PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20107192-6 2010 In hearts of untreated diabetic mice, the expression and activity of Akt/Pim-1 signaling declined along with O-N-acetylglucosamine modification of Akt, inhibition of pentose phosphate pathway, activation of oxidative stress, and accumulation of glycation end products. Pentosephosphates 166-183 thymoma viral proto-oncogene 1 Mus musculus 69-72 24832603-11 2014 Collectively, these data indicate that estradiol promotes glucose metabolism in mTORC1 hyperactive cells through the pentose phosphate pathway via Akt reactivation and G6PD upregulation, thereby enhancing cell survival under oxidative stress. Pentosephosphates 117-134 thymoma viral proto-oncogene 1 Mus musculus 147-150 20542491-10 2010 In addition, BFT stimulated the activity of pentose phosphate pathway enzymes, leading to reduction of oxidative stress, phosphorylation/activation of VEGF receptor-2 and Akt and increased Pim-1, pBad and Bcl-2 levels. Pentosephosphates 44-61 thymoma viral proto-oncogene 1 Mus musculus 171-174 28209124-6 2017 RESULTS: Combined metabolomics and transcriptomic analyses revealed that Akt1-induced muscle growth mediated a metabolic shift involving reductions in glycolysis and oxidative phosphorylation, but enhanced pentose phosphate pathway activation and increased branch chain amino acid accumulation. Pentosephosphates 206-223 thymoma viral proto-oncogene 1 Mus musculus 73-77 24990892-0 2014 Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury. Pentosephosphates 30-47 thymoma viral proto-oncogene 1 Mus musculus 84-87 24832603-0 2014 Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells. Pentosephosphates 19-36 thymoma viral proto-oncogene 1 Mus musculus 93-96 19068483-6 2009 PI3K/Akt regulated early steps of de novo synthesis by modulating phosphoribosylpyrophosphate production by the non-oxidative pentose phosphate pathway and late steps by modulating activity of the bifunctional enzyme aminoimidazole-carboxamide ribonucleotide transformylase IMP cyclohydrolase, an enzyme not previously known to be regulated. Pentosephosphates 126-143 thymoma viral proto-oncogene 1 Mus musculus 5-8