PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6721570-9 1984 AHH activity in circulating monocytes and lymphocytes may be stimulated by topical tar and/or steroid therapy of psoriasis. Steroids 94-101 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-3 33258555-5 2021 BPA affected the expression of genes related to steroid hormone synthesis in KGN cells, including the decreased expression of the steroidogenic acute regulatory protein, ferredoxin, and ferredoxin reductase genes during progesterone synthesis; upregulating the expression of cytochrome p450 oxidoreductase gene associated with E2 and T synthesis; and the downregulated cytochrome P450 family 1 subfamily A member 1 and cytochrome P450 family 1 subfamily B member 1 in E2 degradation. Steroids 48-55 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 419-464 4111407-0 1971 Suppression of 7,12-dimethylbenz( )anthracene-produced adrenal necrosis by steroids capable of inducing aryl hydrocarbon hydroxylase. Steroids 75-83 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 104-132 29275510-7 2018 Our data suggest that 100 muM BPA increased CYP1B1 and HSD17B14 gene and protein expression and release of endogenous estradiol, which was associated with increased ROS production and DNA double-strand breaks, upregulation of genes and/or proteins in steroid synthesis and metabolism, and activation of Nrf2-regulated stress response pathways. Steroids 251-258 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 44-50 29197745-4 2018 Other well-known pro-tumorigenic activities of CYP1B1 rely on metabolic bioactivation of xenobiotics and steroid hormones into their carcinogenic derivatives. Steroids 105-121 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 47-53 23757320-11 2013 The inferior outcome identified with methylation of the cytochrome p450 gene CYP1B1, an enzyme involved in drug metabolism and steroid synthesis, warrants further investigation. Steroids 127-134 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 77-83 29152048-3 2017 The position of the nitrogen atom in the aromatic ring has little influence on their inhibition potency, but compounds with a pyridinyl at C2 of the steroid nucleus are more potent CYP1B1 inhibitors than those with a pyridinyl at C3 or C4. Steroids 149-156 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 181-187 28322972-2 2017 Surprisingly, CYP1B1 was also shown to be important in regulating endogenous metabolic pathways, including the metabolism of steroid hormones, fatty acids, melatonin, and vitamins. Steroids 125-141 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 14-20 28139960-1 2016 Cytochrome P450 1B1 (CYP1B1) is an anticancer therapeutic target due to its overexpression in a number of steroid hormone-related cancers. Steroids 106-121 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 28139960-1 2016 Cytochrome P450 1B1 (CYP1B1) is an anticancer therapeutic target due to its overexpression in a number of steroid hormone-related cancers. Steroids 106-121 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 27687674-0 2016 Targeting cytochrome P450 (CYP) 1B1 with steroid derivatives. Steroids 41-48 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 10-35 27687674-2 2016 Surprisingly, few steroids were reported as inhibitors of CYP1B1. Steroids 18-26 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 58-64 22336992-3 2012 We investigated maternal functional polymorphisms of CYP17, CYP19, and CYP1B1, which control three major enzymatic steps in sex steroid biosynthesis and metabolism, in relation to childhood behaviors. Steroids 128-135 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 71-77 22951915-10 2012 In addition, mRNA transcripts of factors involved in steroid metabolism, such as CYP11A1, CYP1B1, CYP19A1 and CYP2B7P1, were deregulated in PCOS CCs, and this could explain the abnormal steroidogenesis observed in these women. Steroids 53-60 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 90-96 18544568-1 2008 Cytochrome P450 1B1 (CYP1B1) is involved in the activation of many carcinogens and in the metabolism of steroid hormones. Steroids 104-120 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 20505544-3 2010 We evaluated the relationship between steroid hormone metabolism genotypes at COMT, CYP1A2, CYP1B1, CYP3A4, CYP19, SULT1A1, and SULT1E1 with hormone levels and menopausal features. Steroids 38-53 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 92-98 18544568-1 2008 Cytochrome P450 1B1 (CYP1B1) is involved in the activation of many carcinogens and in the metabolism of steroid hormones. Steroids 104-120 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 16567417-1 2006 Cytochrome P450 (CYP) 1B1, which catalyzes 17beta-estradiol 4-hydroxylation, is expressed in steroid-related tissues including ovary, testis, and adrenal gland. Steroids 93-100 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-25 17914928-8 2008 CYP1B1 protein is involved in the metabolism of steroids, retinol and retinal, arachidonate, and melatonin. Steroids 48-56 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 11740343-0 2001 Effect of two mutations of human CYP1B1, G61E and R469W, on stability and endogenous steroid substrate metabolism. Steroids 85-92 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 33-39 14961553-1 2003 CYP1B1 metabolites receive particular attention because of their causative role in malignant transformation of various steroid-related organs. Steroids 119-126 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 11740343-6 2001 CYP1B1 is able to metabolize steroid hormones. Steroids 29-45 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 11221602-1 2000 Cytochrome P4501B1 (CYP1B1) is involved in the activation of many carcinogens and in the metabolism of steroid hormones, including 17beta-oestradiol (E2) and testosterone. Steroids 103-119 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-18 11221602-1 2000 Cytochrome P4501B1 (CYP1B1) is involved in the activation of many carcinogens and in the metabolism of steroid hormones, including 17beta-oestradiol (E2) and testosterone. Steroids 103-119 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 20-26 10426814-7 1999 These results indicate that the polymorphisms in the human CYP1B1 gene cause some alterations in catalytic function towards procarcinogens and steroid hormones and thus may make some contribution to susceptibilities of individuals towards mammary and lung cancers in humans. Steroids 143-159 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 59-65 11093812-1 2000 The expression of CYP1A1 and CYP1B1, encoding enzymes known to play a central role in oxidative metabolism of a wide range of compounds including steroids, was significantly increased in anti-estrogen-resistant human breast cancer cell lines. Steroids 146-154 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 29-35