PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31554002-9	2020	3-methyladenine promoted cell viability and ZO-1 expression, down-regulated Beclin-1 and atg5 expression, while Rapamycin (Rap) had an opposite effect.	3-methyladenine	0-15	beclin 1, autophagy related	Mus musculus	76-84	
33887379-7	2021	Furthermore, the PI3K inhibitor (LY294002 or 3-MA) and/or PAP reversed the Cd-induced upregulated expression of LC3 II, Beclin-1, and PI3K class III, with a synergy between PI3K inhibitor and PAP against Cd-induced autophagy.	3-methyladenine	45-49	beclin 1, autophagy related	Mus musculus	120-128	
28624177-5	2017	In contrast, light chain 3 II and beclin-1 levels were significantly less and those of cleaved caspase-3 significantly greater in the 3-methyladenine group.	3-methyladenine	134-149	beclin 1, autophagy related	Mus musculus	34-42	
28962872-6	2017	Caspase-mediated apoptosis by genipin and everolimus is further potentiated by the autophagy inhibitor 3-methyladenine revealing a protective role for Beclin1-mediated autophagy induced by the treatment.	3-methyladenine	103-118	beclin 1, autophagy related	Mus musculus	151-158	
28872080-14	2017	Compared with the allicin treatment group, the 7 d survival rate, lung SOD activity, and the expressions of LC3B and Beclin-1 were decreased in the 3-MA group (P<0.05); the lung morphological damage scores, the levels of TNF-alpha and IL-6 in the BALF, and MDA content in the lung were increased significantly in the 3-MA group (P<0.05).	3-methyladenine	148-152	beclin 1, autophagy related	Mus musculus	117-125	
30651797-11	2019	After 3-MA treatment the expression levels of Beclin1 and LC3-II/I were decreased, compared with CLP group, but accumulation of p62 occurred, and the degree of renal injury was increased.	3-methyladenine	6-10	beclin 1, autophagy related	Mus musculus	46-53	
21463664-7	2011	Immunoblotting analysis showed that 3-MA pretreatment reduced post-TBI Beclin-1 and LC3-II levels, and maintained p62/SQSTM1 (p62) levels.	3-methyladenine	36-40	beclin 1, autophagy related	Mus musculus	71-79	
26964766-11	2016	Simultaneously, both in vivo and in vitro, 3-MA significantly decreased the expression of LC3-II and Beclin-1, and maintained p62 at high level after ICH.	3-methyladenine	43-47	beclin 1, autophagy related	Mus musculus	101-109	
26501338-11	2015	The 3-MA treatment decreased levels of Beclin-1 and Atg 7 but increased levels of p62 in the ethanol-fed WT and KI mice whereas rapamycin had the opposite effects, validating inhibition and stimulation of autophagy, respectively.	3-methyladenine	4-8	beclin 1, autophagy related	Mus musculus	39-47	
22222116-7	2012	Knockdown of Beclin 1 by either RNA interference or co-treatment with the autophagy inhibitor, 3-methyladenine(3-MA), significantly enhanced the melatonin-induced apoptosis in mouse hepatoma H22 cells.	3-methyladenine	95-110	beclin 1, autophagy related	Mus musculus	13-21	
22222116-7	2012	Knockdown of Beclin 1 by either RNA interference or co-treatment with the autophagy inhibitor, 3-methyladenine(3-MA), significantly enhanced the melatonin-induced apoptosis in mouse hepatoma H22 cells.	3-methyladenine	111-115	beclin 1, autophagy related	Mus musculus	13-21	
15558033-5	2004	This non-apoptotic death of double knockout cells was suppressed by inhibitors of autophagy, including 3-methyl adenine, was dependent on autophagic proteins APG5 and Beclin 1 (capable of binding to Bcl-2/Bcl-x(L)), and was also modulated by Bcl-x(L).	3-methyladenine	103-119	beclin 1, autophagy related	Mus musculus	167-175	
35447319-8	2022	Furthermore, 3-MA causes lower Beclin-1, higher mTOR and p62 on both gene and protein levels, while the expression of t-tau, p-tau, GSK-3beta and CDK5 are upregulated, demonstrating that impaired autophagy disturbs the clearance of tau.	3-methyladenine	13-17	beclin 1, autophagy related	Mus musculus	31-39