PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29749471-9	2018	Furthermore, blockade of temozolomide (TMZ)-induced autophagy by 3-methyladenine (3-MA) resulted in enhanced activation of apoptotic markers, as well as tumor suppresor protein p53 (p53) expression in U87MG cells.	3-methyladenine	82-86	tumor protein p53	Homo sapiens	177-180	
29749471-9	2018	Furthermore, blockade of temozolomide (TMZ)-induced autophagy by 3-methyladenine (3-MA) resulted in enhanced activation of apoptotic markers, as well as tumor suppresor protein p53 (p53) expression in U87MG cells.	3-methyladenine	82-86	tumor protein p53	Homo sapiens	182-185	
29492901-11	2018	CONCLUSIONS: From our results we conclude that DENSpm-induced apoptotic cell death is increased when autophagy is inhibited by 3-MA or Beclin-1 siRNA through PA depletion and PA catabolic activation in colon cancer cells, regardless p53 mutation status.	3-methyladenine	127-131	tumor protein p53	Homo sapiens	233-236	
24173208-13	2014	Following 3-MA pretreatment, cisplatin-induced autophagy was found to be markedly reduced (a 3-fold reduction) in wild-type p53 compared to null-type p53 cells.	3-methyladenine	10-14	tumor protein p53	Homo sapiens	124-127	
26021729-8	2015	3-MA and Atg5 siRNA increased the ox-LDL-induced increases of the p53 protein level and the annexin V-positive staining, which was decreased by z-vad-fmk.	3-methyladenine	0-4	tumor protein p53	Homo sapiens	66-69	
19337030-4	2009	Furthermore, we found that pretreatment with the autophagy inhibitor 3-methyladenine or beclin 1 siRNA further activated p53 and its downstream apoptotic pathways, while the autophagy inducer rapamycin showed the opposite effects.	3-methyladenine	69-84	tumor protein p53	Homo sapiens	121-124	
23238993-6	2013	The protective role of autophagy in cell growth inhibition by CP-31398 and RITA is supported by the finding that the AMPK inhibitor compound C or the autophagy inhibitors chloroquine or 3-methyladenine sensitize both pancreatic adenocarcinoma cell lines to the apoptotic response induced by p53-reactivating molecules.	3-methyladenine	186-201	tumor protein p53	Homo sapiens	291-294	
21262221-6	2011	Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy.	3-methyladenine	47-51	tumor protein p53	Homo sapiens	90-93	
21262221-6	2011	Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy.	3-methyladenine	47-51	tumor protein p53	Homo sapiens	198-201	
21262221-7	2011	In addition, we also found that 3-MA efficiently abrogated silibinin"s cyto-protective effect against mitomycin C-induced cell death, and reversed the suppressive efficacy of silibinin on p53 expression, suggesting that autophagy contributed to silibinin"s cyto-protective effect against mitomycin C-induced cell death in A375-S2 cells.	3-methyladenine	32-36	tumor protein p53	Homo sapiens	188-191	
21262221-6	2011	Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy.	3-methyladenine	30-45	tumor protein p53	Homo sapiens	90-93	
21262221-6	2011	Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy.	3-methyladenine	30-45	tumor protein p53	Homo sapiens	198-201	
9479003-4	1998	Moreover, we established that 3-methyladenine, a relatively minor DNA lesion produced by most methylating agents (which form mainly 7-methylguanine), can specifically induce sister chromatid exchange, chromatid and chromosome gaps and breaks, S phase arrest, the accumulation of p53, and apoptosis.	3-methyladenine	30-45	tumor protein p53	Homo sapiens	279-282