PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32030632-0 2020 Arsenite Increases Linc-ROR in Human Bronchial Epithelial Cells that Can Be Inhibited by Antioxidant Factors. Arsenites 0-8 long intergenic non-protein coding RNA, regulator of reprogramming Homo sapiens 19-27 32030632-3 2020 However, whether long intergenic non-coding RNA, regulator of reprogramming (linc-ROR) is involved in arsenite-induced oxidative stress has not been explored. Arsenites 102-110 long intergenic non-protein coding RNA, regulator of reprogramming Homo sapiens 17-85 32030632-4 2020 In this study, we found that arsenite dose responsively increased the expression of linc-ROR in human bronchial epithelial (HBE) cells, along with elevated oxidative stress demonstrated by increased intracellular reactive oxygen species (ROS) and DNA damage, as well as decreased antioxidant glutathione and superoxide dismutase. Arsenites 29-37 long intergenic non-protein coding RNA, regulator of reprogramming Homo sapiens 84-92 32030632-5 2020 We further found that the pre-treatment with N-acetylcysteine, a widely used ROS scavenger, and the over-expression of antioxidant NRF2 protein, both significantly reduced arsenite-induced oxidative stress in arsenite-treated HBE cells, and the linc-ROR over-expression was also inhibited, suggesting that oxidative stress is a key factor for the increase of linc-ROR in arsenite-treated HBE cells. Arsenites 172-180 long intergenic non-protein coding RNA, regulator of reprogramming Homo sapiens 245-253 32030632-5 2020 We further found that the pre-treatment with N-acetylcysteine, a widely used ROS scavenger, and the over-expression of antioxidant NRF2 protein, both significantly reduced arsenite-induced oxidative stress in arsenite-treated HBE cells, and the linc-ROR over-expression was also inhibited, suggesting that oxidative stress is a key factor for the increase of linc-ROR in arsenite-treated HBE cells. Arsenites 172-180 long intergenic non-protein coding RNA, regulator of reprogramming Homo sapiens 359-367 32030632-6 2020 Moreover, our results of bio-informatic analysis showed that arsenite-induced oxidative stress might modulate linc-ROR expression via 3 genes and the up-regulated linc-ROR in arsenite-induced oxidative stress may get involved in cellular processes such as cellular stress response, RNA metabolism, and DNA repair. Arsenites 61-69 long intergenic non-protein coding RNA, regulator of reprogramming Homo sapiens 110-118 32030632-6 2020 Moreover, our results of bio-informatic analysis showed that arsenite-induced oxidative stress might modulate linc-ROR expression via 3 genes and the up-regulated linc-ROR in arsenite-induced oxidative stress may get involved in cellular processes such as cellular stress response, RNA metabolism, and DNA repair. Arsenites 61-69 long intergenic non-protein coding RNA, regulator of reprogramming Homo sapiens 163-171 32030632-6 2020 Moreover, our results of bio-informatic analysis showed that arsenite-induced oxidative stress might modulate linc-ROR expression via 3 genes and the up-regulated linc-ROR in arsenite-induced oxidative stress may get involved in cellular processes such as cellular stress response, RNA metabolism, and DNA repair. Arsenites 175-183 long intergenic non-protein coding RNA, regulator of reprogramming Homo sapiens 110-118 32030632-6 2020 Moreover, our results of bio-informatic analysis showed that arsenite-induced oxidative stress might modulate linc-ROR expression via 3 genes and the up-regulated linc-ROR in arsenite-induced oxidative stress may get involved in cellular processes such as cellular stress response, RNA metabolism, and DNA repair. Arsenites 175-183 long intergenic non-protein coding RNA, regulator of reprogramming Homo sapiens 163-171 32030632-7 2020 Collectively, our study demonstrates that oxidative stress plays the key role in arsenite-induced over-expression of linc-ROR, and linc-ROR may be a new clue for exploring the mechanism of arsenite toxicity. Arsenites 81-89 long intergenic non-protein coding RNA, regulator of reprogramming Homo sapiens 117-125