PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20152896-8	2010	Importantly, the manganese-mediated expression and activity of HIF-1alpha protein were largely blocked by treatment with the inhibitor of p38 MAPK (SB203580), JNK-1/2 (SP600125), or ERK-1/2 (PD98059), suggesting roles of these MAPKs in the manganese-induced HIF-1alpha protein expression and activity.	Manganese	17-26	mitogen-activated protein kinase 8	Homo sapiens	159-166	
22179285-5	2012	Manganese treatment             also led to increased phosphorylation of extracellular-regulated protein kinase-1/2             (ERK-1/2), c-Jun N-terminal kinase-1 (JNK-1), protein kinase B (PKB), S6 and eukaryotic             translation initiation factor-2alpha (eIF-2alpha) in A549 cells.	Manganese	0-9	mitogen-activated protein kinase 8	Homo sapiens	139-164	
22179285-5	2012	Manganese treatment             also led to increased phosphorylation of extracellular-regulated protein kinase-1/2             (ERK-1/2), c-Jun N-terminal kinase-1 (JNK-1), protein kinase B (PKB), S6 and eukaryotic             translation initiation factor-2alpha (eIF-2alpha) in A549 cells.	Manganese	0-9	mitogen-activated protein kinase 8	Homo sapiens	166-171	
20589745-1	2011	Multiple studies demonstrate that manganese (Mn) exposure potentiates inflammatory mediator output from activated glia; this increased output is associated with enhanced mitogen activated protein kinase (MAPK: p38, ERK and JNK) activity.	Manganese	34-43	mitogen-activated protein kinase 8	Homo sapiens	223-226	
20648640-8	2010	As ONS is known to activate mitogen-activated protein kinases (MAPKs) and MAPK activation has been implicated in astrocyte swelling, we examined the effect of manganese on the activation of MAPKs and found an increased phosphorylation of extracellular signal-regulated kinase (ERK)1/2, C-Jun amino-terminal kinase (JNK)1/2/3, and p38-MAPK.	Manganese	159-168	mitogen-activated protein kinase 8	Homo sapiens	315-324	
20152896-7	2010	Interestingly, manganese treatment also caused activation of p38 MAPK, JNK-1/2, ERK-1/2, and ATF-2, but not of PKB or NF-kappaB in Hep2 cells.	Manganese	15-24	mitogen-activated protein kinase 8	Homo sapiens	71-78	
20152896-9	2010	Moreover, treatment with SP600125 or SB203580, but not PD98059, had partial inhibitory effects on the stability of HIF-1alpha protein induced by manganese, suggesting that p38 MAPK and JNK-1/2 also contribute to the Mn-mediated HIF-1alpha protein stability.	Manganese	145-154	mitogen-activated protein kinase 8	Homo sapiens	185-192	
17045426-6	2006	Manganese caused a two- to four-fold increase in SAPK/JNK and ERK 1/2 phosphorylation, with no observed effects on p38 kinase.	Manganese	0-9	mitogen-activated protein kinase 8	Homo sapiens	54-57