PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7703274-1 1995 The NADPH-adrenodoxin complex with adrenodoxin is responsible for the transformation of the two-electron flow from NADH to the mono-electron flow to cytochrome P-450 in the steroid-hydroxyl enzyme system of mitochondria of kidney crust. Steroids 173-180 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 149-165 9003190-1 1997 Cytochrome P450 (P450) 3A4 is the most abundant human P450 and oxidizes a diversity of substrates, including various drugs, steroids, carcinogens, and macrolide natural products. Steroids 124-132 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-26 8603034-6 1996 Cytochrome P450-dependent enzymes are involved in the synthesis and/or degradation of many endogenous compounds, such as steroids and retinoic acid. Steroids 121-129 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 9248661-2 1997 Multiple forms of cytochrome P450 (CYP) catalyse the oxidation of chemicals of endogenous and exogenous origin, including drugs, carcinogens, steroids and eicosanoids. Steroids 142-150 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-33 9248661-2 1997 Multiple forms of cytochrome P450 (CYP) catalyse the oxidation of chemicals of endogenous and exogenous origin, including drugs, carcinogens, steroids and eicosanoids. Steroids 142-150 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 35-38 8591087-1 1995 BACKGROUND: Liarozole binds to the cytochrome P-450-dependent hydroxylating enzymes involved in steroid biosynthesis and retinoic acid catabolism. Steroids 96-103 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 35-51 8444412-4 1993 Purification and subfractionation of microsomal protein yielded a fraction of cytochrome P-450, which required NADPH and NADPH-cytochrome P-450 reductase and catalyzed 7 alpha-hydroxylation of the side-chain oxygenated 3 beta-hydroxy-delta 5-C27-steroids but was inactive toward cholesterol. Steroids 246-254 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 78-94 8143890-1 1993 Estrogens are synthesized from C19 steroids by a unique form of cytochrome P450, aromatase cytochrome P-450 (P-450AROM; the product of the CYP19 gene). Steroids 35-43 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-107 1730667-1 1992 Aromatase, a cytochrome P-450, catalyzes the formation of aromatic C18 estrogenic steroids from C19 androgens. Steroids 82-90 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 13-29 1423213-2 1992 The increased steroid production demonstrated by most of the pathological tissue samples examined here was associated with either an unchanged or dramatically decreased specific microsomal content of cytochrome P-450. Steroids 14-21 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 200-216 1331779-1 1992 Aromatase, a cytochrome P-450, catalyzes the formation of aromatic C18 estrogenic steroids from C19 androgens. Steroids 82-90 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 13-29 1640215-4 1992 Cytochrome P450 enzymes are involved in the metabolism of drugs, carcinogens, steroids, pesticides, hydrocarbons and natural products. Steroids 78-86 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 1720447-2 1991 Multiple isoforms of cytochrome P450 (P450) have been discovered that are important biomedically to drug pharmacokinetics, chemical carcinogenesis, and metabolism of endogenous agents such as steroids, arachidonic acids, and prostaglandins. Steroids 192-200 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 21-36 1920538-2 1991 Cytochrome P-450 catalyzes oxidations of a wide variety of compounds including steroids, drugs and toxicants. Steroids 79-87 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 32357628-3 1992 Recent purification and characterization of specific steroidogenic enzymes, such as cytochrome P-450, that are involved in adrenal steroid biosynthesis have made it possible to generate specific antibodies and DNA probes against the enzymes that catalyze specific reaction(s) in the complicated biochemical cascade of steroidogenesis. Steroids 53-60 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 84-100 2328938-2 1990 The CYP21B gene encodes an adrenal microsomal cytochrome P-450, which is specific for steroid 21-hydroxylation (P450c21). Steroids 86-93 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 46-62 1709343-2 1991 This loss in drug metabolism is due to the loss of the cytochrome P-450 component of the mixed function oxidase (the enzyme system primarily responsible for the oxidation of drugs, carcinogens and certain classes of endogenous substances such as steroids, fatty acids and prostaglandins). Steroids 246-254 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 55-71 2133086-1 1990 A series of 17 alpha-acetylenic steroids was examined with regard to ability to inactivate human liver microsomal cytochrome P-450 (P-450) IIA4, an enzyme involved in the oxidation of a number of drugs, carcinogens, and steroids, including estrogens and progestogens. Steroids 32-40 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 114-130 34867397-1 2021 NADPH:cytochrome P450 oxidoreductase (POR) is the obligate electron donor for microsomal cytochrome P450 (CYP) enzymes involved in the biosynthesis of endogenous substances like bile acids and other steroids as well as in the oxidative metabolism of xenobiotics. Steroids 199-207 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 89-104 2134683-3 1990 The cytochrome P-450 enzymes are also responsible for the metabolism of endogenous substrates including fatty acids, prostaglandins and all classes of steroids. Steroids 151-159 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-20 33809117-3 2021 A clearer understanding of CYP expression is important in the pathogenesis of breast cancer as several isoforms play critical roles in metabolising steroid hormones and xenobiotics that contribute to the genesis of breast cancer. Steroids 148-155 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 27-30 34867397-1 2021 NADPH:cytochrome P450 oxidoreductase (POR) is the obligate electron donor for microsomal cytochrome P450 (CYP) enzymes involved in the biosynthesis of endogenous substances like bile acids and other steroids as well as in the oxidative metabolism of xenobiotics. Steroids 199-207 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 106-109 35132941-5 2022 To investigate the activation pathway of synthesized N-formyl pyrazoline substituted steroid derivatives, a molecular docking study was performed on human cytochrome P450-(CYP17A1: PDB ID 5IRQ) with the help of the free AutoDock Vina. Steroids 85-92 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 155-170 34563259-5 2021 Studies with ovarian theca cells taken from PCOS women have demonstrated increased androgen production due to augmented ovarian steroidogenesis attributed to mainly altered expression of critical enzymes (Cytochrome P450 enzymes: CYP17, CYP21, CYP19, CYP11A) in the steroid hormone biosynthesis pathway. Steroids 266-273 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 205-220 3367901-0 1988 Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone. Steroids 66-73 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-55 2761265-0 1989 Specificity of steroid binding to testicular microsomal cytochrome P-450. Steroids 15-22 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 56-72 2761265-2 1989 On the basis of the concept that steroids accumulate in the lipid phase of endoplasmic reticulum membranes and approach the active sites of steroidogenic cytochromes P-450 from a hydrophobic environment, we describe a procedure that allows calculation of spectral dissociation constants Ks for steroid interaction with testicular microsomal cytochrome P-450 after correction for hydrophobic association of ligand with the membrane. Steroids 33-41 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 341-357 2761265-2 1989 On the basis of the concept that steroids accumulate in the lipid phase of endoplasmic reticulum membranes and approach the active sites of steroidogenic cytochromes P-450 from a hydrophobic environment, we describe a procedure that allows calculation of spectral dissociation constants Ks for steroid interaction with testicular microsomal cytochrome P-450 after correction for hydrophobic association of ligand with the membrane. Steroids 33-40 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 341-357 2643542-1 1989 Because steroids reach high concentrations within the adrenal cortex, effects of the direct interaction of steroids and cytochrome P450 enzymes are possible and may involve oxidative damage. Steroids 8-16 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 120-135 3254979-5 1988 These results suggest that MCZ, but not KCZ, has inducing activity for hepatic cytochrome P-450-dependent oxidative metabolism of steroids and xenobiotics, in addition to its known inhibitory activity. Steroids 130-138 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 79-95 3419164-6 1988 Under the same conditions metopirone and spironolactone, known to bind cytochrome P-450 11 beta at the steroid binding site, also inhibited the reaction. Steroids 103-110 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 71-87 3419164-7 1988 Altogether these results show that for aldosterone synthesis from 18-hydroxycorticosterone to take place, the steroid binding site on cytochrome P-450 must be accessible to 18-hydroxycorticosterone and that the cytochrome P-450 must be the direct donor of reducing equivalents. Steroids 110-117 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 134-150 3419164-7 1988 Altogether these results show that for aldosterone synthesis from 18-hydroxycorticosterone to take place, the steroid binding site on cytochrome P-450 must be accessible to 18-hydroxycorticosterone and that the cytochrome P-450 must be the direct donor of reducing equivalents. Steroids 110-117 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 211-227 3493777-0 1987 Significance of cytochrome P-450 (P-450 HFLa) of human fetal livers in the steroid and drug oxidations. Steroids 75-82 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 16-32 3718550-0 1986 [Hydroxylation of steroids in a dienzyme system consisting of cytochrome P-450 and immobilized adrenodoxin]. Steroids 18-26 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 62-78 3320551-2 1987 The pathway of biosynthesis of these steroids from cholesterol involves a sequence of transformations using cytochrome P-450 enzymes which varies within the adrenal cortex as a result of the differential localization of enzymes within the zones. Steroids 37-45 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 108-124 3320551-4 1987 These may include the following: (1) the normal morphological and functional zonation of the adrenal cortex may be regulated by gradients of steroids in the adrenal cortex; (2) destruction of cytochrome P-450 enzymes on interaction with certain steroids which act as pseudosubstrates may form part of the pathogenesis of some steroidogenic enzyme deficiencies. Steroids 141-149 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 192-208 3320551-4 1987 These may include the following: (1) the normal morphological and functional zonation of the adrenal cortex may be regulated by gradients of steroids in the adrenal cortex; (2) destruction of cytochrome P-450 enzymes on interaction with certain steroids which act as pseudosubstrates may form part of the pathogenesis of some steroidogenic enzyme deficiencies. Steroids 245-253 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 192-208 3320551-6 1987 Under some pathological conditions, individual cytochrome P-450 enzyme activities may become rate-limiting, with consequent overproduction of precursor steroids, leading to mineralocorticoid or androgen excess. Steroids 152-160 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 47-63 3111839-5 1987 Spectrophotometric studies also revealed direct binding of ketoconazole to cytochrome P-450 component by inducing type II difference spectra in all tissue preparations examined, indicating that ketoconazole is possibly a universal inhibitor of NADPH-cytochrome P-450 dependent monooxygenases which are involved in metabolism of many substances including steroids, toxins, carcinogens and others. Steroids 354-362 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 75-91 3085302-3 1986 A conclusion is drawn that cytochrome P-450 takes an active part not only in oxidation of different xenobiotics and steroid hormones but also in the synthesis and decomposition of prostaglandins--the most important cell regulators. Steroids 116-132 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 27-43 3549274-2 1986 The pathway of biosynthesis of these steroids from cholesterol involves a sequence of transformations using cytochrome P-450 enzymes. Steroids 37-45 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 108-124 3094971-6 1986 Aminoglutethimide, however, blocks other cytochrome P-450-mediated steroid hydroxylations, requires concomitant glucocorticoid administration, and is associated with initial side effects. Steroids 67-74 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 41-57 3549274-3 1986 The hypothesis presented here is that damage to cytochrome P-450 enzymes on interaction with certain steroids, synthesized by the adrenal cortex itself, may be of pathological and perhaps physiological importance. Steroids 101-109 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 48-64 3549274-4 1986 The interaction between cytochrome P-450 enzymes and these steroids, which act as pseudosubstrates, may form part of the pathogenesis of some steroidogenic enzyme deficiencies, with consequent overproduction of precursor steroids, leading to mineralocorticoid or androgen excess. Steroids 59-67 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-40 3549274-4 1986 The interaction between cytochrome P-450 enzymes and these steroids, which act as pseudosubstrates, may form part of the pathogenesis of some steroidogenic enzyme deficiencies, with consequent overproduction of precursor steroids, leading to mineralocorticoid or androgen excess. Steroids 221-229 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-40 3911848-0 1985 Biochemical properties of cytochrome P-450 in relation to steroid oxygenation. Steroids 58-65 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 26-42 7297566-12 1981 The monooxygenase activities, the sensitivity to in vitro alpha-naphthoflavone and metyrapone, the results of steroid metabolism, and slab gel electrophoresis are strong indications for multiplicity of human liver cytochrome P-450. Steroids 110-117 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 214-230 4004771-1 1985 It is well established that liver microsomal cytochrome P-450 participates in steroid metabolism and probably also in the metabolism of anti-oestrogens such as tamoxifen (Nolvadex). Steroids 78-85 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 45-61 6740183-5 1984 Cytochrome P-450 has a well known sine-qua-non activity in steroid hydroxylations within steroid tissues, and a decrease in the levels of this heme-enzyme might be expected to result in impaired steroidogenesis. Steroids 59-66 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 6740183-5 1984 Cytochrome P-450 has a well known sine-qua-non activity in steroid hydroxylations within steroid tissues, and a decrease in the levels of this heme-enzyme might be expected to result in impaired steroidogenesis. Steroids 89-96 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 6353196-2 1983 The content and inventory of the types of cytochrome P-450 is readily modified following in vivo treatment of animals with "inducing agents" such as barbiturates, steroids and polycyclic hydrocarbons. Steroids 163-171 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 42-58 6274987-0 1981 Side chain hydroxylation of C27-steroids and vitamin D3 by a cytochrome P-450 enzyme system isolated from human liver mitochondria. Steroids 32-40 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 61-77 6274987-7 1981 The cytochrome P-450 preparation catalyzed 26-hydroxylation of C27-steroids and 25-hydroxylation of vitamin D3 when reconstructed with NADPH, the ferredoxin and the ferredoxin reductase. Steroids 67-75 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-20 6274987-11 1981 It is concluded that human liver mitochondria contain cytochrome P-450 involved in the oxidation of the side chain of C27-steroids and vitamin D3. Steroids 122-130 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 54-70 4039724-0 1985 Inhibition of testicular cytochrome P-450-dependent steroid biosynthesis by cis-platinum. Steroids 52-59 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 25-41 6091677-1 1984 Selective chemical modification of adrenocortical cytochrome P-450 responsible for the key stages in steroid biogenesis has been carried out. Steroids 101-108 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 50-66 6786868-2 1981 Many xenobiotics inhibit steroid hormone production as a result of interactions with cytochrome P-450-containing hydroxylases in adrenal mitochondria or microsomes. Steroids 25-40 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 85-101 939705-1 1976 The cytochrome P-450 is known to be a key enzymic component in steroid hydroxylation. Steroids 63-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-20 223025-1 1979 Cytochrome P450 in the mitochondria of the adrenal cortex functions in the monooxygenation reactions for the biosynthesis of various steroid hormones, such as cholesterol side chain cleavage, hydroxylation at 11 beta-position and that at 18-position of the steroid structure. Steroids 133-140 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 223025-1 1979 Cytochrome P450 in the mitochondria of the adrenal cortex functions in the monooxygenation reactions for the biosynthesis of various steroid hormones, such as cholesterol side chain cleavage, hydroxylation at 11 beta-position and that at 18-position of the steroid structure. Steroids 257-264 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 592792-0 1977 Ligand binding to human placental cytochrome P-450: interaction of steroids and heme-binding ligands. Steroids 67-75 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 34-50 838934-0 1977 [Effect of catatoxic steroids on the conformation of cytochrome P-450]. Steroids 21-29 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 53-69 1275497-0 1976 Spironolactone and cytochrome P-450: impairment of steroid 21-hydroxylation in the adrenal cortex. Steroids 51-58 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 19-35 1120111-4 1975 (1) The hydrophilic sulfate group directs the steroid molecule so that it only interacts with the active site of cytochrome P-450 with its non-sulfurylated, hydrophobic end. Steroids 46-53 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 113-129 4550000-0 1974 Spironolactone and cytochrome P-450: impairment of steroid hydroxylation in the adrenal cortex. Steroids 51-58 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 19-35 1142995-0 1975 Interactions of steroids with human placental cytochrome P-450 in the presence of carbon monoxide. Steroids 16-24 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 46-62 4155922-0 1973 The role of cytochrome P-450 and P-448 in drug and steroid hydroxylations. Steroids 51-58 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 12-38 4375425-0 1973 Testicular cytochrome P-450 and iron-sulfur protein as related to steroid metabolism. Steroids 66-73 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 11-27 1120111-5 1975 (2) The sulfate group interacts with the enzyme surface resulting in exposure of a slightly different part of the hydrophobic end of the substrate to the active site of cytochrome P-450 than when the same end of the free steroid is exposed to the active site of the enzyme. Steroids 221-228 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 169-185 4335684-0 1971 Cytochrome P-450 from the adrenal cortex: interaction of steroids and the hydroxylation reaction. Steroids 57-65 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 4401153-2 1972 Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations. Steroids 61-68 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 12-38 5535939-0 1970 Effect of adrenalectomy on the substrate interaction with cytochrome P-450 in the hydroxylation of steroid hormones by liver microsomes. Steroids 99-115 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 58-74 4391249-0 1969 Cytochrome P-450 in steroid biogenesis. Steroids 20-27 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 11946722-0 1972 On the participation of cytochrome P-450 in the formation of 16, 17-dihydroxylated C(19) steroids from 16-dehydro-C(19) steroids. Steroids 89-97 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-40 11946722-0 1972 On the participation of cytochrome P-450 in the formation of 16, 17-dihydroxylated C(19) steroids from 16-dehydro-C(19) steroids. Steroids 120-128 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-40 33400885-1 2021 INTRODUCTION: Cytochrome P450 (CYP) metabolizes vital endogenous (steroids, vitamins) and exogenous (drugs, toxins) substrates. Steroids 66-74 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 14-29 4185033-0 1969 The role of cytochrome P-450 in the mechanism of inhibition of steroid 11 beta-hydroxylation by dicumarol. Steroids 63-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 12-28 33400885-1 2021 INTRODUCTION: Cytochrome P450 (CYP) metabolizes vital endogenous (steroids, vitamins) and exogenous (drugs, toxins) substrates. Steroids 66-74 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 31-34 33252269-3 2020 The aim of this study was to investigate the relationship between polymorphisms of the drug-metabolizing enzyme gene, cytochrome P450 (CYP450), and the drug transporter gene, ATP-binding cassette subfamily B member 1 (ABCB1), as well as their DNA methylation status with the pathogenesis of steroid-induced ONFH. Steroids 291-298 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 118-133 32888176-1 2021 BACKGROUND: Cytochrome P450 (CYP) enzymes are involved in the metabolism of many important endogenous substrates (steroids, melatonin), drugs and toxic xenobiotics. Steroids 114-122 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 12-27 28344492-3 2017 Cytochrome P450 (CYP) enzymes, an essential source of variability in drug-response, play role in not only phase I-dependent metabolism of xenobiotics but also metabolism of endogenous compounds such as steroids, vitamins and fatty acids. Steroids 202-210 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 30607725-0 2018 A New Method for Quantitative Determination of Steroid Metabolites of Cytochrome P450-Dependent Reactions Using Fluorescent Spectroscopy. Steroids 47-54 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 70-85 29069987-1 2018 Cytochrome P450 enzymes are required for the synthesis of cholesterol and steroid hormones. Steroids 74-90 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 28668640-1 2018 The cytochrome P450 monooxygenases (P450s) are thiolate heme proteins that can, often under physiological conditions, catalyze many distinct oxidative transformations on a wide variety of molecules, including relatively simple alkanes or fatty acids, as well as more complex compounds such as steroids and exogenous pollutants. Steroids 293-301 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-19 28731962-1 2017 Cytochrome P450 oxidoreductase (POR) has played a potential role in the metabolism of drugs and steroids by supplying electrons to microsomal cytochrome P450 (CYP) enzymes. Steroids 96-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 142-157 28731962-1 2017 Cytochrome P450 oxidoreductase (POR) has played a potential role in the metabolism of drugs and steroids by supplying electrons to microsomal cytochrome P450 (CYP) enzymes. Steroids 96-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 159-162 28344492-3 2017 Cytochrome P450 (CYP) enzymes, an essential source of variability in drug-response, play role in not only phase I-dependent metabolism of xenobiotics but also metabolism of endogenous compounds such as steroids, vitamins and fatty acids. Steroids 202-210 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-20 23851904-0 2013 GC-MS-based quantitative signatures of cytochrome P450-mediated steroid oxidation induced by rifampicin. Steroids 64-71 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-54 27267697-1 2016 Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Steroids 73-81 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 26658226-0 2016 Metabolism of Oral Turinabol by Human Steroid Hormone-Synthesizing Cytochrome P450 Enzymes. Steroids 38-53 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 67-82 26658226-1 2016 The human mitochondrial cytochrome P450 enzymes CYP11A1, CYP11B1, and CYP11B2 are involved in the biosynthesis of steroid hormones. Steroids 114-130 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-39 24642534-4 2014 NADPH-cytochrome P450 oxidoreductase (POR) is a membrane-bound enzyme required for electron transfer to cytochrome P450 (CYP), vital in the processes of the metabolism of drugs and steroid production in humans. Steroids 181-188 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 6-21 24642534-4 2014 NADPH-cytochrome P450 oxidoreductase (POR) is a membrane-bound enzyme required for electron transfer to cytochrome P450 (CYP), vital in the processes of the metabolism of drugs and steroid production in humans. Steroids 181-188 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 104-119 24642534-4 2014 NADPH-cytochrome P450 oxidoreductase (POR) is a membrane-bound enzyme required for electron transfer to cytochrome P450 (CYP), vital in the processes of the metabolism of drugs and steroid production in humans. Steroids 181-188 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 121-124 23474437-0 2014 Cytochrome P450-mediated metabolic alterations in preeclampsia evaluated by quantitative steroid signatures. Steroids 89-96 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 23474437-2 2014 The association between various cytochrome P450 (CYP)-mediated steroid metabolic markers and preeclampsia risk was therefore investigated. Steroids 63-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 32-47 23474437-2 2014 The association between various cytochrome P450 (CYP)-mediated steroid metabolic markers and preeclampsia risk was therefore investigated. Steroids 63-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 49-52 23474437-8 2014 Our metabolic profiling suggests the CYP-mediated alterations in steroid metabolism and hydroxylation in pregnancy-induced hypertension. Steroids 65-72 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 37-40 23851904-2 2013 METHODS: Urinary steroid profiling based on gas chromatography-mass spectrometry (GC-MS) was used for simultaneous quantification of CYP-mediated regioselective hydroxysteroids and their substrates, including 26 androgens, 9 estrogens, 5 progestins, and 7 corticoids. Steroids 17-24 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 133-136 23851904-3 2013 The quantitative data were visualized using a hierarchically clustered heat map to allow identification of CYP-mediated steroid signatures. Steroids 120-127 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 107-110 23851904-8 2013 CONCLUSIONS: This CYP-mediated steroid signature profile allows simultaneous assessment of CYP1A, CYP1B, CYP2C, CYP3A, CYP11B, CYP17A, CYP19A, and CYP21A in urine samples. Steroids 31-38 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-21 23632015-1 2013 Cytochrome P450 enzymes have major roles in the metabolism of steroids, drugs, carcinogens, eicosanoids, and numerous other chemicals. Steroids 62-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 23587001-1 2013 The mammalian cytochrome P450 (CYP) enzymes play important roles in drug metabolism, steroid biosynthesis, and xenobiotic degradation. Steroids 85-92 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 14-29 23587001-1 2013 The mammalian cytochrome P450 (CYP) enzymes play important roles in drug metabolism, steroid biosynthesis, and xenobiotic degradation. Steroids 85-92 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 31-34 21763268-0 2011 C-26 vs. C-27 hydroxylation of insect steroid hormones: regioselectivity of a microsomal cytochrome P450 from a hormone-resistant cell line. Steroids 38-54 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 89-104 23092891-1 2012 Cytochrome P450 enzymes catalyze the biosynthesis of steroid hormones and metabolize drugs. Steroids 53-69 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 22687469-1 2012 Mammalian cytochrome P450 (CYP) comprise a large group of enzymes that play many important roles in the biosynthesis of steroid hormones and vitamins. Steroids 120-136 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 10-25 22687469-1 2012 Mammalian cytochrome P450 (CYP) comprise a large group of enzymes that play many important roles in the biosynthesis of steroid hormones and vitamins. Steroids 120-136 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 27-30 22687469-4 2012 In recent years, however, significant progress has been made in the X-ray crystallographic analysis of mammalian CYP enzymes involved in the steroid hormone and vitamin D(3) metabolism. Steroids 141-156 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 113-116 21763268-3 2011 26-Hydroxylation of the insect steroid hormone 20-hydroxyecdysone by a microsomal cytochrome P450 was previously found to be responsible for hormonal resistance in a Chironomus cell line mainly producing the (25S)-epimer of 20,26-dihydroxyecdysone. Steroids 31-46 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 82-97 20844025-2 2010 This is due to disruption of electron transfer from mutant POR to microsomal cytochrome P450 (CYP) enzymes that play a key role in glucocorticoid and sex steroid synthesis. Steroids 154-161 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 77-92 21193036-1 2011 Cytochrome P450 enzymes play an important role in steroid hormone biosynthesis of the human adrenal gland, e.g., the production of cortisol and aldosterone. Steroids 50-65 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 20844025-2 2010 This is due to disruption of electron transfer from mutant POR to microsomal cytochrome P450 (CYP) enzymes that play a key role in glucocorticoid and sex steroid synthesis. Steroids 154-161 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 94-97 20218941-6 2010 In addition to CYP gene expression, nuclear receptor proteins regulate the expression of complex gene networks, and therefore mediate the metabolism and modify the effects of steroid hormones, fat-soluble vitamins, and free fatty acids on the metabolic, reproductive, and developmental processes of mammals. Steroids 175-191 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 15-18 21226440-11 2010 All patients were prescribed "azole" antifungal agents and five patients were also on high-dose steroids, both agents known to induce cytochrome P-450 enzymes and hence potentiating dapsone toxicity. Steroids 96-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 134-150 18955142-2 2008 In this study we investigated whether past oral contraceptive (OC) administration or current dietary isoflavonoids (IF) affected expression and/or activity of steroid hormone-metabolizing cytochrome P450 (CYP) enzymes using complementary primate and cell culture models. Steroids 159-174 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 188-203 19473111-0 2009 Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications. Steroids 55-63 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 27-42 19473111-2 2009 Human cytochrome P450 (CYP) enzymes present in probably every tissue are found responsible for biosynthesis and catabolism of steroids, which could result in either active or inactive metabolites. Steroids 126-134 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 6-21 19473111-2 2009 Human cytochrome P450 (CYP) enzymes present in probably every tissue are found responsible for biosynthesis and catabolism of steroids, which could result in either active or inactive metabolites. Steroids 126-134 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 23-26 19473111-3 2009 In addition, exposure to endogenous and exogenous steroids that causes modulation of CYP activities may substantially affect the pharmacokinetic behavior of a given drug. Steroids 50-58 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 85-88 19473111-4 2009 OBJECTIVE: This article summarizes our current understanding of the ability of steroids to act as substrates, inhibitors or heteroactivators for human CYP enzymes, with a specific focus on their functional consequences. Steroids 79-87 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 151-154 19473111-5 2009 METHODS: In the current review, we compare the mechanisms and regulation of CYP-mediated biotransformation of steroids, and in particular examine the diverse tissue distributions and biological roles of individual CYPs. Steroids 110-118 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 76-79 19324859-1 2009 PURPOSE: Cytochrome P450 (CYP) enzymes metabolize endogenous compounds such as steroid hormones, fatty acids, and xenobiotics, including drugs and carcinogens. Steroids 79-95 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 9-24 19324859-1 2009 PURPOSE: Cytochrome P450 (CYP) enzymes metabolize endogenous compounds such as steroid hormones, fatty acids, and xenobiotics, including drugs and carcinogens. Steroids 79-95 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 26-29 18955142-2 2008 In this study we investigated whether past oral contraceptive (OC) administration or current dietary isoflavonoids (IF) affected expression and/or activity of steroid hormone-metabolizing cytochrome P450 (CYP) enzymes using complementary primate and cell culture models. Steroids 159-174 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 205-208 18388875-1 2008 The cytochrome P450 (CYP) gene superfamily comprises a large group of hemoproteins with diverse functions in steroid, lipid, and xenobiotic metabolism. Steroids 109-116 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-19 18388875-1 2008 The cytochrome P450 (CYP) gene superfamily comprises a large group of hemoproteins with diverse functions in steroid, lipid, and xenobiotic metabolism. Steroids 109-116 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 21-24 16183271-0 2005 A thiolate ligand on a cytochrome P-450 mimic permits the use of simple environmentally benign oxidants for biomimetic steroid hydroxylation in water. Steroids 119-126 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 23-39 18646550-5 2008 CYP isoenzymes participate in metabolic pathways important for proper physiological functioning of the human organism, i.e.: cholesterol, bile acid and oxysterol biosynthesis; metabolism of fatty acids, prostaglandins, prostacyclins, leukotrienes, steroid hormones, ketone bodies, vitamines A and D. CYP isoenzymes participate in the metabolism of over 80% of drugs and other xenobiotic substances which can be present in the human organism. Steroids 248-264 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 18646550-5 2008 CYP isoenzymes participate in metabolic pathways important for proper physiological functioning of the human organism, i.e.: cholesterol, bile acid and oxysterol biosynthesis; metabolism of fatty acids, prostaglandins, prostacyclins, leukotrienes, steroid hormones, ketone bodies, vitamines A and D. CYP isoenzymes participate in the metabolism of over 80% of drugs and other xenobiotic substances which can be present in the human organism. Steroids 248-264 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 300-303 17253801-0 2007 Regioselective oxyfunctionalization of unactivated carbons in steroids by a model of cytochrome P-450: osmiumporphyrin complex/tert-butyl hydroperoxide system. Steroids 62-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 85-101 17786620-2 2007 Utilizing a photochemical action spectrum, he demonstrated that a cytochrome P450 was responsible for steroid 21 hydroxylation catalyzed by microsomes prepared from adrenal cortex tissue. Steroids 102-109 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 66-81 15644946-1 2004 The cytochrome p450 (CYP) superfamily is responsible for the oxidation, peroxidation, and (or) reduction of vitamins, steroids, xenobiotics, and the majority of cardiovascular drugs in an oxygen- and NADPH-dependent manner. Steroids 118-126 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-19 15608133-7 2005 This is the first demonstration of cytochrome P450-mediated oxidation of a steroid glucuro-conjugate. Steroids 75-82 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 35-50 16143297-0 2005 Steroid hydroxylations: a paradigm for cytochrome P450 catalyzed mammalian monooxygenation reactions. Steroids 0-7 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-54 16922637-4 2005 These interactions may occur not only in the liver, but also in the brain, and may change the activity of CYP towards the metabolism of drugs, sex steroids, neurosteroids and amine neurotransmitters. Steroids 147-155 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 106-109 15876406-0 2005 New assumptions about oxidative processes involved in steroid hormone biosynthesis: is the role of cytochrome P-450-activated dioxygen limited to hydroxylation reactions or are dioxygen insertion reactions also possible? Steroids 54-69 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 99-115 15644946-1 2004 The cytochrome p450 (CYP) superfamily is responsible for the oxidation, peroxidation, and (or) reduction of vitamins, steroids, xenobiotics, and the majority of cardiovascular drugs in an oxygen- and NADPH-dependent manner. Steroids 118-126 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 21-24 15669763-0 2004 Biomimetic oxidation of unactivated carbons in steroids by a model of cytochrome P-450, oxorutheniumporphyrinate complex. Steroids 47-55 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 70-86 15356430-8 2004 Because several inflammatory cytokines down-regulate gene expression of major cytochrome P-450 and/or other enzymes with the specific effects on mRNA levels, protein expression, and enzyme activity, thus affecting the metabolism of several endogenous lipophilic substances such as steroids, lipid-soluble vitamins, prostaglandins, leukotrienes, thromboxanes, and exogenous substances, their irregularities in the body may eventually lead to the flare of latent diseases in some predisposed subjects. Steroids 281-289 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 78-94 15543094-7 2004 These proinflammatory cytokines down-regulate gene expression of major cytochrome P-450 and/or other enzymes with the specific effects on mRNA levels, protein expression, and enzyme activity, thus affecting metabolism of several endogenous lipophilic substances, such as steroids, lipid-soluble vitamins, prostaglandins, leukotrienes, thromboxanes, and exogenous substances. Steroids 271-279 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 71-87 15669763-1 2004 Biomimetic oxidation of unactivated carbons for structurally different steroids was studied with a model of cytochrome P-450, oxorutheniumporphyrinate complex, which is generated in situ by 2,6-dichloropyridine N-oxide as an oxygen donor and (5,10,15,20-tetramesitylporphyrinate) ruthenium(II) carbonyl complex and HBr as catalysts. Steroids 71-79 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 108-124 12174676-0 2001 Cytochrome P450 polymorphisms as risk factors for steroid hormone-related cancers. Steroids 50-65 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 15237850-1 2004 The cytochrome P450 (P450) field came out of interest in the metabolism of drugs, carcinogens, and steroids, which remain major focal points. Steroids 99-107 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-19 12374776-1 2002 Cytochrome P450 mono-oxygenases (CYP) play an essential role in steroid metabolism, and there is speculation that sex hormones might influence cardiac mass and physiology. Steroids 64-71 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 11263680-1 2001 Mammalian NADPH-ferredoxin reductase (EC 1.18.1.2) functions in the mitochondrial electron transport chain for cytochrome P-450-dependent steroid hydroxylation. Steroids 138-145 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 111-127 15135080-5 2004 Hydroxylation by cytochrome P450 (CYP) enzymes and conjugation with glucuronide and sulfate are among the major hepatic pathways of steroid inactivation. Steroids 132-139 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-32 15135080-5 2004 Hydroxylation by cytochrome P450 (CYP) enzymes and conjugation with glucuronide and sulfate are among the major hepatic pathways of steroid inactivation. Steroids 132-139 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 34-37 12452431-1 2002 Cytochrome P450 (P450) reactions are of interest because of their relevance to the oxidative metabolism of drugs, steroids, carcinogens, and other chemicals. Steroids 114-122 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 12171873-2 2002 IFNs affect cytochrome P450 (CYP) enzymes, which metabolize many endogenous (e.g., steroids, fatty acids) and exogenous (e.g., drugs) substrates. Steroids 83-91 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 12-27 12171873-2 2002 IFNs affect cytochrome P450 (CYP) enzymes, which metabolize many endogenous (e.g., steroids, fatty acids) and exogenous (e.g., drugs) substrates. Steroids 83-91 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 29-32 12126389-0 2002 Catalytic oxidations of steroid substrates by artificial cytochrome p-450 enzymes. Steroids 24-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 57-73 11869873-2 2002 The environmental pollutant 3-methylsulfonyl-DDE (3-MeSO2-DDE) and the cytochrome P450 (CYP) inhibitors ketoconazole, metyrapone and aminoglutethimide were studied for their effects on the steroid formation. Steroids 189-196 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 88-91 12664659-5 2002 The CYP gene products such as CYP3A, CYP2B and PPAR are essential for metabolism of endogenous steroid hormones, fatty acids and various xenobiotics including drugs. Steroids 95-111 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-7 12174676-2 2001 Many steroids and environmental carcinogens are subject to cytochrome P450 (P450)-mediated metabolism that generates reactive metabolites and modulates steroid potency, thereby influencing tumor initiation and promotion respectively. Steroids 5-13 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 59-74 12174676-2 2001 Many steroids and environmental carcinogens are subject to cytochrome P450 (P450)-mediated metabolism that generates reactive metabolites and modulates steroid potency, thereby influencing tumor initiation and promotion respectively. Steroids 5-12 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 59-74 11893055-5 2001 Recent work uses a mimic of the enzyme class cytochrome P-450 to achieve the selective hydroxylations of steroids with complete domination by the geometry of the catalyst-substrate complex. Steroids 105-113 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 45-61 10746939-4 2000 Our laboratory is using the human H295R adrenocortical carcinoma cell line to examine chemicals for their potential to interfere with the activity and/or expression of several key cytochrome P450 (CYP) enzymes involved in the biosynthesis of steroid hormones. Steroids 242-258 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 180-195 10746939-4 2000 Our laboratory is using the human H295R adrenocortical carcinoma cell line to examine chemicals for their potential to interfere with the activity and/or expression of several key cytochrome P450 (CYP) enzymes involved in the biosynthesis of steroid hormones. Steroids 242-258 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 197-200 11122720-2 2000 Nearly 50% of all clinically used medications and endogenous steroids are metabolized by the CYP enzyme 3A4, which explains why many of the important potential drug interactions involved this enzyme. Steroids 61-69 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 93-96 10498654-8 1999 Significant correlations emerged between the levels of different CYP forms, protein adducts, and plasma levels of sex steroids. Steroids 118-126 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-68 10630892-0 1999 Metabolism of anabolic steroids by recombinant human cytochrome P450 enzymes. Steroids 23-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 53-68