PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21550955-9 2011 She was initially treated with steroids after a hormonal profile suggested NICTH (normal fasting insulin, C-peptide, cosyntropin and glucagon stimulation tests, and negative insulin antibodies). Steroids 31-39 insulin Homo sapiens 97-104 21747118-5 2011 In this study, we examined this hypothesis by evaluating the effect of insulin on steroid synthesis in prostate cancer cell lines. Steroids 82-89 insulin Homo sapiens 71-78 21747118-7 2011 Similarly, insulin treatment upregulated intracellular testosterone levels and secreted androgens, with the concentrations of steroids observed similar to the levels reported in prostate cancer patients. Steroids 126-134 insulin Homo sapiens 11-18 21550955-9 2011 She was initially treated with steroids after a hormonal profile suggested NICTH (normal fasting insulin, C-peptide, cosyntropin and glucagon stimulation tests, and negative insulin antibodies). Steroids 31-39 insulin Homo sapiens 106-115 21470423-7 2011 CONCLUSIONS: Critically ill surgical patients are at an increased risk for fluctuating blood glucose concentrations ranging < 80 mg/dl or >= 150 mg/dl in particular if they are of advanced age and require administration of insulin, noradrenaline, and/or steroids. Steroids 260-268 insulin Homo sapiens 229-236 21538049-4 2011 The metabolic changes induced by the synthetic steroids used in contraception, such as lipoprotein changes, insulin response to glucose, and coagulation factors have been considered as potential markers of cardiovascular and venous risk. Steroids 47-55 insulin Homo sapiens 108-115 20561594-8 2011 In a multivariate Cox proportional hazards model, high-risk disease (hazard ratio [HR], 2.34; 95% CI, 1.09-5.28; P = .029) and pretransplantation c-peptide level >3.6 ng/mL (HR, 1.05; 95% CI, 1.01-1.09; P = .013) were independent predictors of OS when adjusted for systemic steroids and regimen intensity. Steroids 277-285 insulin Homo sapiens 146-155 21059865-9 2011 Nevertheless, urinary excretion of ACTH-stimulated C19 and C21 steroid metabolites was significantly higher during hyperinsulinaemia than at basal insulin levels (both P < 0.005). Steroids 63-70 insulin Homo sapiens 120-127 21059865-10 2011 Changes in steroid metabolites molar ratios suggested stimulation by insulin of 5 alpha-reductase activity. Steroids 11-18 insulin Homo sapiens 69-76 21537417-8 2011 CONCLUSION: We treated a patient with type B insulin resistance syndrome showing recurrent fasting hypoglycemia with steroids and azathioprine. Steroids 117-125 insulin Homo sapiens 45-52 21084397-3 2011 OBJECTIVE: To characterize the adipose tissue of women with PCOS and controls matched pair-wise for age and BMI, and to identify factors, among adipose tissue characteristics and serum sex steroids, that are associated with insulin sensitivity in PCOS. Steroids 189-197 insulin Homo sapiens 224-231 21463250-6 2011 It has been shown that steroid hormones have an important role in susceptibility and development of diabetes in animal models, in humans its role is less clear, however the most evident effect is on the perimenopausal women, in this stage the decrease in gonadal steroids produces an increase on susceptibility to develop diabetes mellitus; in men, hypoandrogenism is associated with an increased prevalence of insulin resistance. Steroids 23-30 insulin Homo sapiens 411-418 20685772-2 2010 In this case we describe a patient with steroid-induced hyperglycaemia who obtained a large positive impact on glycaemic control from a small reduction in her steroid dose, sufficient to alleviate the need for insulin. Steroids 40-47 insulin Homo sapiens 210-217 20978464-10 2010 CONCLUSIONS: These two novel immunosuppressive regimens are effective, well tolerated, and the first calcineurin inhibitor/steroid-sparing islet protocols resulting in long-term insulin independence. Steroids 123-130 insulin Homo sapiens 178-185 21122280-4 2010 We demonstrated that androgen and insulin gene transcriptional levels are independent to sports activity and therefore potentially suitable for drug monitoring and/or drug doping (such as anabolic androgen steroid AAS abuse) and or gene doping. Steroids 206-213 insulin Homo sapiens 34-41 20685772-2 2010 In this case we describe a patient with steroid-induced hyperglycaemia who obtained a large positive impact on glycaemic control from a small reduction in her steroid dose, sufficient to alleviate the need for insulin. Steroids 159-166 insulin Homo sapiens 210-217 20659093-9 2010 Although long-term follow-up is limited by discontinuation of efalizumab and transition to conventional imunnosuppression (including CNI in four cases), these results demonstrate that insulin independence after islet transplantation can be achieved with a CNI and steroid-free regimen. Steroids 264-271 insulin Homo sapiens 184-191 20887595-2 2010 Dehydroepiandrosterone (DHEA), the most abundant steroid hormone, has been shown to influence sensitivity to reactive oxygen species, insulin sensitivity and expression of peroxisome proliferator-activated receptor-alpha. Steroids 49-64 insulin Homo sapiens 134-141 20484128-0 2010 Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men. Steroids 4-12 insulin Homo sapiens 61-68 20484128-4 2010 RESULTS: Following intervention, the postprandial triglyceride response displayed a diverging response with a decline in group T and an increase in group E; the postprandial glucose-dependent insulinotropic polypeptide (GIP) response increased in group T. Insulin sensitivity increased in group T but remained unaltered in group E. CONCLUSIONS: In healthy young men, short-term changes in sex steroids affect postprandial triglyceride and GIP response and insulin sensitivity. Steroids 393-401 insulin Homo sapiens 192-199 20410219-0 2010 Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects. Steroids 60-67 insulin Homo sapiens 30-37 20484479-11 2010 CONCLUSIONS: In seven patients with type B insulin resistance, standardized treatment with rituximab, cyclophosphamide, and pulse steroids results in remission of the disease. Steroids 130-138 insulin Homo sapiens 43-50 20410219-2 2010 We investigated whether reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet in healthy young males would impair the incretin effect. Steroids 84-91 insulin Homo sapiens 54-61 19060555-2 2008 The advent of a steroid-free immunosuppressive protocol in 2000 resulted in most recipients becoming insulin independent and remaining so for a year. Steroids 16-23 insulin Homo sapiens 101-108 20122448-1 2010 It is believed that insulin and insulin-like growth factor I (IGF-I) are abused by professional athletes, either alone or in combination with growth hormone (GH) and anabolic steroids. Steroids 175-183 insulin Homo sapiens 20-27 19966179-10 2010 The findings are of relevance in the context of developmental programming of insulin resistance by prenatal steroids and excess weight gain. Steroids 108-116 insulin Homo sapiens 77-84 20829624-10 2010 Patients experiencing diabetes mellitus in the context of exogenously administered glucocorticoids may well require insulin therapy for the period that the high levels of steroids are being administered. Steroids 171-179 insulin Homo sapiens 116-123 19602554-0 2009 Growth hormone and sex steroid effects on serum glucose, insulin, and lipid concentrations in healthy older women and men. Steroids 23-30 insulin Homo sapiens 57-64 19602554-2 2009 OBJECTIVE: The aim of the study was to assess GH and/or sex steroid administration effects on serum glucose, insulin, insulin sensitivity, and lipids in older individuals. Steroids 60-67 insulin Homo sapiens 109-116 19602554-2 2009 OBJECTIVE: The aim of the study was to assess GH and/or sex steroid administration effects on serum glucose, insulin, insulin sensitivity, and lipids in older individuals. Steroids 60-67 insulin Homo sapiens 118-125 19460510-8 2009 Insulin resistance tended to be more frequent among patients treated with protocols including calcineurin inhibitors (CNI) and steroids. Steroids 127-135 insulin Homo sapiens 0-7 19856711-0 2009 Adrenal plasma steroid relations in glucocorticoid-naive premenopausal rheumatoid arthritis patients during insulin-induced hypoglycemia test compared to matched normal control females. Steroids 15-22 insulin Homo sapiens 108-115 19107429-18 2009 Insulin also affects on the synthesis and biological availability of the male and female sex steroids, including androgens, progesterone, and estrogens. Steroids 93-101 insulin Homo sapiens 0-7 19773396-14 2009 CONCLUSION: Our results suggest significant associations of NAFLD with markers of visceral obesity and insulin resistance in both genders and gender-specific associations with parameters of body fat distribution and sex steroids. Steroids 220-228 insulin Homo sapiens 103-110 19154958-13 2009 Female sex steroids are likely to affect insulin sensitivity through modulation of adiponectin and body fat. Steroids 11-19 insulin Homo sapiens 41-48 18834871-0 2009 Sex steroids enhance insulin receptors and glucose oxidation in Chang liver cells. Steroids 4-12 insulin Homo sapiens 21-28 18834871-1 2009 BACKGROUND: The present study was designed to assess the effect of sex steroids (testosterone and 17beta-estradiol) on insulin receptor expression, insulin binding and glucose oxidation in human liver cell line. Steroids 71-79 insulin Homo sapiens 119-126 19318223-15 2009 Progesterone and other steroid hormones were associated with markers of insulin resistance, inflammatory activity, and renal function. Steroids 23-30 insulin Homo sapiens 72-79 18728170-7 2008 MAIN OUTCOME MEASURES: Post hoc analysis of the relationships among sex steroid hormones with insulin resistance, body mass index (BMI), and presence or absence of coronary artery disease as determined by coronary angiography. Steroids 72-88 insulin Homo sapiens 94-101 18473907-2 2008 In the other hand, sexual steroids has effects on peripheral tissues, and since the skeletal muscle is the main responsible for peripheral glucose uptake, it would be possible that the sexual steroids induce directly in the muscle a decrease of the sensibility of this tissue to insulin action. Steroids 192-200 insulin Homo sapiens 279-286 18460333-1 2008 Insulin resistance is a common disorder caused by a wide variety of physiological insults, some of which include poor diet, inflammation, anti-inflammatory steroids, hyperinsulinemia, and dyslipidemia. Steroids 156-164 insulin Homo sapiens 0-7 19145814-3 2008 Obtained results showed possibility of the participation of changed steroid metabolism in pathogenesis of androgen disorders in aged male patients with diabetes mellitus types II depending on insulin sensitivity. Steroids 68-75 insulin Homo sapiens 192-199 18725905-12 2008 He re-presented 18 months later with an insulin requirement during an asthma exacerbation treated with steroids. Steroids 103-111 insulin Homo sapiens 40-47 18589153-9 2008 The metabolic picture in lung transplanted patients on low-dose steroid therapy was characterized by normal insulin-stimulated glucose, leucine, and free fatty acid metabolism. Steroids 64-71 insulin Homo sapiens 108-115 17999993-10 2008 Insulin resistance (HOMA-R) of the whole group increased significantly, mainly due to a rise in HOMA-R in patients on steroids (n = 18). Steroids 118-126 insulin Homo sapiens 0-7 17999993-14 2008 However, in patients receiving steroids, conversion leads to an increase in insulin resistance while insulin output remains the same. Steroids 31-39 insulin Homo sapiens 76-83 17999993-14 2008 However, in patients receiving steroids, conversion leads to an increase in insulin resistance while insulin output remains the same. Steroids 31-39 insulin Homo sapiens 101-108 17726076-0 2007 Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism. Steroids 10-17 insulin Homo sapiens 37-44 17976198-0 2007 Oestradiol replacement treatment and glucose homeostasis in two men with congenital aromatase deficiency: evidence for a role of oestradiol and sex steroids imbalance on insulin sensitivity in men. Steroids 148-156 insulin Homo sapiens 170-177 18045959-6 2007 The main outcome measures were established before data collection and included sex steroid receptor status of tumours and insulin expression in fresh tissue in response to exogenous sex steroids. Steroids 186-194 insulin Homo sapiens 122-129 17726076-15 2007 CONCLUSIONS: 1) Acute sex steroid withdrawal reduces insulin sensitivity in young healthy IHH men. Steroids 26-33 insulin Homo sapiens 53-60 17726076-16 2007 2) The acuity of the hypogonadism and absence of changes in body mass index or leptin levels suggest that sex steroids modulate insulin sensitivity in the absence of apparent or detectable changes in body composition. Steroids 110-118 insulin Homo sapiens 128-135 15986111-10 2005 Adiposity correlated directly with estrogens in postmenopausal women and with insulin, resulting in lower SHBG and increased levels of free sex steroids. Steroids 144-152 insulin Homo sapiens 78-85 17392500-5 2007 In addition to gonadotropic hormones, such growth factors as insulin, insulin-like growth factor 1, and epidermal growth factor have been shown to modulate luteal steroid hormone synthesis and steroidogenic enzyme expression as either independent effects or via amplification or modulation of the action of gonadotropic hormones or cAMP. Steroids 163-178 insulin Homo sapiens 61-68 17454168-2 2007 The use of insulin-sensitizer compounds, such as metformin, permits great improvement of such metabolic abnormality, restoring ovarian function and gonadal steroid synthesis and reducing insulin resistance. Steroids 156-163 insulin Homo sapiens 11-18 17110071-3 2006 First, exploration of the early steps in the generation of the internal steroidal hormonal signal involved in lifespan extension via the insulin/IGF-like signaling pathway in the nematode by two research groups revealed that the product of cholestanoic acid derivatives metabolized by a cytochrome P-450-like protein activates a protein with homology to the mammalian nuclear receptor superfamily, a process strikingly similar to the steroid hormone signaling pathway documented in mammalian systems. Steroids 434-449 insulin Homo sapiens 137-144 16439034-0 2006 A case of slowly progressive type 1 diabetes with unstable glycemic control caused by unusual insulin antibody and successfully treated with steroid therapy. Steroids 141-148 insulin Homo sapiens 94-101 16439034-5 2006 Steroid pulse therapy (1000 mg for 3 days) aimed at reducing the possible effect of the IA on his insulin resistance and glycemic instability successfully decreased IA titer (from 89.8 to 58.3%), lowered its binding capacity (51.8-9.8 x 10(-8) M), increased glucose infusion rate (from 2.84 to 5.55 mg/kg/min) and improved glycemic control (HbA(1c): from 10.0 to 7.4%) with reduced blood glucose excursion. Steroids 0-7 insulin Homo sapiens 98-105 16402927-1 2006 OBJECTIVE: This study was conducted in order to evaluate the effect of glucose-insulin homeostasis on adrenal steroids and was designed to separate the effects of hyperglycaemia from those of insulin. Steroids 110-118 insulin Homo sapiens 79-86 16410665-1 2005 Dehydroepiandrosterone (DHEA), the most abundant human adrenal steroid, improves insulin sensitivity and obesity in human and model animals. Steroids 63-70 insulin Homo sapiens 81-88 15977304-5 2005 These may include insulin-antagonistic action of hormones like catecholamines, glucocorticoids, sex steroids and adipokines as well as dysregulation of autonomic nervous activity and they could contribute to the early development of insulin resistance. Steroids 100-108 insulin Homo sapiens 18-25 17316544-3 2007 Different mechanisms might explain post-transplantation glucose metabolism disorders: ischemia-reperfusion disorders, whether renal, hepatic or cardiac, are responsible for insulin-resistance, which is increased by post-transplantation steroids; the detrimental effect of non-steroid immunosuppressive drugs on insulin-secretion could also be involved, especially with calcineurin inhibitors. Steroids 236-244 insulin Homo sapiens 173-180 17316544-3 2007 Different mechanisms might explain post-transplantation glucose metabolism disorders: ischemia-reperfusion disorders, whether renal, hepatic or cardiac, are responsible for insulin-resistance, which is increased by post-transplantation steroids; the detrimental effect of non-steroid immunosuppressive drugs on insulin-secretion could also be involved, especially with calcineurin inhibitors. Steroids 236-243 insulin Homo sapiens 173-180 17316544-10 2007 Finally, steroids are mainly detrimental because they accentuate insulin resistance whereas anticalcineurins, in particular tacrolimus, lower insulin synthesis. Steroids 9-17 insulin Homo sapiens 65-72 17097651-13 2007 CONCLUSION(S): The low SHBG expression in the stromal compartment of endometria from women with PCOS with insulin resistance may contribute to generate an abnormal steroid milieu in the endometria of these women. Steroids 164-171 insulin Homo sapiens 106-113 16569741-2 2006 OBJECTIVE: Our objective was to evaluate insulin sensitivity after islet transplantation performed under tacrolimus-based immunosuppression that used minimal steroids. Steroids 158-166 insulin Homo sapiens 41-48 16680182-1 2006 The development by the Edmonton group of a sirolimus-based, steroid-free, low-tacrolimus regimen is a significant breakthrough that allows the rate of insulin independence after islet transplantation to increase from 13% to 80% at 1 year; however, the rate is reduced to 50% at 3 years, attributed to prolonged tacrolimus exposure. Steroids 60-67 insulin Homo sapiens 151-158 16549165-19 2006 CONCLUSION: The present study revealed that beside the daily dose of steroids, TNF-alpha -238 G/A genotype may contribute to insulin resistance in renal transplant recipients. Steroids 69-77 insulin Homo sapiens 125-132 16790847-3 2006 The introduction of a steroid-free antirejection protocol and islets prepared from two donors led to high rates of insulin independence. Steroids 22-29 insulin Homo sapiens 115-122 16898535-2 2006 Recently it has been suggested that proteinuria and steroid treatment may independently affect insulin sensitivity. Steroids 52-59 insulin Homo sapiens 95-102 16898535-12 2006 In conclusion, an increase in insulin resistance with compensatory enhanced beta-cell secretion is a typical finding in children with INS treated with steroids. Steroids 151-159 insulin Homo sapiens 30-37 15579527-0 2004 Insulin resistance after renal transplantation: the effect of steroid dose reduction and withdrawal. Steroids 62-69 insulin Homo sapiens 0-7 15541479-3 2005 The steroid was also found to diminish the insulin responsiveness of the cells in terms of cell survival, DNA synthesis, glucose transport, and glucose oxidation, this last effect possibly involving reduced phosphatidylinositol 3-kinase (PI3-kinase) activity. Steroids 4-11 insulin Homo sapiens 43-50 15797950-1 2005 BACKGROUND: Inflammatory markers and insulin resistance are independent cardiovascular risk factors and are thought to be influenced by sex steroids. Steroids 140-148 insulin Homo sapiens 37-44 15717807-1 2004 UNLABELLED: The aim of our study was to investigate if there is any significant relationship between adrenal steroid hormone dehydroepiandrosterone-sulphate (DHEAS) and insulin resistance, as there are some previous signs in the literature suggesting such relationship but the results are not conclusive. Steroids 109-124 insulin Homo sapiens 169-176 15248817-1 2004 The age-related decline in serum dehydroepiandrosterone (DHEA) and its sulfated ester (DHEA-S) has suggested that a relative deficiency of these steroids may be causally related to the development of chronic diseases generally associated with aging, including insulin resistance, obesity, cardiovascular disease, cancer, reductions of the immune defense, depression and a general deterioration in the sensation of well-being. Steroids 145-153 insulin Homo sapiens 260-267 15171749-2 2004 The aim of this study was to test the hypothesis that these steroid-binding proteins are markers of insulin resistance and obesity in adult patients with the metabolic syndrome. Steroids 60-67 insulin Homo sapiens 100-107 15194387-1 2004 Insulin independence after islet transplantation has been significantly improved by using new steroid-free immunosuppressive protocols and increased islet mass. Steroids 94-101 insulin Homo sapiens 0-7 15216452-2 2004 By using insulin pump therapy with insulin lispro, it was possible to balance diabetes control with changes of steroid replacement therapy. Steroids 111-118 insulin Homo sapiens 9-16 15216452-2 2004 By using insulin pump therapy with insulin lispro, it was possible to balance diabetes control with changes of steroid replacement therapy. Steroids 111-118 insulin Homo sapiens 35-42 15041369-2 2004 The development by the Edmonton group of a sirolimus-based, steroid-free, low-tacrolimus regimen was a significant breakthrough that allowed the rate of insulin independence after islet transplantation to increase from 13% to 80% at 1 year. Steroids 60-67 insulin Homo sapiens 153-160 14617207-6 2003 The introduction of a steroid-free, sirolimus-based, anti-rejection protocol and islets prepared from two (or rarely three) donors led to high rates of insulin independence. Steroids 22-29 insulin Homo sapiens 152-159 12965873-5 2004 Furthermore, basal insulin concentrations were higher during hydrocortisone than during saline infusion (P < 0.01), indicating the presence of steroid-induced insulin resistance. Steroids 146-153 insulin Homo sapiens 19-26 12965873-5 2004 Furthermore, basal insulin concentrations were higher during hydrocortisone than during saline infusion (P < 0.01), indicating the presence of steroid-induced insulin resistance. Steroids 146-153 insulin Homo sapiens 162-169 14714273-2 2003 There is also evidence that this steroid may influence the insulin sensitivity. Steroids 33-40 insulin Homo sapiens 59-66 11834135-3 2002 However, outside this "physiological window" these steroids may promote insulin resistance. Steroids 51-59 insulin Homo sapiens 72-79 14671189-14 2003 Insulin seems to enhance 5alpha reduction of steroids in PCOS but was not associated with the elevated cortisol production rate. Steroids 45-53 insulin Homo sapiens 0-7 14641693-1 2003 AIM: Leptin and insulin may interact in regulating ovarian steroid synthesis. Steroids 59-66 insulin Homo sapiens 16-23 14641693-10 2003 Insulin may stimulate ovarian steroid synthesis not only through its own receptors, but also by acting on the leptin expression of these cells. Steroids 30-37 insulin Homo sapiens 0-7 12649905-9 2003 She was treated with steroid, nasal desmopressin, and insulin for her steroid induced diabetes mellitus. Steroids 70-77 insulin Homo sapiens 54-61 12378184-0 2002 Intrauterine growth restriction and postnatal steroid treatment effects on insulin sensitivity in preterm neonates. Steroids 46-53 insulin Homo sapiens 75-82 11888840-0 2002 The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor. Steroids 16-24 insulin Homo sapiens 46-53 11888840-5 2002 These divergent changes in the two groups enabled us to study the effects of sex steroids and GH on insulin sensitivity and lipid concentrations. Steroids 81-89 insulin Homo sapiens 100-107 12721674-0 2003 [Novel aspects in the mechanisms of steroid diabetes and the regulation of hepatic glucose production by insulin and steroids]. Steroids 36-43 insulin Homo sapiens 105-112 12460054-1 2002 After renal transplantation for congenital cystic kidney disease of unknown origin, a 14-year-old boy, who was previously normoglycemic, had "steroid-induced" diabetes mellitus, which was treated with insulin. Steroids 142-149 insulin Homo sapiens 201-208 19087413-8 2002 It has been hypothesised that obesity, especially central fat deposits, linked to insulin resistance, increases circulating hormones such as oestrogens, androgens, insulin, insulin-like growth factor-1 (IGF-1), and decreased levels of hormone-binding proteins such as steroid hormone-binding globulin and IGF-1 binding protein-1. Steroids 268-275 insulin Homo sapiens 82-89 11895468-0 2002 Endocrine abnormalities in healthy first-degree relatives of type 2 diabetes patients--potential role of steroid hormones and leptin in the development of insulin resistance. Steroids 105-112 insulin Homo sapiens 155-162 11834135-9 2002 Insulin-sensitizing agents can reverse many of the effects of insulin resistance and may have a future place in the treatment of polycystic ovarian syndrome and other conditions associated with steroid-induced insulin resistance. Steroids 194-201 insulin Homo sapiens 0-7 11834135-9 2002 Insulin-sensitizing agents can reverse many of the effects of insulin resistance and may have a future place in the treatment of polycystic ovarian syndrome and other conditions associated with steroid-induced insulin resistance. Steroids 194-201 insulin Homo sapiens 210-217 11834135-10 2002 Recognition and treatment of sex steroid-associated insulin resistance at an early stage in patients may reduce their risk of developing Type II (non-insulin-dependent) diabetes mellitus, hypertension and dyslipidaemia, and so may improve fertility and reduce cardiovascular risk. Steroids 33-40 insulin Homo sapiens 52-59 11834135-10 2002 Recognition and treatment of sex steroid-associated insulin resistance at an early stage in patients may reduce their risk of developing Type II (non-insulin-dependent) diabetes mellitus, hypertension and dyslipidaemia, and so may improve fertility and reduce cardiovascular risk. Steroids 33-40 insulin Homo sapiens 150-157 12235642-5 2002 In separate tissue culture experiments, LNCaP and PC-3 cell growth was also measured in response to the addition of testosterone, estradiol, or insulin to steroid-stripped FBS. Steroids 155-162 insulin Homo sapiens 144-151 11752041-7 2002 In conclusion, steroid withdrawal resulted in a decrease in insulin resistance and a reduction in lipids, and tacrolimus trough level reduction resulted in an improved pancreatic beta-cell secretion capacity. Steroids 15-22 insulin Homo sapiens 60-67 11771903-6 2001 Another effect of insulin was the acquisition by oocytes of steroid sensitivity during folliculogenesis. Steroids 60-67 insulin Homo sapiens 18-25 11721156-6 2001 During steroid pulse therapy, the patients who were treated with insulin needed a higher dosage of insulin; after steroid pulse therapy, the dosage returned to baseline. Steroids 7-14 insulin Homo sapiens 65-72 11721156-6 2001 During steroid pulse therapy, the patients who were treated with insulin needed a higher dosage of insulin; after steroid pulse therapy, the dosage returned to baseline. Steroids 7-14 insulin Homo sapiens 99-106 11443175-1 2001 Hyperandrogenism observed in women with a variety of insulin-resistant states is thought to be due to a stimulatory effect of insulin on ovarian steroid hormone production. Steroids 145-160 insulin Homo sapiens 53-60 11453956-10 2001 In 14 prepubertal children, exogenous sex steroid priming resulted in lower insulin sensitivity (P < 0.05) compared to nonprimed tests. Steroids 42-49 insulin Homo sapiens 76-83 11574492-5 2001 RESULTS: Insulin increased the basal secretion of steroid hormones, and furthermore augmented LH-stimulated oestrogen and progesterone accumulation in granulosa cell cultures. Steroids 50-57 insulin Homo sapiens 9-16 11443175-1 2001 Hyperandrogenism observed in women with a variety of insulin-resistant states is thought to be due to a stimulatory effect of insulin on ovarian steroid hormone production. Steroids 145-160 insulin Homo sapiens 126-133 11263561-0 2001 Impact of cyclosporine and low-dose steroid therapy on insulin sensitivity and beta-cell function in patients with long-term liver grafts. Steroids 36-43 insulin Homo sapiens 55-62 11310428-6 2001 Furthermore, both insulin and IGF-I stimulate the synthesis of sex steroids, and inhibit the synthesis of sex hormone-binding globulin (SFIBG), a binding protein that regulates the bioavailability of circulating sex steroids to tissues. Steroids 67-75 insulin Homo sapiens 18-25 11310428-6 2001 Furthermore, both insulin and IGF-I stimulate the synthesis of sex steroids, and inhibit the synthesis of sex hormone-binding globulin (SFIBG), a binding protein that regulates the bioavailability of circulating sex steroids to tissues. Steroids 216-224 insulin Homo sapiens 18-25 11310428-11 2001 For cancers of the endometrium, breast and prostate, these findings are discussed in the context of relationships between insulin and IGF-I and levels of bioavailable sex steroids. Steroids 171-179 insulin Homo sapiens 122-129 11213069-15 2001 Insulin dependence in our population rarely resolved, even after lowering tacrolimus and steroid doses. Steroids 89-96 insulin Homo sapiens 0-7 11041233-2 2000 Insulin-like growth factor (IGF) system is one of the growth factor systems that are believed to modulate steroid hormone actions in the endometrium through autocrine/paracrine mechanisms. Steroids 106-121 insulin Homo sapiens 0-7 11113656-1 2000 Background: The purpose of our study was to investigate the association of C-peptide and steroid hormones in males and females with type 2 diabetes compared to controls. Steroids 89-105 insulin Homo sapiens 75-84 10746005-4 1999 Indeed, insulin resistance does not stand as the sole cause for type 2 diabetes, as suggested by cases of severe insulin resistance in diabetes-free, non aged, obese or acromegalic patients, as well as in patients treated with steroids. Steroids 227-235 insulin Homo sapiens 8-15 10523332-1 1999 Arterial stiffness may be influenced by sex steroids and insulin; the association with fasting insulin level may be stronger in women than in men. Steroids 44-52 insulin Homo sapiens 95-102 10440591-2 1999 The current study was undertaken to examine the effects of obesity, fat distribution, and insulin resistance on plasma levels of aldosterone and other adrenal steroids that might contribute to sequelae of obesity. Steroids 159-167 insulin Homo sapiens 90-97 10493303-1 1999 There is ample evidence that breast cancer susceptibility is induced during the developmental stages of the human breast where, in a manner related to sex-steroid hormones, insulin plays an important role. Steroids 155-162 insulin Homo sapiens 173-180 10440591-10 1999 DISCUSSION: We conclude that visceral adiposity and insulin resistance are associated with increased plasma aldosterone and other adrenal steroids that may contribute to cardiovascular diseases in obese women. Steroids 138-146 insulin Homo sapiens 52-59 9589685-1 1998 To evaluate the possible involvement of ovarian steroids on the opioid-mediated disorders of insulin in patients affected by polycystic ovary syndrome (PCOS), we studied 40 PCOS women. Steroids 48-56 insulin Homo sapiens 93-100 11038778-0 1998 [The effects of FSH,LH and insulin on steroids production by granulosa cells from polycystic ovaries syndrome]. Steroids 38-46 insulin Homo sapiens 27-34 11038778-5 1998 Insulin markedly augmented FSH and LH-stimulated steroid accumulation by two groups of granulosa cells. Steroids 49-56 insulin Homo sapiens 0-7 10335318-0 1999 Insulin versus oral agents for "steroid-induced" diabetes. Steroids 32-39 insulin Homo sapiens 0-7 10356596-10 1999 CONCLUSIONS: These results indicate an abnormal adrenal steroid hormone secretion in DyM, which may contribute to peripheral insulin sensitivity as well as cognitive impairment in these patients. Steroids 56-63 insulin Homo sapiens 125-132 10084566-14 1999 Thus, short-term (2.5-day) fasting during the sex steroid-replete midluteal phase of the menstrual cycle in healthy young women profoundly suppresses 24-h serum leptin and insulin (and to a lesser degree, IGF-I) concentrations, augments cortisol release, but fails to alter daily LH, estradiol, or progesterone concentrations. Steroids 50-57 insulin Homo sapiens 172-179 10374406-3 1998 RESULTS: The growth of HCE16/3 cells was found to be little affected by estradiol and progesterone while insulin was a mitogen for HCE16/3 cells in phenol redfree medium with steroid-stripped serum. Steroids 175-182 insulin Homo sapiens 105-112 9736801-1 1998 OBJECTIVE: To identify the effect of the menstrual cycle and sex steroid hormone levels on insulin sensitivity in healthy women with non-insulin-dependent diabetic parents. Steroids 65-80 insulin Homo sapiens 91-98 9467587-13 1998 Plasmapheresis followed by steroid treatment can lower the insulin antibody concentration, abolish severe hypoglycemia, and improve insulin biodistribution and glucose tolerance in insulin autoimmune hypoglycemia. Steroids 27-34 insulin Homo sapiens 59-66 9467587-13 1998 Plasmapheresis followed by steroid treatment can lower the insulin antibody concentration, abolish severe hypoglycemia, and improve insulin biodistribution and glucose tolerance in insulin autoimmune hypoglycemia. Steroids 27-34 insulin Homo sapiens 132-139 9543152-9 1998 In granulosa cell cultures from small antral follicles (< or = 13 mm), insulin and IGF-I stimulated steroid production to a similar degree, whereas IGF-II was less effective. Steroids 103-110 insulin Homo sapiens 74-81 9211130-1 1997 Our aim was to investigate the effect of GnRH-agonist (GnRH-a) induced suppression of plasma sex steroids on serum GH, insulin like growth factor-I (IGF-I) and insulin levels after an oral glucose load (OGTT) in women with polycystic ovary syndrome (PCOS). Steroids 97-105 insulin Homo sapiens 119-126 9296913-1 1997 Presented survey summarises insulin-steroid interactions. Steroids 36-43 insulin Homo sapiens 28-35 9296913-2 1997 Beside the well known resistance to insulin induced by steroid hormones, also the central effect of insulin, its influence on the system hypophysis-adrenals, and its stimulatory effect on the generation of steroids in adrenals and ovaries are reviewed. Steroids 55-62 insulin Homo sapiens 36-43 9296913-2 1997 Beside the well known resistance to insulin induced by steroid hormones, also the central effect of insulin, its influence on the system hypophysis-adrenals, and its stimulatory effect on the generation of steroids in adrenals and ovaries are reviewed. Steroids 206-214 insulin Homo sapiens 100-107 9296913-3 1997 Insulin-steroid interactions are further illustrated by pathogenesis of the polycystic ovary syndrome and by our study on dehydroepiandrosterone regulation. Steroids 8-15 insulin Homo sapiens 0-7 9165659-7 1997 Both LH and insulin hypersecretion are most often a result of the steroid secretory abnormalities. Steroids 66-73 insulin Homo sapiens 12-19 8943799-5 1996 For instance, concomitant alterations in sex steroid levels have been found in both men and women with abdominal (visceral) obesity which have also been reported to be significantly correlated with the insulin resistant-dyslipidemic state found in abdominal obese subjects. Steroids 45-52 insulin Homo sapiens 202-209 9059564-9 1997 When insulin was simultaneously infused once steady-state DHEA levels had been attained, we observed a decline only in DHEA, DHEA-FA and DHEAS levels, with no effect on other steroids examined. Steroids 175-183 insulin Homo sapiens 5-12 8609836-4 1996 The aim of the present study was to factor out quantitatively the main components of the insulin pathway that are responsible for the peripheral hypersecretion observed after steroids. Steroids 175-183 insulin Homo sapiens 89-96 8773746-16 1996 Thus insulin increases the biological availability of potent steroids, primarily testosterone, through the suppression of SHBG synthesis. Steroids 61-69 insulin Homo sapiens 5-12 8609836-7 1996 After steroids, insulin sensitivity decreased from 6.00 +/- 1.29 to 4.23 +/- 1.04 min-1/(microU/mL) (P < .04). Steroids 6-14 insulin Homo sapiens 16-23 8964590-2 1996 Pharmacological administration of anabolic steroids to both men and women increases glucose and insulin concentrations and also insulin resistance. Steroids 43-51 insulin Homo sapiens 96-103 9017275-11 1996 Elevated cortisol levels, deficiencies in sex-specific steroid hormones and excess androgens result in insulin resistance. Steroids 55-71 insulin Homo sapiens 103-110 8550768-3 1996 Granulosa cells were incubated with insulin with or without gonadotropins for 48 h. Insulin augmented not only basal production of estradiol and progesterone, but also LH-stimulated steroid accumulation in granulosa cell cultures from N and PCO. Steroids 182-189 insulin Homo sapiens 36-43 8550768-3 1996 Granulosa cells were incubated with insulin with or without gonadotropins for 48 h. Insulin augmented not only basal production of estradiol and progesterone, but also LH-stimulated steroid accumulation in granulosa cell cultures from N and PCO. Steroids 182-189 insulin Homo sapiens 84-91 8550768-5 1996 Preincubation with insulin for 48 h increased subsequent basal and LH-induced, but not FSH-stimulated, steroid production. Steroids 103-110 insulin Homo sapiens 19-26 7719392-5 1995 In addition, we examined the relation between these sex steroid hormones and insulin response to an oral glucose tolerance test. Steroids 56-72 insulin Homo sapiens 77-84 8536147-8 1995 Differences in sex steroids may explain the observation of a markedly higher insulin sensitivity in women than in men. Steroids 19-27 insulin Homo sapiens 77-84 7584526-12 1995 The insulin requirements in diabetic patients during surgery vary from 0.25-0.40 U per gram glucose in normal weight patients, 0.4-0.8 U per gram glucose in case of obesity, liver disease, steroid therapy or sepsis, to 0.8-1.2 U per gram glucose in patients undergoing cardiopulmonary bypass surgery. Steroids 189-196 insulin Homo sapiens 4-11 9420856-13 1995 Elevated insulin levels could therefore affect steroid production in human granulosa cells and presumably alter the menstrual cycle and fertility. Steroids 47-54 insulin Homo sapiens 9-16 7536204-0 1995 Differential effects of insulin and insulin-like growth factor I on the production of plasma steroid-binding globulins by human hepatoblastoma-derived (Hep G2) cells. Steroids 93-100 insulin Homo sapiens 24-31 7626178-7 1995 Insulin resistance (probably due to steroid therapy) associated with high peripheral and potentially low hepatic insulin levels (due to the systemic drainage of the transplanted pancreas) could be the main causes of the remaining lipoprotein abnormalities. Steroids 36-43 insulin Homo sapiens 0-7 7964428-0 1994 Relationship between visceral fat, steroid hormones and insulin sensitivity in premenopausal obese women. Steroids 35-42 insulin Homo sapiens 56-63 7523316-1 1994 The insulin-like growth factor (IGF) system is thought to function as a mediator of steroid hormone actions in the endometrium. Steroids 84-99 insulin Homo sapiens 4-11 7926656-0 1994 Insulin as an amplifier of gonadotropin action on steroid production: mechanisms and sites of action in goldfish prematurational full-grown ovarian follicles. Steroids 50-57 insulin Homo sapiens 0-7 7926656-8 1994 These findings suggest that insulin, but not IGF-I, is capable of participating in the regulation of ovarian steroid biosynthesis through effects at multiple steps within the steroid cascade and that ovarian responsiveness to insulin changes during the course of follicular development in the goldfish. Steroids 109-116 insulin Homo sapiens 28-35 7926656-8 1994 These findings suggest that insulin, but not IGF-I, is capable of participating in the regulation of ovarian steroid biosynthesis through effects at multiple steps within the steroid cascade and that ovarian responsiveness to insulin changes during the course of follicular development in the goldfish. Steroids 175-182 insulin Homo sapiens 28-35 8412766-8 1993 This phenomenon might be related to a direct effect of insulin on enzyme systems involved in the biosynthetic pathway of adrenal steroids or, alternatively, to an intra-adrenal CRH/corticotropin mechanism acting on the adrenal cortex in a paracrine manner. Steroids 129-137 insulin Homo sapiens 55-62 8126125-2 1994 This study was conducted to assess the influence of physiological concentrations of insulin on serum adrenal steroid levels by lowering circulating insulin in nondiabetic men through the administration of the biguanide metformin. Steroids 109-116 insulin Homo sapiens 84-91 8126125-2 1994 This study was conducted to assess the influence of physiological concentrations of insulin on serum adrenal steroid levels by lowering circulating insulin in nondiabetic men through the administration of the biguanide metformin. Steroids 109-116 insulin Homo sapiens 148-155 8027240-7 1994 The effects of sex steroids during steps 2 and 3 of the clamp at higher (supraphysiological) insulin levels were less clear. Steroids 19-27 insulin Homo sapiens 93-100 8171559-0 1994 Successful intraportal islet transplantation reverses non-steroid-related insulin resistance in humans. Steroids 58-65 insulin Homo sapiens 74-81 7822696-8 1994 Oral steroids treatment for long-term insulin treated diabetic patients required a very close daily diabetic or/and internist survey. Steroids 5-13 insulin Homo sapiens 38-45 8243453-3 1993 Increased placental steroid production causes an increase in hormone-binding globulin production, insulin resistance, and prolactinoma growth. Steroids 20-27 insulin Homo sapiens 98-105 7688335-4 1993 The median serum insulin concentration increased and median serum IGFBP-1 concentration decreased in the steroid treated group but not in the elemental diet group. Steroids 105-112 insulin Homo sapiens 17-24 8500495-4 1993 Insulin and the androgens reduce the synthesis of Sex Hormone Binding Globulin (SHBG) at the hepatic level, thus increasing the amount of free steroids able to act at the level of the hormone-dependent tissues. Steroids 143-151 insulin Homo sapiens 0-7 8345794-1 1993 Estrogen/progestin steroid combinations adversely affect glucose tolerance and insulin resistance, but their effects in combined hormone replacement therapy (HRT) have rarely been evaluated. Steroids 19-26 insulin Homo sapiens 79-86 8472630-7 1993 In case of hyperglycemia occurring in 12 of 15 patients due to the administration of steroid, insulin was used to normalize blood glucose levels (average 0.47 +/- 0.21 IU/kg/day). Steroids 85-92 insulin Homo sapiens 94-101 8425626-12 1993 CONCLUSION: The present study demonstrates that both insulin and IGF-I receptor genes are expressed and that insulin and IGF-I can stimulate steroid production in human thecal cells. Steroids 141-148 insulin Homo sapiens 109-116 8333058-0 1993 Acute deterioration of pancreatic graft function presumably determined by steroid-induced insulin resistance: a case report. Steroids 74-81 insulin Homo sapiens 90-97 1485940-2 1992 Its consequences for the metabolism of the periphery seems to be insulin resistance caused by a combination of a relative hypercortisolaemia and a relative deficiency of sex steroid hormones. Steroids 174-190 insulin Homo sapiens 65-72 1619986-0 1992 Reversal of steroid-induced insulin resistance by a nicotinic-acid derivative in man. Steroids 12-19 insulin Homo sapiens 28-35 1385468-0 1992 Steroid and peptide regulation of insulin-like growth factor-binding proteins secreted by human endometrial stromal cells is dependent on stromal differentiation. Steroids 0-7 insulin Homo sapiens 34-41 1426306-4 1992 RESULTS: Insulin and IGF-I stimulate ovarian growth and potentiate the actions of gonadotropins on ovarian steroid synthesis. Steroids 107-114 insulin Homo sapiens 9-16 1445172-10 1992 Several studies in humans have demonstrated an acute decline in serum concentrations of the adrenal steroids DHEA and DHEA-sulfate in response to experimentally-induced hyperinsulinaemia, but the regulatory role of insulin on adrenal androgen metabolism in normal physiology or disease remains speculative. Steroids 100-108 insulin Homo sapiens 174-181 1619986-1 1992 A recent report suggested that the glucose-free fatty acid (FFA) cycle may contribute to steroid-induced insulin resistance in rats, and that glucose tolerance could be restored to normal when FFA levels were lowered with nicotinic acid. Steroids 89-96 insulin Homo sapiens 105-112 1778178-0 1991 Insulin as an effector of human ovarian and adrenal steroid metabolism. Steroids 52-59 insulin Homo sapiens 0-7 1730815-7 1992 The insulin-induced change in this steroid ratio was due to a relative increase in precursor (17 alpha-hydroxyprogesterone) and decrease in product (androstenedione) responsiveness to ACTH. Steroids 35-42 insulin Homo sapiens 4-11 1730815-9 1992 Again, the insulin-induced change in this steroid ratio was due to a relative increase in precursor (17 alpha-hydroxypregnenolone) and decrease in product (dehydroepiandrosterone) responsiveness to ACTH. Steroids 42-49 insulin Homo sapiens 11-18 1505608-4 1992 These results suggest that the degree of glucose intolerance and insulin resistance depends on the steroid used and on the dose given, although long-term treatment with deflazacort has a smaller effect on glucose metabolism than betamethasone. Steroids 99-106 insulin Homo sapiens 65-72 1549847-1 1992 Although steroids can induce insulin resistance, it is not known whether additional defects in insulin secretion are necessary for the development of diabetes. Steroids 9-17 insulin Homo sapiens 29-36 1541386-10 1992 High-dose steroid therapy reversed the rejection in all instances, with apparent preservation of C-peptide secretion. Steroids 10-17 insulin Homo sapiens 97-106 1954880-6 1991 These results indicate that insulin mediators mimic insulin"s effects on cytotrophoblastic aromatase and 3 beta HSD activities and suggest that inositolglycan mediators are the signal transduction mechanism responsible for insulin"s regulation of human placental steroid hormone biosynthesis. Steroids 263-278 insulin Homo sapiens 28-35 1954880-6 1991 These results indicate that insulin mediators mimic insulin"s effects on cytotrophoblastic aromatase and 3 beta HSD activities and suggest that inositolglycan mediators are the signal transduction mechanism responsible for insulin"s regulation of human placental steroid hormone biosynthesis. Steroids 263-278 insulin Homo sapiens 52-59 1954880-6 1991 These results indicate that insulin mediators mimic insulin"s effects on cytotrophoblastic aromatase and 3 beta HSD activities and suggest that inositolglycan mediators are the signal transduction mechanism responsible for insulin"s regulation of human placental steroid hormone biosynthesis. Steroids 263-278 insulin Homo sapiens 52-59 1778178-1 1991 Evidence is accumulating that insulin is a potent effector of human steroid hormone metabolism. Steroids 68-83 insulin Homo sapiens 30-37 2080856-2 1990 It is probably synthesized in the liver, plasma concentrations being regulated by, amongst other things, androgen/oestrogen balance, thyroid hormones, insulin and dietary factors, it is involved in transport of sex steroids in plasma and its concentration is a major factor regulating their distribution between the protein-bound and free states. Steroids 215-223 insulin Homo sapiens 151-158 1779020-0 1991 Effect of steroid-therapy on insulin sensitivity in insulin-dependent diabetic patients after kidney transplantation. Steroids 10-17 insulin Homo sapiens 29-36 1779020-8 1991 However, nondiabetic steroid-treated renal graft recipients show insulin resistance comparable to IDDM patients. Steroids 21-28 insulin Homo sapiens 65-72 1864771-7 1991 The responses of insulin and hGH to exercise were not related to the OC use per se but rather to the steroid status, either endogenous or exogenous. Steroids 101-108 insulin Homo sapiens 17-24 1835649-5 1991 These studies show that experimentally-induced hyperinsulinemia lowers serum DHA and DHA-sulfate levels, and suggest that insulin reduces serum concentrations of these steroids by inhibiting production rather than by increasing clearance. Steroids 168-176 insulin Homo sapiens 52-59 2253832-5 1990 To further evaluate the hypothesis that residual insulin resistance was due to chronic steroid therapy. Steroids 87-94 insulin Homo sapiens 49-56 2203480-0 1990 Exogenous insulin and additional energy affect follicular distribution, follicular steroid concentrations, and granulosa cell human chorionic gonadotropin binding in swine. Steroids 83-90 insulin Homo sapiens 10-17 2253832-10 1990 We conclude that short-term (one year) combined kidney-pancreas transplantation improves glucose metabolism by restoring normal rates of hepatic glucose production and reducing peripheral insulin resistance; chronic steroid therapy is the major determinant of residual reduced insulin action. Steroids 216-223 insulin Homo sapiens 188-195 2253832-10 1990 We conclude that short-term (one year) combined kidney-pancreas transplantation improves glucose metabolism by restoring normal rates of hepatic glucose production and reducing peripheral insulin resistance; chronic steroid therapy is the major determinant of residual reduced insulin action. Steroids 216-223 insulin Homo sapiens 277-284 2104810-1 1990 Recent in vitro studies implicate the ovary as an extra-hepatic source of insulin-like growth factors (IGFs) with production regulated by gonadotropins and local steroids. Steroids 162-170 insulin Homo sapiens 74-81 2159194-6 1990 When low-density lipoprotein was provided as steroid substrate, a stimulatory effect of insulin on progesterone accumulation was observed with a minimum dose of 10 ng/ml. Steroids 45-52 insulin Homo sapiens 88-95 2168254-0 1990 Intractable diabetic ketoacidosis due to insulin antibody--response to steroid therapy. Steroids 71-78 insulin Homo sapiens 41-48 2112109-7 1990 Hindquarters from the high dose NG and low and high dose NE rats perfused with insulin (100 microU/ml) released 22% less phenylalanine than control rats perfused with the same insulin concentration (P less than 0.01) but the net suppression below baseline was similar in the control and steroid-treated groups. Steroids 287-294 insulin Homo sapiens 79-86 34220706-4 2021 On the other hand, a severe COVID-19 infection, and its treatment with steroids, can have a specific negative impact on diabetes itself, leading to worsening of hyperglycemia through increased insulin resistance and reduced beta-cell secretory function. Steroids 71-79 insulin Homo sapiens 193-200 18684447-5 2009 INTERVENTION(S): The transcriptional activity of SULT2A1 and adrenal steroid production was quantified after exposure to various treatments (e.g., forskolin, insulin, testosterone, and combinations thereof). Steroids 69-76 insulin Homo sapiens 158-165 34811800-5 2022 Hyperglycaemia following steroid administration can be managed either by increasing basal and prandial insulin doses, typically by 50% to 80%, or by adding a variable rate intravenous insulin infusion (VRIII). Steroids 25-32 insulin Homo sapiens 103-110 34764940-0 2021 Steroid Metabolism in Children and Adolescents With Obesity and Insulin Resistance: Altered SRD5A and 20alpha/20betaHSD Activity. Steroids 0-7 insulin Homo sapiens 64-71 35245460-3 2022 During development, the intake of nutrients promotes signaling through insulin-like systems that govern the growth of cells and tissues and also regulates the timely production of the steroid hormones that initiate the juvenile-adult transition. Steroids 184-191 insulin Homo sapiens 71-78 35550182-0 2022 Insulin Dosing and Glycemic Outcomes among Steroid-treated Hospitalized Patients. Steroids 43-50 insulin Homo sapiens 0-7 35550182-9 2022 Further prospective studies are needed to identify insulin regimens that will optimize glycemic control in steroid treated patients while minimizing hypoglycemia risk. Steroids 107-114 insulin Homo sapiens 51-58 35477646-17 2022 CONCLUSIONS: This insulin protocol gradually brought the blood glucose level within target levels in severe COVID-19 patients treated with high-dose steroid. Steroids 149-156 insulin Homo sapiens 18-25 2529264-2 1989 To determine whether this fall in serum DHEA-S levels might have been due to insulin-stimulated 1) hydrolysis of DHEA-S to dehydroepiandrosterone (DHEA), 2) conversion of DHEA-S/DHEA to androstenedione, and/or 3) urinary excretion of these steroids, 10 additional men were studied by the hyperinsulinemic-euglycemic clamp technique. Steroids 240-248 insulin Homo sapiens 77-84 2532472-0 1989 Steroid biosynthesis in the Sertoli-Leydig cell tumor: effects of insulin and luteinizing hormone. Steroids 0-7 insulin Homo sapiens 66-73 2678633-7 1989 Furthermore, suppression of hepatic glucose production was normal, and insulin secretion was normally enhanced in relation to the degree of insulin resistance in the steroid-treated patients. Steroids 166-173 insulin Homo sapiens 71-78 2571541-3 1989 At each rate of insulin infusion, the rate of leucine oxidation was increased (P less than .001) after steroid treatment. Steroids 103-110 insulin Homo sapiens 16-23 2571541-6 1989 These data provide strong evidence that the protein wasting associated with glucocorticosteroid therapy is in part the result of steroid-induced resistance to the antiproteolytic effect of insulin and an increase in the oxidation (and thus wasting) of one essential amino acid, leucine. Steroids 88-95 insulin Homo sapiens 189-196 2678633-8 1989 In conclusion, steroid-induced insulin resistance in kidney-transplanted patients is due to alterations in the nonoxidative pathway of glucose metabolism. Steroids 15-22 insulin Homo sapiens 31-38 2671596-4 1989 More recent studies indicate that glucose intolerance, insulin resistance, increased cardiovascular disease risk profiles, cerebral dangers, musculoskeletal injuries, prostate cancer, psychosis and schizophrenic episodes, among others, accompany anabolic steroid intake. Steroids 255-262 insulin Homo sapiens 55-62 2482797-11 1989 The association with insulin raises the possibility of a synchronized modulation of the actions of sex steroids and IGFs by nutritional intake. Steroids 103-111 insulin Homo sapiens 21-28 2642919-0 1989 Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome. Steroids 38-45 insulin Homo sapiens 0-7 3075895-3 1988 Impaired insulin sensitivity, from acromegaly, Cushing"s disease or steroid therapy, induces diabetes only in a small proportion of the population, and they may be those who have an inherited cell defect. Steroids 68-75 insulin Homo sapiens 9-16 3549761-0 1987 Insulin resistance and diminished glucose tolerance in powerlifters ingesting anabolic steroids. Steroids 87-95 insulin Homo sapiens 0-7 3309859-2 1987 She had two physical findings suggestive of possible insulin action: cystic ovarian enlargement with gonadotropin-independent steroid secretion and persistent, severe myocardial hypertrophy. Steroids 126-133 insulin Homo sapiens 53-60 3304908-1 1987 A previous study demonstrated that the net steroid balance, i.e., the total rate of cholesterogenesis, was within the normal range in insulin-treated patients with both insulin-dependent and noninsulin-dependent diabetes mellitus (NIDD). Steroids 43-50 insulin Homo sapiens 169-176 3281654-1 1988 The effect of steroid hormones on insulin binding and the amount of insulin-receptor mRNA was examined in IM-9 lymphocytes. Steroids 14-30 insulin Homo sapiens 34-41 3312602-1 1987 The development of antiinsulin antibodies during insulin therapy for steroid induced diabetes was documented in a group of patients with systemic lupus erythematosus and other connective tissue disorders. Steroids 69-76 insulin Homo sapiens 23-30 3549761-3 1987 Powerlifters who ingested anabolic steroids had diminished glucose tolerance compared to the nonsteroid-using group, despite having substantially higher postglucose serum insulin concentrations. Steroids 35-43 insulin Homo sapiens 171-178 3549761-4 1987 Postglucose insulin responses were also higher in steroid users than in the sedentary nonobese and sedentary obese reference groups. Steroids 50-57 insulin Homo sapiens 12-19 3549761-5 1987 These results indicate that powerlifters who ingest anabolic steroids have diminished glucose tolerance, which is likely to be secondary to insulin resistance. Steroids 61-69 insulin Homo sapiens 140-147 2990678-0 1985 Effects of adrenocorticotropic hormone, human chorionic gonadotropin, and insulin on steroid production by human adrenocortical carcinoma cells in culture. Steroids 85-92 insulin Homo sapiens 74-81 2949204-4 1986 Administration of subcutaneous steroids with insulin relieved the problem, but could not be stopped without relapse. Steroids 31-39 insulin Homo sapiens 45-52 3512314-0 1986 Persistence of insulin resistance in polycystic ovarian disease after inhibition of ovarian steroid secretion. Steroids 92-99 insulin Homo sapiens 15-22 4056873-6 1985 Immunosuppression, evidenced by a lower initial total lymphocyte count and a higher incidence of infections, was present in the steroid group; hyperglycemia requiring insulin treatment was more common in those patients. Steroids 128-135 insulin Homo sapiens 167-174 3539458-0 1986 Insulin action and dynamics modelled in patients taking the anabolic steroid methandienone (Dianabol). Steroids 69-76 insulin Homo sapiens 0-7 2946276-1 1986 It has been proposed that a nonsteroidal hormone such as insulin may directly exert an influence through estrogen receptors and alter the biologic behavior of steroid hormone target tissue. Steroids 159-174 insulin Homo sapiens 57-64 3900126-1 1985 In mammals, insulin stimulates granulosa cell aromatase activity and steroid production and is a regulating factor of oocyte maturation. Steroids 69-76 insulin Homo sapiens 12-19 6141989-0 1984 Insulin sensitivity in pancreatitis, liver diseases, steroid treatment and hyperthyroidism assessed by glucose, insulin and somatostatin infusion. Steroids 53-60 insulin Homo sapiens 0-7 6382082-7 1984 These results suggest that insulin may be a regulator of steroid biosynthesis in the thecal and stromal compartments of the human ovary. Steroids 57-64 insulin Homo sapiens 27-34 6408271-6 1983 However, anabolic steroid caused greater gain of water requiring a more liberal use of diuretics, but prevented the gains of fat, triglyceride and insulin that occurred in the control group. Steroids 18-25 insulin Homo sapiens 147-154 6141989-2 1984 Insulin sensitivity for glucose utilization decreased in subjects with liver disease, steroid treatment and hyperthyroidism irrespective of the presence or absence of glucose intolerance. Steroids 86-93 insulin Homo sapiens 0-7 6141989-3 1984 Hyperinsulinism was associated in most of the subjects with liver disease and steroid treatment, but even in normo-insulinemic subjects, insulin insensitivity was observed. Steroids 78-85 insulin Homo sapiens 5-12 6765122-7 1982 Insulin requirements will be increased (1) by infection, (2) in patients with hepatic disease, (3) in obese patients, (4) in steroid-treated patients, and (5) during cardiovascular surgery. Steroids 125-132 insulin Homo sapiens 0-7 6801979-4 1982 This combination of steroids produced marked insulin resistance to which the pancreas could respond by further insulin secretion. Steroids 20-28 insulin Homo sapiens 45-52 6998996-11 1980 Therefore, it remains to be seen whether these steroid hormones would cause, by the same mechanism, a decrease in insulin binding (and insulin resistance) during late pregnancy and in the secretory phase of the cycle. Steroids 47-54 insulin Homo sapiens 114-121 7041639-7 1982 A significant correlation was found between percent specific 125I-insulin binding and steroid dose, expressed as mg/kg body weight/day, in those patients. Steroids 86-93 insulin Homo sapiens 66-73 7034525-5 1982 Insulin therapy was necessary in 15 episodes in 11 patients, but in three episodes the insulin dosage was reduced while the steroid dosage remained high. Steroids 124-131 insulin Homo sapiens 0-7 6998996-11 1980 Therefore, it remains to be seen whether these steroid hormones would cause, by the same mechanism, a decrease in insulin binding (and insulin resistance) during late pregnancy and in the secretory phase of the cycle. Steroids 47-54 insulin Homo sapiens 135-142 1165627-0 1975 [Insulin and proinsulin secretion under contraceptive steroid administration (author"s transl)]. Steroids 54-61 insulin Homo sapiens 1-8 6997328-3 1980 A significant decrease was observed in insulin binding on circulating monocytes 24, 48, and 72 h after both steroids, mainly due to reduced receptor affinity. Steroids 108-116 insulin Homo sapiens 39-46 6997328-4 1980 Furthermore, steroid treatment increased insulinemia which did not appear to be related to insulin binding. Steroids 13-20 insulin Homo sapiens 41-48 274319-4 1978 It is suggested that corticosteroids may act via insulin release, since both blood glucose and blood insulin levels rise after steroid injection. Steroids 28-35 insulin Homo sapiens 49-56 1196559-7 1975 These data suggest that this 19-nor progestogen steroid can affect the peripheral activity of insulin and thus require higher blood levels in order to obtain the same glucose homeostasis. Steroids 48-55 insulin Homo sapiens 94-101 1102319-0 1975 Insulin metabolism, insulin sensitivity and hormonal responses to insulin infusion in patients taking oral contraceptive steroids. Steroids 121-129 insulin Homo sapiens 0-7 1102319-0 1975 Insulin metabolism, insulin sensitivity and hormonal responses to insulin infusion in patients taking oral contraceptive steroids. Steroids 121-129 insulin Homo sapiens 66-73 7420218-10 1980 These preliminary results suggest that anabolic steroids may be useful to stimulate anabolism and growth in uremic children, and that their effect is mediated by an increase in insulin secretion and/or an improvement in tissue sensitivity to insulin. Steroids 48-56 insulin Homo sapiens 177-184 1165627-0 1975 [Insulin and proinsulin secretion under contraceptive steroid administration (author"s transl)]. Steroids 54-61 insulin Homo sapiens 13-23 5328767-4 1966 Corticosteroids stimulated the hydrolysis of albumin and oxyhaemoglobin with trypsin between 10% and 200% and inhibited the hydrolysis of insulin by 15% (steroid/substrate molar ratio, 5:1). Steroids 7-14 insulin Homo sapiens 138-145 4797058-2 1973 Plasma insulin levels in patients with adrenal gland diseases and during steroid treatment]. Steroids 73-80 insulin Homo sapiens 7-14 1159064-2 1975 In order to evaluate the effects of steroid-induced hyperglycemia on insulin responses, a model for the duplication of blood glucose concentration in serial studies was developed. Steroids 36-43 insulin Homo sapiens 69-76 1159064-9 1975 The insulin response to the glucose pulse also was significantly lower during steroid treatment. Steroids 78-85 insulin Homo sapiens 4-11 4574972-4 1973 Both have good kidney function after 8 and 15 months and are completely rehabilitated.The requirement for insulin decreased in both patients during the period of renal insufficiency and increased following transplantation; this seemed to be related to the large dose of steroids given because now that a maintenance level of steroids has been established, both patients require the same dosage of insulin as they did before the onset of renal insufficiency. Steroids 270-278 insulin Homo sapiens 106-113 4574972-4 1973 Both have good kidney function after 8 and 15 months and are completely rehabilitated.The requirement for insulin decreased in both patients during the period of renal insufficiency and increased following transplantation; this seemed to be related to the large dose of steroids given because now that a maintenance level of steroids has been established, both patients require the same dosage of insulin as they did before the onset of renal insufficiency. Steroids 270-278 insulin Homo sapiens 397-404 4574972-4 1973 Both have good kidney function after 8 and 15 months and are completely rehabilitated.The requirement for insulin decreased in both patients during the period of renal insufficiency and increased following transplantation; this seemed to be related to the large dose of steroids given because now that a maintenance level of steroids has been established, both patients require the same dosage of insulin as they did before the onset of renal insufficiency. Steroids 325-333 insulin Homo sapiens 106-113 5056489-0 1972 [Deficient plasma steroid increase following insulin administration in pituitary dwarfism. Steroids 18-25 insulin Homo sapiens 45-52 9752382-6 1966 There is great potential usefulness for oral hypoglycemic combination therapy (with steroids temporarily if necessary) as a replacement for insulin in the treatment of immunologically-produced insulin resistance. Steroids 84-92 insulin Homo sapiens 193-200 13096910-0 1953 Relationship of potassium to steroid diabetes in general and steroid hormone-induced insulin resistance in particular. Steroids 61-76 insulin Homo sapiens 85-92 13892770-0 1962 Studies on steroid treatment of chronic insulin resistance. Steroids 11-18 insulin Homo sapiens 40-47 34017312-9 2021 In patients with CF and prediabetic conditions, after complete evaluation of the OGTT trend, glucometrics, glycemic values measured during pulmonary exacerbations and/or steroid therapy, early initiation of insulin therapy could have beneficial effects on clinical outcomes of patients with CF and prediabetes. Steroids 170-177 insulin Homo sapiens 207-214 33053159-0 2021 Metabolomics of lean/overweight insulin resistant females reveals alterations in steroids and fatty acids. Steroids 81-89 insulin Homo sapiens 32-39 33462741-10 2021 These results suggest that excess aldosterone and/or other steroids in the context of PA may negatively affect insulin action without adversely impacting beta-cell function. Steroids 59-67 insulin Homo sapiens 111-118 32418984-5 2020 Steroid-induced hyperglycemia with insulin resistance, lipolysis, and ketogenesis occurred and were likely to have precipitated the ketoacidosis. Steroids 0-7 insulin Homo sapiens 35-42 32628394-3 2020 We assessed the safety of a weight-based insulin protocol for persons treated with supraphysiological doses of steroids to examine the efficacy of using this protocol in patients with diabetes treated with prednisone or methylprednisolone. Steroids 111-119 insulin Homo sapiens 41-48 32628394-4 2020 AREAS OF UNCERTAINTY: There is uncertainty about the optimal dosing of insulin to manage steroid-induced hyperglycemia; thus, a weight-based protocol was created with the goal of reaching euglycemia faster than current practice in persons with diabetes. Steroids 89-96 insulin Homo sapiens 71-78 33463901-5 2021 The release of major stress and steroid hormones, catecholamine overload, and glucagon all participate in generating a state of insulin resistance with increased hepatic glucose output and glycogen breakdown. Steroids 32-39 insulin Homo sapiens 128-135 31067313-7 2019 Postoperatively, the steroid group had a 16.7 mg/dl (SD = 11.1) increase in blood glucose (P = .042) and 53.5 unit/24 hour (SD = 28.4) increase in insulin requirement (P = .019), compared with no change in controls. Steroids 21-28 insulin Homo sapiens 147-154 31727688-0 2020 Steroid Metabolomic Signature of Insulin Resistance in Childhood Obesity. Steroids 0-7 insulin Homo sapiens 33-40 31471733-0 2020 Insulin secretion improvement during steroid therapy for autoimmune pancreatitis according to the onset of diabetes mellitus. Steroids 37-44 insulin Homo sapiens 0-7 31471733-13 2020 Insulin secretion improved during steroid therapy for AIP in patients with concurrent DM. Steroids 34-41 insulin Homo sapiens 0-7 31852847-3 2019 We evaluated biomarkers from Duchenne Muscular Dystrophy patients, finding that, compared with chronic daily steroid use, weekend steroid use was associated with reduced serum insulin, free fatty acids, and branched chain amino acids, as well as reduction in fat mass despite having similar BMIs. Steroids 130-137 insulin Homo sapiens 176-183 31674860-1 2019 Considerable researches on sex steroids and insulin action have suggested a mutual interaction between hyperandrogenemia and insulin resistance (IR). Steroids 31-39 insulin Homo sapiens 125-132 31209710-9 2019 Adding insulin injections after steroid shows more sonographic improvement than steroid alone. Steroids 32-39 insulin Homo sapiens 7-14 31209710-12 2019 Adding insulin injections after steroid has more sonographic improvement than steroid alone. Steroids 32-39 insulin Homo sapiens 7-14 31067313-9 2019 Diabetic burn patients who receive intraoperative steroid have increased postoperative blood glucose levels, insulin requirements, and complication rates compared with patients who do not receive steroids. Steroids 50-57 insulin Homo sapiens 109-116 30895163-0 2019 Combination Therapy with Empagliflozin and Insulin Results in Successful Glycemic Control: A Case Report of Uncontrolled Diabetes Caused by Autoimmune Pancreatitis and Subsequent Steroid Treatment. Steroids 179-186 insulin Homo sapiens 43-50 30144380-0 2019 Feasibility and safety of using an automated decision support system for insulin therapy in the treatment of steroid-induced hyperglycemia in patients with acute graft-versus-host disease: A randomized trial. Steroids 109-116 insulin Homo sapiens 73-80 31357645-6 2019 The increases of many of these steroids were likely beneficial to patients, including immunoprotective adrenal androgens and their metabolites, neuroactive steroids that stimulate mental activity but protect from excitotoxicity, steroids that suppress pain perception and fear, steroids that consolidate insulin secretion, and steroids that improve xenobiotic clearance. Steroids 31-39 insulin Homo sapiens 304-311 30719358-10 2019 This is to our knowledge the first case reported in which the patient required a very significant amount of extra insulin (nearly five times his typical total daily dose) after using high potency topical steroid cream. Steroids 204-211 insulin Homo sapiens 114-121 30016819-6 2019 OB/GYNs administered steroids to insulin-dependent and poorly controlled diabetics more often than MFMs (75 vs. 46% and 59 vs. 37% respectively, p < 0.05 for both). Steroids 21-29 insulin Homo sapiens 33-40 29396325-0 2018 The response of C19- and some C21-steroids during Synacthen and insulin tolerance test. Steroids 34-42 insulin Homo sapiens 64-71 27540825-4 2018 After 9 years of oral steroid treatment she was diagnosed with SIDM necessitating insulin therapy. Steroids 22-29 insulin Homo sapiens 82-89 29540896-3 2018 The use of antenatal steroids in mothers at risk of preterm delivery complicates management of hyperglycaemia in the immediate antepartum period and requires appropriate dosing adjustments of insulin therapy. Steroids 21-29 insulin Homo sapiens 192-199 30152588-3 2018 Hyperglycaemia following steroid administration can be managed by variable rate intravenous insulin infusion (VRIII) or continuous subcutaneous insulin infusion (CSII) in women who are willing and able to safely self-manage insulin dose adjustment. Steroids 25-32 insulin Homo sapiens 92-99 30152588-3 2018 Hyperglycaemia following steroid administration can be managed by variable rate intravenous insulin infusion (VRIII) or continuous subcutaneous insulin infusion (CSII) in women who are willing and able to safely self-manage insulin dose adjustment. Steroids 25-32 insulin Homo sapiens 144-151 30152588-3 2018 Hyperglycaemia following steroid administration can be managed by variable rate intravenous insulin infusion (VRIII) or continuous subcutaneous insulin infusion (CSII) in women who are willing and able to safely self-manage insulin dose adjustment. Steroids 25-32 insulin Homo sapiens 144-151 29942286-1 2018 Background: Cytochrome P450 family 17 subfamily A member 1 (CYP17A1) gene encodes a key enzyme in the synthesis and metabolism of steroid hormones and has been associated with various factors, such as hypertension, insulin resistance, and polycystic ovary syndrome. Steroids 130-146 insulin Homo sapiens 215-222 28869151-9 2018 Insulin resistance was present in 29% associated with BMI Z-score and waist circumference and 40% had dyslipidemia associated with %FM, both of which were steroid independent. Steroids 155-162 insulin Homo sapiens 0-7 27540825-5 2018 Following intravitreal dexamethasone implant, her oral steroid use was tapered with subsequent improvement in her diabetes and eventual cessation of insulin. Steroids 55-62 insulin Homo sapiens 149-156 28500659-0 2017 Insulin sensitivity in relation to fat distribution and plasma adipocytokines among abusers of anabolic androgenic steroids. Steroids 115-123 insulin Homo sapiens 0-7 28720321-7 2017 RESULTS: Multivariate analysis showed "Age", "BMI" and "use of steroids" to be significantly related, in different combinations, to the glucose metabolism parameters "insulin resistance", "fasting insulin level" and "stimulated insulin secretion". Steroids 63-71 insulin Homo sapiens 167-174 28720321-7 2017 RESULTS: Multivariate analysis showed "Age", "BMI" and "use of steroids" to be significantly related, in different combinations, to the glucose metabolism parameters "insulin resistance", "fasting insulin level" and "stimulated insulin secretion". Steroids 63-71 insulin Homo sapiens 197-204 28720321-7 2017 RESULTS: Multivariate analysis showed "Age", "BMI" and "use of steroids" to be significantly related, in different combinations, to the glucose metabolism parameters "insulin resistance", "fasting insulin level" and "stimulated insulin secretion". Steroids 63-71 insulin Homo sapiens 197-204 26879182-1 2016 OBJECTIVE: To evaluate the effect of electroacupuncture (EA) in a rat model of chronic steroid-induced insulin resistance (SIIR). Steroids 87-94 insulin Homo sapiens 103-110 27914732-1 2017 AIMS: We examined interaction of sex steroid hormones and obesity with regard to insulin resistance (IR) and type 2 diabetes (T2D) by using nationally representative data from the US. Steroids 37-44 insulin Homo sapiens 81-88 27640750-3 2016 In that respect, gonadal steroids also influence the secretion of insulin in a sex-specific manner. Steroids 25-33 insulin Homo sapiens 66-73 26491824-10 2015 Of these, we found to be interesting the association with monacolin K, a natural statin that reduces cholesterol levels starting point of the synthesis of steroids, including androgens, and lipoic acid, known for its anti-inflammatory, antioxidant and insulin-sensitizing activity. Steroids 155-163 insulin Homo sapiens 252-259 27512005-11 2016 Our novel findings indicate that adiponectin affects basal and insulin-stimulated expression of key steroidogenic genes and production of steroid hormones by the porcine uterus during maternal recognition of pregnancy and implantation. Steroids 138-154 insulin Homo sapiens 63-70 27070590-12 2016 Prenatal steroid exposure worsened insulin resistance in animals fed a high-fat diet. Steroids 9-16 insulin Homo sapiens 35-42 27293433-8 2016 We are led to conclude that Ang II in combination with insulin/IGF-1 had an evident synergistic stimulatory effect on ERK1/2 activation in H295R cells and the effect may be responsible for the enhanced steroid hormone production induced by Ang II plus insulin/IGF-1. Steroids 202-217 insulin Homo sapiens 55-62 27287189-11 2016 These findings support the hypothesis that portal insulin administration influences circulating SHBG and sex steroids. Steroids 109-117 insulin Homo sapiens 50-57 26008639-6 2016 Patients with MDS and DM can experience worsening of diabetic control due to multiple factors that exacerbate hyperglycemia and insulin resistance such as stress, infections, adjunct drugs (e.g. steroids to control nausea), and others. Steroids 195-203 insulin Homo sapiens 128-135 27668526-0 2016 The Response of C19 Delta5-steroids to ACTH Stimulation and Hypoglycemia in Insulin Tolerance Test for Adrenal Insufficiency. Steroids 27-35 insulin Homo sapiens 76-83 26361681-3 2015 Steroids mainly cause peripheral insulin resistance. Steroids 0-8 insulin Homo sapiens 33-40 26624584-1 2015 OBJECTIVES: Conditions of hypoandrogenism in men have been linked to insulin resistance, suggesting that alterations in normal sex steroid physiology could play a role in the pathogenesis of Type 2 diabetes mellitus (T2DM). Steroids 131-138 insulin Homo sapiens 69-76 25936143-5 2015 Thus, the insufficiency of the amount or action of these sex steroids causes obesity and insulin resistance. Steroids 61-69 insulin Homo sapiens 89-96 25851902-10 2015 We conclude that modification of the functional groups attached to the D-ring of the hydrocortisone steroid molecule produces compounds with altered structure-function GR agonist activity with decreased impact on insulin secretion and reduced adipogenic potential but with preservation of anti-inflammatory activity. Steroids 100-107 insulin Homo sapiens 213-220 25448501-4 2015 A functionally significant variant within the promoter region of CYP17 has been linked to variation in steroid production, and some evidence suggests that this polymorphism could alter transcription of CYP17 in an insulin-dependent manner. Steroids 103-110 insulin Homo sapiens 214-221 25993680-5 2015 The Edmonton group demonstrated that most patients who received islet infusions from more than one donor and were treated with steroid-free immunosuppressive drugs displayed a considerable decline in the initial insulin independence rates at eight years following the transplantation, but showed permanent C-peptide secretion, which facilitated glycemic control and protected patients against hypoglycemic episodes. Steroids 127-134 insulin Homo sapiens 212-219 24769781-0 2014 Insulin requirements in non-critically ill hospitalized patients with diabetes and steroid-induced hyperglycemia. Steroids 83-90 insulin Homo sapiens 0-7 25866823-5 2015 In addition, the interaction among insulin, insulin-like growth factors (IGFs), and ovarian steroid hormones, such as estrogen and progesterone, could act synergistically during cancer development. Steroids 92-99 insulin Homo sapiens 35-42 25503565-1 2015 Insulin resistance is a cardinal feature of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, ageing and steroid use, among others. Steroids 157-164 insulin Homo sapiens 0-7 25503565-4 2015 Here, we compare cell autonomous models of insulin resistance induced by the cytokine tumour necrosis factor-alpha or by the steroid dexamethasone to construct detailed transcriptional and epigenomic maps associated with cellular insulin resistance. Steroids 125-132 insulin Homo sapiens 43-50 25503565-4 2015 Here, we compare cell autonomous models of insulin resistance induced by the cytokine tumour necrosis factor-alpha or by the steroid dexamethasone to construct detailed transcriptional and epigenomic maps associated with cellular insulin resistance. Steroids 125-132 insulin Homo sapiens 230-237 25823225-4 2014 Exposure of fully-grown oocytes to steroids or growth factors (insulin/IGFs) initiates various signaling cascade, leading to formation and activation of maturation-promoting factor (MPF), a key enzyme that catalyzes entry into M-phase of meiosis I and II. Steroids 35-43 insulin Homo sapiens 63-70 24986533-1 2014 OBJECTIVE: Dysregulation of enzymes that control local tissue steroid metabolism has been implicated in the pathogenesis of obesity and insulin resistance; however, longitudinal changes in glucocorticoid metabolism have not been investigated. Steroids 62-69 insulin Homo sapiens 136-143 24326001-15 2014 CONCLUSION: Inpatient insulin protocols implemented by a GMS are successful in obtaining glycemic control with minimal side effects in patients with and without diabetes, even when they are on a high-dose steroid regimen. Steroids 205-212 insulin Homo sapiens 22-29 24769781-11 2014 CONCLUSION: The data suggest that non-critically ill patients with hyperglycemia receiving steroids require a higher percentage of TDD insulin therapy as nutritional insulin to achieve normoglycemia. Steroids 91-99 insulin Homo sapiens 135-142 24769781-11 2014 CONCLUSION: The data suggest that non-critically ill patients with hyperglycemia receiving steroids require a higher percentage of TDD insulin therapy as nutritional insulin to achieve normoglycemia. Steroids 91-99 insulin Homo sapiens 166-173 24008489-8 2013 Compared with siblings, insulin resistance was significantly higher in CCS who received platinum plus cranial radiotherapy (CRT, 92% brain tumors) and in those who received steroids but no platinum (majority leukemia). Steroids 173-181 insulin Homo sapiens 24-31 25316147-2 2014 Metformin, sulfonylureas, thiazolidinediones and insulin are well known available therapies for the treatment of steroid induced hyperglycemia. Steroids 113-120 insulin Homo sapiens 49-56 23202146-3 2014 This common state of peripheral insulin resistance arises also due to steroid spectra changes. Steroids 70-77 insulin Homo sapiens 32-39 24296614-3 2014 Hyperglycemia was determined without any clinical sign and metformin was started for steroid-induced insulin resistance. Steroids 85-92 insulin Homo sapiens 101-108 24008489-11 2013 CONCLUSIONS: Exposure to platinum, CRT, or steroids is associated with insulin resistance and cardiovascular risk factors and should be taken into consideration in the development of screening recommendations for cardiovascular risk. Steroids 43-51 insulin Homo sapiens 71-78 23825975-13 2013 CONCLUSIONS: The associations of sex steroid hormones with insulin resistance are different depending on the estrogen status. Steroids 37-53 insulin Homo sapiens 59-66 22286551-0 2012 Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes. Steroids 0-7 insulin Homo sapiens 16-23 23814973-8 2012 Several mechanisms contribute to the development of hyperglycemia and steroid-induced diabetes, including decreased peripheral insulin sensitivity, increased hepatic glucose production, and inhibition of pancreatic insulin production and secretion. Steroids 70-77 insulin Homo sapiens 127-134 22777326-5 2012 The average insulin user also used anabolic steroids (95.1%) and practiced polypharmacy by incorporating 16.2 +- 5.6 PEDs in his or her yearly routine. Steroids 44-52 insulin Homo sapiens 12-19 23675265-6 2012 RESULTS: It was found that pre incubation of normal neutrophils with insulin to reach equilibrium binding decreased both ER and PR numbers by 50% without changing the dissociation constants of the steroids binding. Steroids 198-206 insulin Homo sapiens 69-76 22211848-3 2012 It has been suggested that sex steroid hormones may play a causal role in the development of insulin resistance and type II diabetes. Steroids 31-38 insulin Homo sapiens 93-100 24904848-8 2013 After discontinuing the steroid, the insulin antibody titer decreased dramatically, and she did not have any episode of hypoglycemia since. Steroids 24-31 insulin Homo sapiens 37-44 22762934-10 2013 After excluding diabetics, median glucose values at 4 hours (170 mmol/L vs 188 mmol/L, P=.06) and final insulin requirements (2.9 U/h vs 8.4 U/h, P=.01) were lower with LD steroids; and more patients were off insulin infusions (74% LD vs 53% HD, P=.02). Steroids 172-180 insulin Homo sapiens 209-216 21986665-5 2012 Our findings together indicate that steroid compounds may represent an alternative approach for designing non-TZD PPARgamma ligands in the treatment of insulin resistance. Steroids 36-43 insulin Homo sapiens 152-159 22311908-9 2012 These data demonstrate that cardiotonic steroids and insulin compete for cellular endocytosis resources and suggest that, under conditions where circulating insulin concentrations are high, cardiotonic steroid-mediated natriuresis could be impaired. Steroids 40-48 insulin Homo sapiens 157-164 22664497-0 2012 Associations of adipokines & insulin resistance with sex steroids in patients with breast cancer. Steroids 61-69 insulin Homo sapiens 33-40 22311908-9 2012 These data demonstrate that cardiotonic steroids and insulin compete for cellular endocytosis resources and suggest that, under conditions where circulating insulin concentrations are high, cardiotonic steroid-mediated natriuresis could be impaired. Steroids 40-47 insulin Homo sapiens 157-164 23155702-2 2012 The objective was to determine the probability of receiving steroid treatment following an insulin tolerance test (ITT) for short-stature evaluation and to evaluate the utility of a subsequent cortrosyn stimulation test (CST) in determining adrenal sufficiency. Steroids 60-67 insulin Homo sapiens 91-98 22257509-2 2012 Insulin is a potent regulator of human sexual steroid hormone production and modulates their signals at receptor level. Steroids 46-61 insulin Homo sapiens 0-7