PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30260385-9 2018 The induction of apoptosis and Caspase 3 activity by SAC, DADS and DTS were increased by stably knocking down of ATG5 expression with shRNA in RAW264.7 cells or treating with 5 mM 3-MA in primary macrophages. 3-methyladenine 180-184 caspase 3 Mus musculus 31-40 31091975-7 2019 Pretreatment of neuro-2a cells with 3-methyladenine, an inhibitor of autophagy, attenuated honokiol-induced cell autophagy, caspase-3 activation, DNA damage and cell apoptosis. 3-methyladenine 36-51 caspase 3 Mus musculus 124-133 33352257-6 2021 Further analysis indicated that a certain dosage of 3-MA and rapamycin decreased apoptosis and the caspase-3 expression, which suggested that As-induced autophagy regulated AML-12 cells apoptosis through the expressions of PI3K, mTOR, P62 and Bcl-2. 3-methyladenine 52-56 caspase 3 Mus musculus 99-108 29259166-10 2017 Inhibition of autophagy by 3-MA suppressed autophagosome formation, reduced the apoptotic activation (cleaved caspase-3 and Bcl2) and the appearance of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive neurons, underlining that apoptosis and autophagy pathways are intricately intertwined. 3-methyladenine 27-31 caspase 3 Mus musculus 110-119 28634253-14 2017 TNF-alpha-mediated induction of cleaved caspase-3 was downregulated by rapamycin, but upregulated by 3-MA, respectively. 3-methyladenine 101-105 caspase 3 Mus musculus 40-49 25795167-8 2015 In vivo, 3-MA blocks the rapid increase in caspase-3 cleavage induced by the blockade of NMDA receptors and prevents the resulting long-term decrease in Gad67-GFP neurons in layers II-IV. 3-methyladenine 9-13 caspase 3 Mus musculus 43-52 24359187-6 2014 In the G93A-NSC cells, there was a more marked accumulation of the LC3-II autophagy protein, attributable to autophagic stress; 3-methyladenine, which acts on initiation of autophagy, fully rescued G93A-NSC viability and reduced the activation of caspase 3/7 indicating this was a secondary event; the metabolic handling of hypoxia was inappropriate possibly contributing to the autophagic stress. 3-methyladenine 128-143 caspase 3 Mus musculus 247-258 24122153-9 2014 Moreover, both 3-MA and necrostatin-1 treatment could suppress cleaved caspase-3 and LC3-II production, whereas zVAD treatment could inhibit caspase-3 cleavage but increased LC3-II protein levels at 72 h after ICH. 3-methyladenine 15-19 caspase 3 Mus musculus 71-80 35175747-9 2022 Further, the autophagy activator rapamycin (Rap) and the inhibitor 3-methylademine (3-MA) were introduced, which showed that the apoptosis rate and the ratio of Bax/Bcl-2 as well as the protein expression level of cleaved caspase-3 increased significantly with the pretreatment of Rap and decreased remarkably with the pretreatment of 3-MA. 3-methyladenine 84-88 caspase 3 Mus musculus 222-231 28863387-7 2017 The levels of caspase-3, -9, -12 expression in both mRNA and protein in oocytes vitrified with 3-methyladenine were significantly higher than that vitrified without 3-methyladenine. 3-methyladenine 95-110 caspase 3 Mus musculus 14-27 28863387-7 2017 The levels of caspase-3, -9, -12 expression in both mRNA and protein in oocytes vitrified with 3-methyladenine were significantly higher than that vitrified without 3-methyladenine. 3-methyladenine 165-180 caspase 3 Mus musculus 14-27 26557017-8 2015 However, pretreatment with 3-methyladenine (3MA), the specific inhibitor for autophagy, decreased cell viability, whereas increased the cleavage of PARP and caspase-3 in the SNP-treated MC3T3-E1 cells. 3-methyladenine 27-42 caspase 3 Mus musculus 157-166 26557017-8 2015 However, pretreatment with 3-methyladenine (3MA), the specific inhibitor for autophagy, decreased cell viability, whereas increased the cleavage of PARP and caspase-3 in the SNP-treated MC3T3-E1 cells. 3-methyladenine 44-47 caspase 3 Mus musculus 157-166 22736198-10 2012 Both 3-MA and NEC-1 suppressed TBI-induced caspase-3 activation and LC3-II formation, Z-VAD only inhibited caspase-3 activation but increased LC3-II expression at 24 h post-TBI. 3-methyladenine 5-9 caspase 3 Mus musculus 43-52 33380391-4 2020 The effect of 3-MA treatment for 24 h on LPS-induced apoptosis of mDPC-23 cells was evaluated by detecting the expressions of apoptosis-related proteins caspase-3 and Bax using Western blotting. 3-methyladenine 14-18 caspase 3 Mus musculus 153-162 33380391-7 2020 Treatment with 3-MA markedly lowered caspase-3 and Bax protein expressions in LPS-stimulated cells (P < 0.05). 3-methyladenine 15-19 caspase 3 Mus musculus 37-46 32545902-9 2020 Addition of 3MA caused a significant increase of P62, superoxides, and caspase 3/7 activities in the 661 W cells cultured in high glucose but not in low glucose. 3-methyladenine 12-15 caspase 3 Mus musculus 71-82 32882870-14 2020 Whereas, 3-methyladenine/chloroquine weakened FKB+doxorubicin-induced apoptosis (decreased DNA fragmentation/caspase-3). 3-methyladenine 9-24 caspase 3 Mus musculus 109-118 31892570-8 2020 Finally, the combined treatment of 3-MA or CQ with DDP further up-regulated DDP-induced caspase-3 activity in vitro and exhibited synergistic anti-tumor effects on mice. 3-methyladenine 35-39 caspase 3 Mus musculus 88-97