PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34169390-0 2021 Molecular screening of glycyrrhizin-based inhibitors against ACE2 host receptor of SARS-CoV-2. Glycyrrhizic Acid 23-35 angiotensin converting enzyme 2 Homo sapiens 61-65 34427852-5 2022 Our results showed that GA significantly attenuated LPS-induced ALI and decreased the production of inflammatory factors, including IL-1beta, MCP-1, COX2, HMGB1, and adhesion molecules, such as E-selectin, VCAM-1, and modulated expression of angiotensin-converting enzyme 2 (ACE2). Glycyrrhizic Acid 24-26 angiotensin converting enzyme 2 Homo sapiens 242-273 34427852-5 2022 Our results showed that GA significantly attenuated LPS-induced ALI and decreased the production of inflammatory factors, including IL-1beta, MCP-1, COX2, HMGB1, and adhesion molecules, such as E-selectin, VCAM-1, and modulated expression of angiotensin-converting enzyme 2 (ACE2). Glycyrrhizic Acid 24-26 angiotensin converting enzyme 2 Homo sapiens 275-279 34427852-6 2022 Moreover, treatment of ACE2 inhibitor (MLN-4760) reversed the effects of GA on the secretion of pro-inflammatory factors in ALI. Glycyrrhizic Acid 73-75 angiotensin converting enzyme 2 Homo sapiens 23-27 34427852-7 2022 Additionally, GA exerts its protective effect by regulating the ACE2 and caveolin-1/NF-kappaB signaling pathway. Glycyrrhizic Acid 14-16 angiotensin converting enzyme 2 Homo sapiens 64-68 34427852-8 2022 In conclusion, this study showed that GA alleviated LPS-induced ALI by upregulating ACE2 and inhibiting the caveolin-1/NF-kappaB signaling pathway. Glycyrrhizic Acid 38-40 angiotensin converting enzyme 2 Homo sapiens 84-88 34684671-7 2021 Autodocking analysis revealed that the S protein has several GA-binding pockets including one at the interaction interface to the receptor angiotensin-converting enzyme 2 (ACE2) and another at the inner side of the receptor-binding domain (RBD) which might impact the close-to-open conformation change of the S protein required for ACE2 interaction. Glycyrrhizic Acid 61-63 angiotensin converting enzyme 2 Homo sapiens 139-170 34684671-7 2021 Autodocking analysis revealed that the S protein has several GA-binding pockets including one at the interaction interface to the receptor angiotensin-converting enzyme 2 (ACE2) and another at the inner side of the receptor-binding domain (RBD) which might impact the close-to-open conformation change of the S protein required for ACE2 interaction. Glycyrrhizic Acid 61-63 angiotensin converting enzyme 2 Homo sapiens 172-176 34684671-7 2021 Autodocking analysis revealed that the S protein has several GA-binding pockets including one at the interaction interface to the receptor angiotensin-converting enzyme 2 (ACE2) and another at the inner side of the receptor-binding domain (RBD) which might impact the close-to-open conformation change of the S protein required for ACE2 interaction. Glycyrrhizic Acid 61-63 angiotensin converting enzyme 2 Homo sapiens 332-336 34427852-0 2022 Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway. Glycyrrhizic Acid 0-17 angiotensin converting enzyme 2 Homo sapiens 94-125 34427852-0 2022 Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway. Glycyrrhizic Acid 0-17 angiotensin converting enzyme 2 Homo sapiens 127-131 34899289-6 2021 Glycyrrhizin and glycyrrhetinic acid inhibit the synthesis of inflammatory factors and inflammatory mediators by blocking the binding of ACE 2 to virus spike protein, and exert antiviral and antibacterial effects. Glycyrrhizic Acid 0-12 angiotensin converting enzyme 2 Homo sapiens 137-142 34507112-7 2021 Glycyrrhizin in vitro connects and changes conformation of ACE2 receptors, which are vital for SARS-CoV-2 penetration into host cells. Glycyrrhizic Acid 0-12 angiotensin converting enzyme 2 Homo sapiens 59-63 32902005-7 2021 The most recently published papers on the distribution of ACE2 in the human body and documented binding of GZ to this receptor, as well as its antiviral activity, suggest that GZ can be used as a therapeutic for COVID-19 and as a preventive agent against SARS-CoV-2. Glycyrrhizic Acid 176-178 angiotensin converting enzyme 2 Homo sapiens 58-62 34183961-7 2021 Results: Saikosaponin A (e.g. in Bupleurum chinense), Baicalin (e.g. in several species in the genus Scutellaria), Glycyrrhizin (Glycyrrhiza glabra), MLN-4760 and Umifenovir better occupied ACE2 to inhibit viral RBD binding and are suggested as the top five inhibitors of the SARS-CoV-2 binding site of ACE2. Glycyrrhizic Acid 115-127 angiotensin converting enzyme 2 Homo sapiens 190-194 34183961-7 2021 Results: Saikosaponin A (e.g. in Bupleurum chinense), Baicalin (e.g. in several species in the genus Scutellaria), Glycyrrhizin (Glycyrrhiza glabra), MLN-4760 and Umifenovir better occupied ACE2 to inhibit viral RBD binding and are suggested as the top five inhibitors of the SARS-CoV-2 binding site of ACE2. Glycyrrhizic Acid 115-127 angiotensin converting enzyme 2 Homo sapiens 303-307 35279013-6 2022 In the compositions of GB-1, glycyrrhizic acid can inhibit the binding between ACE2 and RBD with Wuhan type, except K417N-E484K-N501Y mutation. Glycyrrhizic Acid 29-46 angiotensin converting enzyme 2 Homo sapiens 79-83 32574273-11 2020 Importantly, GL has anti-inflammatory properties by itself via toll like receptor 4 (TLR4) antagonism and therefore compensates for the reduced protection of the downregulated ACE2. Glycyrrhizic Acid 13-15 angiotensin converting enzyme 2 Homo sapiens 176-180