PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34358615-1 2021 Inherited autosomal recessive mutations of the manganese (Mn) transporter gene SLC39A14 in humans, results in elevated blood and brain Mn concentrations and childhood-onset dystonia-parkinsonism. Manganese 47-56 solute carrier family 39 member 14 Homo sapiens 79-87 33925013-4 2021 Significant progress was achieved in understanding the role of Mn transporters, such as SLC39A14, SLC39A8, and SLC30A10, in the regulation of systemic and brain manganese handling. Manganese 161-170 solute carrier family 39 member 14 Homo sapiens 88-96 34202493-2 2021 Loss of ZIP14 function leads to manganese overload in both humans and mice. Manganese 32-41 solute carrier family 39 member 14 Homo sapiens 8-13 32626807-0 2020 Benign SLC39A14 Course of Dystonia-Parkinsonism Secondary to Inherited Manganese Accumulation. Manganese 71-80 solute carrier family 39 member 14 Homo sapiens 7-15 32392784-0 2020 The Functions of ZIP8, ZIP14, and ZnT10 in the Regulation of Systemic Manganese Homeostasis. Manganese 70-79 solute carrier family 39 member 14 Homo sapiens 23-28 32392784-4 2020 In the past eight years, mutations of genes encoding metal transporters ZIP8 (SLC39A8), ZIP14 (SLC39A14), and ZnT10 (SLC30A10) have been identified to cause dysregulated manganese homeostasis in humans, highlighting the critical roles of these genes in manganese metabolism. Manganese 170-179 solute carrier family 39 member 14 Homo sapiens 88-93 32392784-4 2020 In the past eight years, mutations of genes encoding metal transporters ZIP8 (SLC39A8), ZIP14 (SLC39A14), and ZnT10 (SLC30A10) have been identified to cause dysregulated manganese homeostasis in humans, highlighting the critical roles of these genes in manganese metabolism. Manganese 170-179 solute carrier family 39 member 14 Homo sapiens 95-103 32392784-4 2020 In the past eight years, mutations of genes encoding metal transporters ZIP8 (SLC39A8), ZIP14 (SLC39A14), and ZnT10 (SLC30A10) have been identified to cause dysregulated manganese homeostasis in humans, highlighting the critical roles of these genes in manganese metabolism. Manganese 253-262 solute carrier family 39 member 14 Homo sapiens 88-93 32392784-4 2020 In the past eight years, mutations of genes encoding metal transporters ZIP8 (SLC39A8), ZIP14 (SLC39A14), and ZnT10 (SLC30A10) have been identified to cause dysregulated manganese homeostasis in humans, highlighting the critical roles of these genes in manganese metabolism. Manganese 253-262 solute carrier family 39 member 14 Homo sapiens 95-103 33911374-2 2021 These disorders, predominantly described in children and adolescents, involve mutations in three manganese transporter genes, i.e., SLC30A10 and SLC39A14 which lead to manganese overload, and SLC39A8, which leads to manganese deficiency. Manganese 97-106 solute carrier family 39 member 14 Homo sapiens 145-153 33911374-2 2021 These disorders, predominantly described in children and adolescents, involve mutations in three manganese transporter genes, i.e., SLC30A10 and SLC39A14 which lead to manganese overload, and SLC39A8, which leads to manganese deficiency. Manganese 168-177 solute carrier family 39 member 14 Homo sapiens 145-153 31699897-0 2019 The solute carriers ZIP8 and ZIP14 regulate manganese accumulation in brain microvascular endothelial cells and control brain manganese levels. Manganese 44-53 solute carrier family 39 member 14 Homo sapiens 29-34 31699897-0 2019 The solute carriers ZIP8 and ZIP14 regulate manganese accumulation in brain microvascular endothelial cells and control brain manganese levels. Manganese 126-135 solute carrier family 39 member 14 Homo sapiens 29-34 31699897-4 2019 In this study, we have determined that Zrt- and Irt-like protein 8 (ZIP8) and ZIP14 support Mn2+-uptake by BMVECs and that neither DMT1 nor an endocytosis-dependent pathway play any significant role in Mn2+-uptake. Manganese 92-96 solute carrier family 39 member 14 Homo sapiens 78-83 31541377-0 2019 ZIP14 is degraded in response to manganese exposure. Manganese 33-42 solute carrier family 39 member 14 Homo sapiens 0-5 31261654-0 2019 Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14. Manganese 0-9 solute carrier family 39 member 14 Homo sapiens 60-65 31636842-2 2019 In mammalian cells, Zn transporters such as ZIP8 and ZIP14 have been found to function as the transporters for Mn(II) and Cd(II), contributing to the maintenance of Mn homeostasis and metallothionein-independent transports of Cd, respectively. Manganese 111-117 solute carrier family 39 member 14 Homo sapiens 53-58 31028174-8 2019 The generation of a ZIP14-deficient CaCo-2 cell line enabled the identification of ZIP14 as the major transporter mediating basolateral manganese uptake in enterocytes. Manganese 136-145 solute carrier family 39 member 14 Homo sapiens 20-25 31028174-8 2019 The generation of a ZIP14-deficient CaCo-2 cell line enabled the identification of ZIP14 as the major transporter mediating basolateral manganese uptake in enterocytes. Manganese 136-145 solute carrier family 39 member 14 Homo sapiens 83-88 29685658-2 2018 Homozygous exonic mutations in the manganese transporter SLC39A14 have recently been associated with a pediatric-onset neurodegenerative disorder characterized by brain manganese accumulation and clinical signs of manganese neurotoxicity, including parkinsonism-dystonia. Manganese 35-44 solute carrier family 39 member 14 Homo sapiens 57-65 31089831-3 2019 While the manganese efflux transporter SLC30A10 and the uptake transporter SLC39A14 work synergistically to reduce the manganese load, SLC39A8 has an opposing function facilitating manganese uptake into the organism. Manganese 119-128 solute carrier family 39 member 14 Homo sapiens 75-83 29685658-2 2018 Homozygous exonic mutations in the manganese transporter SLC39A14 have recently been associated with a pediatric-onset neurodegenerative disorder characterized by brain manganese accumulation and clinical signs of manganese neurotoxicity, including parkinsonism-dystonia. Manganese 169-178 solute carrier family 39 member 14 Homo sapiens 57-65 28789954-0 2018 Familial manganese-induced neurotoxicity due to mutations in SLC30A10 or SLC39A14. Manganese 9-18 solute carrier family 39 member 14 Homo sapiens 73-81 29498153-1 2018 BACKGROUND: Mutations in SLC39A14 cause a recessive disorder of manganese (Mn) metabolism that manifests as childhood onset progressive neurodegeneration characterized by parkinsonism and dystonia. Manganese 64-73 solute carrier family 39 member 14 Homo sapiens 25-33 29382362-1 2018 BACKGROUND: The SLC39A14, SLC30A10 and SLC39A8 are considered to be key genes involved in manganese (Mn) homeostasis in humans. Manganese 90-99 solute carrier family 39 member 14 Homo sapiens 16-24 24576911-0 2014 Interleukin-6 enhances manganese accumulation in SH-SY5Y cells: implications of the up-regulation of ZIP14 and the down-regulation of ZnT10. Manganese 23-32 solute carrier family 39 member 14 Homo sapiens 101-106 28860195-8 2017 Compared with wild-type controls, Slc39a14 single and Slc30a10/Slc39a14 double knockouts had higher manganese levels in the blood and brain but not in the liver. Manganese 100-109 solute carrier family 39 member 14 Homo sapiens 34-42 28860195-8 2017 Compared with wild-type controls, Slc39a14 single and Slc30a10/Slc39a14 double knockouts had higher manganese levels in the blood and brain but not in the liver. Manganese 100-109 solute carrier family 39 member 14 Homo sapiens 63-71 28860195-11 2017 Thus, transport activities of both SLC39A14 and SLC30A10 are required for hepatic manganese excretion. Manganese 82-91 solute carrier family 39 member 14 Homo sapiens 35-43 28860195-12 2017 Compared with Slc30a10 single knockouts, Slc39a14 single and Slc30a10/Slc39a14 double knockouts had lower thyroid manganese levels and normal thyroid function. Manganese 114-123 solute carrier family 39 member 14 Homo sapiens 41-49 28536273-16 2017 Humans with altered ZIP14 function would lack this gatekeeper function of ZIP14 and therefore would be prone to manganese-related neurological diseases. Manganese 112-121 solute carrier family 39 member 14 Homo sapiens 20-25 28536273-16 2017 Humans with altered ZIP14 function would lack this gatekeeper function of ZIP14 and therefore would be prone to manganese-related neurological diseases. Manganese 112-121 solute carrier family 39 member 14 Homo sapiens 74-79 28536273-9 2017 The intensity of MR images from brains of the Zip14 KO mice is indicative of major manganese accumulation. Manganese 83-92 solute carrier family 39 member 14 Homo sapiens 46-51 27231142-0 2016 Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia. Manganese 30-39 solute carrier family 39 member 14 Homo sapiens 13-21 24576911-9 2014 These results suggest that both the up-regulation of ZIP14 and the down-regulation of ZnT10 by IL-6 might have enhanced the accumulation of manganese in SH-SY5Y cells. Manganese 140-149 solute carrier family 39 member 14 Homo sapiens 53-58 22898811-2 2012 Among the ZIP proteins, ZIP8 is most closely related to ZIP14, which can transport iron, zinc, manganese, and cadmium. Manganese 95-104 solute carrier family 39 member 14 Homo sapiens 56-61 22318508-3 2012 Two likely candidates are the recently identified transmembrane proteins ZIP14 and ZIP8, which have been shown to mediate the cellular uptake of a number of divalent metal ions including zinc, iron, manganese, and cadmium. Manganese 199-208 solute carrier family 39 member 14 Homo sapiens 73-78 19375483-9 2009 The role of ZIP14 in the uptake of cadmium and manganese is also discussed. Manganese 47-56 solute carrier family 39 member 14 Homo sapiens 12-17