PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21238487-8	2011	Recently it was shown that G2019S, the most common diseasing-causing mutant of LRRK2, has dramatic effects on the kinase activity of LRRK2: while activity of wild-type LRRK2 is inhibited by manganese, the G2019S mutation abrogates this inhibition.	Manganese	190-199	leucine rich repeat kinase 2	Homo sapiens	79-84	
26123245-9	2015	We also explore the effect of divalent cations as catalytic cofactors for G2019S LRRK2-mediated tau phosphorylation and show that manganese does not support kinase activity but inhibits the efficient ability of magnesium to catalyze LRRK2-mediated phosphorylation of tau.	Manganese	130-139	leucine rich repeat kinase 2	Homo sapiens	81-86	
26123245-9	2015	We also explore the effect of divalent cations as catalytic cofactors for G2019S LRRK2-mediated tau phosphorylation and show that manganese does not support kinase activity but inhibits the efficient ability of magnesium to catalyze LRRK2-mediated phosphorylation of tau.	Manganese	130-139	leucine rich repeat kinase 2	Homo sapiens	233-238	
23628791-0	2013	Down-regulation of LRRK2 in control and DAT transfected HEK cells increases manganese-induced oxidative stress and cell toxicity.	Manganese	76-85	leucine rich repeat kinase 2	Homo sapiens	19-24	
30481588-9	2019	Notably, manganese (Mn) exposure leads to a PD-like neurological disorder referred to as manganism-and induces pathogenic PTMs of alpha-synuclein and LRRK2.	Manganese	9-18	leucine rich repeat kinase 2	Homo sapiens	150-155	
30645642-0	2019	LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia.	Manganese	38-47	leucine rich repeat kinase 2	Homo sapiens	0-5	
29408508-0	2018	Role of LRRK2 in manganese-induced neuroinflammation and microglial autophagy.	Manganese	17-26	leucine rich repeat kinase 2	Homo sapiens	8-13	
21238487-8	2011	Recently it was shown that G2019S, the most common diseasing-causing mutant of LRRK2, has dramatic effects on the kinase activity of LRRK2: while activity of wild-type LRRK2 is inhibited by manganese, the G2019S mutation abrogates this inhibition.	Manganese	190-199	leucine rich repeat kinase 2	Homo sapiens	133-138	
21238487-8	2011	Recently it was shown that G2019S, the most common diseasing-causing mutant of LRRK2, has dramatic effects on the kinase activity of LRRK2: while activity of wild-type LRRK2 is inhibited by manganese, the G2019S mutation abrogates this inhibition.	Manganese	190-199	leucine rich repeat kinase 2	Homo sapiens	133-138	
21238487-9	2011	Based on the in vitro kinetic properties of LRRK2 in the presence of manganese, we proposed that LRRK2 may be a sensor of cytoplasmic manganese levels and that the G2019S mutant has lost this function.	Manganese	69-78	leucine rich repeat kinase 2	Homo sapiens	44-49	
21238487-9	2011	Based on the in vitro kinetic properties of LRRK2 in the presence of manganese, we proposed that LRRK2 may be a sensor of cytoplasmic manganese levels and that the G2019S mutant has lost this function.	Manganese	134-143	leucine rich repeat kinase 2	Homo sapiens	97-102	
20205471-0	2010	Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2).	Manganese	33-42	leucine rich repeat kinase 2	Homo sapiens	83-111	
20205471-0	2010	Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2).	Manganese	33-42	leucine rich repeat kinase 2	Homo sapiens	113-118