PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2442519-4	1987	The binding of other calmodulin antagonists and calcium antagonists, including prenylamine, R24571, and diltiazem, to these calcium-binding proteins abolishes the cooperativity between two felodipine-binding sites, resulting in felodipine binding to the remaining site with a 20-25-fold greater affinity.	Diltiazem	104-113	calmodulin 1	Homo sapiens	21-31	
2964236-0	1988	Verapamil, diltiazem and nifedipine interactions with calmodulin stimulated (Ca2+ + Mg2+)-ATPase.	Diltiazem	11-20	calmodulin 1	Homo sapiens	54-64	
2964236-1	1988	The functional interactions of the three prototype Ca2+ antagonists, verapamil, diltiazem and nifedipine, were examined in relation to the calmodulin regulated plasma membrane Ca2+ pump ATPase.	Diltiazem	80-89	calmodulin 1	Homo sapiens	139-149	
2964236-4	1988	Half-maximal activation by 6 nM calmodulin was antagonized by 10(-3) M verapamil and 10(-3) M diltiazem 25.1 and 12.1% respectively.	Diltiazem	94-103	calmodulin 1	Homo sapiens	32-42	
3038124-3	1987	Of the four Ca2+ entry blockers tested, only verapamil and diltiazem specifically inhibited the calmodulin-stimulated (Ca2+ + Mg2+)-ATPase activity, the basal enzyme activity being unaltered by these drugs.	Diltiazem	59-68	calmodulin 1	Homo sapiens	96-106	
3038124-5	1987	Calmodulin concentration effect curves showed the inhibition by verapamil (10(-3) M) and diltiazem (10(-3) M) to be non-competitive.	Diltiazem	89-98	calmodulin 1	Homo sapiens	0-10	
3484629-6	1986	The concentrations of unlabeled bepridil, W-7, prenylamine, verapamil and diltiazem producing 50% inhibition (IC50) of the binding of [3H]bepridil to calmodulin were 4 microM, 28 microM, 45 microM, 130 microM and 700 microM, respectively.	Diltiazem	74-83	calmodulin 1	Homo sapiens	150-160	
6847674-3	1983	Hydrophobic ligands including the calmodulin antagonist, R24571 and Ca2+ antagonists, prenylamine and diltiazem, bind to calmodulin and potentiate felodipine binding by as much as 20 fold.	Diltiazem	102-111	calmodulin 1	Homo sapiens	121-131	
6747823-9	1984	Inhibition of superprecipitation by diltiazem was apparent at a concentration of 10(-6) M, was manifest by a rightward shift in the pCa relationship and could be attenuated by exogenous calmodulin.	Diltiazem	36-45	calmodulin 1	Homo sapiens	186-196	
6875846-4	1983	The relaxations produced by these calmodulin antagonists and prenylamine could not be overcome by contractile agonists which release Ca++ from internal stores (histamine and serotonin), whereas the relaxations produced by felodipine, verapamil and diltiazem were readily reversed by either of these agonists.	Diltiazem	248-257	calmodulin 1	Homo sapiens	34-44	
6307716-1	1983	The effect of three calcium antagonists (verapamil, nifedipine and diltiazem) on the calcium-induced activation of phosphodiesterase (a calmodulin dependent process) was investigated.	Diltiazem	67-76	calmodulin 1	Homo sapiens	136-146	
6307716-3	1983	In the presence of calmodulin, phosphodiesterase activity was stimulated by calcium in the range 4 X 10(-6)-2.5 X 10(-5) M. Diltiazem (10(-6) M), verapamil (10(-6) M) and nifedipine (10(-7) and 10(-6) M) had no influence on phosphodiesterase activity in the presence or absence of calmodulin at any concentration of calcium employed.	Diltiazem	124-133	calmodulin 1	Homo sapiens	19-29