PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33142432-6 2020 Of the 32 novel synthesized derivatives, approximately 20 of the 6(7)-amino-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides demonstrated high antiproliferative potency against wild type leukemia cells K562 and drug-resistant subline K562/4 with the expression of p-glycoprotein (p-gp) compared to the reference agent doxorubicin, which exhibited one order of magnitude lower activity towards K562/4 cells than towards K562 cells. 6(7)-amino-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides 65-123 ATP binding cassette subfamily B member 1 Homo sapiens 263-277 33142432-6 2020 Of the 32 novel synthesized derivatives, approximately 20 of the 6(7)-amino-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides demonstrated high antiproliferative potency against wild type leukemia cells K562 and drug-resistant subline K562/4 with the expression of p-glycoprotein (p-gp) compared to the reference agent doxorubicin, which exhibited one order of magnitude lower activity towards K562/4 cells than towards K562 cells. 6(7)-amino-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides 65-123 ATP binding cassette subfamily B member 1 Homo sapiens 279-283