation, 3-methyladenine, both reduced LC3-GFP puncta formation and viral production, suggesting a role for autophagosomes in ISAV replication. 3-methyladenine 65-80 microtubule associated protein 1 light chain 3 alpha Homo sapiens 95-98 20541008-6 2010 Co-incubation with bafilomycin A1 (10 nM) further increased hypoxia-induced LC3-II levels but 3-methyladenine (3-MA; 10 mM) reduced the elevation in LC3-II levels induced by 8-h hypoxia. 3-methyladenine 94-109 microtubule associated protein 1 light chain 3 alpha Homo sapiens 149-152 20541008-6 2010 Co-incubation with bafilomycin A1 (10 nM) further increased hypoxia-induced LC3-II levels but 3-methyladenine (3-MA; 10 mM) reduced the elevation in LC3-II levels induced by 8-h hypoxia. 3-methyladenine 111-115 microtubule associated protein 1 light chain 3 alpha Homo sapiens 149-152 20541008-13 2010 Co-incubation with 3-MA during hypoxia prevented the protection afforded by hypoxic preconditioning against MPP(+)-induced increases in LC3-II levels and neurotoxicity. 3-methyladenine 19-23 microtubule associated protein 1 light chain 3 alpha Homo sapiens 136-139 20104024-10 2010 3-methyladenine (3-MA) blocked LC3 conversion, and 3-MA and wortmannin significantly enhanced apoptotic signaling in cells treated with celecoxib plus ABT-737. 3-methyladenine 0-15 microtubule associated protein 1 light chain 3 alpha Homo sapiens 31-34 20104024-10 2010 3-methyladenine (3-MA) blocked LC3 conversion, and 3-MA and wortmannin significantly enhanced apoptotic signaling in cells treated with celecoxib plus ABT-737. 3-methyladenine 17-21 microtubule associated protein 1 light chain 3 alpha Homo sapiens 31-34 19331148-7 2009 Pretreatment with 3-methyladenine, an inhibitor of autophagy, partially inhibited the cytotoxicity of TFs, the formation of acidic organelles and LC3 accumulation in the autophagosome. 3-methyladenine 18-33 microtubule associated protein 1 light chain 3 alpha Homo sapiens 146-149 19958950-9 2009 Treatment with 3-MA abrogated the radiation-induced increase in LC3-II in both cell lines and reduced radiosensitivity by 49% and 31% in 8505-C and TPC-1 cells, respectively. 3-methyladenine 15-19 microtubule associated protein 1 light chain 3 alpha Homo sapiens 64-67 19258012-6 2009 In this connection, 3-methyladenine, a Class III phosphoinositide 3-kinase inhibitor, significantly abolished the formation of LC3(+) autophagic vacuoles and the processing of LC3 induced by sc-560. 3-methyladenine 20-35 microtubule associated protein 1 light chain 3 alpha Homo sapiens 127-130 19258012-6 2009 In this connection, 3-methyladenine, a Class III phosphoinositide 3-kinase inhibitor, significantly abolished the formation of LC3(+) autophagic vacuoles and the processing of LC3 induced by sc-560. 3-methyladenine 20-35 microtubule associated protein 1 light chain 3 alpha Homo sapiens 176-179 18174255-7 2008 Autophagy inhibition at an early stage by 3-methyl adenine inhibited the AVO formation and LC3 localization with an enhancement in cell death. 3-methyladenine 42-58 microtubule associated protein 1 light chain 3 alpha Homo sapiens 91-94 18299661-6 2008 GST-MDA-7 caused PERK-dependent vacuolization of LC3-expressing endosomes whose formation was suppressed by incubation with 3-methyladenine, expression of HSP70 or of BiP/GRP78, or by knockdown of ATG5 or Beclin 1 expression, but not by inhibition of the JNK1-3 pathway. 3-methyladenine 124-139 microtubule associated protein 1 light chain 3 alpha Homo sapiens 49-52 18281515-8 2008 GST-MDA-7 caused PERK-dependent vacuolization of LC3-expressing endosomes whose formation was suppressed by incubation with 3-methyladenine, expression of HSP70 or BiP/GRP78, or knockdown of ATG5 or Beclin-1 expression but not by inhibition of the JNK1-3 pathway. 3-methyladenine 124-139 microtubule associated protein 1 light chain 3 alpha Homo sapiens 49-52 16740722-4 2006 Treatment of cells with a specific inhibitor of autophagy (3-methyladenine) attenuated localization of LC3 to autophagosomes but exacerbated cytosolic release of cytochrome c as well as apoptotic cell death as revealed by analysis of subdiploid fraction and cytoplasmic histone-associated DNA fragmentation. 3-methyladenine 59-74 microtubule associated protein 1 light chain 3 alpha Homo sapiens 103-106 34127226-4 2021 Further studies show that fucoidan promotes autophagy showed by the expression of p62/SQSTM1 and microtubule-associated protein light chain 3 (LC3) II, which can be blocked by autophagy inhibitors 3-MA and bafilomycin A1. 3-methyladenine 197-201 microtubule associated protein 1 light chain 3 alpha Homo sapiens 143-146 14713959-8 2004 When autophagy was prevented at an early stage by 3-methyladenine, a phosphatidylinositol 3-phosphate kinase inhibitor, not only the characteristic pattern of LC3 localization, but also the antitumor effect of TMZ was suppressed. 3-methyladenine 50-65 microtubule associated protein 1 light chain 3 alpha Homo sapiens 159-162 34951247-9 2021 The addition of 3-MA had no effect on the expression of SIRT1 protein, but the expression of SIRT1 and LC3-II proteins decreased and the expression of p62 increased after the addition of EX-527. 3-methyladenine 16-20 microtubule associated protein 1 light chain 3 alpha Homo sapiens 103-106 34938341-10 2021 The expression of autophagy-related proteins LC3 (LC3II/LC3I) and P62 was, respectively, downregulated and upregulated after ZnS or 3-MA treatment. 3-methyladenine 132-136 microtubule associated protein 1 light chain 3 alpha Homo sapiens 45-48 34938341-10 2021 The expression of autophagy-related proteins LC3 (LC3II/LC3I) and P62 was, respectively, downregulated and upregulated after ZnS or 3-MA treatment. 3-methyladenine 132-136 microtubule associated protein 1 light chain 3 alpha Homo sapiens 50-60 33349212-20 2021 Furthermore, Western blot showed that expression of Beclin1, lc3-I, lc3-II, atg-5 protein decreased significantly after 3-MA intervention, while the expression of p62 up-regulated, which also confirmed autophagy flow was blocked. 3-methyladenine 120-124 microtubule associated protein 1 light chain 3 alpha Homo sapiens 61-64 34045875-6 2021 Results: EGF treatment significantly increased the protein expression level of LC3 and decreased the protein level of P62 in HG-stimulated podocytes, which was attenuated by autophagy inhibitor, 3-methyladenine. 3-methyladenine 195-210 microtubule associated protein 1 light chain 3 alpha Homo sapiens 79-82 33749503-4 2021 Our data revealed that LC3-II formation and SQSTM1/p62 degradation were noted in H2O2-activated human platelets, which could be blocked by 3-methyladenine and bafilomycin A1, indicating that platelet activation may cause platelet autophagy. 3-methyladenine 139-154 microtubule associated protein 1 light chain 3 alpha Homo sapiens 23-26 33788710-9 2021 In addition, pre-treatment of PC-3 cells with specific inhibitor of autophagy (3-methyladenine) and co-treatment with alpha-santalol attenuated the expression of LC3-II and phospho-AKT, and significantly reduced the cell viability. 3-methyladenine 79-94 microtubule associated protein 1 light chain 3 alpha Homo sapiens 162-165 33870866-7 2021 Subsequent findings revealed that autophagosome accumulation was caused by the inhibition of autophagy flux by transfection mRFP-GFP-LC3 adenovirus in the presence of autophagy inhibitor 3-MA and CQ. 3-methyladenine 187-191 microtubule associated protein 1 light chain 3 alpha Homo sapiens 133-136 33349212-20 2021 Furthermore, Western blot showed that expression of Beclin1, lc3-I, lc3-II, atg-5 protein decreased significantly after 3-MA intervention, while the expression of p62 up-regulated, which also confirmed autophagy flow was blocked. 3-methyladenine 120-124 microtubule associated protein 1 light chain 3 alpha Homo sapiens 68-71 32895198-12 2020 3-MA significantly inhibited the EV71-induced autophagy of THP-1 macrophages and reduced LC3 conversion (LC3-II/LC3-I) and p62 protein expression at 8 h after EV71 infection (P < 0.01). 3-methyladenine 0-4 microtubule associated protein 1 light chain 3 alpha Homo sapiens 89-92 33155911-16 2020 The ratios of LC3-II to LC3-Iwere significantly lower in the 3-MA treated OGD group than in the non-3-MA treated OGD group (p<0.05). 3-methyladenine 61-65 microtubule associated protein 1 light chain 3 alpha Homo sapiens 14-17 32099325-9 2020 3-methyladenine (3-MA) significantly decreased LC3 (LC3II)+ puncta, but genipin rescuect 3d this reduction. 3-methyladenine 0-15 microtubule associated protein 1 light chain 3 alpha Homo sapiens 47-50 32099325-9 2020 3-methyladenine (3-MA) significantly decreased LC3 (LC3II)+ puncta, but genipin rescuect 3d this reduction. 3-methyladenine 0-15 microtubule associated protein 1 light chain 3 alpha Homo sapiens 52-57 32099325-9 2020 3-methyladenine (3-MA) significantly decreased LC3 (LC3II)+ puncta, but genipin rescuect 3d this reduction. 3-methyladenine 17-21 microtubule associated protein 1 light chain 3 alpha Homo sapiens 47-50 32099325-9 2020 3-methyladenine (3-MA) significantly decreased LC3 (LC3II)+ puncta, but genipin rescuect 3d this reduction. 3-methyladenine 17-21 microtubule associated protein 1 light chain 3 alpha Homo sapiens 52-57 33155911-16 2020 The ratios of LC3-II to LC3-Iwere significantly lower in the 3-MA treated OGD group than in the non-3-MA treated OGD group (p<0.05). 3-methyladenine 61-65 microtubule associated protein 1 light chain 3 alpha Homo sapiens 24-27 31949972-7 2019 We found that postconditioning with dexmedetomidine and 3-methyladenine (3MA, an autophagy inhibitor) increased the cell survival meanwhile reduced the production of autophagic vesicles and the expression of LC3 and Beclin 1. 3-methyladenine 56-71 microtubule associated protein 1 light chain 3 alpha Homo sapiens 208-211 31949972-7 2019 We found that postconditioning with dexmedetomidine and 3-methyladenine (3MA, an autophagy inhibitor) increased the cell survival meanwhile reduced the production of autophagic vesicles and the expression of LC3 and Beclin 1. 3-methyladenine 73-76 microtubule associated protein 1 light chain 3 alpha Homo sapiens 208-211 30693689-7 2018 When curcumin and 3-MA were given concurrently, the number of surviving dopamine neurons, protein expression of TFEB, LAMP2A and LC3-II increased (P<0.05 or P<0.01), and both protein expression and mRNA expression of alpha-Syn decreased (P<0.05 or P<0.01) compared with MPTP model group; but the number of surviving dopamine neurons and protein expression of LAMP2A and LC3-II decreased compared with curcumin group (all P<0.05). 3-methyladenine 18-22 microtubule associated protein 1 light chain 3 alpha Homo sapiens 129-132 30221728-5 2018 Treatment with pristimerin dose-dependently induced an increase of light chain 3B (LC3-II), whereas autophagy inhibitor 3-methyladenine (3-MA) inhibited pristimerin-induced LC3-II accumulation and cytotoxic effects. 3-methyladenine 120-135 microtubule associated protein 1 light chain 3 alpha Homo sapiens 173-176 30221728-5 2018 Treatment with pristimerin dose-dependently induced an increase of light chain 3B (LC3-II), whereas autophagy inhibitor 3-methyladenine (3-MA) inhibited pristimerin-induced LC3-II accumulation and cytotoxic effects. 3-methyladenine 137-141 microtubule associated protein 1 light chain 3 alpha Homo sapiens 173-176 30221728-9 2018 Treatment with 3-MA inhibited LC3-II accumulation and cell death induced by a combination of paclitaxel and pristimerin. 3-methyladenine 15-19 microtubule associated protein 1 light chain 3 alpha Homo sapiens 30-33 30116320-9 2018 Inhibiting autophagy using 3-MA, resulted in a significant decrease in LC3-II, beclin-1 and LDH, as well as increase in the expression of BIP, CHOP, caspase 3, cleaved caspase 3 and Bax. 3-methyladenine 27-31 microtubule associated protein 1 light chain 3 alpha Homo sapiens 71-74 30693689-7 2018 When curcumin and 3-MA were given concurrently, the number of surviving dopamine neurons, protein expression of TFEB, LAMP2A and LC3-II increased (P<0.05 or P<0.01), and both protein expression and mRNA expression of alpha-Syn decreased (P<0.05 or P<0.01) compared with MPTP model group; but the number of surviving dopamine neurons and protein expression of LAMP2A and LC3-II decreased compared with curcumin group (all P<0.05). 3-methyladenine 18-22 microtubule associated protein 1 light chain 3 alpha Homo sapiens 370-373 28934130-7 2017 To clarify the role of autophagy and apoptosis in the effect of ISL, we used the autophagy inhibitor-3-methyladenine (3-MA) to attenuate the punctate fluorescence staining pattern of the p62/sequestosome 1 (SQSTM1, red fluorescence) and LC3 (green fluorescence) proteins after ISL treatment, and 3-MA inhibited the cytotoxicity of ISL. 3-methyladenine 101-116 microtubule associated protein 1 light chain 3 alpha Homo sapiens 237-240 28944925-9 2017 Furthermore, the expression levels of LC3-II and Atg7 in HK-2 cells were significantly upregulated by iohexol administration; however, LC3-II and Atg7 expression was decreased by 3-MA treatment. 3-methyladenine 179-183 microtubule associated protein 1 light chain 3 alpha Homo sapiens 38-41 28944925-9 2017 Furthermore, the expression levels of LC3-II and Atg7 in HK-2 cells were significantly upregulated by iohexol administration; however, LC3-II and Atg7 expression was decreased by 3-MA treatment. 3-methyladenine 179-183 microtubule associated protein 1 light chain 3 alpha Homo sapiens 135-138 29207188-12 2018 In contrast, GA-induced LC3 conversion was significantly inhibited by 3 methlyadenine (3MA), an inhibitor of PI3K-regulated autophagy. 3-methyladenine 87-90 microtubule associated protein 1 light chain 3 alpha Homo sapiens 24-27 28934130-7 2017 To clarify the role of autophagy and apoptosis in the effect of ISL, we used the autophagy inhibitor-3-methyladenine (3-MA) to attenuate the punctate fluorescence staining pattern of the p62/sequestosome 1 (SQSTM1, red fluorescence) and LC3 (green fluorescence) proteins after ISL treatment, and 3-MA inhibited the cytotoxicity of ISL. 3-methyladenine 118-122 microtubule associated protein 1 light chain 3 alpha Homo sapiens 237-240 27735867-6 2016 An increase in LC3-II levels was also observed, which was reverted by 3-methyladenine (3-MA) (an early stage autophagy-inhibitor) but further increased by E-64d/pepstatin (late-stage autophagy inhibitors). 3-methyladenine 70-85 microtubule associated protein 1 light chain 3 alpha Homo sapiens 15-18 28612524-8 2017 Exposure to 3-MA was also associated with lower expressions of LC3 and Beclin1, with HepG2 cells showing typical apoptotic characteristics. 3-methyladenine 12-16 microtubule associated protein 1 light chain 3 alpha Homo sapiens 63-66 28659924-7 2017 Consistently, the addition of 3-MA, an inhibitor of LC3-related autophagy, partially restored macrophage polarization. 3-methyladenine 30-34 microtubule associated protein 1 light chain 3 alpha Homo sapiens 52-55 27735867-6 2016 An increase in LC3-II levels was also observed, which was reverted by 3-methyladenine (3-MA) (an early stage autophagy-inhibitor) but further increased by E-64d/pepstatin (late-stage autophagy inhibitors). 3-methyladenine 87-91 microtubule associated protein 1 light chain 3 alpha Homo sapiens 15-18 26112695-13 2016 3-MA attenuated the increased expression of LC3-II and eosinophil cationic protein in HL-60 cells induced by IL-5 (P = 0.034 for both). 3-methyladenine 0-4 microtubule associated protein 1 light chain 3 alpha Homo sapiens 44-47 30090427-6 2016 Verified by the autophagy inhibitor 3-MA, the expression of LC3 and SQSTM1/p62 was upregulated in nano-scale silica particles in a size- and dose-dependent manner, while the micro-scale particles had an inhibitory effect. 3-methyladenine 36-40 microtubule associated protein 1 light chain 3 alpha Homo sapiens 60-63 26943028-5 2016 Inhibiting MB-induced autophagy with the autophagy inhibitor 3-methyladenine (3-MA) significantly decreased apoptosis, with a reduction of growth inhibition; inhibiting MB-induced apoptosis with the pan-caspase inhibitor Z-VAD-FMK did not decrease autophagy but elevated LC3-II levels, indicating that MB-induced autophagy is cytotoxic and may be upstream of apoptosis. 3-methyladenine 61-76 microtubule associated protein 1 light chain 3 alpha Homo sapiens 271-274 26943028-5 2016 Inhibiting MB-induced autophagy with the autophagy inhibitor 3-methyladenine (3-MA) significantly decreased apoptosis, with a reduction of growth inhibition; inhibiting MB-induced apoptosis with the pan-caspase inhibitor Z-VAD-FMK did not decrease autophagy but elevated LC3-II levels, indicating that MB-induced autophagy is cytotoxic and may be upstream of apoptosis. 3-methyladenine 78-82 microtubule associated protein 1 light chain 3 alpha Homo sapiens 271-274 26496360-11 2015 An autophagy inhibitor, methyladenine (3-MA) induced death and attenuated the level of elevated LC3 in MCF-7/TAM cells. 3-methyladenine 39-43 microtubule associated protein 1 light chain 3 alpha Homo sapiens 96-99 24970676-8 2014 The transformation of LC3-I to LC3-II which was induced by TM, was reversed following treatment with 3-MA. 3-methyladenine 101-105 microtubule associated protein 1 light chain 3 alpha Homo sapiens 22-25 25216025-7 2015 Pre-treatment of the cells with class III PI3K inhibitor 3-methyladenine or Atg5 shRNA attenuated JA-induced LC3-II expression and LC3 puncta formation, indicating the involvement of class III PI3K and Atg5. 3-methyladenine 57-72 microtubule associated protein 1 light chain 3 alpha Homo sapiens 109-112 25216025-7 2015 Pre-treatment of the cells with class III PI3K inhibitor 3-methyladenine or Atg5 shRNA attenuated JA-induced LC3-II expression and LC3 puncta formation, indicating the involvement of class III PI3K and Atg5. 3-methyladenine 57-72 microtubule associated protein 1 light chain 3 alpha Homo sapiens 131-134 25948188-8 2015 Compared with the YM155 group, the protein levels of LC-3 and caspase-3 were lower in YM155 combined with 3-MA group. 3-methyladenine 106-110 microtubule associated protein 1 light chain 3 alpha Homo sapiens 53-57 25132643-8 2014 Co-treating cells with 2",3"-DMF and 3-methyladenine, an inhibitor of LC3 lipidation, reduced the activation of caspase-8. 3-methyladenine 37-52 microtubule associated protein 1 light chain 3 alpha Homo sapiens 70-73 25295079-4 2014 In addition, western blot analysis was performed to determine the effect of 3-methyl adenine (3-MA) activity on the inhibition of autophagy, SB203580 inhibition of the p38-mitogen-activated protein kinase (MAPK) pathway, and Beclin 1, LC3, p62, p38 and phosphorylated (p)-p38 protein expression. 3-methyladenine 94-98 microtubule associated protein 1 light chain 3 alpha Homo sapiens 235-238 24970676-8 2014 The transformation of LC3-I to LC3-II which was induced by TM, was reversed following treatment with 3-MA. 3-methyladenine 101-105 microtubule associated protein 1 light chain 3 alpha Homo sapiens 31-34 24359187-6 2014 In the G93A-NSC cells, there was a more marked accumulation of the LC3-II autophagy protein, attributable to autophagic stress; 3-methyladenine, which acts on initiation of autophagy, fully rescued G93A-NSC viability and reduced the activation of caspase 3/7 indicating this was a secondary event; the metabolic handling of hypoxia was inappropriate possibly contributing to the autophagic stress. 3-methyladenine 128-143 microtubule associated protein 1 light chain 3 alpha Homo sapiens 67-70 25034786-2 2014 In the present study, clioquinol was found to trigger autophagy by inducing LC3 lipidation and autophagosome formation which was abolished by an autophagy inhibitor 3-methyladenine. 3-methyladenine 165-180 microtubule associated protein 1 light chain 3 alpha Homo sapiens 76-79 23525265-4 2013 Pretreatment of 1321N1 astrocytoma cells with 3-MA (5 mmol/L) decreased the PCN-induced acidic vesicular organelle and autophagosome formation as measured using acridine orange and green fluorescent protein-LC3 -LC3 fluorescence, respectively. 3-methyladenine 46-50 microtubule associated protein 1 light chain 3 alpha Homo sapiens 207-210 23525265-4 2013 Pretreatment of 1321N1 astrocytoma cells with 3-MA (5 mmol/L) decreased the PCN-induced acidic vesicular organelle and autophagosome formation as measured using acridine orange and green fluorescent protein-LC3 -LC3 fluorescence, respectively. 3-methyladenine 46-50 microtubule associated protein 1 light chain 3 alpha Homo sapiens 212-215 23663345-6 2013 SFN-induced LC3-II protein could be attenuated and enhanced by 3-MA and Rapa respectively. 3-methyladenine 63-67 microtubule associated protein 1 light chain 3 alpha Homo sapiens 12-15 23372817-7 2013 Autophagic inhibitor 3-methyladenine (3-MA) decreased LC3-II levels, reduced the infarct volume, and mimicked some protective effect of 15d-PGJ(2) against cerebral I/R injury. 3-methyladenine 21-36 microtubule associated protein 1 light chain 3 alpha Homo sapiens 54-57 23372817-7 2013 Autophagic inhibitor 3-methyladenine (3-MA) decreased LC3-II levels, reduced the infarct volume, and mimicked some protective effect of 15d-PGJ(2) against cerebral I/R injury. 3-methyladenine 38-42 microtubule associated protein 1 light chain 3 alpha Homo sapiens 54-57 23866663-10 2013 The protein level of beclin-1 and the ratio of LC3 II to LC3 I in cells pretreated with 3-MA were reduced, while that of p62 was increased. 3-methyladenine 88-92 microtubule associated protein 1 light chain 3 alpha Homo sapiens 47-50 23866663-10 2013 The protein level of beclin-1 and the ratio of LC3 II to LC3 I in cells pretreated with 3-MA were reduced, while that of p62 was increased. 3-methyladenine 88-92 microtubule associated protein 1 light chain 3 alpha Homo sapiens 57-60 23354080-7 2013 Inhibition of autophagy by 3-methyl-adenine (an inhibitor of class III phosphatidylinositol-3 kinase; 3-MA) reduced the cleavage of LC3 in T24 cells after baicalin treatment. 3-methyladenine 27-43 microtubule associated protein 1 light chain 3 alpha Homo sapiens 132-135