PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34052845-8	2021	In vivo, 3-MA and LY294002 repressed Ti particle-stimulated osteolysis and osteoclastogenesis and reduced expression of the pro-inflammatory factors TNF-alpha, IL-1beta, and IL-6.	3-methyladenine	9-13	interleukin 6	Homo sapiens	174-178	
31965901-8	2020	These results revealed the essential role of autophagy in endothelial cell integrity and revealed that the disruption of endothelial autophagy could lead to significant pathological IL6-dependent EndMT and organ fibrosis.Abbreviations: 3-MA: 3-methyladenine; ATG5: autophagy related 5; EndMT: endothelial-to-mesenchymal transition; HES: hematoxylin and eosin stain; HFD: high-fat diet; HMVECs: human microvascular endothelial cells; IFNG: interferon gamma; IL6: interleukin 6; MTS: Masson"s trichrome staining; NFD: normal-fat diet; siRNA: small interfering RNA; SMAD3: SMAD family member 3; TGFB: transforming growth factor beta; TNF: tumor necrosis factor; VEGFA: vascular endothelial growth factor A.	3-methyladenine	242-257	interleukin 6	Homo sapiens	182-185	
35563682-5	2022	Following preconditioning, both Rapa and 3-MA-treated hASCs demonstrated preservation of stemness, as well as upregulated transcription of cyclooxygenase-2 (COX2) and interleukin-6 (IL-6).	3-methyladenine	41-45	interleukin 6	Homo sapiens	167-180	
34565256-5	2021	The results showed that LPS induced NF-kappaB-related pulmonary inflammation in observers and silicosis patients, as confirmed by an increase in the expression of IL-1beta, IL-6, TNF-alpha, and p65, which could be inhibited by 3-MA treatment.	3-methyladenine	227-231	interleukin 6	Homo sapiens	173-177	
34213019-9	2022	The autophagy inhibitor 3-methyladenine (3MA) significantly abrogated the LPS-sustained inflammatory effect by reducing the expression of IL-6, TNF-alpha, COX-2, and ICAM-1 in HGFs.	3-methyladenine	41-44	interleukin 6	Homo sapiens	138-142	
29915584-8	2018	In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production.	3-methyladenine	67-82	interleukin 6	Homo sapiens	253-257	
29915584-8	2018	In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production.	3-methyladenine	84-88	interleukin 6	Homo sapiens	253-257	
25961745-8	2015	3-MA, NAC and DPI inhibited HG-induced interleukin-6 production in BMSCs.	3-methyladenine	0-4	interleukin 6	Homo sapiens	39-52	
34213019-9	2022	The autophagy inhibitor 3-methyladenine (3MA) significantly abrogated the LPS-sustained inflammatory effect by reducing the expression of IL-6, TNF-alpha, COX-2, and ICAM-1 in HGFs.	3-methyladenine	24-39	interleukin 6	Homo sapiens	138-142	
34122411-4	2021	Here we demonstrate that inhibition of autophagy by treatment with 3-methyladenine (3-MA) or by silencing autophagy-related (ATG)5 promoted interleukin (IL)-6-dependent EndMT in human umbilical vein endothelial cells (HUVECs) and human renal glomerular endothelial cells (HRGECs), and autophagy inactivation was associated with EndMT in patients with chronic allograft dysfunction.	3-methyladenine	67-82	interleukin 6	Homo sapiens	140-158	
34122411-4	2021	Here we demonstrate that inhibition of autophagy by treatment with 3-methyladenine (3-MA) or by silencing autophagy-related (ATG)5 promoted interleukin (IL)-6-dependent EndMT in human umbilical vein endothelial cells (HUVECs) and human renal glomerular endothelial cells (HRGECs), and autophagy inactivation was associated with EndMT in patients with chronic allograft dysfunction.	3-methyladenine	84-88	interleukin 6	Homo sapiens	140-158	
34122411-5	2021	IL-6 level was significantly higher in the culture medium of HUVECs transfected with ATG5 siRNA or treated with 3-MA compared to the respective control groups.	3-methyladenine	112-116	interleukin 6	Homo sapiens	0-4	
35563682-5	2022	Following preconditioning, both Rapa and 3-MA-treated hASCs demonstrated preservation of stemness, as well as upregulated transcription of cyclooxygenase-2 (COX2) and interleukin-6 (IL-6).	3-methyladenine	41-45	interleukin 6	Homo sapiens	182-186