PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22824279-5 2012 Here, we quantitatively measure the mechanical unfolding of a PAS domain, ARNT PAS-B, using single-molecule atomic force microscopy. Aminosalicylic Acid 62-65 aryl hydrocarbon receptor nuclear translocator Homo sapiens 74-78 23240775-4 2013 In one route, we used in vitro NMR and biochemical screening to identify small molecules that selectively bind within the ARNT PAS (Per-ARNT-Sim) domain that recruits TACC3, identifying KG-548 as an ARNT/TACC3 disruptor. Aminosalicylic Acid 127-130 aryl hydrocarbon receptor nuclear translocator Homo sapiens 122-126 23240775-4 2013 In one route, we used in vitro NMR and biochemical screening to identify small molecules that selectively bind within the ARNT PAS (Per-ARNT-Sim) domain that recruits TACC3, identifying KG-548 as an ARNT/TACC3 disruptor. Aminosalicylic Acid 127-130 aryl hydrocarbon receptor nuclear translocator Homo sapiens 136-140 23240775-4 2013 In one route, we used in vitro NMR and biochemical screening to identify small molecules that selectively bind within the ARNT PAS (Per-ARNT-Sim) domain that recruits TACC3, identifying KG-548 as an ARNT/TACC3 disruptor. Aminosalicylic Acid 127-130 aryl hydrocarbon receptor nuclear translocator Homo sapiens 136-140 16520375-6 2006 A PAS swap heterodimer, where the DR bHLH domain was fused to Arnt PAS A and the Arnt bHLH fused to DR PAS A, gave strong DNA binding, but dimerization was only effective with the native arrangement, suggesting the PAS A domain is critical for each process via distinct mechanisms. Aminosalicylic Acid 2-5 aryl hydrocarbon receptor nuclear translocator Homo sapiens 62-66 20171126-1 2010 The aryl hydrocarbon receptor (AhR) is a basic helix-loop-helix protein that belongs to the superfamily of environment-sensing PAS (Per-ARNT-Sim) proteins. Aminosalicylic Acid 127-130 aryl hydrocarbon receptor nuclear translocator Homo sapiens 136-140 16520375-6 2006 A PAS swap heterodimer, where the DR bHLH domain was fused to Arnt PAS A and the Arnt bHLH fused to DR PAS A, gave strong DNA binding, but dimerization was only effective with the native arrangement, suggesting the PAS A domain is critical for each process via distinct mechanisms. Aminosalicylic Acid 2-5 aryl hydrocarbon receptor nuclear translocator Homo sapiens 81-90 11179451-6 2001 Metabolic [(32)P]orthophosphate labeling of human ARNT-transfected COS-1 cells, in conjunction with phosphoamino acid analysis, Edman degradation, and phosphopeptide mapping, demonstrated that ARNT is predominantly phosphorylated on serine residues and that serine 348 (S348) in the PAS domain is phosphorylated. Aminosalicylic Acid 283-286 aryl hydrocarbon receptor nuclear translocator Homo sapiens 193-197 14638687-3 2004 Dimerization among bHLH.PAS proteins is additionally regulated by the PAS region, which controls the specificity of partner choice such that HIF-alpha and DR must dimerize with the aryl hydrocarbon nuclear translocator (Arnt) to form functional DNA binding complexes. Aminosalicylic Acid 24-27 aryl hydrocarbon receptor nuclear translocator Homo sapiens 220-224 14638687-7 2004 In contrast, the presence of the PAS domains of Arnt had little effect on DNA binding by Arnt homodimers, and these bound DNA with a KD of 45 nM. Aminosalicylic Acid 33-36 aryl hydrocarbon receptor nuclear translocator Homo sapiens 48-52 14638687-8 2004 In the case of the DR, both high affinity DNA binding and dimer stability were specific to its native PAS domain, since a chimera in which the PAS A domain was substituted with the equivalent domain of Arnt generated a destabilized protein that bound DNA poorly. Aminosalicylic Acid 102-105 aryl hydrocarbon receptor nuclear translocator Homo sapiens 202-206 14668441-3 2003 HIF is a heterodimeric protein complex composed of two members of the basic helix-loop-helix Per-ARNT-Sim (PAS) (ARNT, aryl hydrocarbon receptor nuclear translocator) domain family of transcriptional activators, HIFalpha and ARNT. Aminosalicylic Acid 107-110 aryl hydrocarbon receptor nuclear translocator Homo sapiens 97-101 14668441-3 2003 HIF is a heterodimeric protein complex composed of two members of the basic helix-loop-helix Per-ARNT-Sim (PAS) (ARNT, aryl hydrocarbon receptor nuclear translocator) domain family of transcriptional activators, HIFalpha and ARNT. Aminosalicylic Acid 107-110 aryl hydrocarbon receptor nuclear translocator Homo sapiens 113-117 14668441-3 2003 HIF is a heterodimeric protein complex composed of two members of the basic helix-loop-helix Per-ARNT-Sim (PAS) (ARNT, aryl hydrocarbon receptor nuclear translocator) domain family of transcriptional activators, HIFalpha and ARNT. Aminosalicylic Acid 107-110 aryl hydrocarbon receptor nuclear translocator Homo sapiens 119-165 14668441-3 2003 HIF is a heterodimeric protein complex composed of two members of the basic helix-loop-helix Per-ARNT-Sim (PAS) (ARNT, aryl hydrocarbon receptor nuclear translocator) domain family of transcriptional activators, HIFalpha and ARNT. Aminosalicylic Acid 107-110 aryl hydrocarbon receptor nuclear translocator Homo sapiens 113-117 10702253-3 2000 HIF-1 is a heterodimer composed of two members of the basic helix-loop-helix transcription factor superfamily containing a PAS (PER-ARNT-SIM) domain: HIF-1alpha and HIF-1beta/ARNT. Aminosalicylic Acid 123-126 aryl hydrocarbon receptor nuclear translocator Homo sapiens 132-136 10702253-3 2000 HIF-1 is a heterodimer composed of two members of the basic helix-loop-helix transcription factor superfamily containing a PAS (PER-ARNT-SIM) domain: HIF-1alpha and HIF-1beta/ARNT. Aminosalicylic Acid 123-126 aryl hydrocarbon receptor nuclear translocator Homo sapiens 175-179 24001774-6 2013 Our crystallographic visualization of AHR PAS-A dimerization leads us to propose a mode of heterodimerization with ARNT that is supported by both biochemical and cell-based data. Aminosalicylic Acid 42-45 aryl hydrocarbon receptor nuclear translocator Homo sapiens 115-119 29948506-1 2019 Aryl hydrocarbon-receptor nuclear translocator (ARNT2) is a member of the bHLH PAS (basic helix-loop-helix Period/ARNT/Single-minded) family of transcription factors. Aminosalicylic Acid 79-82 aryl hydrocarbon receptor nuclear translocator Homo sapiens 0-46 24107188-5 2014 The ancient Per ARNT Sim (PAS) and cGMP-specific phosphodiesterases, Adenylyl cyclases and FhlA (GAF) family domains show a similar architecture, and the identification of prokaryotic counterparts of GAF domains involved in trafficking provides an additional connection for the endomembrane system back into the pre-eukaryotic world. Aminosalicylic Acid 26-29 aryl hydrocarbon receptor nuclear translocator Homo sapiens 16-20 10340472-1 1999 Aromatic hydrocarbon nuclear translocator (Arnt) is an ubiquitously expressed protein that contains basic helix-loop-helix (bHLH) and Per-AhR-Arnt-Sim (PAS) motifs. Aminosalicylic Acid 152-155 aryl hydrocarbon receptor nuclear translocator Homo sapiens 0-41 10340472-1 1999 Aromatic hydrocarbon nuclear translocator (Arnt) is an ubiquitously expressed protein that contains basic helix-loop-helix (bHLH) and Per-AhR-Arnt-Sim (PAS) motifs. Aminosalicylic Acid 152-155 aryl hydrocarbon receptor nuclear translocator Homo sapiens 43-47 10496070-7 1999 Such interactive domains were identified in amino acids 369-465 containing the C-terminal of HNF-4 and amino acids 1-458 containing basic helix-loop-helix (bHLH) and Per-ARNT-AHR-Sim (PAS) domains of ARNT in normoxia. Aminosalicylic Acid 184-187 aryl hydrocarbon receptor nuclear translocator Homo sapiens 170-174 9632792-2 1998 The receptor belongs to the basic helix-loop-helix (bHLH)-Per-Arnt-Sim (PAS) family of factors, which, in addition to the bHLH motif, contain a PAS region of homology. Aminosalicylic Acid 72-75 aryl hydrocarbon receptor nuclear translocator Homo sapiens 62-66 9632792-4 1998 We have studied the role of the PAS domain in dimerization and DNA binding specificity of the dioxin receptor and Arnt by monitoring the abilities of the individual bHLH domains and different bHLH-PAS fragments to dimerize and bind DNA in vitro and recognize target genes in vivo. Aminosalicylic Acid 32-35 aryl hydrocarbon receptor nuclear translocator Homo sapiens 114-118 8816435-4 1996 Both the bHLH and PAS motifs of Arnt were critical for dimerization with HIF-1 alpha. Aminosalicylic Acid 18-21 aryl hydrocarbon receptor nuclear translocator Homo sapiens 32-36 7628454-0 1995 Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex. Aminosalicylic Acid 32-35 aryl hydrocarbon receptor nuclear translocator Homo sapiens 136-140 7628454-0 1995 Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex. Aminosalicylic Acid 57-60 aryl hydrocarbon receptor nuclear translocator Homo sapiens 136-140 7628454-4 1995 Selectivity for PAS dimerization was noted in our hybrid interaction system, as dioxin receptor or Arnt PAS-mediated homodimers were not detected. Aminosalicylic Acid 16-19 aryl hydrocarbon receptor nuclear translocator Homo sapiens 99-103 7628454-5 1995 Surprisingly, however, the PAS domain of Per could dimerize with both the dioxin receptor and Arnt subunits in vitro, and disrupt the ability of these subunits to form a DNA binding heterodimer. Aminosalicylic Acid 27-30 aryl hydrocarbon receptor nuclear translocator Homo sapiens 94-98 28416634-8 2017 The availability of ARNT itself is modulated by another basic helix-loop-helix (bHLH)-Per-ARNT-SIM (PAS) protein, the repressor of AhR function (AhRR). Aminosalicylic Acid 100-103 aryl hydrocarbon receptor nuclear translocator Homo sapiens 20-24 28416634-8 2017 The availability of ARNT itself is modulated by another basic helix-loop-helix (bHLH)-Per-ARNT-SIM (PAS) protein, the repressor of AhR function (AhRR). Aminosalicylic Acid 100-103 aryl hydrocarbon receptor nuclear translocator Homo sapiens 90-94