PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21304987-4	2011	On the contrary, inhibition of S1PL with 4-deoxypyridoxine or knockdown of S1PL with siRNA increased S1P(int) and potentiated motility of HPAECs to S1P(ext) or serum.	4-deoxypyridoxine	41-58	sphingosine-1-phosphate lyase 1	Homo sapiens	31-35	
23756681-5	2013	As results, we discovered that 4-deoxypyridoxine (DOP), which inhibits the degradation of intracellular S1P by inhibiting S1P lyase (SPL) activity, minimized the chemically induced apoptosis of insulinoma cell lines as S1P did.	4-deoxypyridoxine	31-48	sphingosine-1-phosphate lyase 1	Homo sapiens	122-131	
23756681-5	2013	As results, we discovered that 4-deoxypyridoxine (DOP), which inhibits the degradation of intracellular S1P by inhibiting S1P lyase (SPL) activity, minimized the chemically induced apoptosis of insulinoma cell lines as S1P did.	4-deoxypyridoxine	31-48	sphingosine-1-phosphate lyase 1	Homo sapiens	133-136	
23756681-5	2013	As results, we discovered that 4-deoxypyridoxine (DOP), which inhibits the degradation of intracellular S1P by inhibiting S1P lyase (SPL) activity, minimized the chemically induced apoptosis of insulinoma cell lines as S1P did.	4-deoxypyridoxine	50-53	sphingosine-1-phosphate lyase 1	Homo sapiens	122-131	
23756681-5	2013	As results, we discovered that 4-deoxypyridoxine (DOP), which inhibits the degradation of intracellular S1P by inhibiting S1P lyase (SPL) activity, minimized the chemically induced apoptosis of insulinoma cell lines as S1P did.	4-deoxypyridoxine	50-53	sphingosine-1-phosphate lyase 1	Homo sapiens	133-136	
23756681-6	2013	Also, supplementation of DOP in the culture media protected the regression of isolated islets that have been maintained ex vivo at least for 18 h providing the evidence of increasing viability of isolated islets with DOP, which impaired SPL activity.	4-deoxypyridoxine	25-28	sphingosine-1-phosphate lyase 1	Homo sapiens	237-240	
23756681-6	2013	Also, supplementation of DOP in the culture media protected the regression of isolated islets that have been maintained ex vivo at least for 18 h providing the evidence of increasing viability of isolated islets with DOP, which impaired SPL activity.	4-deoxypyridoxine	217-220	sphingosine-1-phosphate lyase 1	Homo sapiens	237-240	
22444536-11	2012	Furthermore, we treated HT-29 cells with different concentrations of 4-deoxypyridoxine (DOP), which competitively inhibits pyridoxal-5-phosphate (P5P), an essential cofactor for SPL activity, and observed a significant decrease in (2E)-hexadecenal relative to the untreated cells.	4-deoxypyridoxine	69-86	sphingosine-1-phosphate lyase 1	Homo sapiens	178-181	
22444536-11	2012	Furthermore, we treated HT-29 cells with different concentrations of 4-deoxypyridoxine (DOP), which competitively inhibits pyridoxal-5-phosphate (P5P), an essential cofactor for SPL activity, and observed a significant decrease in (2E)-hexadecenal relative to the untreated cells.	4-deoxypyridoxine	88-91	sphingosine-1-phosphate lyase 1	Homo sapiens	178-181