PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19360465-3 2010 Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth. Steroids 186-201 transforming growth factor beta 1 Homo sapiens 284-288 21246940-3 2010 This study aimed to determine whether the ratio of hepatocyte growth factor (HGF) to transforming growth factor beta 1 (TGF beta1) in lupus nephritis could be a prognostic factor for response to therapy with cyclophosphamide and steroids at six months. Steroids 229-237 transforming growth factor beta 1 Homo sapiens 120-129 19408724-1 2009 OBJECTIVE: To investigate the effects of intralesional steroid, interferon alpha-2b or verapamil injection on proliferation, apoptosis and TGF-beta1 expression in keloid and hypertrophic scar in vivo. Steroids 55-62 transforming growth factor beta 1 Homo sapiens 139-148 19317336-9 2008 Serum TGF-beta1 was highest in steroid naive mild asthma group when compared to the moderate asthma and asthma in remission groups (47.44 ng/ml vs. 38.64 ng/ml and 47.44 ng/ml vs. 35.94 ng/ml, p = 0.013 and 0.001, respectively). Steroids 31-38 transforming growth factor beta 1 Homo sapiens 6-15 17075808-9 2006 CONCLUSION: These findings indicate that baseline expression of renal HGF and TGFbeta1 predicts short-term renal outcome after therapy with CYC and steroids. Steroids 148-156 transforming growth factor beta 1 Homo sapiens 78-86 17066266-8 2007 TGF-beta1 and TGF-beta3 were identified as main regulative factors, due to the finding that steroid hormone inducible TGF-beta1 and TGF-beta3 inhibited cell-cell fusion, whereas antibody-mediated TGF-beta neutralization induced cell-cell fusions. Steroids 92-107 transforming growth factor beta 1 Homo sapiens 0-9 17066266-8 2007 TGF-beta1 and TGF-beta3 were identified as main regulative factors, due to the finding that steroid hormone inducible TGF-beta1 and TGF-beta3 inhibited cell-cell fusion, whereas antibody-mediated TGF-beta neutralization induced cell-cell fusions. Steroids 92-107 transforming growth factor beta 1 Homo sapiens 118-127 17066266-8 2007 TGF-beta1 and TGF-beta3 were identified as main regulative factors, due to the finding that steroid hormone inducible TGF-beta1 and TGF-beta3 inhibited cell-cell fusion, whereas antibody-mediated TGF-beta neutralization induced cell-cell fusions. Steroids 92-107 transforming growth factor beta 1 Homo sapiens 0-8 17595868-5 2007 TGF-beta, whose expression is modulated by ovarian steroids, regulates cell growth, differentiation, apoptosis, inflammatory and immune responses, extracellular matrix deposition, adhesion molecules, proteases, and protease inhibitor expression. Steroids 51-59 transforming growth factor beta 1 Homo sapiens 0-8 16753358-7 2006 Additionally, inflammatory mediators, such as transforming growth factor-beta1, tumor necrosis factor-alpha and p38 mitogen activating protein kinase, similarly show differential expression and activity based on sex and the presence of sex steroids. Steroids 240-248 transforming growth factor beta 1 Homo sapiens 46-107 16353668-7 2005 We conclude that in Y-1 cells TGF-beta inhibits the expression of SF-1 gene at a transcriptional level, and we postulate that the inhibitory effect of TGF-beta on steroid hormone synthesis in the adrenal cortex could be due to an attenuated transcription of Sf-1. Steroids 163-178 transforming growth factor beta 1 Homo sapiens 151-159 14577262-5 2003 CONCLUSION: The effects of systemical steroid use on the nasal polyps may depend on decreasing the infiltration of eosinophils and the expression of TGF beta 1. Steroids 38-45 transforming growth factor beta 1 Homo sapiens 149-159 16323822-4 2005 The synthesis of IGFs is down-regulated by many locally produced growth factors, particularly trasforming growth factor beta (TGF-beta) and cortisol, and this probably accounts for the osteoporotic effects of this steroid, whereas PTH is stimulatory. Steroids 214-221 transforming growth factor beta 1 Homo sapiens 126-134 15625562-4 2004 TGF-b in turn inhibits steroid hormone output by attenuating both basal and ACTH-dependent expression of CYP17. Steroids 23-38 transforming growth factor beta 1 Homo sapiens 0-5 14746683-21 2003 (3) Concentration of TGF beta and TGF beta mRNA expression after therapy was clearly lower than that before therapy in steroid responsive group (P < 0.01). Steroids 119-126 transforming growth factor beta 1 Homo sapiens 21-29 12847477-14 2003 We hypothesize that these immunoregulatory and remodeling effects elicited by steroids might be, at least in part, mediated by the induction of TGF-beta. Steroids 78-86 transforming growth factor beta 1 Homo sapiens 144-152 14746683-21 2003 (3) Concentration of TGF beta and TGF beta mRNA expression after therapy was clearly lower than that before therapy in steroid responsive group (P < 0.01). Steroids 119-126 transforming growth factor beta 1 Homo sapiens 34-42 12765654-10 2003 In conclusion, this study shows that TGF is expressed in the goldfish ovary, and that both activin and TGFbeta affect steroid production, which provides evidence that these members of the TGFbeta superfamily may act as local regulators of ovarian function in a teleost. Steroids 118-125 transforming growth factor beta 1 Homo sapiens 103-110 12765654-10 2003 In conclusion, this study shows that TGF is expressed in the goldfish ovary, and that both activin and TGFbeta affect steroid production, which provides evidence that these members of the TGFbeta superfamily may act as local regulators of ovarian function in a teleost. Steroids 118-125 transforming growth factor beta 1 Homo sapiens 188-195 12456342-4 2003 During endometrial maturation, progesterone, retinoic acid and TGF-beta act cooperatively, providing a remarkable biological balance to regulate expression of MMPs in the highly steroid-sensitive endometrium. Steroids 178-185 transforming growth factor beta 1 Homo sapiens 63-71 12485615-4 2003 Recently, new data indicated that activin/TGFbeta and sex steroid signalling are linked; explicitly, that the pathways cross-talk intracellularly. Steroids 58-65 transforming growth factor beta 1 Homo sapiens 42-49 12470522-9 2002 The regulation of TGFbeta signalling by ovarian steroid hormones may be one mechanism by which the OSE responds to cyclic changes in the underlying follicles. Steroids 48-64 transforming growth factor beta 1 Homo sapiens 18-25 11162896-3 2000 Cells were also treated with different concentration of TGFbeta1 in the presence of forskolin, combined steroid production was measured at the end of 48 h and after 3 h incubation with 22R-hydroxycholesterol. Steroids 104-111 transforming growth factor beta 1 Homo sapiens 56-64 11786088-8 2002 TGF-beta1 gene expression was noted in 23 of 29 steroid resistant (SR) children with NS not caused by lupus nephritis and in 18 of 20 FSGS patients. Steroids 48-55 transforming growth factor beta 1 Homo sapiens 0-9 11786088-9 2002 In contrast TGF-beta1 gene expression was detected in only 3 of 14 steroid-sensitive patients (P < 0.001). Steroids 67-74 transforming growth factor beta 1 Homo sapiens 12-21 11786088-11 2002 In patients with steroid-resistant NS, intrarenal TGF-beta1 gene expression showed a positive predictive value of 90% and a negative predictive value of 88% to identify FSGS (P < 0.0001). Steroids 17-24 transforming growth factor beta 1 Homo sapiens 50-59 11728950-3 2001 The aim of this study is to determine the usefulness of urinary TGF-beta1 values to monitor therapeutic effects of steroids in patients with immunoglobulin A (IgA) nephropathy. Steroids 115-123 transforming growth factor beta 1 Homo sapiens 64-73 11728950-9 2001 The activation rate of urinary TGF-beta1 also decreased significantly after steroid therapy. Steroids 76-83 transforming growth factor beta 1 Homo sapiens 31-40 11728950-10 2001 Urinary TGF-beta1 values therefore may be useful to assess disease activity or the effects of steroid therapy in patients with IgA nephropathy. Steroids 94-101 transforming growth factor beta 1 Homo sapiens 8-17 11162896-5 2000 Inhibition in combined steroid production was apparent at the highest concentration of TGFbeta1 tested. Steroids 23-30 transforming growth factor beta 1 Homo sapiens 87-95 11162896-9 2000 These results suggest that the effect of TGFbeta1 on steroid production and possibly follicular development may be in part due to its effects on StAR expression. Steroids 53-60 transforming growth factor beta 1 Homo sapiens 41-49 10453058-9 1999 Steroids regulate the interactions between glia and neurons and glial gene expression, including GFAP and TGF-beta1. Steroids 0-8 transforming growth factor beta 1 Homo sapiens 106-115 10706107-2 2000 As ovarian surface epithelial cells are growth inhibited by transforming growth factor beta (TGF-beta), we tested whether steroid hormones could regulate the expression of TGF-beta1 or its receptors in ovarian cancer cells, as assessed by quantitative reverse transcription-PCR. Steroids 122-138 transforming growth factor beta 1 Homo sapiens 172-181 10690900-3 2000 TGFbeta1 is an important regulator of human adrenal development, with marked effects on steroid-producing cell function, and the production of distinct TGFbeta subtypes has been suggested to be regulated by steroid hormones in several tissues. Steroids 88-95 transforming growth factor beta 1 Homo sapiens 0-8 10690900-3 2000 TGFbeta1 is an important regulator of human adrenal development, with marked effects on steroid-producing cell function, and the production of distinct TGFbeta subtypes has been suggested to be regulated by steroid hormones in several tissues. Steroids 88-95 transforming growth factor beta 1 Homo sapiens 0-7 10690900-3 2000 TGFbeta1 is an important regulator of human adrenal development, with marked effects on steroid-producing cell function, and the production of distinct TGFbeta subtypes has been suggested to be regulated by steroid hormones in several tissues. Steroids 207-223 transforming growth factor beta 1 Homo sapiens 0-8 10690900-3 2000 TGFbeta1 is an important regulator of human adrenal development, with marked effects on steroid-producing cell function, and the production of distinct TGFbeta subtypes has been suggested to be regulated by steroid hormones in several tissues. Steroids 207-223 transforming growth factor beta 1 Homo sapiens 0-7 9704843-1 1998 The anabolic steroid stanozolol upregulates collagen synthesis through the action of transforming growth factor-beta1. Steroids 13-20 transforming growth factor beta 1 Homo sapiens 85-117 10503723-7 1999 Our findings indicate that blocking the action of TGF-beta opposes progesterone-mediated suppression of MMPs and blocks the ability of this steroid to prevent experimental endometriosis. Steroids 140-147 transforming growth factor beta 1 Homo sapiens 50-58 10468953-7 1999 CONCLUSIONS: TGF-beta1 expression is associated with active steroid secretion in normal adrenal tissue, as well as in benign cortical adenomas, while this relationship is lost in primary adrenal malignancies. Steroids 60-67 transforming growth factor beta 1 Homo sapiens 13-22 10468953-8 1999 These data provide indirect evidence for a regulatory role played by TGF-beta1 on steroid secretory pathways. Steroids 82-89 transforming growth factor beta 1 Homo sapiens 69-78 10342839-16 1999 Thus, the progressive rise of steroid levels in vivo might account for the observed changes in TGFbeta1 and TGFbeta receptor expression in vivo. Steroids 30-37 transforming growth factor beta 1 Homo sapiens 95-103 10342839-16 1999 Thus, the progressive rise of steroid levels in vivo might account for the observed changes in TGFbeta1 and TGFbeta receptor expression in vivo. Steroids 30-37 transforming growth factor beta 1 Homo sapiens 95-102 10406078-6 1999 Since it has become increasingly evident that steroids can regulate growth through growth factors, ECA is also an ideal model for investigating the role for gonadal steroids in the loss of TGF-beta growth regulation in the etiopathogenesis of ECA. Steroids 165-173 transforming growth factor beta 1 Homo sapiens 189-197 9185506-10 1997 IL-1beta transcription was abrogated; in contrast, TGF-beta1 mRNA synthesis was steroid resistant. Steroids 80-87 transforming growth factor beta 1 Homo sapiens 51-60 9665020-7 1998 Hyaluronic acid, fibronectin receptor, and TGF-beta levels also increased in patients with acute steroid-resistant rejection; hyaluronic acid: 290 +/- 10.8 micrograms/l vs 154 +/- 13.6 micrograms/l and 131 +/- 11.7 micrograms/l in patients with steroid-sensitive and no rejection, respectively; fibronectin receptor: 1003 +/- 23.5 ng/ml vs 573 +/- 24.8 ng/ml and 428 +/- 13.6 ng/ ml in patients with steroid-sensitive and no rejection, respectively; and TGF-beta: 393 +/- 14.9 pg/ml versus 315 +/- 10.7 pg/ml and 233 +/- 8.9 pg/ml in patients with steroid-sensitive and no rejection, respectively. Steroids 97-104 transforming growth factor beta 1 Homo sapiens 43-51 9665020-9 1998 The increase in laminin, hyaluronic acid, fibronectin receptor, and TGF-beta during acute steroid-resistant rejection may be stimulated by the rejection-related release of cytokines and adhesion molecules which paralleled the increase in ECM parameters. Steroids 90-97 transforming growth factor beta 1 Homo sapiens 68-76 16984422-4 1997 One such strategy is the use of glucocorticoid steroids such as dexamethasone, which normally have the opposite effect of transforming growth factor-beta1, namely the impairment of wound healing. Steroids 47-55 transforming growth factor beta 1 Homo sapiens 122-154 16984422-5 1997 When used in conjunction with transforming growth factor-beta1, glucocorticoid steroids may normalize the effect of transforming growth factor-beta1 on collagen synthesis, thereby reducing excessive collagen deposition and fibrosis. Steroids 79-87 transforming growth factor beta 1 Homo sapiens 116-148 8915658-6 1996 The study shows that TGF-beta 1 is present in the endometrial tissue and its secretion is modulated during the menstrual cycle, as demonstrated immunohistochemically; its production seems to be controlled by ovarian steroids. Steroids 216-224 transforming growth factor beta 1 Homo sapiens 21-31 9078494-4 1997 Activin or TGF beta reduced, in a dose-dependent manner, both basal and FSH-stimulated production of both steroids. Steroids 106-114 transforming growth factor beta 1 Homo sapiens 11-19 8892643-7 1996 Therefore, although both types of cytokines were processed by Golgi, only TNF-alpha and the inducible component of TGF-beta production were protein kinase C or steroid-regulated processes. Steroids 160-167 transforming growth factor beta 1 Homo sapiens 115-123 8593810-6 1996 Although an E2 dose-dependent increase in TGF beta protein accumulation in osteoclast-conditioned medium was measured at 4 h of treatment, a steroid dose-dependent decrease in the accumulation of active TGF beta was measured after 18 h of estrogen treatment. Steroids 141-148 transforming growth factor beta 1 Homo sapiens 203-211 8770176-7 1996 Transforming growth factor-beta 1, known to blunt the effect of steroids on Na+ transport, had no effect on anion secretion. Steroids 64-72 transforming growth factor beta 1 Homo sapiens 0-33 9627689-2 1996 A mechanism of action of vitamin D3 and other steroid hormones is to enhance the secretion of transforming growth factor-beta (TGF-beta) in target cells. Steroids 46-53 transforming growth factor beta 1 Homo sapiens 94-125 9627689-2 1996 A mechanism of action of vitamin D3 and other steroid hormones is to enhance the secretion of transforming growth factor-beta (TGF-beta) in target cells. Steroids 46-53 transforming growth factor beta 1 Homo sapiens 127-135 8902054-2 1996 Steroid action on target tissues is often associated with increase in TGF-beta isoforms. Steroids 0-7 transforming growth factor beta 1 Homo sapiens 70-78 8902054-12 1996 TGF-beta may also be involved in the progression of breast tumors from the steroid-sensitive to steroid-insensitive state (King et al., 1989). Steroids 75-82 transforming growth factor beta 1 Homo sapiens 0-8 8902054-12 1996 TGF-beta may also be involved in the progression of breast tumors from the steroid-sensitive to steroid-insensitive state (King et al., 1989). Steroids 96-103 transforming growth factor beta 1 Homo sapiens 0-8 8593810-7 1996 The steroid specificity of the increased TGF beta accumulation was confirmed by demonstrating that the E2-induced increase in TGF beta protein levels in the medium was inhibited by cotreatment with a specific E2 antagonist. Steroids 4-11 transforming growth factor beta 1 Homo sapiens 41-49 8593810-7 1996 The steroid specificity of the increased TGF beta accumulation was confirmed by demonstrating that the E2-induced increase in TGF beta protein levels in the medium was inhibited by cotreatment with a specific E2 antagonist. Steroids 4-11 transforming growth factor beta 1 Homo sapiens 126-134 8206321-0 1994 Effects of transforming growth factor-beta on human fetal adrenal steroid production. Steroids 66-73 transforming growth factor beta 1 Homo sapiens 11-42 7616873-5 1995 Compared with the sex steroids, incubation of the cells with IGF-I or TGF-beta 1 resulted in at least a two-fold increase of total HOB cell numbers. Steroids 22-30 transforming growth factor beta 1 Homo sapiens 70-80 7954416-6 1994 In contrast, the mRNAs for TGF-beta 1, -beta 2, and -beta 3 and bioactive TGF-beta proteins transiently increased (3-10-fold) at 2 to 10 weeks of steroid deprivation and then returned by 24 weeks to the lower levels of the parental MCF-7 cells. Steroids 146-153 transforming growth factor beta 1 Homo sapiens 27-59 7954416-6 1994 In contrast, the mRNAs for TGF-beta 1, -beta 2, and -beta 3 and bioactive TGF-beta proteins transiently increased (3-10-fold) at 2 to 10 weeks of steroid deprivation and then returned by 24 weeks to the lower levels of the parental MCF-7 cells. Steroids 146-153 transforming growth factor beta 1 Homo sapiens 27-35 7954416-8 1994 The long-term steroid-deprived sublines showed a loss of regulation of proliferation by TGF-alpha or anti-TGF-alpha antibodies and a 10-fold decrease in sensitivity to the growth-suppressive effects of TGF-beta 1, despite little change in receptor levels for these factors. Steroids 14-21 transforming growth factor beta 1 Homo sapiens 202-212 8206321-1 1994 Transforming growth factor-beta (TGF-beta) was found to inhibit basal and ACTH-stimulated steroid production by cultured human fetal adrenal cells. Steroids 90-97 transforming growth factor beta 1 Homo sapiens 0-31 8206321-1 1994 Transforming growth factor-beta (TGF-beta) was found to inhibit basal and ACTH-stimulated steroid production by cultured human fetal adrenal cells. Steroids 90-97 transforming growth factor beta 1 Homo sapiens 33-41 8404670-3 1993 Dex had no significant effect on TGF beta mRNA or total protein production, but treatment with Dex resulted in a steroid dose-dependent activation of up to 90% of the TGF beta produced by the hOBs. Steroids 113-120 transforming growth factor beta 1 Homo sapiens 167-175 7959634-4 1994 Regulation of TGF-beta s by steroids and retinoids appears to involve predominantly posttranscriptional mechanisms. Steroids 28-36 transforming growth factor beta 1 Homo sapiens 14-22 8242773-4 1993 The glucocorticoid dexamethasone (10(-7) M) elevated PAI-1 and acted in concert with TGF-beta in this regard at both the antigen and mRNA levels; interleukin-4 (IL-4) (250 pM) failed to mimic the steroid in its regulation of PAI-1 formation. Steroids 196-203 transforming growth factor beta 1 Homo sapiens 85-93 1939646-7 1991 The results showed that dexamethasone caused an increase in TGF beta production and a dose-dependent two to fourfold increase in TGF-beta 1 mRNA in activated as well as in unstimulated T cells, 1 h after exposure of the cultures to the steroid. Steroids 236-243 transforming growth factor beta 1 Homo sapiens 129-139 1326450-0 1992 Regulation of steroid production in cultured porcine thecal cells by transforming growth factor-beta. Steroids 14-21 transforming growth factor beta 1 Homo sapiens 69-100 1939646-8 1991 The increase in TGF-beta 1 mRNA levels by dexamethasone was further potentiated two to threefold by cycloheximide, suggesting that the steroid effect may be due to inhibition of the synthesis of proteins that decrease TGF-beta 1 gene transcription or the stability of its transcripts. Steroids 135-142 transforming growth factor beta 1 Homo sapiens 16-26 1939646-8 1991 The increase in TGF-beta 1 mRNA levels by dexamethasone was further potentiated two to threefold by cycloheximide, suggesting that the steroid effect may be due to inhibition of the synthesis of proteins that decrease TGF-beta 1 gene transcription or the stability of its transcripts. Steroids 135-142 transforming growth factor beta 1 Homo sapiens 218-228 1851115-3 1991 TGF-beta has been previously reported to be a potent inhibitor of steroid formation in OAC cells. Steroids 66-73 transforming growth factor beta 1 Homo sapiens 0-8 1851115-12 1991 The different sensitivities of steroidogenic enzymes to factors which regulate growth and differentiation such as TGF-beta may play a role in determining the nature of steroids released from adrenocortical cells. Steroids 168-176 transforming growth factor beta 1 Homo sapiens 114-122 2199468-5 1990 An increase in TGF-beta 1 mRNA was detected following loss of steroid sensitivity. Steroids 62-69 transforming growth factor beta 1 Homo sapiens 15-25 2070681-6 1991 TGF-beta reverses the adverse affects of glucocorticoids on wound healing and thus may be useful in the treatment of chronic ulcers or wounds in patients whose normal responses have been impaired by therapy with steroids, radiation or other drugs. Steroids 212-220 transforming growth factor beta 1 Homo sapiens 0-8 1947220-10 1991 These results suggest that EGF, TGF-beta, IGF-I, oestradiol and androstendione as well as PGE2 have para- and/or autocrine modulatory effects on basal and FSH-stimulated inhibin secretion by mature porcine g-cells in vitro and further demonstrate that the secretion of the proteohormone inhibin and the steroid progesterone are closely related. Steroids 303-310 transforming growth factor beta 1 Homo sapiens 32-40 2285587-10 1990 Steroid-deprived T-47-D cells acquire sensitivity to stimulation by TGF beta and have raised TGF beta 1 and TGF beta 2 mRNA levels. Steroids 0-7 transforming growth factor beta 1 Homo sapiens 68-76 2285587-10 1990 Steroid-deprived T-47-D cells acquire sensitivity to stimulation by TGF beta and have raised TGF beta 1 and TGF beta 2 mRNA levels. Steroids 0-7 transforming growth factor beta 1 Homo sapiens 93-103 2393857-8 1990 Progression to steroid autonomy in T-47-D cells was accompanied by an upregulation of transforming growth factor (TGF) alpha, TGF beta 1, and TGF beta 2 mRNA. Steroids 15-22 transforming growth factor beta 1 Homo sapiens 126-136 2393857-9 1990 However, TGF beta 1 mRNA was downregulated in two ZR-75-1 steroid-deprived clones. Steroids 58-65 transforming growth factor beta 1 Homo sapiens 9-19 2696842-5 1989 With both the mouse S115 and human T-47-D systems, changes in sensitivity to several growth factors accompany progression; responses to TGF beta 1 are of particular interest in the T-47-D cells where this growth factor becomes stimulatory in the steroid insensitive state. Steroids 246-253 transforming growth factor beta 1 Homo sapiens 136-146 2084113-0 1990 Regulation of transforming growth factor-beta subtypes by members of the steroid hormone superfamily. Steroids 73-88 transforming growth factor beta 1 Homo sapiens 14-45 2084113-9 1990 We have shown that active TGF-beta has a much shorter in vivo half-life than latent TGF-beta, suggesting that the TGF-beta induced by retinoids and steroids may act locally at the site of production. Steroids 148-156 transforming growth factor beta 1 Homo sapiens 26-34 2084113-9 1990 We have shown that active TGF-beta has a much shorter in vivo half-life than latent TGF-beta, suggesting that the TGF-beta induced by retinoids and steroids may act locally at the site of production. Steroids 148-156 transforming growth factor beta 1 Homo sapiens 84-92 2084113-9 1990 We have shown that active TGF-beta has a much shorter in vivo half-life than latent TGF-beta, suggesting that the TGF-beta induced by retinoids and steroids may act locally at the site of production. Steroids 148-156 transforming growth factor beta 1 Homo sapiens 84-92 2084113-10 1990 Since many tumor cells retain sensitivity to the growth inhibitory effects of active TGF-beta, the use of members of the steroid hormone superfamily for inducing this potent growth inhibitor locally at the tumor site may have therapeutic potential. Steroids 121-136 transforming growth factor beta 1 Homo sapiens 85-93 33032603-11 2020 These data suggest that steroids may be an effective therapy for treatment of asthma patients whose disease is primarily driven by elevated TGF-beta1 levels. Steroids 24-32 transforming growth factor beta 1 Homo sapiens 140-149 34344357-17 2021 The potential mechanism may be related to IL-1beta augmenting TGF-beta1-induced steroid-resistant EMT through MAPK signaling pathways. Steroids 80-87 transforming growth factor beta 1 Homo sapiens 62-71 2696842-11 1989 Furthermore, TGF beta 1 may have different effects in steroid responsive and unresponsive cells. Steroids 54-61 transforming growth factor beta 1 Homo sapiens 13-23 3164432-7 1988 The molecular basis of the interactions observed was investigated by considering (1) the binding to specific receptors, (2) transfection experiments, in order to examine if the interference of the anti-steroid with TGF-beta activities occurs at the transcriptional level as in the case of glucocorticoid induction. Steroids 202-209 transforming growth factor beta 1 Homo sapiens 215-223 31434801-7 2019 TLR4 and TNFR1 were significantly increased in steroid-refractory aGVHD patients compared with steroid-effective patients (P < 0.05).CONCLUSIONA combination of TLR4, TNFR1, TGF-beta, and Elafin could be a new 4-biomarker panel to assist aGVHD diagnosis, grading, and evaluation of steroid sensitivity for clinical aGVHD patients.TRIAL REGISTRATIONChiCTR1900022292 "Clinical Research of Umbilical Cord-Derived Mesenchymal Stromal Cells in the Prophylaxis of Graft-Versus-Host Disease After HLA-Haploidentical Stem-Cell Transplantation. Steroids 47-54 transforming growth factor beta 1 Homo sapiens 176-184 30753845-8 2019 In PBMCs, exposure to these steroids resulted in the increase of mRNA and secreted protein levels of IL-1beta, TNFalpha, and IL-6 cytokines, as well as in the increase of INFgamma mRNA level, decrease of IL-2 mRNA level, increase of TGFbeta mRNA level, and decrease of IL-4 mRNA and IL-10 secreted protein levels. Steroids 28-36 transforming growth factor beta 1 Homo sapiens 233-240 28584963-0 2017 Steroid-resistant autoimmune myelofibrosis in a patient with autoimmune hepatitis and Evans syndrome complicated with increased expression of TGF-beta in the bone marrow: a case report. Steroids 0-7 transforming growth factor beta 1 Homo sapiens 142-150 30711747-0 2019 A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-beta1 in Steroid-Resistant Airway Diseases. Steroids 99-106 transforming growth factor beta 1 Homo sapiens 63-95 23280432-0 2013 Transforming growth factor-beta1 and IL-13 response to allergen predict steroid needs in asthmatic children. Steroids 72-79 transforming growth factor beta 1 Homo sapiens 0-32 26609908-12 2016 CONCLUSION: Low-dosage steroid therapy reversed or delayed the renal failure progression in severe chronic AAN patients, which may be associated with the suppression of MCP-1 and TGF-beta1 activities. Steroids 23-30 transforming growth factor beta 1 Homo sapiens 179-188 23770322-0 2013 TGFbeta1 alters androgenic metabolites and hydroxysteroid dehydrogenase enzyme expression in human prostate reactive stromal primary cells: Is steroid metabolism altered by prostate reactive stromal microenvironment? Steroids 50-57 transforming growth factor beta 1 Homo sapiens 0-8 23770322-7 2013 Also TGFbeta1-treated prostate stromal cells exhibited changes in the gene expression of enzymes involved in steroid metabolism including up-regulation of 3beta hydroxysteroid dehydrogenase (HSD), and down-regulation of 17betaHSD5, and 17betaHSD2. Steroids 109-116 transforming growth factor beta 1 Homo sapiens 5-13 23153702-7 2012 However, the treatment with both steroids decreased the secretion of TNF-alpha, IL-18 and TGF-beta1 by EEC in the presence of ESC. Steroids 33-41 transforming growth factor beta 1 Homo sapiens 90-99 23178794-0 2013 Transforming growth factor-beta1 promotes Treg commitment in nasal polyposis after intranasal steroid treatment. Steroids 94-101 transforming growth factor beta 1 Homo sapiens 0-32 23178794-6 2013 RESULTS: TGF-beta1, p-Smad2, IL-10, SOCS3, and Foxp3 expression was higher in steroid-treated NP patients than in untreated NP patients. Steroids 78-85 transforming growth factor beta 1 Homo sapiens 9-18 23178794-7 2013 Conversely, expression of p-STAT3, Smad7, IL-17A, and RORc was higher in untreated NP patients than in steroid-treated NP patients, demonstrating that TGF-beta1 was more likely to contribute to Treg commitment in Chinese NP patients after intranasal steroid treatment. Steroids 103-110 transforming growth factor beta 1 Homo sapiens 151-160 23178794-7 2013 Conversely, expression of p-STAT3, Smad7, IL-17A, and RORc was higher in untreated NP patients than in steroid-treated NP patients, demonstrating that TGF-beta1 was more likely to contribute to Treg commitment in Chinese NP patients after intranasal steroid treatment. Steroids 250-257 transforming growth factor beta 1 Homo sapiens 151-160 23193535-0 2012 Steroid resistance in nasal polyposis: role of glucocorticoid receptor and TGF-beta1. Steroids 0-7 transforming growth factor beta 1 Homo sapiens 75-84 22665336-7 2012 The serum TGF-beta levels of the nephrotic phase were significantly lower than those of remission phase or control group, and returned to normal control levels after steroid therapy. Steroids 166-173 transforming growth factor beta 1 Homo sapiens 10-18