PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27550354-2 2016 Ciprofloxacin, linezolid, para-aminosalicylic acid (PAS), and rifampin were observed to have strong inhibitory effects, with the concentrations for a 50% inhibitory effect (IC50s) being 35.1, 31.1, 37.6, and 48.1 muM, respectively, for OAT1 and >100, 21.9, 24.6, and 30.2 muM, respectively, for OAT3. Aminosalicylic Acid 26-50 solute carrier family 22 member 6 Homo sapiens 236-240 27550354-2 2016 Ciprofloxacin, linezolid, para-aminosalicylic acid (PAS), and rifampin were observed to have strong inhibitory effects, with the concentrations for a 50% inhibitory effect (IC50s) being 35.1, 31.1, 37.6, and 48.1 muM, respectively, for OAT1 and >100, 21.9, 24.6, and 30.2 muM, respectively, for OAT3. Aminosalicylic Acid 52-55 solute carrier family 22 member 6 Homo sapiens 236-240 27550354-5 2016 Among the tested drugs, the highest drug-drug interaction (DDI) indexes were found for PAS, which were 9.3 to 13.9 for OAT1 and 12.0 to 17.7 for OAT3, and linezolid, which were 1.18 to 2.15 for OAT1 and 1.7 to 3.01 for OAT3. Aminosalicylic Acid 87-90 solute carrier family 22 member 6 Homo sapiens 119-123 27550354-5 2016 Among the tested drugs, the highest drug-drug interaction (DDI) indexes were found for PAS, which were 9.3 to 13.9 for OAT1 and 12.0 to 17.7 for OAT3, and linezolid, which were 1.18 to 2.15 for OAT1 and 1.7 to 3.01 for OAT3. Aminosalicylic Acid 87-90 solute carrier family 22 member 6 Homo sapiens 119-129 34432302-7 2022 RESULTS: PAS inhibited OAT1- and OAT3-mediated tenofovir uptake in vitro. Aminosalicylic Acid 9-12 solute carrier family 22 member 6 Homo sapiens 23-27