PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14632424-4 2003 When tested using the CBG (corticosteroid binding globulin) affinities of 31 benchmark steroids, the FLUFF-BALL technique produced results comparable to standard 3D-QSAR methods. Steroids 87-95 serpin family A member 6 Homo sapiens 27-58 25850625-0 2015 Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation. Steroids 83-90 serpin family A member 6 Homo sapiens 40-71 24237147-2 2013 The substitution of the progesterone 3-oxo group for a 3-O-methoxyimino group was shown to diminish the affinity of the steroid for transcortin by approximately one order of magnitude irrespective of the substituent"s orientation. Steroids 120-127 serpin family A member 6 Homo sapiens 132-143 22242800-0 2012 Multi-target QSAR and docking study of steroids binding to corticosteroid-binding globulin and sex hormone-binding globulin. Steroids 39-47 serpin family A member 6 Homo sapiens 59-90 22242800-1 2012 The QSAR and docking studies were performed on fifty seven steroids with binding affinities for corticosteroid-binding globulin (CBG) and eighty four steroids with binding affinities for sex hormone-binding globulin (SHBG). Steroids 59-67 serpin family A member 6 Homo sapiens 96-127 22242800-1 2012 The QSAR and docking studies were performed on fifty seven steroids with binding affinities for corticosteroid-binding globulin (CBG) and eighty four steroids with binding affinities for sex hormone-binding globulin (SHBG). Steroids 59-67 serpin family A member 6 Homo sapiens 129-132 22242800-6 2012 The multi-target QSAR model (CBG and SHBG) was found to be more effective in describing the CBG and SHBG affinity of steroids in comparison to the one target models (QSAR (SHGB) model, QSAR model (CBG)). Steroids 117-125 serpin family A member 6 Homo sapiens 29-32 22242800-6 2012 The multi-target QSAR model (CBG and SHBG) was found to be more effective in describing the CBG and SHBG affinity of steroids in comparison to the one target models (QSAR (SHGB) model, QSAR model (CBG)). Steroids 117-125 serpin family A member 6 Homo sapiens 92-95 22242800-6 2012 The multi-target QSAR model (CBG and SHBG) was found to be more effective in describing the CBG and SHBG affinity of steroids in comparison to the one target models (QSAR (SHGB) model, QSAR model (CBG)). Steroids 117-125 serpin family A member 6 Homo sapiens 92-95 22242800-9 2012 The theoretical study defined physicochemical, electronic and structural requirements for selective and effective binding of steroids to the CBG and SHBG active sites. Steroids 125-133 serpin family A member 6 Homo sapiens 141-144 20610591-4 2010 This results in a p.Gly237Val substitution that is predicted to influence the positioning of two beta-sheets that constitute part of the CBG steroid-binding site. Steroids 141-148 serpin family A member 6 Homo sapiens 137-140 20610591-10 2010 CONCLUSION: We describe a novel CBG variant that lacks steroid binding activity. Steroids 55-62 serpin family A member 6 Homo sapiens 32-35 19643161-0 2010 Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin. Steroids 34-49 serpin family A member 6 Homo sapiens 75-106 16325409-2 2006 A quantitative structure-activity relationship (QSAR) study to predict the relative affinities of the steroid "benchmark" data set to the corticosteroid-binding globulin (CBG) is described. Steroids 102-109 serpin family A member 6 Homo sapiens 138-169 16325409-2 2006 A quantitative structure-activity relationship (QSAR) study to predict the relative affinities of the steroid "benchmark" data set to the corticosteroid-binding globulin (CBG) is described. Steroids 102-109 serpin family A member 6 Homo sapiens 171-174 16325409-3 2006 It is shown that the 3D-chiral quadratic indices closely correlate with the measured CBG affinity values for the 31 steroids. Steroids 116-124 serpin family A member 6 Homo sapiens 85-88 16700005-1 2006 Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) circulate in plasma and bind their cognate ligands with high affinity, offering a steroid delivery system to target tissues by a variety of mechanisms. Steroids 47-54 serpin family A member 6 Homo sapiens 73-76 25695888-1 2015 CONTEXT: Plasma corticosteroid-binding globulin (CBG) transports cortisol but high progesterone levels at the maternal-fetal interface can displace cortisol from its steroid-binding site. Steroids 23-30 serpin family A member 6 Homo sapiens 49-52 22337907-2 2012 Single nucleotide polymorphisms (SNP) in the human CBG (SERPINA6) gene that disrupt CBG production or steroid binding are considered rare. Steroids 102-109 serpin family A member 6 Homo sapiens 51-54 22337907-2 2012 Single nucleotide polymorphisms (SNP) in the human CBG (SERPINA6) gene that disrupt CBG production or steroid binding are considered rare. Steroids 102-109 serpin family A member 6 Homo sapiens 56-64 19643161-5 2010 These crystal structures have set the stage for mechanistic studies of CBG function which have so far shown that helix D plays a key role in coupling RCL movement and steroid-binding site integrity, and provided evidence for an allosteric mechanism that modulates steroid binding and release from CBG. Steroids 167-174 serpin family A member 6 Homo sapiens 71-74 19643161-5 2010 These crystal structures have set the stage for mechanistic studies of CBG function which have so far shown that helix D plays a key role in coupling RCL movement and steroid-binding site integrity, and provided evidence for an allosteric mechanism that modulates steroid binding and release from CBG. Steroids 264-271 serpin family A member 6 Homo sapiens 71-74 19643161-7 2010 This recent insight into the structure and function of CBG reveals how naturally occurring genetic CBG mutations affect steroid binding, and helps understand how proteolysis of CBG enhances the targeted delivery of biologically active steroids to their sites of action. Steroids 120-127 serpin family A member 6 Homo sapiens 55-58 19643161-7 2010 This recent insight into the structure and function of CBG reveals how naturally occurring genetic CBG mutations affect steroid binding, and helps understand how proteolysis of CBG enhances the targeted delivery of biologically active steroids to their sites of action. Steroids 120-127 serpin family A member 6 Homo sapiens 99-102 19643161-7 2010 This recent insight into the structure and function of CBG reveals how naturally occurring genetic CBG mutations affect steroid binding, and helps understand how proteolysis of CBG enhances the targeted delivery of biologically active steroids to their sites of action. Steroids 120-127 serpin family A member 6 Homo sapiens 99-102 19643161-7 2010 This recent insight into the structure and function of CBG reveals how naturally occurring genetic CBG mutations affect steroid binding, and helps understand how proteolysis of CBG enhances the targeted delivery of biologically active steroids to their sites of action. Steroids 235-243 serpin family A member 6 Homo sapiens 55-58 19643161-7 2010 This recent insight into the structure and function of CBG reveals how naturally occurring genetic CBG mutations affect steroid binding, and helps understand how proteolysis of CBG enhances the targeted delivery of biologically active steroids to their sites of action. Steroids 235-243 serpin family A member 6 Homo sapiens 99-102 19643161-7 2010 This recent insight into the structure and function of CBG reveals how naturally occurring genetic CBG mutations affect steroid binding, and helps understand how proteolysis of CBG enhances the targeted delivery of biologically active steroids to their sites of action. Steroids 235-243 serpin family A member 6 Homo sapiens 99-102 19172388-8 2009 Cortisol seems to facilitate liberation of CBG in a paracrine manner, perhaps through membrane action of the steroid. Steroids 109-116 serpin family A member 6 Homo sapiens 43-46 19011238-4 2009 We have, therefore, examined how amino acid substitutions in the human CBG RCL influence steroid binding before and after its cleavage by neutrophil elastase. Steroids 89-96 serpin family A member 6 Homo sapiens 71-74 19011238-8 2009 Remarkably, several substitutions (E334A, V336R, G340S, and T342P) increased the steroid binding affinities of human CBG even before elastase cleavage, consistent with the concept that CBG normally toggles between a high affinity ligand binding state where the RCL is fully exposed and a lower affinity state in which the RCL is partly inserted into beta-sheet A. Steroids 81-88 serpin family A member 6 Homo sapiens 117-120 19011238-8 2009 Remarkably, several substitutions (E334A, V336R, G340S, and T342P) increased the steroid binding affinities of human CBG even before elastase cleavage, consistent with the concept that CBG normally toggles between a high affinity ligand binding state where the RCL is fully exposed and a lower affinity state in which the RCL is partly inserted into beta-sheet A. Steroids 81-88 serpin family A member 6 Homo sapiens 185-188 15368918-4 2004 The performance of ALPHA was tested in detail employing the CBG (corticosteroid binding globulin) affinity of 31 benchmark steroids, supplemented with 11 steroids as an external test set. Steroids 123-131 serpin family A member 6 Homo sapiens 65-96 15579914-4 2004 Tamoxifen increased steroid-binding proteins (SHBG and CBG) and suppressed circulating androgens and IGF-I. Steroids 20-27 serpin family A member 6 Homo sapiens 55-58 13129576-5 2003 The ETM is used to study the 3D QSAR of the corticosteroid-binding globulin (CBG) binding affinity to 31 steroids, and resulting models have a comparable to current 3D methods such as CoMFA. Steroids 105-113 serpin family A member 6 Homo sapiens 44-75 13129576-5 2003 The ETM is used to study the 3D QSAR of the corticosteroid-binding globulin (CBG) binding affinity to 31 steroids, and resulting models have a comparable to current 3D methods such as CoMFA. Steroids 105-113 serpin family A member 6 Homo sapiens 77-80 12733052-0 2003 Homology model of human corticosteroid binding globulin: a study of its steroid binding ability and a plausible mechanism of steroid hormone release at the site of inflammation. Steroids 125-140 serpin family A member 6 Homo sapiens 24-55 12086522-3 2002 Its performance was tested with respect to the CBG (corticosteroid binding globulin) affinity of 31 benchmark steroids. Steroids 110-118 serpin family A member 6 Homo sapiens 47-50 12353665-1 2002 The access of reproductive steroids to their target cells varies considerably between tissues, and is influenced to a great extent by their interactions with plasma steroid-binding proteins, and with SHBG and CBG in particular. Steroids 27-35 serpin family A member 6 Homo sapiens 209-212 12353665-1 2002 The access of reproductive steroids to their target cells varies considerably between tissues, and is influenced to a great extent by their interactions with plasma steroid-binding proteins, and with SHBG and CBG in particular. Steroids 27-34 serpin family A member 6 Homo sapiens 209-212 12353665-2 2002 An increased awareness of how SHBG and CBG function within the blood circulation, and within extravascular compartments of steroid-responsive target tissues, needs to be incorporated into the design and evaluation of therapies involving the administration of both natural and synthetic steroids, which influence female reproduction and healthy aging. Steroids 286-294 serpin family A member 6 Homo sapiens 39-42 12086522-3 2002 Its performance was tested with respect to the CBG (corticosteroid binding globulin) affinity of 31 benchmark steroids. Steroids 110-118 serpin family A member 6 Homo sapiens 52-83 12086522-4 2002 It appeared that the electronic structure of the steroids, i.e., the "spectra" derived from molecular orbital energies, is directly related to the CBG binding affinities. Steroids 49-57 serpin family A member 6 Homo sapiens 147-150 12086537-6 2002 For 31 benchmark steroids, a 5-descriptor QSAR model (M1) between the corticosteroid-binding globulin (CBG) binding affinity of the steroids and 5-descriptor subset is developed. Steroids 17-25 serpin family A member 6 Homo sapiens 70-101 12086537-6 2002 For 31 benchmark steroids, a 5-descriptor QSAR model (M1) between the corticosteroid-binding globulin (CBG) binding affinity of the steroids and 5-descriptor subset is developed. Steroids 17-25 serpin family A member 6 Homo sapiens 103-106 12086537-6 2002 For 31 benchmark steroids, a 5-descriptor QSAR model (M1) between the corticosteroid-binding globulin (CBG) binding affinity of the steroids and 5-descriptor subset is developed. Steroids 132-140 serpin family A member 6 Homo sapiens 70-101 12086537-6 2002 For 31 benchmark steroids, a 5-descriptor QSAR model (M1) between the corticosteroid-binding globulin (CBG) binding affinity of the steroids and 5-descriptor subset is developed. Steroids 132-140 serpin family A member 6 Homo sapiens 103-106 11604024-1 2001 Data for 31 steroids binding to the corticosteroid binding globulin (CBG) were modeled using E-state molecular structure descriptors and a kappa shape index. Steroids 12-20 serpin family A member 6 Homo sapiens 36-67 11604024-1 2001 Data for 31 steroids binding to the corticosteroid binding globulin (CBG) were modeled using E-state molecular structure descriptors and a kappa shape index. Steroids 12-20 serpin family A member 6 Homo sapiens 69-72 11277718-5 2001 The MEDV-13 is used to study the QSAR of the corticosteroid-binding globulin (CBG) binding affinity of the steroids and the activity inhibiting angiotensin-converting enzyme (ACE) of dipeptides, and resulting models have a comparable quality to the current three-dimensional (3D) methods such as CoMFA though the MEDV-13 is a descriptor based on two-dimensional topological information. Steroids 107-115 serpin family A member 6 Homo sapiens 45-76 11207196-5 2001 The steroid environment of the CBG in I differed greatly from that in the peripheral maternal and fetal circulations, because the progesterone:cortisol molar ratio in I was 75-fold higher than that in M and 7- to 10-fold higher than that in the fetal circulation. Steroids 4-11 serpin family A member 6 Homo sapiens 31-34 11207196-7 2001 The binding parameters for I-CBG stripped of endogenous steroids and lipids were close to those for M-CBG but different from those of fetal CBG (P < 0.001). Steroids 56-64 serpin family A member 6 Homo sapiens 29-32 11207196-8 2001 These data reflect the physiological relevance of the CBG-steroid interaction, especially with very CBG-loaded progesterone at the fetomaternal interface during late pregnancy. Steroids 58-65 serpin family A member 6 Homo sapiens 54-57 11207196-8 2001 These data reflect the physiological relevance of the CBG-steroid interaction, especially with very CBG-loaded progesterone at the fetomaternal interface during late pregnancy. Steroids 58-65 serpin family A member 6 Homo sapiens 100-103 11277718-5 2001 The MEDV-13 is used to study the QSAR of the corticosteroid-binding globulin (CBG) binding affinity of the steroids and the activity inhibiting angiotensin-converting enzyme (ACE) of dipeptides, and resulting models have a comparable quality to the current three-dimensional (3D) methods such as CoMFA though the MEDV-13 is a descriptor based on two-dimensional topological information. Steroids 107-115 serpin family A member 6 Homo sapiens 78-81 11293272-3 2000 In particular, the steroids complexing corticosteroid binding globulin (CBG) that are used as a benchmark measuring the performance of drug design methods have been applied to compare between individual methods. Steroids 19-27 serpin family A member 6 Homo sapiens 39-70 11293272-3 2000 In particular, the steroids complexing corticosteroid binding globulin (CBG) that are used as a benchmark measuring the performance of drug design methods have been applied to compare between individual methods. Steroids 19-27 serpin family A member 6 Homo sapiens 72-75 10634411-11 2000 These results suggest that Asp367 is an important determinant of CBG steroid-binding activity and that normal negative regulation of the hypothalamic-pituitary-adrenal axis is maintained by relatively normal serum-free cortisol concentrations, despite a marked reduction in the steroid-binding affinity of this novel human CBG variant, which we have designated as CBG-Lyon. Steroids 69-76 serpin family A member 6 Homo sapiens 65-68 10969874-4 2000 A scheme for the analysis of such data with the PLS analysis has been proposed and tested using the steroids data with corticosteroid binding globulin (CBG) affinity. Steroids 100-108 serpin family A member 6 Homo sapiens 119-150 10969874-4 2000 A scheme for the analysis of such data with the PLS analysis has been proposed and tested using the steroids data with corticosteroid binding globulin (CBG) affinity. Steroids 100-108 serpin family A member 6 Homo sapiens 152-155 9879503-1 1998 A structure-activity analysis of a series of steroids binding to corticosteroid-binding globulin was made using the electrotopological state index for each atom in the molecule. Steroids 45-53 serpin family A member 6 Homo sapiens 65-96 10487686-1 1999 In humans, steroid hormones circulate in the blood mainly bound to specific steroid transport proteins, namely corticosteroid-binding globulin (CBG) for cortisol and sex hormone-binding globulin (SHBG) for testosterone and estradiol. Steroids 11-18 serpin family A member 6 Homo sapiens 111-142 10487686-1 1999 In humans, steroid hormones circulate in the blood mainly bound to specific steroid transport proteins, namely corticosteroid-binding globulin (CBG) for cortisol and sex hormone-binding globulin (SHBG) for testosterone and estradiol. Steroids 11-18 serpin family A member 6 Homo sapiens 144-147 10399051-0 1999 Levels of sex hormone-binding globulin and corticosteroid-binding globulin mRNAs in corpus luteum of human subjects: correlation with serum steroid hormone levels. Steroids 140-155 serpin family A member 6 Homo sapiens 43-74 10052964-6 1999 Here, the method has been used to predict the corticosteroid-binding globulin binding affinity of the "benchmark" steroids, expanded from the usual 31 compounds to 43 compounds. Steroids 114-122 serpin family A member 6 Homo sapiens 46-77 9694568-5 1998 Therefore, patients investigated for Cushing"s syndrome may show a falsely positive dexamethasone suppression test, and patients with adrenal insufficiency on steroid replacement may require increased doses of steroids; furthermore, increased corticosteroid-binding-globulin levels are also associated with chronic anticonvulsant administration. Steroids 159-166 serpin family A member 6 Homo sapiens 243-274 9739422-2 1998 In addition to the well known steroid secreting activity of cumulus cells, the results obtained here demonstrate the secretion of a corticosteroid-binding globulin (CBG)-like protein. Steroids 30-37 serpin family A member 6 Homo sapiens 165-168 9768330-0 1998 Effects of sex steroid hormones on corticosteroid-binding globulin gene expression in human endometrial cancer cell line Ishikawa. Steroids 15-31 serpin family A member 6 Homo sapiens 35-66 9694568-5 1998 Therefore, patients investigated for Cushing"s syndrome may show a falsely positive dexamethasone suppression test, and patients with adrenal insufficiency on steroid replacement may require increased doses of steroids; furthermore, increased corticosteroid-binding-globulin levels are also associated with chronic anticonvulsant administration. Steroids 210-218 serpin family A member 6 Homo sapiens 243-274 9435904-4 1997 In this application, the corticosteroid-binding globulin (CBG) binding affinity of the well-known steroid data set is examined. Steroids 32-39 serpin family A member 6 Homo sapiens 58-61 18406714-3 1995 In particular, the presence of plasma membrane binding sites for both CBG and SHBG on steroid target cells, and evidence for interactions between CBG and specific proteinases at sites of inflammation or tissue remodeling, suggest that these proteins control steroid hormone bioavailability and/or action in a highly selective or targeted fashion. Steroids 86-93 serpin family A member 6 Homo sapiens 70-73 8964582-2 1996 The role of CBG as a specific steroid carrier, a structurally conserved glycoprotein of 50-60 kD in vertebrate species, is well documented, but this knowledge has often been limited to the young or adult life since CBG levels are low in the neonate. Steroids 30-37 serpin family A member 6 Homo sapiens 12-15 18406714-1 1995 The plasma steroid-binding proteins, sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG), transport steroid hormones in the blood and regulate their access to target tissues. Steroids 11-18 serpin family A member 6 Homo sapiens 77-108 18406714-1 1995 The plasma steroid-binding proteins, sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG), transport steroid hormones in the blood and regulate their access to target tissues. Steroids 11-18 serpin family A member 6 Homo sapiens 110-113 18406714-3 1995 In particular, the presence of plasma membrane binding sites for both CBG and SHBG on steroid target cells, and evidence for interactions between CBG and specific proteinases at sites of inflammation or tissue remodeling, suggest that these proteins control steroid hormone bioavailability and/or action in a highly selective or targeted fashion. Steroids 258-273 serpin family A member 6 Homo sapiens 146-149 18406714-1 1995 The plasma steroid-binding proteins, sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG), transport steroid hormones in the blood and regulate their access to target tissues. Steroids 126-142 serpin family A member 6 Homo sapiens 77-108 18406714-1 1995 The plasma steroid-binding proteins, sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG), transport steroid hormones in the blood and regulate their access to target tissues. Steroids 126-142 serpin family A member 6 Homo sapiens 110-113 7480097-1 1995 A problem in the evaluation of pharmacokinetic interactions between prednisolone and cortisol is that both steroids bind to cortisol binding globulin (CBG) and albumin. Steroids 107-115 serpin family A member 6 Homo sapiens 124-149 8540288-5 1995 These findings suggest that the synthesis of endometrial steroid-binding proteins in the out-of-phase endometrium is conserved, as that in the in-phase endometrium, whereas the decreased progesterone level might up-regulate CBG expression with down-regulation of SHBG expression. Steroids 57-64 serpin family A member 6 Homo sapiens 224-227 7480097-1 1995 A problem in the evaluation of pharmacokinetic interactions between prednisolone and cortisol is that both steroids bind to cortisol binding globulin (CBG) and albumin. Steroids 107-115 serpin family A member 6 Homo sapiens 151-154 7480097-2 1995 The binding of both steroids to CBG is saturable in the therapeutic concentration range. Steroids 20-28 serpin family A member 6 Homo sapiens 32-35 7878688-1 1994 Corticosteroid-binding globulin (CBG or transcortin) is a specific plasma glycoprotein, which binds steroid hormones (cortisol, corticosterone, and progesterone), and plays a role in transporting these steroids, altering their concentrations in blood, and influencing their biological actions. Steroids 100-116 serpin family A member 6 Homo sapiens 0-31 7734053-1 1995 Recently, much evidence has indicated that sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) play a role in the intracellular action of sex steroids in target cells. Steroids 168-176 serpin family A member 6 Homo sapiens 83-114 7734053-1 1995 Recently, much evidence has indicated that sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) play a role in the intracellular action of sex steroids in target cells. Steroids 168-176 serpin family A member 6 Homo sapiens 116-119 7990113-5 1994 Two data sets of steroids binding to the corticosteroid-binding-globulin and thermolysin inhibitors were analyzed in terms of the conventional CoMFA method (Lennard-Jones and Coulomb potential fields) and the new comparative molecular similarity indices analysis (CoMSIA). Steroids 17-25 serpin family A member 6 Homo sapiens 41-72 7749500-0 1995 Opposite effects of thyroid hormones on binding proteins for steroid hormones (sex hormone-binding globulin and corticosteroid-binding globulin) in humans. Steroids 61-77 serpin family A member 6 Homo sapiens 112-143 7878688-1 1994 Corticosteroid-binding globulin (CBG or transcortin) is a specific plasma glycoprotein, which binds steroid hormones (cortisol, corticosterone, and progesterone), and plays a role in transporting these steroids, altering their concentrations in blood, and influencing their biological actions. Steroids 100-116 serpin family A member 6 Homo sapiens 33-36 7878688-1 1994 Corticosteroid-binding globulin (CBG or transcortin) is a specific plasma glycoprotein, which binds steroid hormones (cortisol, corticosterone, and progesterone), and plays a role in transporting these steroids, altering their concentrations in blood, and influencing their biological actions. Steroids 100-116 serpin family A member 6 Homo sapiens 40-51 7878688-1 1994 Corticosteroid-binding globulin (CBG or transcortin) is a specific plasma glycoprotein, which binds steroid hormones (cortisol, corticosterone, and progesterone), and plays a role in transporting these steroids, altering their concentrations in blood, and influencing their biological actions. Steroids 202-210 serpin family A member 6 Homo sapiens 0-31 7878688-1 1994 Corticosteroid-binding globulin (CBG or transcortin) is a specific plasma glycoprotein, which binds steroid hormones (cortisol, corticosterone, and progesterone), and plays a role in transporting these steroids, altering their concentrations in blood, and influencing their biological actions. Steroids 202-210 serpin family A member 6 Homo sapiens 33-36 7878688-1 1994 Corticosteroid-binding globulin (CBG or transcortin) is a specific plasma glycoprotein, which binds steroid hormones (cortisol, corticosterone, and progesterone), and plays a role in transporting these steroids, altering their concentrations in blood, and influencing their biological actions. Steroids 202-210 serpin family A member 6 Homo sapiens 40-51 7899442-4 1994 Possibility of penetration of only one CBG variant through syncytiotrophoblast membrane suggests the presence of different mechanisms of these glycoproteins" participation in the hormonal effects of steroids associated with them. Steroids 199-207 serpin family A member 6 Homo sapiens 39-42 8136299-0 1994 Identification of the cysteine in the steroid-binding site of human corticosteroid binding globulin by site-directed mutagenesis and site-specific chemical modification. Steroids 38-45 serpin family A member 6 Homo sapiens 68-99 8031716-1 1994 Human corticosteroid-binding globulin (CBG) contains four tryptophan residues at positions 141, 185, 266 and 371; one of which is thought to be located in the steroid-binding site. Steroids 13-20 serpin family A member 6 Homo sapiens 39-42 8031716-3 1994 Analyses of the resulting mutants indicate that Trp371 is most likely located in the steroid-binding site, and that hydrophobic interactions between Trp141 and the steroid molecule or other amino-acids in the CBG polypeptide may also contribute to high-affinity interactions between CBG and its steroid ligands. Steroids 85-92 serpin family A member 6 Homo sapiens 209-212 8031716-3 1994 Analyses of the resulting mutants indicate that Trp371 is most likely located in the steroid-binding site, and that hydrophobic interactions between Trp141 and the steroid molecule or other amino-acids in the CBG polypeptide may also contribute to high-affinity interactions between CBG and its steroid ligands. Steroids 164-171 serpin family A member 6 Homo sapiens 209-212 8031716-3 1994 Analyses of the resulting mutants indicate that Trp371 is most likely located in the steroid-binding site, and that hydrophobic interactions between Trp141 and the steroid molecule or other amino-acids in the CBG polypeptide may also contribute to high-affinity interactions between CBG and its steroid ligands. Steroids 164-171 serpin family A member 6 Homo sapiens 209-212 8180202-8 1994 As we have previously found, glycosylation at Asn238 is essential for the production of CBG with steroid-binding activity, but when the mutant containing only one oligosaccharide at this position was enzymatically deglycosylated, its steroid-binding activity was unaltered. Steroids 97-104 serpin family A member 6 Homo sapiens 88-91 8180202-9 1994 This suggests that interaction between this carbohydrate chain and the polypeptide is necessary for the folding and creation of the steroid-binding site only during CBG biosynthesis. Steroids 132-139 serpin family A member 6 Homo sapiens 165-168 1620285-7 1992 Very probably, pathological production or excessive dosage of steroids that are negligibly bound to SHBG or CBG will produce CSF and brain levels in the near micromolar range. Steroids 62-70 serpin family A member 6 Homo sapiens 108-111 8268315-0 1993 [The effect of steroids on binding of transcortin with human syncytiotrophoblasts]. Steroids 15-23 serpin family A member 6 Homo sapiens 38-49 8268315-2 1993 It was shown that native CBG variants stripped of steroids lose their ability to interact with specific membrane sites. Steroids 50-58 serpin family A member 6 Homo sapiens 25-28 8318949-3 1993 The excellent agreement (r = 0.98) seen between the present study and a binding assay indicates that the polyclonal antibodies used recognize only intact steroid-binding CBG. Steroids 154-161 serpin family A member 6 Homo sapiens 170-173 1504007-5 1992 To assess the impact of each substitution on the steroid binding affinity of CBG, each mutation was introduced separately into a normal human CBG cDNA, and the normal and mutated cDNAs were expressed in Chinese hamster ovary cells. Steroids 49-56 serpin family A member 6 Homo sapiens 77-80 1504007-7 1992 We therefore conclude that residue 93 may play an important role in determining the structure of the CBG steroid binding site. Steroids 105-112 serpin family A member 6 Homo sapiens 101-104 1430842-1 1992 The abnormal concentrations of steroid hormones and free fatty acids in the plasma of HIV-infected subjects are associated with qualitative and quantitative alterations in two of the major steroid hormones carrier proteins, sex steroid-binding protein (SBP) and corticosteroid-binding globulin (CBG). Steroids 31-47 serpin family A member 6 Homo sapiens 262-293 1430842-1 1992 The abnormal concentrations of steroid hormones and free fatty acids in the plasma of HIV-infected subjects are associated with qualitative and quantitative alterations in two of the major steroid hormones carrier proteins, sex steroid-binding protein (SBP) and corticosteroid-binding globulin (CBG). Steroids 31-47 serpin family A member 6 Homo sapiens 295-298 1783881-1 1991 Earlier views indicated that globulin (corticosteroid-binding globulin (CBG) or sex hormone-binding globulin (SBG)) but not albumin binding in plasma, protects steroids from splanchnic metabolism in man. Steroids 160-168 serpin family A member 6 Homo sapiens 39-70 1778174-1 1991 Two steroid-binding proteins circulate in plasma, corticosteroid-binding globulin and sex hormone-binding globulin. Steroids 4-11 serpin family A member 6 Homo sapiens 50-81 1778174-8 1991 There are, as yet, no published reports on the control of CBG binding by steroids. Steroids 73-81 serpin family A member 6 Homo sapiens 58-61 1778174-9 1991 For both SHBG and CBG, if an appropriate steroid is present when the binding protein is itself bound to its receptor, rapid induction of adenylate cyclase activity and the accumulation of intracellular cAMP occur. Steroids 41-48 serpin family A member 6 Homo sapiens 18-21 1783881-1 1991 Earlier views indicated that globulin (corticosteroid-binding globulin (CBG) or sex hormone-binding globulin (SBG)) but not albumin binding in plasma, protects steroids from splanchnic metabolism in man. Steroids 160-168 serpin family A member 6 Homo sapiens 72-75 1783881-6 1991 The "complex", probably most realistic, model includes 13 steroids, which can simultaneously bind to plasma albumin, CBG and SBG. Steroids 58-66 serpin family A member 6 Homo sapiens 117-120 1862072-2 1991 To map the steroid-binding domain and to investigate the folding pathways of hCBG, we have established an expression system based on infection of insect cells with a recombinant baculovirus encoding hCBG. Steroids 11-18 serpin family A member 6 Homo sapiens 199-203 1862072-7 1991 Comparison of the steroid-binding properties of intracellular and secreted hCBG with that synthesized in vitro in the rabbit reticulocyte lysate system suggests that this protein undergoes a maturation process during transport through the secretory pathway. Steroids 18-25 serpin family A member 6 Homo sapiens 75-79 1646610-3 1991 We assume that this protein is a component of membrane recognition system for transcortin-steroid complexes. Steroids 90-97 serpin family A member 6 Homo sapiens 78-89 1958574-1 1991 Phylogenetic comparisons of the primary structure of corticosteroid binding globulin (CBG) have revealed several conserved domains that include sites for N-glycosylation and a region which probably represents a portion of the steroid binding site. Steroids 60-67 serpin family A member 6 Homo sapiens 86-89 1822399-2 1991 It is now not only demonstrated that this plasma glycoprotein, a steroid carrier, can be internalized by glucocorticoid target tissues, but it is also certain that CBG mRNA is synthesized by extra-hepatic tissues. Steroids 65-72 serpin family A member 6 Homo sapiens 164-167 1659892-7 1991 Collectively, these findings suggest that both normal CBG and pCBG are involved in the guided transport of steroid hormones to the target cells and transmembrane transfer of hormones and/or hormonal signals. Steroids 107-123 serpin family A member 6 Homo sapiens 54-57 2765544-3 1989 Transcortin binding to the membrane was steroid-dependent: transcortin-cortisol complex bound to the membranes substantially more weakly than transcortin-progesterone, and specific binding of transcortin devoid of steroid was not detected. Steroids 40-47 serpin family A member 6 Homo sapiens 0-11 2268356-4 1990 This suggests that transcortin-cortisol complex penetrates the plasma membrane and the transcortin-bound steroid can thus enter syncytiotrophoblast and exert its hormonal effects on this tissue. Steroids 105-112 serpin family A member 6 Homo sapiens 19-30 2268356-4 1990 This suggests that transcortin-cortisol complex penetrates the plasma membrane and the transcortin-bound steroid can thus enter syncytiotrophoblast and exert its hormonal effects on this tissue. Steroids 105-112 serpin family A member 6 Homo sapiens 87-98 2765544-3 1989 Transcortin binding to the membrane was steroid-dependent: transcortin-cortisol complex bound to the membranes substantially more weakly than transcortin-progesterone, and specific binding of transcortin devoid of steroid was not detected. Steroids 40-47 serpin family A member 6 Homo sapiens 59-70 2765544-3 1989 Transcortin binding to the membrane was steroid-dependent: transcortin-cortisol complex bound to the membranes substantially more weakly than transcortin-progesterone, and specific binding of transcortin devoid of steroid was not detected. Steroids 214-221 serpin family A member 6 Homo sapiens 0-11 3135173-2 1988 This study examines the effect of physiological concentrations of FFA on the binding of these steroids to purified CBG and to the serum of pregnant women. Steroids 94-102 serpin family A member 6 Homo sapiens 115-118 2710140-7 1989 Furthermore, the single cysteine in rat CBG corresponds to one of two cysteines in human CBG, and this may be significant because a cysteine is located in the human CBG steroid binding site. Steroids 169-176 serpin family A member 6 Homo sapiens 89-92 2710140-7 1989 Furthermore, the single cysteine in rat CBG corresponds to one of two cysteines in human CBG, and this may be significant because a cysteine is located in the human CBG steroid binding site. Steroids 169-176 serpin family A member 6 Homo sapiens 89-92 3135173-1 1988 The steroid hormones, progesterone (P4) and cortisol (F), have different biological activities but are both bound to human corticosteroid binding globulin (CBG) with similar affinity. Steroids 4-11 serpin family A member 6 Homo sapiens 123-154 3250027-0 1988 Human transcortin (CBG): fatty acids induce selective steroid binding changes associated with immunological modifications. Steroids 54-61 serpin family A member 6 Homo sapiens 6-17 3250027-0 1988 Human transcortin (CBG): fatty acids induce selective steroid binding changes associated with immunological modifications. Steroids 54-61 serpin family A member 6 Homo sapiens 19-22 3250041-6 1988 This paper describes a method for the chromatographic separation of the two variants of CBG without a loss of binding activity towards steroids for each of the two characteristic bands of this protein. Steroids 135-143 serpin family A member 6 Homo sapiens 88-91 3135173-4 1988 Unsaturated fatty acids (UFA) had a dose-dependent inhibitory effect (P less than 0.001) on steroid binding to CBG which was offset by saturated fatty acid-induced potentiation of binding (P less than 0.01) when both were present with CBG. Steroids 92-99 serpin family A member 6 Homo sapiens 111-114 3135173-1 1988 The steroid hormones, progesterone (P4) and cortisol (F), have different biological activities but are both bound to human corticosteroid binding globulin (CBG) with similar affinity. Steroids 4-11 serpin family A member 6 Homo sapiens 156-159 3135173-8 1988 Scatchard analysis of steroid binding to purified CBG indicated that the UFAs influenced the association constant (Ka) and the number of binding sites (n) for F and P4 binding differently. Steroids 22-29 serpin family A member 6 Homo sapiens 50-53 2967419-5 1988 The heritability index for variability of the plasma content of steroids was 45.4% (p less than .05) for total cortisol, 50.6% (P less than .05) for unbound plasma cortisol, 57.8% (P less than .05) for DHEA-S, and 32.4% (P greater than .05) for CBG. Steroids 64-72 serpin family A member 6 Homo sapiens 245-248 3379127-17 1988 However, small fractions of the respective steroids are bound to transcortin and albumin. Steroids 43-51 serpin family A member 6 Homo sapiens 65-76 2839166-1 1988 Corticosteroid-Binding globulin (CBG) is a plasma protein that binds certain steroid hormones, mainly cortisol and progesterone. Steroids 77-93 serpin family A member 6 Homo sapiens 0-31 2839166-1 1988 Corticosteroid-Binding globulin (CBG) is a plasma protein that binds certain steroid hormones, mainly cortisol and progesterone. Steroids 77-93 serpin family A member 6 Homo sapiens 33-36 2839166-4 1988 These events are critically dependent upon a steroid being bound to CBG. Steroids 45-52 serpin family A member 6 Homo sapiens 68-71 3056181-12 1988 At this time, we believe that CBG"s hormonal role is compatible with a hypothesis that encompasses the view that unbound steroid hormones can diffuse into cells in some tissues and that both free and bound steroid can enter cells in others. Steroids 121-137 serpin family A member 6 Homo sapiens 30-33 3125170-7 1988 This was in contrast to the results obtained with 3,20-18O-labeled progesterone and partially purified transcortin, where a complete loss of 18O label in the protein-bound steroid was found. Steroids 172-179 serpin family A member 6 Homo sapiens 103-114 3125170-9 1988 These results indicate a participation of steroid oxo groups in the binding of progesterone to transcortin. Steroids 42-49 serpin family A member 6 Homo sapiens 95-106 3125170-10 1988 Of the possible mechanisms discussed, imine bonds between the steroid and transcortin seem most likely although other types of interactions cannot be ruled out. Steroids 62-69 serpin family A member 6 Homo sapiens 74-85 3056181-12 1988 At this time, we believe that CBG"s hormonal role is compatible with a hypothesis that encompasses the view that unbound steroid hormones can diffuse into cells in some tissues and that both free and bound steroid can enter cells in others. Steroids 121-128 serpin family A member 6 Homo sapiens 30-33 2841062-9 1988 The association of reduced plasma cortisol and decreased CBG binding capacity in EH may be closely related to altered steroid metabolism, which may be partly explained by an abnormality resembling a relative deficiency in adrenal 17 alpha- and 11 beta-hydroxylation. Steroids 118-125 serpin family A member 6 Homo sapiens 57-60 3732369-8 1986 The disposition rate of these two steroids is thus similar, in spite of their metabolic control by different enzymatic pathways and major influence of saturable transcortin binding on prednisolone elimination. Steroids 34-42 serpin family A member 6 Homo sapiens 161-172 3665128-4 1987 These changes suggest that both endogenous and exogenous glucocorticoids can modulate circulating levels of CBG and may have important implications for patients receiving steroid therapy. Steroids 171-178 serpin family A member 6 Homo sapiens 108-111 3475428-3 1986 The association of reduced plasma cortisol and CBG binding capacity in EH may be closely related to altered steroid metabolism which may be partly explained by an abnormality mimicking a relative deficiency in adrenal 17 alpha- and 11 beta-hydroxylation. Steroids 108-115 serpin family A member 6 Homo sapiens 47-50 3579210-5 1987 There was, however, a linear relationship between TBC and the progesterone + cortisol sum, such that a unit increase in TBC was accompanied by an approximate unit increase in the total concentration of the two main transcortin binding steroids. Steroids 235-243 serpin family A member 6 Homo sapiens 215-226 3918139-6 1985 The steroid binding specificities of human and ape (CBG corticosterone greater than cortisol greater than progesterone greater than or equal to testosterone) were also different from those of Old World monkey CBG (corticosterone much greater than cortisol approximately equal to progesterone greater than testosterone). Steroids 4-11 serpin family A member 6 Homo sapiens 52-55 3940269-6 1986 Increasing amounts of each of the three unlabeled steroids produced progressive decrements in the binding of all three labeled steroids to transcortin. Steroids 50-58 serpin family A member 6 Homo sapiens 139-150 3940269-6 1986 Increasing amounts of each of the three unlabeled steroids produced progressive decrements in the binding of all three labeled steroids to transcortin. Steroids 127-135 serpin family A member 6 Homo sapiens 139-150 6503216-2 1984 The mean (+/- SD) plasma concentration of transcortin was 45.0 +/- 6.7 mg/l in women not taking oral contraceptive steroids and 41.2 +/- 6.7 mg/l in healthy male volunteers. Steroids 115-123 serpin family A member 6 Homo sapiens 42-53 3968514-6 1985 Investigation of the steroid binding characteristics of CBGv revealed a reduced association-rate constant (Ka = 1.05 X 10(9) l/mol) and dissociation half-time (12.5 min) when compared with normal CBG (Ka = 1.39 X 10(9) l/mol and 25 min at 0 degree C) but an apparently normal steroid binding specificity. Steroids 21-28 serpin family A member 6 Homo sapiens 56-59 3968514-6 1985 Investigation of the steroid binding characteristics of CBGv revealed a reduced association-rate constant (Ka = 1.05 X 10(9) l/mol) and dissociation half-time (12.5 min) when compared with normal CBG (Ka = 1.39 X 10(9) l/mol and 25 min at 0 degree C) but an apparently normal steroid binding specificity. Steroids 276-283 serpin family A member 6 Homo sapiens 56-59 6323875-1 1984 We used a sensitive radioimmunoassay for corticosteroid-binding-globulin (CBG) to demonstrate that a human hepatoma-derived cell line secretes a protein which: (a) the radioimmunoassay cannot distinguish from CBG; (b) has the same Stokes" radius as CBG; (c) is absorbed by a steroid affinity column which is specific for CBG. Steroids 48-55 serpin family A member 6 Homo sapiens 74-77 6645482-3 1983 A further purification on hydroxylapatite yielded pure transcortin with preserved steroid-binding activity. Steroids 82-89 serpin family A member 6 Homo sapiens 55-66 6419776-7 1983 In order to explain this discrepancy, we tested, in the present study, the specificity of PCMB on a blood plasma steroid binding protein: human transcortin. Steroids 113-120 serpin family A member 6 Homo sapiens 144-155 6676104-8 1983 The transcortin concentrations determined by the RIA (Y) and those by the conventional steroid-binding assay (X) revealed a good correlation (Y = 1.01 X + 6.25) in normal serum, and the immunoreactivity and steroid binding activity revealed a good correlation in heat and acid-inactivated transcortin. Steroids 87-94 serpin family A member 6 Homo sapiens 4-15 6676104-8 1983 The transcortin concentrations determined by the RIA (Y) and those by the conventional steroid-binding assay (X) revealed a good correlation (Y = 1.01 X + 6.25) in normal serum, and the immunoreactivity and steroid binding activity revealed a good correlation in heat and acid-inactivated transcortin. Steroids 207-214 serpin family A member 6 Homo sapiens 4-15 7074030-5 1982 They have one steroid binding site per CBG molecule. Steroids 14-21 serpin family A member 6 Homo sapiens 39-42 6887851-3 1983 Recent results, obtained in several laboratories, on the physicochemical properties of the human corticosteroid-binding globulin (CBG, transcortin) makes this glycoprotein perhaps the best known one among the steroid-binding serum proteins. Steroids 104-111 serpin family A member 6 Homo sapiens 130-133 6887851-3 1983 Recent results, obtained in several laboratories, on the physicochemical properties of the human corticosteroid-binding globulin (CBG, transcortin) makes this glycoprotein perhaps the best known one among the steroid-binding serum proteins. Steroids 104-111 serpin family A member 6 Homo sapiens 135-146 6887851-6 1983 Influence of the entrance of hydrophilic or hydrophobic substituents into the steroid molecule illuminates the difference between typically hydrophobic binders such as the progesterone-binding globulin (PBG) of the pregnant guinea-pig and typically hydrophilic binders such as CBG. Steroids 78-85 serpin family A member 6 Homo sapiens 277-280 6355814-8 1983 Entrance of hydroxy groups into the steroid molecule increases the affinity to CBG; the contributions to the free energy of complex formation, resulting from individual substitutions or other alterations in the steroid molecule, are additive. Steroids 36-43 serpin family A member 6 Homo sapiens 79-82 6355814-8 1983 Entrance of hydroxy groups into the steroid molecule increases the affinity to CBG; the contributions to the free energy of complex formation, resulting from individual substitutions or other alterations in the steroid molecule, are additive. Steroids 211-218 serpin family A member 6 Homo sapiens 79-82 710260-0 1978 [Nature of the steroid-binding center of human transcortin]. Steroids 15-22 serpin family A member 6 Homo sapiens 47-58 474674-1 1979 Corticosteroid-binding globulin (CBG) is produced by the liver in small concentrations and binds steroids with high affinity. Steroids 97-105 serpin family A member 6 Homo sapiens 0-31 474674-1 1979 Corticosteroid-binding globulin (CBG) is produced by the liver in small concentrations and binds steroids with high affinity. Steroids 97-105 serpin family A member 6 Homo sapiens 33-36 207879-1 1978 Association and dissociation rate constants of steroid complexes with progesterone-binding globulin (PBG) and with corticosteroid-binding globulin have been determined, utilizing the fluorescence quenching phenomenon observed on steroid binding to protein. Steroids 47-54 serpin family A member 6 Homo sapiens 115-146 618541-0 1978 Kinetic and equilibrium studies on steroid interaction with human corticosteroid-binding globulin. Steroids 35-42 serpin family A member 6 Homo sapiens 66-97 618541-1 1978 Kinetic and equilibrium studies on the interaction of steroids with human corticosteroid-binding globulin (CBG, transcortin) were performed with pH, temperature, and steroid structure as variables. Steroids 54-62 serpin family A member 6 Homo sapiens 74-105 618541-1 1978 Kinetic and equilibrium studies on the interaction of steroids with human corticosteroid-binding globulin (CBG, transcortin) were performed with pH, temperature, and steroid structure as variables. Steroids 54-62 serpin family A member 6 Homo sapiens 107-110 618541-1 1978 Kinetic and equilibrium studies on the interaction of steroids with human corticosteroid-binding globulin (CBG, transcortin) were performed with pH, temperature, and steroid structure as variables. Steroids 54-62 serpin family A member 6 Homo sapiens 112-123 618541-1 1978 Kinetic and equilibrium studies on the interaction of steroids with human corticosteroid-binding globulin (CBG, transcortin) were performed with pH, temperature, and steroid structure as variables. Steroids 54-61 serpin family A member 6 Homo sapiens 74-105 618541-1 1978 Kinetic and equilibrium studies on the interaction of steroids with human corticosteroid-binding globulin (CBG, transcortin) were performed with pH, temperature, and steroid structure as variables. Steroids 54-61 serpin family A member 6 Homo sapiens 107-110 618541-1 1978 Kinetic and equilibrium studies on the interaction of steroids with human corticosteroid-binding globulin (CBG, transcortin) were performed with pH, temperature, and steroid structure as variables. Steroids 54-61 serpin family A member 6 Homo sapiens 112-123 83166-6 1978 The ESR spectra width (2T) was used to evaluate the polarity of the spin label environment within the steroid binding site: a hydrophobic character was observed for transcortin whereas PBG exhibited a more hydrophilic steroid binding sits. Steroids 102-109 serpin family A member 6 Homo sapiens 165-176 7195404-0 1981 Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. Steroids 13-20 serpin family A member 6 Homo sapiens 107-138 7195404-0 1981 Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. Steroids 56-64 serpin family A member 6 Homo sapiens 107-138 7195404-2 1981 The binding affinities of 21 endogenous steroids for both testosterone-binding globulin (TeBG) and corticosteroid-binding globulin (CBG) were determined under equilibrium conditions using a solid phase method at physiological pH and temperature. Steroids 40-48 serpin family A member 6 Homo sapiens 99-130 7195404-2 1981 The binding affinities of 21 endogenous steroids for both testosterone-binding globulin (TeBG) and corticosteroid-binding globulin (CBG) were determined under equilibrium conditions using a solid phase method at physiological pH and temperature. Steroids 40-48 serpin family A member 6 Homo sapiens 132-135 7195404-3 1981 A computer program was used to solve the complex equilibrium interactions between these steroids and TeBG, CBG, and albumin. Steroids 88-96 serpin family A member 6 Homo sapiens 107-110 7195405-0 1981 Transport of steroid hormones: interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma. Steroids 13-29 serpin family A member 6 Homo sapiens 94-125 7195405-3 1981 From these data, the association constants of the compounds for binding to both TeBG and CBG were calculated and used to predict whether endogenous steroid transport would be altered by the therapeutic administration of the drug. Steroids 148-155 serpin family A member 6 Homo sapiens 89-92 6762710-4 1980 This is due partly to saturable binding of prednisolone to transcortin in plasma, which provides more unbound drug at higher plasma concentrations of steroid. Steroids 150-157 serpin family A member 6 Homo sapiens 59-70 420873-11 1979 The formation of the transcortin-steroid complex and its complete dissociation are accompanied by conformational changes of the protein globule. Steroids 33-40 serpin family A member 6 Homo sapiens 21-32 856038-0 1977 Analysis of rat serum transcortin-steroid hormone association by column chromatography. Steroids 34-49 serpin family A member 6 Homo sapiens 22-33 588587-1 1977 The binding site of transcortin has been studied by using bromoacetyltestosterone and bromoacetylated derivatives of progesterone which were monohydroxylated at different positions of the steroid nucleus. Steroids 188-195 serpin family A member 6 Homo sapiens 20-31 579752-0 1977 [Demonstration of steroid-binding specific proteins (SHBG and CBG) in the amniotic fluid (proceedings)]. Steroids 18-25 serpin family A member 6 Homo sapiens 62-65 28677244-5 2017 Corticosteroid-binding globulin (CBG) is a steroid binding protein that binds and transports cortisol in the blood circulation and is a potential target for endocrine disruption. Steroids 7-14 serpin family A member 6 Homo sapiens 33-36 179872-0 1975 Interaction of purified human transcortin with spin labelled steroids. Steroids 61-69 serpin family A member 6 Homo sapiens 30-41 1189530-1 1975 A combined adsorption-gel filtration technique has been developed for the quantitation of the cortisol-binding capacity of transcortin: Endogenous steroids are removed from plasma by adsorption on uncoated charcoal. Steroids 147-155 serpin family A member 6 Homo sapiens 123-134 33926473-6 2021 Given that CBG serves as the primary transporter of both GCs and reproductive hormones in birds, we aim to review the biological properties of avian CBGs in the context of steroid hormone transportation, stress responses and adaptation to harsh environments, and to provide insight into evolutionary adaptations in CBG functions occurred to accommodate physiological and endocrine changes in birds compared with mammals. Steroids 172-179 serpin family A member 6 Homo sapiens 149-152 31307013-6 2019 Qualitative differences in N-glycosylation at N238 also negatively affect the steroid-binding of CBG in the absence of an N-glycan at N347 caused by a T349A substitution. Steroids 78-85 serpin family A member 6 Homo sapiens 97-100 30452386-3 2019 Measurements of CBG levels are typically based on steroid-binding capacity or immunoassays. Steroids 50-57 serpin family A member 6 Homo sapiens 16-19 30452386-8 2019 We found no evidence of RCL-cleaved CBG in plasma using a heat-dependent polymerization assay, and CBG that resists immunoprecipitation with a monoclonal antibody designed to specifically recognize an intact RCL, bound steroids with a high affinity. Steroids 219-227 serpin family A member 6 Homo sapiens 99-102 30452386-10 2019 Human CBG with a NE-cleaved RCL and low affinity for steroids is absent in blood samples, and CBG ELISA discrepancies likely reflect structural differences that alter epitopes recognized by specific monoclonal antibodies. Steroids 53-61 serpin family A member 6 Homo sapiens 6-9 29678493-5 2018 The analysis shows that steroids such as testosterone with low affinity for corticosteroid-binding globulin (CBG) do not significantly influence the concentration of free cortisol. Steroids 24-32 serpin family A member 6 Homo sapiens 76-107 29678493-5 2018 The analysis shows that steroids such as testosterone with low affinity for corticosteroid-binding globulin (CBG) do not significantly influence the concentration of free cortisol. Steroids 24-32 serpin family A member 6 Homo sapiens 109-112 1069998-5 1976 Specificity of covalent binding to corticosteroid-binding globulin was established by competition analysis with various steroids. Steroids 120-128 serpin family A member 6 Homo sapiens 35-66 4406579-0 1974 The oestrogenic potency of various contraceptive steroids as determined by their effects on transcortin-binding capacity. Steroids 49-57 serpin family A member 6 Homo sapiens 92-103 30452386-2 2019 Human CBG has a reactive center loop (RCL) which, when cleaved by neutrophil elastase (NE), disrupts its steroid-binding activity. Steroids 105-112 serpin family A member 6 Homo sapiens 6-9 29273683-3 2018 Glycosylation of human CBG influences its steroid-binding activity, and there are N-glycosylation sites in the reactive center loops (RCLs) of human and rat CBGs. Steroids 42-49 serpin family A member 6 Homo sapiens 23-26 29273683-4 2018 Proteolysis of the RCL of human CBG causes a structural change that disrupts steroid binding. Steroids 77-84 serpin family A member 6 Homo sapiens 32-35 29273683-5 2018 We now show that mutations of conserved N-glycosylation sites at N238 in human CBG and N230 in rat CBG disrupt steroid binding. Steroids 111-118 serpin family A member 6 Homo sapiens 79-82 29273683-7 2018 Deglycosylation of fully glycosylated human CBG or human CBG with only one N-glycan at N238 with Endo H-reduced steroid-binding affinity, while PNGase F-mediated deglycosylation does not, indicating that steroid binding is preserved by deamidation of N238 when its N-glycan is removed. Steroids 112-119 serpin family A member 6 Homo sapiens 44-47 29273683-7 2018 Deglycosylation of fully glycosylated human CBG or human CBG with only one N-glycan at N238 with Endo H-reduced steroid-binding affinity, while PNGase F-mediated deglycosylation does not, indicating that steroid binding is preserved by deamidation of N238 when its N-glycan is removed. Steroids 112-119 serpin family A member 6 Homo sapiens 57-60 29273683-8 2018 When expressed in N-acetylglucosaminyltransferase-I-deficient Lec1 cells, human and rat CBGs, and a human CBG mutant with only one glycosylation site at N238, have higher (2-4 fold) steroid-binding affinities than when produced by sialylation-deficient Lec2 cells or glycosylation-competent CHO-S cells. Steroids 182-189 serpin family A member 6 Homo sapiens 88-91 29273683-9 2018 Thus, the presence and composition of an N-glycan in this conserved position both appear to influence the steroid binding of CBG. Steroids 106-113 serpin family A member 6 Homo sapiens 125-128 29192420-10 2017 It has been suggested, that mitotane also affects the peripheral metabolism of steroids, especially of transcortin (CBG). Steroids 79-87 serpin family A member 6 Homo sapiens 103-114 29192420-10 2017 It has been suggested, that mitotane also affects the peripheral metabolism of steroids, especially of transcortin (CBG). Steroids 79-87 serpin family A member 6 Homo sapiens 116-119 24816231-10 2016 New data may be expected on the effect of EDs on steroid hormone binding to selective plasma transport proteins, namely transcortin and sex hormone-binding globulin. Steroids 49-64 serpin family A member 6 Homo sapiens 120-131 27026706-0 2016 Identification of Avian Corticosteroid-binding Globulin (SerpinA6) Reveals the Molecular Basis of Evolutionary Adaptations in SerpinA6 Structure and Function as a Steroid-binding Protein. Steroids 163-170 serpin family A member 6 Homo sapiens 57-65 27026706-0 2016 Identification of Avian Corticosteroid-binding Globulin (SerpinA6) Reveals the Molecular Basis of Evolutionary Adaptations in SerpinA6 Structure and Function as a Steroid-binding Protein. Steroids 163-170 serpin family A member 6 Homo sapiens 126-134