PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17169280-0 2006 [Effect of tobacco smoking on leptin serum levels and its relationship with steroid hormones and bone mineral density]. Steroids 76-92 leptin Homo sapiens 30-36 17169280-3 2006 The aim of this study is to analyse the influence of tobacco on serum leptin levels, and its relationship with bone mineral density (BMD) and steroid hormones. Steroids 142-158 leptin Homo sapiens 70-76 16556163-6 2006 The elevated leptin levels found in heart transplant recipients could be due to the result of steroid therapy. Steroids 94-101 leptin Homo sapiens 13-19 17007280-8 2006 Sex steroids have effect on leptin secretion but the associations between leptin and menopause are controversial. Steroids 4-12 leptin Homo sapiens 28-34 16267210-6 2006 The steroid hormones are linked to the regulation of leptin and the leptin receptor and probably interact with other pregnancy-specific, serum-borne factors to regulate leptin dynamics during pregnancy. Steroids 4-20 leptin Homo sapiens 53-59 16267210-6 2006 The steroid hormones are linked to the regulation of leptin and the leptin receptor and probably interact with other pregnancy-specific, serum-borne factors to regulate leptin dynamics during pregnancy. Steroids 4-20 leptin Homo sapiens 68-74 16267210-6 2006 The steroid hormones are linked to the regulation of leptin and the leptin receptor and probably interact with other pregnancy-specific, serum-borne factors to regulate leptin dynamics during pregnancy. Steroids 4-20 leptin Homo sapiens 68-74 16793960-2 2006 The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. Steroids 99-115 leptin Homo sapiens 88-94 16761447-1 2006 BACKGROUND: A relationship between estrogen and leptin has been described during the follicular phase of both spontaneous menstrual cycles and cycles stimulated with exogenous follicle-stimulating hormone (FSH), which suggest that leptin has either a direct effect on or is regulated by gonadal steroids in the human ovary. Steroids 295-303 leptin Homo sapiens 48-54 16761447-1 2006 BACKGROUND: A relationship between estrogen and leptin has been described during the follicular phase of both spontaneous menstrual cycles and cycles stimulated with exogenous follicle-stimulating hormone (FSH), which suggest that leptin has either a direct effect on or is regulated by gonadal steroids in the human ovary. Steroids 295-303 leptin Homo sapiens 231-237 16355805-1 2005 BACKGROUND: It has been reported that there is a relationship between circulating leptin and sex steroid hormones and leptin is able to stimulate estrogen secretion by increasing aromatase activity in adipose stromal cells and breast tissue. Steroids 97-113 leptin Homo sapiens 82-88 16821206-0 2005 Age, insulin, SHBG and sex steroids exert secondary influence on plasma leptin level in women. Steroids 27-35 leptin Homo sapiens 72-78 16821206-23 2005 However insulin, SHBG, sex steroids as well as age may also exert secondary influence on plasma leptin level in certain groups of women. Steroids 27-35 leptin Homo sapiens 96-102 16355805-1 2005 BACKGROUND: It has been reported that there is a relationship between circulating leptin and sex steroid hormones and leptin is able to stimulate estrogen secretion by increasing aromatase activity in adipose stromal cells and breast tissue. Steroids 97-113 leptin Homo sapiens 118-124 11571601-11 2001 Thus, the sexual dimorphism in plasma leptin concentration appears to reflect, at least in part, effects of circulating concentrations of gonadal steroids (especially androgens) and/or primary genetic differences that are independent of amounts of VAT or SAT. Steroids 146-154 leptin Homo sapiens 38-44 15209961-0 2004 Serum leptin level in children with atopic dermatitis-treated topical steroids. Steroids 70-78 leptin Homo sapiens 6-12 15209961-3 2004 In this study, we aimed to assess serum leptin in children with atopic dermatitis (AD)-treated with local steroids. Steroids 106-114 leptin Homo sapiens 40-46 11479138-3 2001 Steroid hormones actively participate in the regulation of leptin secretion; however, non-steroid nuclear hormones have either not been studied or have provided contradictory results. Steroids 0-16 leptin Homo sapiens 59-65 11474147-13 2001 Maternal diabetes and the use of steroids had small but significant effects on the leptin/weight ratio. Steroids 33-41 leptin Homo sapiens 83-89 11415851-1 2001 OBJECTIVE: To investigate the levels and diurnal rhythm of serum leptin in healthy children, and to investigate the association between leptin levels and sex steroids. Steroids 158-166 leptin Homo sapiens 136-142 11415851-11 2001 The changes in leptin levels during puberty follow a gender-specific pattern, probably due to an influence of sex steroids on leptin production. Steroids 114-122 leptin Homo sapiens 15-21 11415851-11 2001 The changes in leptin levels during puberty follow a gender-specific pattern, probably due to an influence of sex steroids on leptin production. Steroids 114-122 leptin Homo sapiens 126-132 16048798-8 2005 The results obtained in this study support that leptin can be considered a gestational hormone implied in the endocrine function of the placenta and that its secretion is at least partially regulated by steroid and peptidic reproductive hormones in trophoblast cells in vitro. Steroids 203-210 leptin Homo sapiens 48-54 15458395-5 2004 Leptin and lipoprotein lipase are two key proteins in adipose tissues that are regulated by transcriptional control with sex steroid hormones. Steroids 125-141 leptin Homo sapiens 0-29 15194576-4 2004 OBJECTIVE: To study the interrelation between serum levels of leptin and adrenal steroids in SLE and RA. Steroids 81-89 leptin Homo sapiens 62-68 15147234-0 2004 Estrus cycle-dependent action of leptin on basal and GH or IGF-I stimulated steroid secretion by whole porcine follicles. Steroids 76-83 leptin Homo sapiens 33-39 12760843-8 2003 These results reiterate the impact of gonadal steroids as mediators of the apparent sexual dimorphism in circulating leptin. Steroids 46-54 leptin Homo sapiens 117-123 12718213-1 2003 AIM: To estimate leptin production in long-term steroid therapy, insulin resistance and obesity. Steroids 48-55 leptin Homo sapiens 17-23 12718213-5 2003 RESULTS: Leptin was highest in patients with bronchial asthma and steroids-induced diabetes mellitus, lower in patients with diabetes mellitus type 2 and obese controls while it was lowest in patients with atopic bronchial asthma. Steroids 66-74 leptin Homo sapiens 9-15 12718213-6 2003 CONCLUSION: Steroids and insulin resistance participate in the regulation of leptin production. Steroids 12-20 leptin Homo sapiens 77-83 12626035-0 2002 Effects of sex steroid hormones and menopause on serum leptin concentrations. Steroids 15-31 leptin Homo sapiens 55-61 11456279-0 2001 Leptin inhibits steroid biosynthesis by human granulosa-lutein cells. Steroids 16-23 leptin Homo sapiens 0-6 11380502-2 2001 It has been shown that sex steroid hormones, in particular testosterone, play an important role in the regulation of serum leptin levels. Steroids 27-34 leptin Homo sapiens 123-129 11380502-11 2001 In conclusion, leptin levels did not change in spite of rapid changes in the steroid milieu, but in the long term increase in body fat stores, new steroid milieu and maybe other factors are important determining factors of serum leptin levels. Steroids 147-154 leptin Homo sapiens 229-235 11126340-0 2000 Interactions between sex steroid hormones and leptin in women. Steroids 25-41 leptin Homo sapiens 46-52 11379347-15 2001 The difference in the serum leptin level of patients with nonalcoholic liver disease and that of patients with alcoholic cirrhosis may be due to a difference in factors such as the levels of cytokines or sex steroids, and/or nutrition. Steroids 208-216 leptin Homo sapiens 28-34 11824513-11 2001 Thus, accumulating evidence suggests that leptin can regulate gonadotropin levels, and its secretion may, in turn, be influenced by GnRH or gonadal steroids but appears to be independent of LH control. Steroids 148-156 leptin Homo sapiens 42-48 11281366-6 2000 The influence of leptin on basal and ACTH-stimulated steroid hormone secretion and enzyme expression was assessed. Steroids 53-68 leptin Homo sapiens 17-23 11281366-9 2000 Leptin decreased the corticotropin-stimulated release of steroid hormones in vitro without any effect on cell proliferation. Steroids 57-73 leptin Homo sapiens 0-6 10711727-0 2000 Effects of recombinant murine leptin[1-147] and leptin fragment 116-130 on steroid secretion and proliferative activity of the regenerating rat adrenal cortex. Steroids 75-82 leptin Homo sapiens 48-54 11154152-0 2000 Cord blood and postnatal serum leptin and its relationship to steroid use and growth in sick preterm infants. Steroids 62-69 leptin Homo sapiens 31-37 11154152-5 2000 Cord blood leptin was greater in infants whose mothers received antenatal steroids (1.98 +/- 1.05 ng/ml vs 0.94 +/- 0.39 ng/ml, p=0.004). Steroids 74-82 leptin Homo sapiens 11-17 11079816-0 2000 Relationship of serum leptin levels with body composition and sex steroid and insulin levels in men and women. Steroids 66-73 leptin Homo sapiens 22-28 11079816-5 2000 Serum leptin levels were related to body composition as assessed by dual-energy x-ray absorptiometry (DEXA) and to circulating sex steroid and insulin levels. Steroids 131-138 leptin Homo sapiens 6-12 11022169-6 2000 It has been shown that leptin secretion by the adipocyte is partly regulated by other hormones, such as insulin, cortisol, and sex steroids, mainly testosterone. Steroids 131-139 leptin Homo sapiens 23-29 10710742-1 2000 OBJECTIVE: To determine whether elevated follicular steroid levels during gonadotropin stimulation cycles are associated with altered circulating leptin concentrations. Steroids 52-59 leptin Homo sapiens 146-152 10961356-2 2000 Therefore, the aim of our study was to investigate leptin and TNF alpha levels and their association with blood pressure, sex steroids, insulin, creatinine and lipids in type 2 diabetic patients. Steroids 126-134 leptin Homo sapiens 51-57 9725824-0 1998 Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids. Steroids 101-109 leptin Homo sapiens 22-28 10521105-1 1999 OBJECTIVE: To evaluate the influence of sex steroids on leptin levels in patients with conditions in which the steroid levels are increased. Steroids 44-52 leptin Homo sapiens 56-62 10521105-1 1999 OBJECTIVE: To evaluate the influence of sex steroids on leptin levels in patients with conditions in which the steroid levels are increased. Steroids 44-51 leptin Homo sapiens 56-62 10603707-1 1999 A possible role of ovarian steroids on the modulation of leptin production has recently been suggested. Steroids 27-35 leptin Homo sapiens 57-63 10603707-2 1999 To investigate the relationship between leptin and ovarian steroids during the normal menstrual cycle, twenty-three healthy, normal-weight women were enrolled in the study. Steroids 59-67 leptin Homo sapiens 40-46 11252835-5 1999 Although the exact mechanisms and interactions with sex steroids are not yet fully established, it is clear that leptin plays a role as an endocrine mediator in sexual development and reproduction. Steroids 56-64 leptin Homo sapiens 113-119 10214609-10 1999 Our results suggest the possibility that leptin, like several other placentally derived substances (e.g. steroid hormones, eicosanoids and cytokines), may be involved in the pathogenesis of pre-eclampsia. Steroids 105-121 leptin Homo sapiens 41-47 11127767-4 2000 Leptin interacts with the steroid synthesis to a degree not yet precisely clarified and possesses receptors in numerous tissues, which suggests extensive local and endocrine effects. Steroids 26-33 leptin Homo sapiens 0-6 10372664-0 1999 Clinical review 107: Role of gonadal steroids in the sexual dimorphisms in body composition and circulating concentrations of leptin. Steroids 37-45 leptin Homo sapiens 126-132 11533945-7 1999 Leptin is released from the adipocytes and may act as a metabolic signal to the hypothalamic areas controlling satiety, energy expenditure, and the regulation of cortisol, insulin, sex steroid and growth hormone release. Steroids 185-192 leptin Homo sapiens 0-6 9725824-5 1998 Gender differences in leptin disappeared when corrected for sex steroid levels or the combination of adiposity and energy expenditure. Steroids 64-71 leptin Homo sapiens 22-28 9873196-0 1998 Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six weeks after birth: relation to body mass index, skinfolds, sex steroids and umbilical cord blood leptin levels. Steroids 158-166 leptin Homo sapiens 40-46 9505271-15 1998 Maternal obesity had no effect on cord leptin, whereas exogenous maternal steroids increased neonatal leptin concentrations. Steroids 74-82 leptin Homo sapiens 102-108 9543124-0 1998 The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty. Steroids 37-44 leptin Homo sapiens 66-72 33311894-0 2020 Serum Leptin Serves as an Inflammatory Activity Marker and Predicts Steroid Response in Autoimmune Hepatitis. Steroids 68-75 leptin Homo sapiens 6-12 9437233-13 1997 However, as females with either overt hypo- or hyper-thyroidism or central hypothyroidism after L-thyroxine therapy show differences in their SDSs, a subtle interaction between sex steroids and thyroid status in modulating leptin secretion, at least in women, may occur. Steroids 181-189 leptin Homo sapiens 223-229 9259579-2 1997 The aim of our study was to measure serum leptin concentrations in a large group of obese children and adolescents to determine the possible role of sex steroid hormones on both leptin serum concentrations and production in human adipocytes. Steroids 153-169 leptin Homo sapiens 178-184 34343670-6 2022 The expression of leptin and its receptor is influenced by numerous factors including sex steroids, stress and stress-induced catecholamines and glucocorticoids though their effect in non-mammalian vertebrates is hard to be generalized due to limited studies. Steroids 90-98 leptin Homo sapiens 18-24 34299256-5 2021 Leptin remained high after treatment with IVIg, whereas steroid treatment lowered leptin below control levels. Steroids 56-63 leptin Homo sapiens 82-88 9329351-3 1997 This prompted us to study prospectively the effects of cross-sex steroid hormones on serum leptin levels in 17 male to female transsexuals and 15 female to male transsexuals. Steroids 65-81 leptin Homo sapiens 91-97 9329351-11 1997 In conclusion, these results indicate that sex steroid hormones, in particular testosterone, play an important role in the regulation of serum leptin levels. Steroids 47-63 leptin Homo sapiens 143-149 9329351-12 1997 The prevailing sex steroid milieu, not genetic sex, is a significant determinant of the sex difference in serum leptin levels. Steroids 19-26 leptin Homo sapiens 112-118 11546926-6 1997 This study revealed that both body weight above normal and female sex steroids seem to be necessary to elevate leptin concentrations, while exogenous insulin has no effect. Steroids 70-78 leptin Homo sapiens 111-117 33311894-4 2020 Serum leptin correlation was assessed on liver function tests, disease activity, T regulatory cells (Tregs), and Th17 cells in the liver biopsies and on steroid treatment response in AIH. Steroids 153-160 leptin Homo sapiens 6-12 33311894-8 2020 High serum leptin was found to be associated with steroid partial or nonresponsiveness at 4 weeks (P = 0.002). Steroids 50-57 leptin Homo sapiens 11-17 33311894-10 2020 Leptin negative cases have more chances of steroid responsiveness and could help in the selection of AIH cases for appropriate therapy. Steroids 43-50 leptin Homo sapiens 0-6 23153703-0 2012 Direct in vitro effect of LH and steroids on leptin gene expression and leptin secretion by porcine luteal cells during the mid-luteal phase of the estrous cycle. Steroids 33-41 leptin Homo sapiens 45-51 29018059-3 2018 The expression of leptin in placenta is regulated by hCG, insulin, steroids, hypoxia and many other growth hormones, suggesting that it might have an important endocrine function in the trophoblastic cells. Steroids 67-75 leptin Homo sapiens 18-24 32392278-8 2020 Branched-chain amino acids and steroid metabolites decreased after leptin, but not after acute caloric restriction. Steroids 31-38 leptin Homo sapiens 67-73 32392278-11 2020 However, leptin"s effects on branched-chain amino acids and steroid metabolites were independent of reduced caloric intake and require further exploration. Steroids 60-67 leptin Homo sapiens 9-15 27356609-5 2016 The steroid treatment group had higher levels of leptin and PAI-1 in both the blood and bone marrow than the control group. Steroids 4-11 leptin Homo sapiens 49-55 23896801-8 2013 CONCLUSION: Adequate control of CAH with steroids seems safe, as it is associated with only mild changes in lipid profile and leptin values. Steroids 41-49 leptin Homo sapiens 126-132 23153703-9 2012 Our results indicate that leptin and OB-Rb genes and proteins are expressed in porcine luteal cells and suggest that steroid hormones (E(2) and P(4)) affect leptin mRNA expression and leptin secretion during the mid-luteal phase of the estrous cycle. Steroids 117-133 leptin Homo sapiens 26-32 23153703-9 2012 Our results indicate that leptin and OB-Rb genes and proteins are expressed in porcine luteal cells and suggest that steroid hormones (E(2) and P(4)) affect leptin mRNA expression and leptin secretion during the mid-luteal phase of the estrous cycle. Steroids 117-133 leptin Homo sapiens 157-163 23153703-9 2012 Our results indicate that leptin and OB-Rb genes and proteins are expressed in porcine luteal cells and suggest that steroid hormones (E(2) and P(4)) affect leptin mRNA expression and leptin secretion during the mid-luteal phase of the estrous cycle. Steroids 117-133 leptin Homo sapiens 157-163 19794290-2 2009 AIM: The aim of the present study was to investigate the effect of low and high doses of leptin on basal and FSH-induced steroids secretion by human luteinized granulosa cells in culture. Steroids 121-129 leptin Homo sapiens 89-95 21955253-0 2012 Leptin promoter G-2548A genotypes and associated serum leptin levels in childhood acute leukemia at diagnosis and under high-dose steroid therapy. Steroids 130-137 leptin Homo sapiens 0-6 20398023-8 2010 According to our results, adiponectin concentrations seem to be driven by inflammation, whereas leptin seems to be increased directly by the use of steroids. Steroids 148-156 leptin Homo sapiens 96-102 19794290-5 2009 In particular, leptin at low concentrations stimulated the secretion of estradiol (1 and 10 ng/ml) and progesterone (10 ng/ml), while at a high concentration (100 ng/ml) it suppressed the secretion of both steroids. Steroids 206-214 leptin Homo sapiens 15-21 19794290-6 2009 A dose-related effect of leptin on FSH-induced steroidogenesis was not evident, since only the suppressive effect of the high concentration of leptin (100 ng/ml) reached statistical significance for both steroids. Steroids 204-212 leptin Homo sapiens 143-149 19794290-7 2009 CONCLUSIONS: These results demonstrate that leptin affects the secretion of steroids in luteinized granulosa cells in a dose-dependent manner. Steroids 76-84 leptin Homo sapiens 44-50 18082739-10 2008 CONCLUSION(S): These results demonstrate for the first time that leptin can modulate the effect of GH on steroids production by human luteinized GC in culture. Steroids 105-113 leptin Homo sapiens 65-71