PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14981072-4 2004 The Ca2+ channel blockers verapamil and diltiazem (10(-6) mol/L) abolished the maintained ET-1-induced [Ca2+]i, but only partially inhibited ET-1-induced cell contraction to 18%. Diltiazem 40-49 endothelin 1 Homo sapiens 90-94 1748812-4 1991 It was partly attenuated by diltiazem, a potent Ca++ entry blocker, but not affected by alpha-adrenoceptor antagonist phentolamine, indicating that endothelin-1 causes vasoconstriction by either the extracellular Ca++ entry or intracellular movement of Ca++ from the cytosolic storage site. Diltiazem 28-37 endothelin 1 Homo sapiens 148-160 1472072-5 1992 Ca2+ channel blockers, Nifedipine, Diltiazem and Verapamil (5 microM), reduced ET-1 chemotaxsis more than 60% (P < 0.001). Diltiazem 35-44 endothelin 1 Homo sapiens 79-83 14981072-4 2004 The Ca2+ channel blockers verapamil and diltiazem (10(-6) mol/L) abolished the maintained ET-1-induced [Ca2+]i, but only partially inhibited ET-1-induced cell contraction to 18%. Diltiazem 40-49 endothelin 1 Homo sapiens 141-145 9787942-11 1998 These findings suggest that CsA induced acute vasoconstriction and renal hypoperfusion are mediated by ET-1 and that diltiazem treatment abolishes these pharmacodynamic effects of CsA despite persistent increase of plasma ET-1 levels. Diltiazem 117-126 endothelin 1 Homo sapiens 222-226 11472982-7 2001 In addition, treatment of HPASM cells with two drug types used in the management of PH-cicaprost, a stable prostacyclin-mimetic; or diltiazem, a calcium-channel blocker-reduced ET-1 release from these cells. Diltiazem 132-141 endothelin 1 Homo sapiens 177-181 9782065-9 1998 Mg as well as diltiazem similarly affected the plasma ET-1 by reducing ET-1 release during the first hour of the reperfusion period. Diltiazem 14-23 endothelin 1 Homo sapiens 54-58 9782065-9 1998 Mg as well as diltiazem similarly affected the plasma ET-1 by reducing ET-1 release during the first hour of the reperfusion period. Diltiazem 14-23 endothelin 1 Homo sapiens 71-75 9782065-11 1998 Ability of Mg, diltiazem and leumedins to decrease the ET-1 plasma level may have direct clinical implications for the use of these agents in patients with coronary artery disease. Diltiazem 15-24 endothelin 1 Homo sapiens 55-59 7712014-15 1995 The biphasic increases in [Ca2+]i and tension induced by 10-5 M ET-3 and by 1O-7M ET-1 were significantly inhibited by pretreatment with 10-5 M of the Ca2+ entry blocker, diltiazem, although the inhibition of the first component of ET-l-induced [Ca2+]i increase was partial.5. Diltiazem 171-180 endothelin 1 Homo sapiens 82-86