PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26102024-5	2015	3-methyladenine (3-MA) inhibited occurrence of autophagy and it leaded to the accumulation of damaged-mitochondria-producing-ROS, and the activation of NLRP3 inflammasome, and subsequently, caused IL-1beta secretion.	3-methyladenine	0-15	interleukin 1 beta	Homo sapiens	197-205	
26102024-5	2015	3-methyladenine (3-MA) inhibited occurrence of autophagy and it leaded to the accumulation of damaged-mitochondria-producing-ROS, and the activation of NLRP3 inflammasome, and subsequently, caused IL-1beta secretion.	3-methyladenine	17-21	interleukin 1 beta	Homo sapiens	197-205	
22972933-4	2012	Dendritic cells treated with LPS and 3-methyladenine secreted enhanced levels of both IL-1beta and IL-23, and supernatants from these cells stimulated the innate secretion of IL-17, IFN-gamma, and IL-22 by gammadelta T cells.	3-methyladenine	37-52	interleukin 1 beta	Homo sapiens	86-94	
28990778-8	2017	Compared with the BaP group, the autophagy inhibitor 3-MA significantly (p < 0.01) inhibited the release of LDH by 70.53% +- 0.46 and NO by 50.36% +- 0.80, the increase of electrical conductivity by 12.08% +- 0.55, and the expressions of pyroptotic marker proteins (Caspase-1, Cox-2, IL-1beta, IL-18).	3-methyladenine	53-57	interleukin 1 beta	Homo sapiens	287-295	
22155150-7	2012	Autophagic inhibitor 3-methyladenine (3-MA) decreased phagocytosis and the expression of ERK whereas increased the expression of NF-kappaB- and caspase-1-mediated IL-1beta release.	3-methyladenine	21-36	interleukin 1 beta	Homo sapiens	163-171	
22155150-7	2012	Autophagic inhibitor 3-methyladenine (3-MA) decreased phagocytosis and the expression of ERK whereas increased the expression of NF-kappaB- and caspase-1-mediated IL-1beta release.	3-methyladenine	38-42	interleukin 1 beta	Homo sapiens	163-171	
31592908-4	2019	The normal human chondrocyte pre-treated with rapamycin or 3-methyladenine, treated with interleukin-1beta (IL-1beta).	3-methyladenine	59-74	interleukin 1 beta	Homo sapiens	89-106	
31592908-4	2019	The normal human chondrocyte pre-treated with rapamycin or 3-methyladenine, treated with interleukin-1beta (IL-1beta).	3-methyladenine	59-74	interleukin 1 beta	Homo sapiens	108-116	
29915584-8	2018	In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production.	3-methyladenine	67-82	interleukin 1 beta	Homo sapiens	240-248	
29915584-8	2018	In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production.	3-methyladenine	84-88	interleukin 1 beta	Homo sapiens	240-248	
22972931-4	2012	We found that 3-MA could enhance LPS-induced NF-kappaB activation and production of TNF-alpha, inducible NO synthase (iNOS), cyclooxygenase-2, IL-1beta, and IL-12.	3-methyladenine	14-18	interleukin 1 beta	Homo sapiens	143-151	
22972931-8	2012	3-MA was found to enhance LPS-induced NF-kappaB activation, iNOS, and pro-IL-1beta expression, and these actions were reversed by either GSK3beta inhibitors or small interfering GSK3beta.	3-methyladenine	0-4	interleukin 1 beta	Homo sapiens	70-82	
29515581-5	2018	Our findings indicated that inhibition of autophagy with 3-methyladenine and Wortmannin markedly reduced IL-1beta secretion induced by LPS + ATP, as did the disruption of the autophagic flux with Bafilomycin A1 and E64d.	3-methyladenine	57-72	interleukin 1 beta	Homo sapiens	105-113	
28120948-7	2017	However, pretreatment with the autophagy inhibitor 3-methyladenine showed the potential in further elevating the apoptosis rate induced by IL-1beta in NP cells.	3-methyladenine	51-66	interleukin 1 beta	Homo sapiens	139-147	
28963466-3	2017	TNFalpha and IL-1beta induced autophagy markers in human umbilical vein endothelial cells and inhibition of autophagy by 3-methyladenine (3-MA) blocked adhesion of Jurkat lymphocytes.	3-methyladenine	121-136	interleukin 1 beta	Homo sapiens	13-21	
28963466-3	2017	TNFalpha and IL-1beta induced autophagy markers in human umbilical vein endothelial cells and inhibition of autophagy by 3-methyladenine (3-MA) blocked adhesion of Jurkat lymphocytes.	3-methyladenine	138-142	interleukin 1 beta	Homo sapiens	13-21	
28714008-8	2017	In contrast, after autophagy inhibited by 3-methyladenine, chondrocyte apoptosis was further increased under IL-1beta treatment.	3-methyladenine	42-57	interleukin 1 beta	Homo sapiens	109-117