PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14981072-4	2004	The Ca2+ channel blockers verapamil and diltiazem (10(-6) mol/L) abolished the maintained ET-1-induced [Ca2+]i, but only partially inhibited ET-1-induced cell contraction to 18%.	Diltiazem	40-49	endothelin 1	Homo sapiens	90-94	
1748812-4	1991	It was partly attenuated by diltiazem, a potent Ca++ entry blocker, but not affected by alpha-adrenoceptor antagonist phentolamine, indicating that endothelin-1 causes vasoconstriction by either the extracellular Ca++ entry or intracellular movement of Ca++ from the cytosolic storage site.	Diltiazem	28-37	endothelin 1	Homo sapiens	148-160	
1472072-5	1992	Ca2+ channel blockers, Nifedipine, Diltiazem and Verapamil (5 microM), reduced ET-1 chemotaxsis more than 60% (P < 0.001).	Diltiazem	35-44	endothelin 1	Homo sapiens	79-83	
14981072-4	2004	The Ca2+ channel blockers verapamil and diltiazem (10(-6) mol/L) abolished the maintained ET-1-induced [Ca2+]i, but only partially inhibited ET-1-induced cell contraction to 18%.	Diltiazem	40-49	endothelin 1	Homo sapiens	141-145	
9787942-11	1998	These findings suggest that CsA induced acute vasoconstriction and renal hypoperfusion are mediated by ET-1 and that diltiazem treatment abolishes these pharmacodynamic effects of CsA despite persistent increase of plasma ET-1 levels.	Diltiazem	117-126	endothelin 1	Homo sapiens	222-226	
11472982-7	2001	In addition, treatment of HPASM cells with two drug types used in the management of PH-cicaprost, a stable prostacyclin-mimetic; or diltiazem, a calcium-channel blocker-reduced ET-1 release from these cells.	Diltiazem	132-141	endothelin 1	Homo sapiens	177-181	
9782065-9	1998	Mg as well as diltiazem similarly affected the plasma ET-1 by reducing ET-1 release during the first hour of the reperfusion period.	Diltiazem	14-23	endothelin 1	Homo sapiens	54-58	
9782065-9	1998	Mg as well as diltiazem similarly affected the plasma ET-1 by reducing ET-1 release during the first hour of the reperfusion period.	Diltiazem	14-23	endothelin 1	Homo sapiens	71-75	
9782065-11	1998	Ability of Mg, diltiazem and leumedins to decrease the ET-1 plasma level may have direct clinical implications for the use of these agents in patients with coronary artery disease.	Diltiazem	15-24	endothelin 1	Homo sapiens	55-59	
7712014-15	1995	The biphasic increases in [Ca2+]i and tension induced by 10-5 M ET-3 and by 1O-7M ET-1 were significantly inhibited by pretreatment with 10-5 M of the Ca2+ entry blocker, diltiazem, although the inhibition of the first component of ET-l-induced [Ca2+]i increase was partial.5.	Diltiazem	171-180	endothelin 1	Homo sapiens	82-86