PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18987317-1 2008 The original experiments reconstituting GroEL-GroES-mediated protein folding were carried out under "nonpermissive" conditions, where the chaperonin system was absolutely required and substrate proteins could not achieve the native state if diluted directly from denaturant into solution. denaturant 263-273 heat shock protein family D (Hsp60) member 1 Homo sapiens 40-45