PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25076120-3 2014 Emerging evidence suggests that sex steroid bioavailability in the endometrium is determined by adjusting their metabolic rate and fate via regulation of cytochrome (CYP) p450 enzymes. Steroids 36-43 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 171-175 26002738-2 2015 P450 enzymes play an important role in the detoxification of exogenous bioactive compounds and hydrophobic xenobiotics (e.g. carcinogens, drugs, environment pollutants, food supplements, medicines, plant products) and in the biotransformation of endogenous bioactive compounds (e.g. amino acids, cholesterol, eicosanoids, saturated/unsaturated fatty acids, melatonin, steroid hormones). Steroids 368-384 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-4 22101253-4 2012 More recently, the roles of these two human ferredoxins in iron-sulfur cluster assembly were assessed, and it was concluded that FDX1 was important solely for its interaction with p450 enzymes to synthesize mitochondrial steroid precursors, whereas FDX2 was used for synthesis of iron-sulfur clusters, but not steroidogenesis. Steroids 221-228 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 180-184 21998091-0 2011 P450(BM3) on steroids: the Swiss Army knife P450 enzyme just gets better. Steroids 13-21 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-8 21825115-2 2011 Recently, progesterone receptor membrane component 1 (PGRMC1), which shares a key structural motif with cytochrome b(5), has been reported to bind to sterol- or steroid-synthesizing P450s, enhancing their activities. Steroids 161-168 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 182-187 21825115-10 2011 In conclusion, in contrast to sterol- or steroid-synthesizing P450s, we found that PGRMC1 negatively modulates the human drug-metabolizing activities of P450 through direct interaction. Steroids 41-48 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 62-67 21825115-10 2011 In conclusion, in contrast to sterol- or steroid-synthesizing P450s, we found that PGRMC1 negatively modulates the human drug-metabolizing activities of P450 through direct interaction. Steroids 41-48 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 62-66 20100815-1 2010 Human cytochrome P450 (P450) enzymes metabolize a variety of endogenous and xenobiotic compounds, including steroids, drugs, and environmental chemicals. Steroids 108-116 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 6-27 21395541-0 2011 Steroid regulation of drug-metabolizing cytochromes P450. Steroids 0-7 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 52-56 21395541-1 2011 Cytochrome P450 (P450) monooxygenases are capable of catalyzing metabolism of various endogenous and exogenous compounds, such as bile acids, fatty acids, retinoids, steroids, drugs and other xenobiotics. Steroids 166-174 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 11-15 21395541-1 2011 Cytochrome P450 (P450) monooxygenases are capable of catalyzing metabolism of various endogenous and exogenous compounds, such as bile acids, fatty acids, retinoids, steroids, drugs and other xenobiotics. Steroids 166-174 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 17-21 21395541-9 2011 Modulation of P450 expression by xenobiotics can affect the subsequent metabolism of not only foreign chemicals, but also steroid hormones. Steroids 122-138 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 14-18 21698750-3 2011 The known activities of a small number of the 13,000 members of the P450 superfamily fall into two general classes: promiscuous enzymes that are not considered as moonlighting and forms that participate in biosynthesis of endogenous compounds, such as steroids, vitamins and play different roles in different tissues, sometimes being moonlighting enzymes. Steroids 252-260 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 68-72 15237850-1 2004 The cytochrome P450 (P450) field came out of interest in the metabolism of drugs, carcinogens, and steroids, which remain major focal points. Steroids 99-107 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 15-19 17216026-1 2006 The cytochrome P450 enzymes (P450s or CYPs) form a large family of heme proteins involved in drug metabolism and in the biosynthesis of steroids, lipids, vitamins and natural products. Steroids 136-144 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 15-19 16719384-1 2006 Testosterone and other steroid hormones have been studied as prototypic examples of endogenous substrates for hepatic cytochrome P450 (P450) enzymes. Steroids 23-39 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 118-140 19409404-6 2009 Differentially expressed genes included the Phase I xenobiotic, fatty acid, sterol and steroid metabolism genes Cyp2b2 and CYP2B6, Cyp3a1 and CYP3A4, and Cyp4a22 and CYP4A11; Phase II conjugation enzyme genes Ugt1a1 and UGT1A1; and Phase III ABC transporter genes Abcb1 and ABCB1. Steroids 87-94 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 123-129 17073778-1 2006 P450 (cytochrome P450) enzymes have major roles in the biosynthesis of endogenous factors such as steroids and eicosanoids, in the termination of the action of endogenous factors such as retinoic acid, in the metabolism of most drugs and xenobiotics and in the generation of toxic and carcinogenic products. Steroids 98-106 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-4 17073778-1 2006 P450 (cytochrome P450) enzymes have major roles in the biosynthesis of endogenous factors such as steroids and eicosanoids, in the termination of the action of endogenous factors such as retinoic acid, in the metabolism of most drugs and xenobiotics and in the generation of toxic and carcinogenic products. Steroids 98-106 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 17-21 21638641-1 2006 Cytochrome P450 (P450) enzymes include a family of related enzymes that are involved in metabolism of vitamins, steroids, fatty acids, and other chemicals. Steroids 112-120 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-21 27699667-1 2006 Testosterone and other steroid hormones have been studied as prototypic examples of endogenous substrates for hepatic cytochrome P450 (P450) enzymes. Steroids 23-39 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 118-140 15548381-8 2004 These results suggest that CYP3A4 and CYP2B6 regulation through PXR activation by persistent pesticides may have an impact on the metabolism of xenobiotic agents and endogenous steroid hormones. Steroids 177-193 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 38-44 12556907-1 2003 In recent studies that addressed the transcriptional control of steroid synthesis, a transcriptional regulating protein of 132 kDa (TReP-132) was cloned and demonstrated to regulate expression of the human P450 side chain cleavage (P450scc) gene. Steroids 64-71 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 206-210 10022426-10 1999 Steroid-producing cells autoantibodies were found in 11/13 (85%) of patients with idiopathic premature ovarian failure associated with autoimmune Addison"s disease, and autoantibodies to 17alpha-hydroxylase and/or P450 side chain cleavage were found 12/13 (92%) of patients; the only case negative for all these three markers suffered from Turner"s syndrome. Steroids 0-7 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 214-218 11889205-3 2002 The enzyme aromatase P450 is responsible for the conversion of androgen precursor steroids to estrogens and may, therefore, have a role in regulating adipose tissue mass and its distribution. Steroids 82-90 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 21-25 11948012-1 2002 In vertebrates the wide variety of cytochromes P(450) (P(450)) is a key for elimination of low molecular weight xenobiotics and for the production and metabolism of steroid hormones. Steroids 165-181 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 47-61 11875815-7 2001 RFP has a potency to induce the enzyme p450, which has the effect of metabolizing steroids or CyA, thus shortening the half-life of these agents. Steroids 82-90 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 39-43 11469727-1 2001 Cytochrome P450 (P450) enzymes play major roles in the metabolism of drugs, carcinogens, steroids, eicosanoids, alkaloids, pesticides, and other important xenobiotics, as well as chemicals normally endogenous to the body. Steroids 89-97 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-21 10630892-6 1999 Human lymphoblast cell microsomes expressing human CYP2B6 incubated with the steroids investigated produced traces of 6beta-hydroxyl metabolites with testosterone and 17alpha-methyltestosterone only. Steroids 77-85 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 51-57 12050123-12 2002 A varied prevalence of hypergonadotropic hypogonadism in patients with AD and value of steroid-producing cells autoantibodies reactive with steroid 17alpha-hydroxylase or P450 side-chain cleavage enzyme as markers of this disease has been discussed. Steroids 87-94 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 171-175 11871398-8 2002 Measurements of kinetic parameters of P450 enzymes that could metabolize both steroids, combined with the fact that CYP3A4 is known to be the most abundant P450 enzyme in the human liver, indicate that CYP3A4 will be of major importance for the in vivo human metabolism of Org 4060 and Org 30659. Steroids 78-86 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 38-42 11871398-8 2002 Measurements of kinetic parameters of P450 enzymes that could metabolize both steroids, combined with the fact that CYP3A4 is known to be the most abundant P450 enzyme in the human liver, indicate that CYP3A4 will be of major importance for the in vivo human metabolism of Org 4060 and Org 30659. Steroids 78-86 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 156-160 9922992-6 1998 The metabolism of steroids and vitamins is catalyzed by P450 and is altered in chronic alcoholics. Steroids 18-26 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 56-60 22217824-1 1992 In the pathways of steroid hormone biosynthesis there are two major types of enzymes: cytochromes P450 and other steroid oxidoreductases. Steroids 19-34 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 98-102 8230303-2 1993 In mammals, a limited number of P-450s are involved in metabolic pathways of steroid synthesis, while most of these enzymes are involved in metabolism of foreign compounds. Steroids 77-84 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 32-38 18406240-2 1998 In this article, we present evidence from molecular genetic studies for involvement of the steroid synthesis gene CYP11a (coding for P450 cholesterol side-chain cleavage) in the aetiology of hyperandrogenism. Steroids 91-98 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 133-137 8969926-9 1996 It is apparent that this method is applicable to many other P450 catalyzed reactions for the synthesis of large amounts of hydroxylated steroid metabolites. Steroids 136-143 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 60-64 8809764-4 1996 Much research is focussed on mammalian P-450s, with their roles in such processes as steroid transformations and the metabolism of carcinogens and other xenobiotics. Steroids 85-92 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 39-45 22217845-0 1992 Inhibitors of P450-dependent steroid biosynthesis: from research to medical treatment. Steroids 29-36 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 14-18 22217845-1 1992 A number of cytochrome P450-dependent enzymes are major targets for both steroidal and nonsteroidal compounds that may be of use in the treatment of a number of androgen-independent, androgen-, estrogen- and other steroid-dependent diseases. Steroids 73-80 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 23-27 4150427-0 1973 The heme protein P-450 in steroid hydroxylation. Steroids 26-33 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 17-22 1386614-6 1992 These findings demonstrate that a low dose of spironolactone is effective in the treatment of rosacea in some male patients and suggest that it is possible that changes in the metabolism of sex steroid hormones such as cytochrome p-450 isozymes have some bearing on the etiology of rosacea. Steroids 194-210 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 230-235 3663605-2 1987 Water proton relaxation rates of various complexes of cholesterol side chain cleavage cytochrome P-450 (-450scc) were investigated to gain information about the structure and dynamics of the steroid binding site. Steroids 191-198 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 97-111 6100256-1 1984 A rate-determining step in the cAMP-dependent action of ACTH on adrenal steroid biosynthesis is the interaction of cholesterol substrate with the cholesterol side-chain cleavage cytochrome P-450 in the mitochondrion. Steroids 72-79 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 189-194 2182263-2 1990 Cytochrome P450 (P450) is the collective term for a group of related enzymes or isozymes which are responsible for the oxidation of numerous drugs and other foreign compounds, as well as many endogenous substrates including prostaglandins, fatty acids and steroids. Steroids 256-264 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-22 2813390-1 1989 The cytochrome P-450 superfamily of enzymes catalyzes the oxidative metabolism of innumerable lipophilic compounds (e.g., drugs, carcinogens, steroids). Steroids 142-150 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 15-20 2540088-3 1989 In the steroid cell tumors, all the P-450 cytochromes were intensely stained. Steroids 7-14 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 36-41 3654968-2 1987 In rat enterocytes, we found two dexamethasone-inducible proteins related to the steroid-inducible liver cytochromes P-450. Steroids 81-88 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 117-122 3795953-2 1986 Steroid products and their analogs induce oxygen-mediated damage of microsomal P-450 activities of cultured Leydig cells, whereas testosterone acetate protects P-450 from this damage [1]. Steroids 0-7 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 79-84 3795953-6 1986 Several steroids which have varying effects on damage of P-450 in cultured Leydig cells inhibited substrate binding similarly (KdI = 3.8-12.8 microM). Steroids 8-16 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 57-62 3795953-8 1986 The results suggest that steroid binding to P-450 is necessary but not sufficient to increase oxygen free-radical damage of the testicular microsomal P-450. Steroids 25-32 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 44-49 3795953-8 1986 The results suggest that steroid binding to P-450 is necessary but not sufficient to increase oxygen free-radical damage of the testicular microsomal P-450. Steroids 25-32 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 150-155 31147443-1 2019 Cytochrome P450 (P450) enzymes are major catalysts involved in the oxidations of most drugs, steroids, carcinogens, fat-soluble vitamins, and natural products. Steroids 93-101 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-22 4348064-0 1972 Haem protein P-450 from the adrenal cortex: interaction with steroids and the hydroxylation reaction. Steroids 61-69 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 13-18 31072872-1 2019 Cytochrome P450 (P450, CYP) enzymes are the major catalysts involved in the oxidation of steroids as well as many other compounds. Steroids 89-97 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-26 28188297-1 2017 The human genome encodes 57 cytochrome P450 genes, whose enzyme products metabolize hundreds of drugs, thousands of xenobiotics, and unknown numbers of endogenous compounds, including steroids, retinoids, and eicosanoids. Steroids 184-192 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 39-43 29371396-1 2018 Mitochondrial cytochromes P450 (P450s) are responsible for important metabolic reactions, including steps involved in steroid and vitamin D metabolism. Steroids 118-125 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 26-30 31339834-1 2019 PURPOSE: Hydroxylation activity at the 6beta-position of steroid hormones (testosterone, progesterone, and cortisol) by human cytochromes P450 (P450 or CYP) 3A4 and CYP3A5 and their molecular docking energy values were compared to understand the catalytic properties of the major forms of human CYP3A, namely, CYP3A4 and CYP3A5. Steroids 57-64 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 126-160 27815210-1 2017 Steroids are synthesized from the adrenal glands and gonads by enzymes of the cytochromes P450 and hydroxysteroid dehydrogenase in nature. Steroids 0-8 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 90-127 27339894-1 2016 Cytochrome P450 (P450) reactions can involve C-C bond cleavage, and several of these are critical in steroid and sterol biosynthesis. Steroids 101-108 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-22