PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23238993-6 2013 The protective role of autophagy in cell growth inhibition by CP-31398 and RITA is supported by the finding that the AMPK inhibitor compound C or the autophagy inhibitors chloroquine or 3-methyladenine sensitize both pancreatic adenocarcinoma cell lines to the apoptotic response induced by p53-reactivating molecules. 3-methyladenine 186-201 tumor protein p53 Homo sapiens 291-294 29492901-11 2018 CONCLUSIONS: From our results we conclude that DENSpm-induced apoptotic cell death is increased when autophagy is inhibited by 3-MA or Beclin-1 siRNA through PA depletion and PA catabolic activation in colon cancer cells, regardless p53 mutation status. 3-methyladenine 127-131 tumor protein p53 Homo sapiens 233-236 29749471-9 2018 Furthermore, blockade of temozolomide (TMZ)-induced autophagy by 3-methyladenine (3-MA) resulted in enhanced activation of apoptotic markers, as well as tumor suppresor protein p53 (p53) expression in U87MG cells. 3-methyladenine 82-86 tumor protein p53 Homo sapiens 177-180 29749471-9 2018 Furthermore, blockade of temozolomide (TMZ)-induced autophagy by 3-methyladenine (3-MA) resulted in enhanced activation of apoptotic markers, as well as tumor suppresor protein p53 (p53) expression in U87MG cells. 3-methyladenine 82-86 tumor protein p53 Homo sapiens 182-185 26021729-8 2015 3-MA and Atg5 siRNA increased the ox-LDL-induced increases of the p53 protein level and the annexin V-positive staining, which was decreased by z-vad-fmk. 3-methyladenine 0-4 tumor protein p53 Homo sapiens 66-69 24173208-13 2014 Following 3-MA pretreatment, cisplatin-induced autophagy was found to be markedly reduced (a 3-fold reduction) in wild-type p53 compared to null-type p53 cells. 3-methyladenine 10-14 tumor protein p53 Homo sapiens 124-127 21262221-6 2011 Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy. 3-methyladenine 30-45 tumor protein p53 Homo sapiens 90-93 21262221-6 2011 Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy. 3-methyladenine 47-51 tumor protein p53 Homo sapiens 90-93 21262221-6 2011 Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy. 3-methyladenine 30-45 tumor protein p53 Homo sapiens 198-201 21262221-6 2011 Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy. 3-methyladenine 47-51 tumor protein p53 Homo sapiens 198-201 21262221-7 2011 In addition, we also found that 3-MA efficiently abrogated silibinin"s cyto-protective effect against mitomycin C-induced cell death, and reversed the suppressive efficacy of silibinin on p53 expression, suggesting that autophagy contributed to silibinin"s cyto-protective effect against mitomycin C-induced cell death in A375-S2 cells. 3-methyladenine 32-36 tumor protein p53 Homo sapiens 188-191 9479003-4 1998 Moreover, we established that 3-methyladenine, a relatively minor DNA lesion produced by most methylating agents (which form mainly 7-methylguanine), can specifically induce sister chromatid exchange, chromatid and chromosome gaps and breaks, S phase arrest, the accumulation of p53, and apoptosis. 3-methyladenine 30-45 tumor protein p53 Homo sapiens 279-282 19337030-4 2009 Furthermore, we found that pretreatment with the autophagy inhibitor 3-methyladenine or beclin 1 siRNA further activated p53 and its downstream apoptotic pathways, while the autophagy inducer rapamycin showed the opposite effects. 3-methyladenine 69-84 tumor protein p53 Homo sapiens 121-124