PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20070537-1 2010 AIMS: Copper and manganese levels are altered in mice both lacking PrPc and prion-infected brains. Manganese 17-26 prion protein Mus musculus 67-71 18332141-2 2008 However, there have also been suggestions that prion protein (PrP) binds manganese. Manganese 73-82 prion protein Mus musculus 62-65 18332141-3 2008 We used isothermal titration calorimetry to identify the manganese binding sites in wild-type mouse PrP. Manganese 57-66 prion protein Mus musculus 100-103 18332141-5 2008 This indicates that PrP binds manganese with affinity similar to other known manganese-binding proteins. Manganese 30-39 prion protein Mus musculus 20-23 18332141-8 2008 Under these conditions, manganese binding resulted in an altered conformation of PrP, displacement of copper, and altered redox chemistry of the metal-protein complex. Manganese 24-33 prion protein Mus musculus 81-84 18332141-9 2008 Cyclic voltammetric measurements suggested a complex redox chemistry involving manganese bound to PrP, whereas copper-bound PrP was able to undergo fully reversible electron cycling. Manganese 79-88 prion protein Mus musculus 98-101 18332141-10 2008 Additionally, manganese binding to PrP converted it to a form able to catalyze aggregation of metal-free PrP. Manganese 14-23 prion protein Mus musculus 35-38 18332141-10 2008 Additionally, manganese binding to PrP converted it to a form able to catalyze aggregation of metal-free PrP. Manganese 14-23 prion protein Mus musculus 105-108 18332141-11 2008 These results further support the notion that manganese binding could cause a conformation change in PrP and trigger changes in the protein similar to those associated with prion disease. Manganese 46-55 prion protein Mus musculus 101-104 12429022-4 2003 The anti-PrP monoclonal antibodies were reactive by Western blot and ELISA with recombinant murine PrPc refolded in the presence or absence of either copper or manganese, and with the disease-susceptible allelic form V136R154Q171 ("VRQ"; where single-letter amino-acid notation has been used) and disease-resistant allelic form A136R154R171 ("ARR") of recombinant ovine PrPc. Manganese 160-169 prion protein Mus musculus 9-12 35038117-8 2022 PrP refolded with nickle or manganese behave similar to apo-PrP, and PrP refolded with copper is least effective. Manganese 28-37 prion protein Mus musculus 0-3