PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34010608-8	2021	Inhibiting autophagy with 3-MA reversed the inhibition of NLRP3 inflammasome activation and diminished the neuroprotective effects of Gas6.	3-methyladenine	26-30	NLR family, pyrin domain containing 3	Mus musculus	58-63	
33895270-9	2021	Treatment with 3-MA, an autophagy inhibitor, eliminated the neuroprotective effects of SAHA on improving cognition in mice, activating autophagy and downregulating the NLRP3 inflammasome.	3-methyladenine	15-19	NLR family, pyrin domain containing 3	Mus musculus	168-173	
30918581-11	2019	Using 3-MA, an autophagy inhibitor, the neuroprotective effects of HNK on mitophagy and NLRP3 inflammasome activation were eliminated.	3-methyladenine	6-10	NLR family, pyrin domain containing 3	Mus musculus	88-93	
33987329-8	2021	Furthermore, 3-methyladenine, an autophagy inhibitor, abolished lycopene"s inhibitory effect on the NLRP3 inflammasome in KCs, which led to increased hepatic IR injury.	3-methyladenine	13-28	NLR family, pyrin domain containing 3	Mus musculus	100-105	
33717152-11	2021	Furthermore, Parkin deletion or pretreated with 3MA (autophagy inhibitor) exacerbated these detrimental actions of IH, which was accompanied with NLRP3 inflammasome activation.	3-methyladenine	48-51	NLR family, pyrin domain containing 3	Mus musculus	146-151	
33217525-10	2021	Moreover, autophagy inhibitor 3-methyladenine (3MA) attenuated PAT-induced increase in cytoplasmic cathepsin B expression, and subsequent LDH release, the activation of NLRP3 inflamosomes, pyroptotic cell death, and inflammation.	3-methyladenine	30-45	NLR family, pyrin domain containing 3	Mus musculus	169-174	
33217525-10	2021	Moreover, autophagy inhibitor 3-methyladenine (3MA) attenuated PAT-induced increase in cytoplasmic cathepsin B expression, and subsequent LDH release, the activation of NLRP3 inflamosomes, pyroptotic cell death, and inflammation.	3-methyladenine	47-50	NLR family, pyrin domain containing 3	Mus musculus	169-174	
35354793-10	2022	Adding the autophagy inhibitor 3-methyladenine or chloroquine attenuated the inhibitory effect of Irisin on beta-GP-induced ROS production, NLRP3 inflammasome activation, pyroptosis, and calcification in VSMCs.	3-methyladenine	31-46	NLR family, pyrin domain containing 3	Mus musculus	140-145	
30254716-11	2018	Both Sirt3-siRNA and autophagy inhibitor 3-MA partially abolished the beneficial effects of melatonin on mitoROS clearance and NLRP3 inflammasome activation, indicating the crucial role of Sirt3-mediated mitophagy.	3-methyladenine	41-45	NLR family, pyrin domain containing 3	Mus musculus	127-132	
33034415-15	2021	The results showed that when 3-MA and BafA1 were applied, the promotion of autophagy by zinc was blocked and that the inhibitory effect of zinc on NLRP3 was reversed.	3-methyladenine	29-33	NLR family, pyrin domain containing 3	Mus musculus	147-152	
34530204-15	2021	Inhibition of autophagy by 3-MA treatment also promoted the activity of NLRP3 inflammasome and the production of IL-1beta and IL-18.	3-methyladenine	27-31	NLR family, pyrin domain containing 3	Mus musculus	72-77	
35628508-7	2022	RAPA treatment (an inducer of autophagy) significantly improved realgar-induced liver injury and NLRP3 inflammasome activation, while 3-MA (an inhibitor of autophagy) aggravated the realgar-induced liver injury and NLRP3 inflammasome activation.	3-methyladenine	134-138	NLR family, pyrin domain containing 3	Mus musculus	97-102	
35628508-7	2022	RAPA treatment (an inducer of autophagy) significantly improved realgar-induced liver injury and NLRP3 inflammasome activation, while 3-MA (an inhibitor of autophagy) aggravated the realgar-induced liver injury and NLRP3 inflammasome activation.	3-methyladenine	134-138	NLR family, pyrin domain containing 3	Mus musculus	215-220