PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10597866-1	1999	Since 1990 it has repeatedly been reported that some histamine H1 receptor antagonists (e.g. terfenadine and astemizole) are able to produce ventricular arrhythmias (e.g. torsade de pointes) when they are given at dosages above the therapeutic range and/or administered together with cytochrome P-450 3A4 inhibitors, such as ketoconazole or erythromycin.	Terfenadine	93-104	histamine H1 receptor	Cavia porcellus	53-74	
10556670-1	1999	Terfenadine, a histamine H(1) receptor antagonist, has been associated with clinical ventricular arrhythmias and in vitro excitation-conduction blocks, whereas anti-ischemic and antiarrhythmic effects have been shown with cicletanine, a prostacyclin generation stimulator.	Terfenadine	0-11	histamine H1 receptor	Cavia porcellus	15-38	
8001268-0	1995	Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine.	Terfenadine	93-104	histamine H1 receptor	Cavia porcellus	44-65	
6129862-5	1982	The unsurmountable antagonism of histamine by terfenadine may result from a slow dissociation of terfenadine from the histamine H1-receptor.	Terfenadine	46-57	histamine H1 receptor	Cavia porcellus	118-139	
6129862-7	1982	It is concluded that terfenadine is a potent, selective histamine H1-receptor antagonist; the kinetics of association/dissociation of terfenadine with histamine H1-receptors may account for the long-lasting antihistaminic effect in various animal models.	Terfenadine	21-32	histamine H1 receptor	Cavia porcellus	56-77