PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15627720-8 2004 Diltiazem (10 micromol/l) significantly dilated AA (26.8 +/- 2.2%), and prevented Ang II-mediated constriction of AA. Diltiazem 0-9 angiotensinogen Rattus norvegicus 82-88 8430823-4 1993 Vasoconstriction to ANG II was significantly inhibited by diltiazem (29 +/- 12 vs. 67 +/- 31%; P < 0.02) in AA. Diltiazem 58-67 angiotensinogen Rattus norvegicus 20-26 8060463-8 1994 The preventive effect of diltiazem against the cyclosporin A-induced hypersensitivity to angiotensin II supports the hypothesis of increased calcium influx during cyclosporin A therapy. Diltiazem 25-34 angiotensinogen Rattus norvegicus 89-103 8293761-5 1993 Chronic treatment with diltiazem alone did not affect the responsiveness to any of the drugs tested, but the augmentation of contractions to angiotensin II (10(-9) to 10(-6) M) after treatment with cyclosporin, was prevented by co-treatment with diltiazem. Diltiazem 23-32 angiotensinogen Rattus norvegicus 141-155 8293761-5 1993 Chronic treatment with diltiazem alone did not affect the responsiveness to any of the drugs tested, but the augmentation of contractions to angiotensin II (10(-9) to 10(-6) M) after treatment with cyclosporin, was prevented by co-treatment with diltiazem. Diltiazem 246-255 angiotensinogen Rattus norvegicus 141-155 8329674-5 1993 With diltiazem (10(-5) M) in the bathing media, 10(-8) M AII caused an abrupt rise and decline in SMC [Ca2+]i in AA, but a sustained elevation in EA (P < 0.02). Diltiazem 5-14 angiotensinogen Rattus norvegicus 57-60 1775187-3 1991 It was demonstrated that the angiotensin II-induced increase in slowly exchanging 45Ca2+ in rat aorta was incompletely (by approximately 60%-70%) inhibited by the organic Ca2+ entry blockers nifedipine, verapamil and diltiazem and by other Ca2+ entry blocking compounds like CoCl2 and chlorpromazine. Diltiazem 217-226 angiotensinogen Rattus norvegicus 29-43 1280721-0 1992 Diltiazem potentiates angiotensin II-mediated renal prostacyclin synthesis. Diltiazem 0-9 angiotensinogen Rattus norvegicus 22-36 1280721-11 1992 We conclude that DIL enhances AII-induced renal prostacyclin synthesis and that this is functionally relevant. Diltiazem 17-20 angiotensinogen Rattus norvegicus 30-33 25661249-0 2015 Protective effects of diltiazem against vascular endothelial cell injury induced by angiotensin-II and hypoxia. Diltiazem 22-31 angiotensinogen Rattus norvegicus 84-98 25661249-4 2015 Our study showed that AngII and hypoxia decreased the mitochondrial membrane potential in VEC, which was significantly inhibited by diltiazem. Diltiazem 132-141 angiotensinogen Rattus norvegicus 22-27 25661249-5 2015 Diltiazem protected against VEC injury induced by the increased concentration of intracellular free calcium, which was associated with AngII and hypoxia. Diltiazem 0-9 angiotensinogen Rattus norvegicus 135-140 25661249-9 2015 Diltiazem, a calcium channel blocker, protected VEC from AngII- and hypoxia-induced injury. Diltiazem 0-9 angiotensinogen Rattus norvegicus 57-62 3866796-8 1985 pretreatment with diltiazem, diltiazem attenuated the pressor responses to angiotensin II. Diltiazem 18-27 angiotensinogen Rattus norvegicus 75-89 3866796-8 1985 pretreatment with diltiazem, diltiazem attenuated the pressor responses to angiotensin II. Diltiazem 29-38 angiotensinogen Rattus norvegicus 75-89 6662118-6 1983 These results demonstrate that at concentration less than 10(-5) mol l-1, diltiazem acts as a selective antagonist of the effect of angiotensin II whilst no such selectivity of action was observed with all concentrations of nifedipine used in the present studies. Diltiazem 74-83 angiotensinogen Rattus norvegicus 132-146 6139380-2 1983 Diltiazem was a potent antagonist of phasic responses induced by low concentrations of K+, tetraethylammonium (TEA), the selective alpha 2-adrenoreceptor agonists UK 14304 or TL99 and angiotensin II (AII). Diltiazem 0-9 angiotensinogen Rattus norvegicus 184-198 6139380-2 1983 Diltiazem was a potent antagonist of phasic responses induced by low concentrations of K+, tetraethylammonium (TEA), the selective alpha 2-adrenoreceptor agonists UK 14304 or TL99 and angiotensin II (AII). Diltiazem 0-9 angiotensinogen Rattus norvegicus 200-203 535823-9 1979 On the other hand, it was demonstrated that the pressor responses to norepinephrine and angiotensin II in the anesthetized normotensive rats were non-competitively inhibited by intravenous administration of diltiazem at a dose which had no effect on the blood pressure. Diltiazem 207-216 angiotensinogen Rattus norvegicus 88-102 2544103-8 1989 In the presence of either verapamil or diltiazem, the effect of ANG II to decrease efferent diameter was sustained (-15 +/- 4%); however, the effect of ANG II on afferent diameter was abolished (-1 +/- 1%). Diltiazem 39-48 angiotensinogen Rattus norvegicus 64-70 3878075-12 1985 Diltiazem opposed angiotensin II-induced responses, such as renal vasoconstriction and reduction of glomerular filtration rate. Diltiazem 0-9 angiotensinogen Rattus norvegicus 18-32 6662118-0 1983 Comparative effects of nifedipine and diltiazem on vascular responses to norepinephrine and angiotensin II. Diltiazem 38-47 angiotensinogen Rattus norvegicus 92-106 6662118-4 1983 At concentrations of 3 X 10(-7) mol l-1 and 10(-6) mol l-1, diltiazem inhibited only the response to angiotensin II without affecting the vasoconstrictor effect of norepinephrine. Diltiazem 60-69 angiotensinogen Rattus norvegicus 101-115 6662118-5 1983 Increase in diltiazem concentration to 10(-5) mol l-1 and 10(-4) mol l-1 was associated with a similar inhibition of the response to angiotensin II and norepinephrine. Diltiazem 12-21 angiotensinogen Rattus norvegicus 133-147