PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15316506-9 2004 Prior exposure of CD4+CD25+ T cells to FP also increased subsequent IL-10 production by these cells when stimulated with allergen, and addition of anti-IL-10 antibody reversed the steroid-induced enhancement of suppression in mixed cultures. Steroids 180-187 interleukin 10 Homo sapiens 68-73 15316506-9 2004 Prior exposure of CD4+CD25+ T cells to FP also increased subsequent IL-10 production by these cells when stimulated with allergen, and addition of anti-IL-10 antibody reversed the steroid-induced enhancement of suppression in mixed cultures. Steroids 180-187 interleukin 10 Homo sapiens 152-157 12842524-4 2003 This study examined the association of increased release of IL-10, stimulated by steroid pretreatment, with reduced myocardial and lung injury after CPB. Steroids 81-88 interleukin 10 Homo sapiens 60-65 15242697-3 2004 Steroids modulate some plasma cytokines (decreasing TNFalpha, IL-8, IL-6 and increasing IL-10), whereas ability to reduce plasma and urinary TNFsr-2 and IL-1ra and peri-operative renal injury is unknown. Steroids 0-8 interleukin 10 Homo sapiens 88-93 15005734-2 2004 Increased plasma levels of IL-10 have been detected in patients under glucocorticoid (GC) therapy, indicating that steroids may exert their suppressive effect, in part, by increasing IL-10 production. Steroids 115-123 interleukin 10 Homo sapiens 27-32 15005734-2 2004 Increased plasma levels of IL-10 have been detected in patients under glucocorticoid (GC) therapy, indicating that steroids may exert their suppressive effect, in part, by increasing IL-10 production. Steroids 115-123 interleukin 10 Homo sapiens 183-188 15005734-3 2004 OBJECTIVES: The aim was to define possible mechanisms by which steroids up-regulate IL-10 production. Steroids 63-71 interleukin 10 Homo sapiens 84-89 15005734-12 2004 CONCLUSION: Our results support the fact that steroids up-regulate constitutive IL-10 production by selectively triggering activation signals on monocytes. Steroids 46-54 interleukin 10 Homo sapiens 80-85 12842524-15 2003 Our findings demonstrate a greater release of IL-10 induced by steroid pretreatment, and better heart and lung protection after CPB. Steroids 63-70 interleukin 10 Homo sapiens 46-51 11231856-7 2001 Furthermore, serum and peritoneal IL-10 levels were significantly higher in the steroid group. Steroids 80-87 interleukin 10 Homo sapiens 34-39 12967785-0 2003 Generation of antigen-specific, interleukin-10-producing T-cells using dendritic cell stimulation and steroid hormone conditioning. Steroids 102-117 interleukin 10 Homo sapiens 32-46 12967785-6 2003 When a co-stimulation-deficient population of DCs was employed for the in vitro, steroid hormone-conditioned stimulations, two additional effects were observed: (a) a further skewing towards antigen-specific IL-10 production and (b) enhanced activation-induced up-regulation of the inhibitory receptor CTLA-4 (CD152). Steroids 81-96 interleukin 10 Homo sapiens 208-213 12070682-12 2002 Serum IL-10 levels in all patients correlated significantly inversely with hemoglobin levels (r=-0.50, P<0.05), total leukocytic count (TLC) (r=-0.58, P<0.01), and intra-articular steroid injection (r=+0.56, P<0.01). Steroids 186-193 interleukin 10 Homo sapiens 6-11 11985524-4 2002 Median IL-10 levels increased throughout the steroid treatment period and were associated strongly with TNF-alpha levels. Steroids 45-52 interleukin 10 Homo sapiens 7-12 11509812-4 2001 The purpose of this study was to evaluate the downregulation of these proinflammatory cytokines by dexamethasone, budesonide and recombinant IL-10 (rIL-10) in order to elucidate the mechanism of the clinical benefit of steroids in babies. Steroids 219-227 interleukin 10 Homo sapiens 141-146 12756159-8 2003 Patients who received combined steroids had lower serum IL-6 and increased IL-10 at end-bypass (P<0.05), although differences were negligible by 24 hours. Steroids 31-39 interleukin 10 Homo sapiens 75-80 11231856-11 2001 CONCLUSIONS: Preoperative steroid administration significantly elevated anti-inflammatory cytokine IL-10 levels, suppressed the levels of inflammatory cytokines IL-6 and C-reactive protein, and prevented postoperative elevation of total bilirubin values. Steroids 26-33 interleukin 10 Homo sapiens 99-104 11255274-1 2001 BACKGROUND AND OBJECTIVES: Interleukin-10 (IL-10) is a pleiotropic cytokine which increases bcl-2 levels and protects cells from steroid or doxorubicin-induced apoptosis. Steroids 129-136 interleukin 10 Homo sapiens 27-41 11255274-1 2001 BACKGROUND AND OBJECTIVES: Interleukin-10 (IL-10) is a pleiotropic cytokine which increases bcl-2 levels and protects cells from steroid or doxorubicin-induced apoptosis. Steroids 129-136 interleukin 10 Homo sapiens 43-48 11059615-6 2000 Before steroid therapy, the levels of IL-10 in the CS group showed a significantly positive correlation with levels of ACE (r=0.868, p<0.05) and lysozyme (r=0.890, p<0.05). Steroids 7-14 interleukin 10 Homo sapiens 38-43 11059615-7 2000 In 5 patients who were analyzed before and after steroid therapy, the levels of IL-10 tended to correlate with a decrease of an abnormal accumulation in gallium-67 citrate. Steroids 49-56 interleukin 10 Homo sapiens 80-85 10210767-3 1999 Preliminary results have shown that antisense oligonucleotides (anti-ICAM), anti-cytokine antibodies (anti-TNF) or recombinant human cytokines (IL-10 or IL-11) are effective in some patients with Crohn"s disease refractory to steroids. Steroids 226-234 interleukin 10 Homo sapiens 144-149 10782906-11 2000 During steroid therapy, plasma levels of the pro-inflammatory cytokine IL-8 fell as early as day 14, while levels of the anti-inflammatory cytokine IL-10 increased on day 21. Steroids 7-14 interleukin 10 Homo sapiens 148-153 10865086-2 2000 Both IL-4 and IL-10 expression vary significantly with relapse/remission in MS and IL-9 is postulated to inhibit steroid-induced apoptosis. Steroids 113-120 interleukin 10 Homo sapiens 14-19 10411704-7 1999 RESULTS: The recipient TNF-alpha high producer genotype and IL-10 high producer genotype were significantly associated with multiple REs (>/=2) in human leukocyte antigen (HLA)-DR mismatched transplants (P = 0.0047 and P = 0.045, respectively), whereas only the TNF-alpha high producer genotype was associated with steroid-resistant REs (P = 0.025). Steroids 318-325 interleukin 10 Homo sapiens 60-65 9445307-7 1998 The ability of steroids to inhibit pro-inflammatory cytokines but to enhance the anti-inflammatory cytokine such as IL-10 may contribute to their beneficial actions in asthma. Steroids 15-23 interleukin 10 Homo sapiens 116-121 9632923-6 1998 Influence of cytokine production may open new therapeutic approach, e.g. IL-10 enema proved to be effective in the treatment of some cases of steroid-resistant ulcerative colitis, while intravenous administration was useful in Crohn"s disease. Steroids 142-149 interleukin 10 Homo sapiens 73-78 9630160-6 1998 Our results show that 7 out of the 9 patients studied displayed increased IL-10 mRNA expression as well as higher serum IL-10 concentration following steroid treatment. Steroids 150-157 interleukin 10 Homo sapiens 120-125 9630160-9 1998 Peak responses of secreted IL-10 by PBMC cultured cells treated with MP were obtained at 48 h. The effect was steroid-specific as IL-10 expression reversed to baseline levels in the presence of the glucocorticoid receptor antagonist RU486. Steroids 110-117 interleukin 10 Homo sapiens 27-32 9630160-9 1998 Peak responses of secreted IL-10 by PBMC cultured cells treated with MP were obtained at 48 h. The effect was steroid-specific as IL-10 expression reversed to baseline levels in the presence of the glucocorticoid receptor antagonist RU486. Steroids 110-117 interleukin 10 Homo sapiens 130-135 9060803-0 1997 Hepatic release of interleukin-10 during cardiopulmonary bypass in steroid-pretreated patients. Steroids 67-74 interleukin 10 Homo sapiens 19-33 9704146-6 1998 The clinical effectiveness of anti-TNF-alpha antibodies and of IL-10 has been demonstrated in steroid-refractory Crohn"s disease patients. Steroids 94-101 interleukin 10 Homo sapiens 63-68 9247454-0 1997 Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn"s disease. Steroids 48-55 interleukin 10 Homo sapiens 30-44 9060803-2 1997 We previously demonstrated that pretreatment with steroids can significantly increase IL-10 production during CPB, but neither the heart nor the lung was found to be its main source. Steroids 50-58 interleukin 10 Homo sapiens 86-91 31849683-10 2019 Compared with the control group, the level of early postoperative IL-10 was significant higher in the steroid group (MD, 17.89; 95% CI, 3.89 to 31.89; P = 0.01). Steroids 102-109 interleukin 10 Homo sapiens 66-71 8572786-13 1996 CONCLUSIONS: Earlier steroid administration in the immunosuppressive protocol for HTx or HLTx may be preferable to reduce the inflammatory response to cardiopulmonary bypass, as reflected by a lower production of tumor necrosis factor alpha and IL-8, and a greater release of IL-10. Steroids 21-28 interleukin 10 Homo sapiens 276-281 35293350-8 2022 Similarly, patients carrying A allele of IL-10-rs1800872 (39.0% of SD VS 26.7% of SS; OR=1.76, p=0.018) and C allele of IL-10-rs1800896 (12.3% of SD VS 3.9% of SS; OR=3.44, p=0.004) had a higher risk of steroid-dependent response. Steroids 203-210 interleukin 10 Homo sapiens 120-125 32054098-5 2020 Our most important findings are the following: In the case of C. pneumoniae seropositive patients we detected pronounced spontaneous interleukin (IL)-10 secretion and, in the case of steroid-resistant patients, IL-10 secretion was at a significantly higher level as compared with in-sensitive patients (p < 0.01). Steroids 183-190 interleukin 10 Homo sapiens 211-216 32054098-6 2020 Furthermore, steroid-resistant seropositive patients produced a significantly higher level of IL-10 spontaneously and under antigen stimulation as compared with steroid-resistant seronegative individuals (p < 0.05). Steroids 13-20 interleukin 10 Homo sapiens 94-99 8958270-9 1996 Soluble TNF-RII, sIL-2R-, and IL-10 levels were significantly elevated 3 days prior to or at the onset of acute steroid-resistant rejection (P < or = 0.01 versus steroid-sensitive rejection and on uneventful postoperative course). Steroids 112-119 interleukin 10 Homo sapiens 30-35 34299256-8 2021 IVIg/steroid treatment significantly decreased IFN-gamma and IL-10 expression. Steroids 5-12 interleukin 10 Homo sapiens 61-66 35525835-12 2022 CONCLUSIONS: PMX-DHP combined with steroid pulse therapy might reduce GRO, IL-10, IL-1Ra, IL-5, IL-6, and MCP-1 levels in ARF, contributing to better oxygenation in the disorder. Steroids 35-42 interleukin 10 Homo sapiens 75-80 25917060-11 2016 Interleukin-6 levels were lower at 6 and 24 hours post-operatively (p<0.001), and Interleukin-10 levels were higher 6 hours post-operatively (p<0.001) in the steroid group. Steroids 164-171 interleukin 10 Homo sapiens 85-99 30753845-8 2019 In PBMCs, exposure to these steroids resulted in the increase of mRNA and secreted protein levels of IL-1beta, TNFalpha, and IL-6 cytokines, as well as in the increase of INFgamma mRNA level, decrease of IL-2 mRNA level, increase of TGFbeta mRNA level, and decrease of IL-4 mRNA and IL-10 secreted protein levels. Steroids 28-36 interleukin 10 Homo sapiens 283-288 27007229-5 2016 Best platelet response to steroid treatment was found among GC genotype of IL-6 (-174) and GG genotype of IL-10 (-1082) in all patients with ITP. Steroids 26-33 interleukin 10 Homo sapiens 106-111 27007229-8 2016 IL-6 (-174) and IL-10 (-1082) genes might play a role in the effectiveness of steroid therapy among patients with ITP. Steroids 78-85 interleukin 10 Homo sapiens 16-21 27801710-5 2017 The review highlights recent observations, such as GCS-induced dysregulation of key transcription factors involved in host defence, role of airway infections altering expression of critical regulatory elements like the noncoding microRNAs, and the importance of interleukin (IL)-10 in reinstating steroid response in key immune cells. Steroids 297-304 interleukin 10 Homo sapiens 262-281 26758116-11 2015 (3) In steroid group, IL-2 and IL-8 in BALF of patient whose fever disappeared after steroid therapy were both significantly lower than that of patients who still had fever (t=2.771, 2.054, P=0.010, 0.049) , but no significant difference was found between the two groups in BALF IL-1 beta, IL-4, IL-6, IL-10, IFN-gamma levels (P>0.05). Steroids 7-14 interleukin 10 Homo sapiens 302-307 24474147-7 2014 Anti-inflammatory cytokine IL-10 showed a 6.3-fold increase in the steroid treatment group versus the controls, indicating anti-inflammatory modulation by steroid treatment. Steroids 67-74 interleukin 10 Homo sapiens 27-32 25617625-1 2015 UNLABELLED: The purpose of the study was to determine the effect of ginseng-based steroid Rg1 on TNF-alpha and IL-10 gene expression in human skeletal muscle against exercise challenge, as well as on its ergogenic outcomes. Steroids 82-89 interleukin 10 Homo sapiens 111-116 24474147-7 2014 Anti-inflammatory cytokine IL-10 showed a 6.3-fold increase in the steroid treatment group versus the controls, indicating anti-inflammatory modulation by steroid treatment. Steroids 155-162 interleukin 10 Homo sapiens 27-32 23178794-6 2013 RESULTS: TGF-beta1, p-Smad2, IL-10, SOCS3, and Foxp3 expression was higher in steroid-treated NP patients than in untreated NP patients. Steroids 78-85 interleukin 10 Homo sapiens 29-34 23683514-2 2013 We previously identified a steroid-enhancing function of vitamin D in patients with SR asthma in restoring the impaired response to steroids for production of the anti-inflammatory cytokine IL-10. Steroids 27-34 interleukin 10 Homo sapiens 190-195 23683514-2 2013 We previously identified a steroid-enhancing function of vitamin D in patients with SR asthma in restoring the impaired response to steroids for production of the anti-inflammatory cytokine IL-10. Steroids 132-140 interleukin 10 Homo sapiens 190-195 21674705-8 2011 Interleukin (IL)-10 was markedly increased at baseline in steroid-responsive patients compared to the nonresponders (P = 0.006; sensitivity: 88.8%; specificity: 66.6% to predict steroid response). Steroids 58-65 interleukin 10 Homo sapiens 0-19 21674705-8 2011 Interleukin (IL)-10 was markedly increased at baseline in steroid-responsive patients compared to the nonresponders (P = 0.006; sensitivity: 88.8%; specificity: 66.6% to predict steroid response). Steroids 178-185 interleukin 10 Homo sapiens 0-19 21674705-10 2011 In contrast, increased expression of IL-10 at an early stage of active steroid-sensitive CD patients supports its usefulness at predicting a good steroid response. Steroids 71-78 interleukin 10 Homo sapiens 37-42 21674705-10 2011 In contrast, increased expression of IL-10 at an early stage of active steroid-sensitive CD patients supports its usefulness at predicting a good steroid response. Steroids 146-153 interleukin 10 Homo sapiens 37-42 19542427-7 2009 Addition of IL-10 enhanced steroid suppression. Steroids 27-34 interleukin 10 Homo sapiens 12-17 19542427-9 2009 Neutralization of IL-10 reduced steroid sensitivity. Steroids 32-39 interleukin 10 Homo sapiens 18-23 19383027-3 2009 METHODS: In this study, we investigated endothelial IL-10 expression in nasal mucosa of healthy- and house dust mite allergic patients, both before and after provocation, and under nasal steroid therapy. Steroids 187-194 interleukin 10 Homo sapiens 52-57 18657352-5 2008 RESULTS: A significant increase of IL-10 and decrease of CCL2 serum levels was observed (p=0.0028 and 0.045 respectively) five days after the onset of steroid treatment but not after one month. Steroids 151-158 interleukin 10 Homo sapiens 35-40 16911685-9 2006 Crohn"s disease patients receiving steroids had a higher secretion rate of RANTES and IL-10. Steroids 35-43 interleukin 10 Homo sapiens 86-91 18793874-7 2008 Foxp3 and IL-10 expression were increased significantly after intranasal steroid treatment (P<0.05). Steroids 73-80 interleukin 10 Homo sapiens 10-15 18027383-9 2008 The steroid group had increased interleukin 10 levels (P = 0.005 compared to controls). Steroids 4-11 interleukin 10 Homo sapiens 32-46 17922695-4 2007 RESULTS: Female sex steroid hormones enhance the life cycle of mDCs, thus increasing the maturation and apoptosis, they also increase the production of interleukin (IL)-10 and IL-27 but only Pg increases the production of IL-13 and down regulates the secretion of IL-23. Steroids 20-36 interleukin 10 Homo sapiens 152-171 18691071-9 2008 However, both steroid therapy and allergen specific immunotherapy are known to elevate endogenous IL-10 levels, which may account for their efficacy, suggesting that further study of IL-10 as a target for treatment of airway inflammatory diseases such as asthma and COPD is warranted. Steroids 14-21 interleukin 10 Homo sapiens 98-103 18691071-9 2008 However, both steroid therapy and allergen specific immunotherapy are known to elevate endogenous IL-10 levels, which may account for their efficacy, suggesting that further study of IL-10 as a target for treatment of airway inflammatory diseases such as asthma and COPD is warranted. Steroids 14-21 interleukin 10 Homo sapiens 183-188 16911685-11 2006 The elevated RANTES and IL-10 secretion from creeping fat in CD is not due to a CD-specific effect but caused by steroid treatment. Steroids 113-120 interleukin 10 Homo sapiens 24-29 16249504-7 2005 RESULTS: Significant associations were found between the IL-10 -1082 SNP and disease recurrence from previously stable disease and the level of steroids required for maintenance therapy. Steroids 144-152 interleukin 10 Homo sapiens 57-62 16573780-1 2006 Association of -1082 AA low producer IL-10 genotype with steroid dependency. Steroids 57-64 interleukin 10 Homo sapiens 37-42 16573780-8 2006 In a stratified analysis, a highly significant association between the -1082 AA IL-10 genotype and the steroid dependency was observed in IBD (p < 0.0001), contributing both UC (p = 0.004) and CD (p = 0.003) to this association. Steroids 103-110 interleukin 10 Homo sapiens 80-85 16573780-11 2006 The steroid-dependent phenotype correlated in UC with extensive disease (p = 0.010) and with the low producer -1082 AA IL-10 genotype (p = 0.002) and in CD with penetrating disease (p = 0.010), arthritis (p = 0.011), and the -1082 AA IL-10 genotype (p = 0.006). Steroids 4-11 interleukin 10 Homo sapiens 119-124 16573780-11 2006 The steroid-dependent phenotype correlated in UC with extensive disease (p = 0.010) and with the low producer -1082 AA IL-10 genotype (p = 0.002) and in CD with penetrating disease (p = 0.010), arthritis (p = 0.011), and the -1082 AA IL-10 genotype (p = 0.006). Steroids 4-11 interleukin 10 Homo sapiens 234-239 16573780-12 2006 CONCLUSIONS: The main conclusion is that carriage of the -1082 AA IL-10 genotype (low producer) is a relevant risk factor for developing steroid-dependent IBD. Steroids 137-144 interleukin 10 Homo sapiens 66-71 16384973-7 2006 IL-10 was higher in the panuveitis group on steroids (P < 0.01). Steroids 44-52 interleukin 10 Homo sapiens 0-5 16384973-12 2006 The increased IL-10 in the steroid treated group suggests glucocorticoid-induced IL-10 upregulation. Steroids 27-34 interleukin 10 Homo sapiens 14-19 16384973-12 2006 The increased IL-10 in the steroid treated group suggests glucocorticoid-induced IL-10 upregulation. Steroids 27-34 interleukin 10 Homo sapiens 81-86 16140223-10 2005 Inhaled steroids resulted in reduced levels of IL-1 beta, IL-6, IL-8, IL-10, and IL-12 (all: P<0.01) in stable COPD (all: ex-smokers) with dose dependency for IL-8, IL-1 beta and IL-12. Steroids 8-16 interleukin 10 Homo sapiens 70-75