PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28436281-2 2018 Roles of human cytochrome P450 (P450) 3A4 in oxidation of an antihistaminic drug terfenadine have been previously investigated in association with terfenadine-ketoconazole interaction. Terfenadine 81-92 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 15-41 28436281-2 2018 Roles of human cytochrome P450 (P450) 3A4 in oxidation of an antihistaminic drug terfenadine have been previously investigated in association with terfenadine-ketoconazole interaction. Terfenadine 147-158 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 15-41 9694927-12 1998 These potential dual actions on HERG currents suggest that precautions should be taken in long-term ketoconazole treatment, particularly for patients who have decreased liver function or are on a drug regimen requiring simultaneous medications that use cytochrome-P450 for breakdown, such as terfenadine or erythromycin, or Class III antiarrhythmic drugs. Terfenadine 292-303 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 253-268 9694927-2 1998 Both compounds use the same cytochrome-P450 metabolic pathway, resulting in an increase in plasma concentration of terfenadine. Terfenadine 115-126 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-43 22616812-2 2012 Further, clinically significant interactions with inhibitors of cytochrome P450 (CYP) have previously been reported for drugs of this therapeutic group, such as terfenadine and astemizole, indicating the possibility of drug-drug interactions involving agents that share the same metabolic pathway. Terfenadine 161-172 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-79 22616812-2 2012 Further, clinically significant interactions with inhibitors of cytochrome P450 (CYP) have previously been reported for drugs of this therapeutic group, such as terfenadine and astemizole, indicating the possibility of drug-drug interactions involving agents that share the same metabolic pathway. Terfenadine 161-172 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 81-84 9270401-2 1997 TDP has been associated with terfenadine use in cases of liver disease, electrolyte abnormalities, concomitant administration of drugs that inhibit cytochrome P-450, or deliberate overdose. Terfenadine 29-40 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 148-164 8257958-4 1993 The increased risk of both H1-antihistamines was associated with exposure to supratherapeutic doses; for terfenadine the risk was also associated with concomitant exposure to the cytochrome P-450 inhibitors ketoconazole, erythromycin and cimetidine. Terfenadine 105-116 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 179-195