PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6604123-3 1983 However, at lower concentrations (2 X 10(-12) M) C3a did not aggregate platelets directly but exhibited highly significant synergism (two-way analysis of variance P less than 0.0001) with ADP in mediating platelet aggregation and release of serotonin. Adenosine Diphosphate 188-191 complement C3 Homo sapiens 49-52 3283237-3 1988 Uptake of 125I-C3a by guinea pig platelets is maximal in 1 min, and stimulation of guinea pig platelets by thrombin, ADP, or the Ca2+ ionophore A23187 showed little influence on binding of the ligand. Adenosine Diphosphate 117-120 complement C3 Homo sapiens 15-18 6604123-6 1983 Further C3a and C3a des-arg exhibited synergism with ADP of equal significance in both aggregation and the release reaction. Adenosine Diphosphate 53-56 complement C3 Homo sapiens 16-19 6604123-7 1983 The concentrations of C3a required for the platelet-stimulating activity involve relatively small number of molecules per platelet (4,000-10,000 for the synergistic reaction with ADP). Adenosine Diphosphate 179-182 complement C3 Homo sapiens 22-25