PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33887379-7 2021 Furthermore, the PI3K inhibitor (LY294002 or 3-MA) and/or PAP reversed the Cd-induced upregulated expression of LC3 II, Beclin-1, and PI3K class III, with a synergy between PI3K inhibitor and PAP against Cd-induced autophagy. 3-methyladenine 45-49 beclin 1, autophagy related Mus musculus 120-128 30651797-11 2019 After 3-MA treatment the expression levels of Beclin1 and LC3-II/I were decreased, compared with CLP group, but accumulation of p62 occurred, and the degree of renal injury was increased. 3-methyladenine 6-10 beclin 1, autophagy related Mus musculus 46-53 31554002-9 2020 3-methyladenine promoted cell viability and ZO-1 expression, down-regulated Beclin-1 and atg5 expression, while Rapamycin (Rap) had an opposite effect. 3-methyladenine 0-15 beclin 1, autophagy related Mus musculus 76-84 28872080-14 2017 Compared with the allicin treatment group, the 7 d survival rate, lung SOD activity, and the expressions of LC3B and Beclin-1 were decreased in the 3-MA group (P<0.05); the lung morphological damage scores, the levels of TNF-alpha and IL-6 in the BALF, and MDA content in the lung were increased significantly in the 3-MA group (P<0.05). 3-methyladenine 148-152 beclin 1, autophagy related Mus musculus 117-125 28962872-6 2017 Caspase-mediated apoptosis by genipin and everolimus is further potentiated by the autophagy inhibitor 3-methyladenine revealing a protective role for Beclin1-mediated autophagy induced by the treatment. 3-methyladenine 103-118 beclin 1, autophagy related Mus musculus 151-158 22222116-7 2012 Knockdown of Beclin 1 by either RNA interference or co-treatment with the autophagy inhibitor, 3-methyladenine(3-MA), significantly enhanced the melatonin-induced apoptosis in mouse hepatoma H22 cells. 3-methyladenine 95-110 beclin 1, autophagy related Mus musculus 13-21 28624177-5 2017 In contrast, light chain 3 II and beclin-1 levels were significantly less and those of cleaved caspase-3 significantly greater in the 3-methyladenine group. 3-methyladenine 134-149 beclin 1, autophagy related Mus musculus 34-42 26964766-11 2016 Simultaneously, both in vivo and in vitro, 3-MA significantly decreased the expression of LC3-II and Beclin-1, and maintained p62 at high level after ICH. 3-methyladenine 43-47 beclin 1, autophagy related Mus musculus 101-109 26501338-11 2015 The 3-MA treatment decreased levels of Beclin-1 and Atg 7 but increased levels of p62 in the ethanol-fed WT and KI mice whereas rapamycin had the opposite effects, validating inhibition and stimulation of autophagy, respectively. 3-methyladenine 4-8 beclin 1, autophagy related Mus musculus 39-47 22222116-7 2012 Knockdown of Beclin 1 by either RNA interference or co-treatment with the autophagy inhibitor, 3-methyladenine(3-MA), significantly enhanced the melatonin-induced apoptosis in mouse hepatoma H22 cells. 3-methyladenine 111-115 beclin 1, autophagy related Mus musculus 13-21 21463664-7 2011 Immunoblotting analysis showed that 3-MA pretreatment reduced post-TBI Beclin-1 and LC3-II levels, and maintained p62/SQSTM1 (p62) levels. 3-methyladenine 36-40 beclin 1, autophagy related Mus musculus 71-79 15558033-5 2004 This non-apoptotic death of double knockout cells was suppressed by inhibitors of autophagy, including 3-methyl adenine, was dependent on autophagic proteins APG5 and Beclin 1 (capable of binding to Bcl-2/Bcl-x(L)), and was also modulated by Bcl-x(L). 3-methyladenine 103-119 beclin 1, autophagy related Mus musculus 167-175 35447319-8 2022 Furthermore, 3-MA causes lower Beclin-1, higher mTOR and p62 on both gene and protein levels, while the expression of t-tau, p-tau, GSK-3beta and CDK5 are upregulated, demonstrating that impaired autophagy disturbs the clearance of tau. 3-methyladenine 13-17 beclin 1, autophagy related Mus musculus 31-39