PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19369420-1 2009 The yeast Smf1p Nramp manganese transporter is posttranslationally regulated by environmental manganese. Manganese 22-31 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 10-14 19369420-2 2009 Smf1p is stabilized at the cell surface with manganese starvation, but is largely degraded in the vacuole with physiological manganese through a mechanism involving the Rsp5p adaptor complex Bsd2p/Tre1p/Tre2p. Manganese 45-54 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 0-5 19369420-2 2009 Smf1p is stabilized at the cell surface with manganese starvation, but is largely degraded in the vacuole with physiological manganese through a mechanism involving the Rsp5p adaptor complex Bsd2p/Tre1p/Tre2p. Manganese 125-134 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 0-5 19369420-3 2009 We now describe an additional level of Smf1p regulation that occurs with toxicity from manganese, but not other essential metals. Manganese 87-96 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 39-44 19369420-5 2009 As with physiological manganese, toxic manganese triggers vacuolar degradation of Smf1p by trafficking through the multivesicular body. Manganese 22-31 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 82-87 19369420-5 2009 As with physiological manganese, toxic manganese triggers vacuolar degradation of Smf1p by trafficking through the multivesicular body. Manganese 39-48 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 82-87 19369420-7 2009 Toxic manganese triggers both endocytosis of cell surface Smf1p and vacuolar targeting of intracellular Smf1p through the exocytic pathway. Manganese 6-15 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 58-63 19369420-7 2009 Toxic manganese triggers both endocytosis of cell surface Smf1p and vacuolar targeting of intracellular Smf1p through the exocytic pathway. Manganese 6-15 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 104-109 19369420-8 2009 Notably, the kinetics of vacuolar targeting for Smf1p are relatively slow with toxic manganese and require prolonged exposures to the metal. Manganese 85-94 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 48-53 19369420-9 2009 Down-regulation of Smf1p by toxic manganese does not require transport activity of Smf1p, whereas such transport activity is needed for Smf1p regulation by manganese starvation. Manganese 34-43 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 19-24 19369420-9 2009 Down-regulation of Smf1p by toxic manganese does not require transport activity of Smf1p, whereas such transport activity is needed for Smf1p regulation by manganese starvation. Manganese 156-165 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 19-24 11829747-2 2002 Smf1p and Smf2p are regulated at the post-translational level by manganese, whereas Smf3p is regulated by iron through a mechanism that, up until now, was unknown. Manganese 65-74 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 0-5 18973803-4 2009 This manganese for antioxidant protection is provided by the Nramp transporters Smf1p and Smf2p, with Smf1p playing a major role. Manganese 5-14 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 80-85 18973803-4 2009 This manganese for antioxidant protection is provided by the Nramp transporters Smf1p and Smf2p, with Smf1p playing a major role. Manganese 5-14 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 102-107 18973803-5 2009 In fact, loss of manganese transport by Smf1p together with loss of the Pmr1p manganese pump is lethal to sod1 Delta cells despite normal manganese SOD2 activity. Manganese 17-26 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 40-45 12923174-1 2003 In the bakers" yeast Saccharomyces cerevisiae, high affinity manganese uptake and intracellular distribution involve two members of the Nramp family of genes, SMF1 and SMF2. Manganese 61-70 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 159-163 12923174-10 2003 Under these conditions, cells lacking both Pho84p and the high affinity Smf1p transporter accumulated low levels of manganese, although there was no major effect on activity of manganese-requiring enzymes. Manganese 116-125 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 72-77 11829747-3 2002 Through promoter and protein-domain swapping experiments, we now demonstrate that the manganese regulation of Smf1p involves an internal protein-coding region that is separate from the N-terminal domain of this transporter. Manganese 86-95 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 110-115 11027260-3 2000 Smf1p and Smf2p function in cellular accumulation of manganese, and the two proteins are coregulated by manganese ions and the BSD2 gene product. Manganese 53-62 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 0-5 11027260-3 2000 Smf1p and Smf2p function in cellular accumulation of manganese, and the two proteins are coregulated by manganese ions and the BSD2 gene product. Manganese 104-113 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 0-5 11027260-4 2000 Under manganese-replete conditions, Bsd2p facilitates trafficking of Smf1p and Smf2p to the vacuole, where these transport proteins are degraded. Manganese 6-15 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 69-74 9115231-5 1997 Genetic suppressor analysis revealed that hyperaccumulation of copper and cadmium in bsd2 mutants is mediated through SMF1, previously shown to encode a plasma membrane transporter for manganese. Manganese 185-194 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 118-122 9988727-9 1999 Supplementation of manganese alone is sufficient to trigger rapid degradation of Smf1p in a Bsd2p-dependent manner. Manganese 19-28 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 81-86 8643535-4 1996 The SMF1 gene codes for a highly hydrophobic protein and its deletion renders the yeast cells sensitive to low manganese concentration. Manganese 111-120 divalent metal ion transporter SMF1 Saccharomyces cerevisiae S288C 4-8