PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22191580-2 2012 We recently reported a gene-environment interaction wherein expression of mutant HTT is associated with neuroprotection against manganese (Mn) toxicity. Manganese 128-137 huntingtin Mus musculus 81-84 19845833-3 2010 We report that striatal cells expressing mutant Huntingtin exhibit elevated sensitivity to cadmium toxicity and resistance to manganese toxicity. Manganese 126-135 huntingtin Mus musculus 48-58 20547568-3 2010 Recently, we discovered that expression of mutant HTT is associated with impaired manganese (Mn) uptake following overexposure in a striatal neuronal cell line and mouse model of HD. Manganese 82-91 huntingtin Mus musculus 50-53 19845833-8 2010 Thus, this disease-toxicant interaction screen has revealed that expression of mutant Huntingtin results in heightened sensitivity to cadmium neurotoxicity and a selective impairment of manganese accumulation. Manganese 186-195 huntingtin Mus musculus 86-96