PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7233455-2 1981 This reaction is specific for those steroids containing the C-17-dihydroxy acetone side chain. Steroids 36-44 cytokine like 1 Homo sapiens 60-64 6824082-4 1983 The term is thus best applied to those steroids with a side chain at C-17, which contains a carboxylic acid group, and to acidic derivatives of such compounds. Steroids 39-47 cytokine like 1 Homo sapiens 69-73 7262018-5 1981 The lipoidal derivative of estradiol was not oxidized by treatment with CrO3, which showed that the lipoidal moiety is linked to the C-17 of the steroid nucleus. Steroids 145-152 cytokine like 1 Homo sapiens 133-137 13824834-0 1959 [On the excretion of C-17 ketogenic steroids in the urine of healthy children: a contribution to the usefulness of various modifications of the Zimmermann reaction]. Steroids 36-44 cytokine like 1 Homo sapiens 21-25 881104-3 1977 The highest affinity is found for steroids with two hydroxyl-groups at C-3 and C-17 in the beta-position and a double bond at C-4-5 or C-5-6. Steroids 34-42 cytokine like 1 Homo sapiens 79-83 352664-15 1978 Overdoses of some drugs and antineoplastic agents appear to be indirect cytotoxic hepatotoxins, and the C-17 alkylated anabolic and contraceptive steroids are indirect, cholestatic hepatotoxins. Steroids 146-154 cytokine like 1 Homo sapiens 104-108 1133527-0 1975 Proceedings: Evidence of steroid C17, 20 lyase activity in ovine foeto-placental tissue. Steroids 25-32 cytokine like 1 Homo sapiens 33-36 4464332-2 1974 Effects of substituents at C-17 upon the rates of solvolysis of 3-tosyloxy steroids. Steroids 75-83 cytokine like 1 Homo sapiens 27-31 4154902-0 1974 [The slow dissociation of the NADH-dehydrogenase complex as a basis for the preferential transfer of hydrogen between the C-17 positions of steroids (author"s transl)]. Steroids 140-148 cytokine like 1 Homo sapiens 122-126 4355810-1 1973 Aggregation in aqueous solution of steroids with stigmastane type C-17 side chains and its influence on their enzymic transformations. Steroids 35-43 cytokine like 1 Homo sapiens 66-70 15439157-0 1950 Stereochemical course of reactions at steroid C17. Steroids 38-45 cytokine like 1 Homo sapiens 46-49 28710629-3 2017 Phytosterols contain the same four-ring nucleus as steroids, and may be converted to high-value steroids by removing the side chain at C17 and minor changes at other sites in the ring structure.Many bacteria, including Mycobacterium spp., are able to degrade phytosterols. Steroids 96-104 cytokine like 1 Homo sapiens 135-138 33556193-4 2021 A reagent and catalyst free protocol for the removal of the C17 side-chain of corticosteroids via anodic oxidation has been developed, enabling several one-pot, multistep procedures for the synthesis of androgen steroids. Steroids 85-93 cytokine like 1 Homo sapiens 60-63 33556193-5 2021 In addition, simultaneous anodic C17 side-chain cleavage and cathodic catalytic hydrogenation of a steroid has been demonstrated, rendering a convenient and highly atom economic procedure for the synthesis of saturated androgens. Steroids 99-106 cytokine like 1 Homo sapiens 33-36 24937183-4 2014 The results from this study showed that steroid 14a, having a carbamate function at C-17, was the most potent against PC-3 cell line (96.6%) while 8c and 8e showed much higher cytotoxic activity (100%) for MCF-7 cell line. Steroids 40-47 cytokine like 1 Homo sapiens 84-88 27892591-2 2016 Compared to other C-C cross-couplings, this method turned out to be an easy and competitive access to biologically interesting C-17 modified steroids. Steroids 141-149 cytokine like 1 Homo sapiens 127-131 25500266-6 2015 C17-C21 steroid substrates exhibited a fast chemistry step followed by slow product release as suggested by "burst" phase kinetics. Steroids 8-15 cytokine like 1 Homo sapiens 0-3 17715402-6 2007 DHEAS is identical to PS except that it contains a carbonyl oxygen instead of an acetyl group at C17 on the steroid D ring. Steroids 108-115 cytokine like 1 Homo sapiens 97-100 24189185-2 2014 These enzymes catalyze NADPH dependent reductions at the C3, C5, C17 and C20 positions on the steroid nucleus and side-chain. Steroids 94-101 cytokine like 1 Homo sapiens 65-68 24276076-1 2014 As the first in class steroid 17alpha-hydroxylase/C17,20-lyase (CYP17) inhibitor, abiraterone acetate (of which the active metabolite is abiraterone) has been shown to improve overall survival in patients with castration-resistant prostate cancer (CRPC)--in those who are chemotherapy-naive and those previously treated with docetaxel. Steroids 22-29 cytokine like 1 Homo sapiens 50-53 23023354-3 2012 Abiraterone acetate is an orally active, potent and selective inhibitor of 17 a hydroxylase and c 17, 20 lyase, which acts by decreasing the de novo production of androgens with no rise in steroids downstream. Steroids 189-197 cytokine like 1 Homo sapiens 96-110 18423938-3 2008 One of them derives from a Norrish I photoreaction which cleaves the C17-C20 bond of the steroid yielding the andro-derivative, a second product comes from a Yang-type photorearrangement which links C18 to C20 yielding a cyclobutane adduct. Steroids 89-96 cytokine like 1 Homo sapiens 69-72 17076760-2 2007 However, the presence, distribution and activity of cytochrome P450 17alpha-hydroxylase/C17, 20-lyase (P450(C17)), a key enzyme required for the conversion of pregnenolone (Delta(5)P) and progesterone (P) into these steroids, are poorly documented. Steroids 216-224 cytokine like 1 Homo sapiens 103-112 17629476-0 2007 Steroids with a carbamate function at C-17, a novel class of inhibitors for human and hamster steroid 5alpha-reductase. Steroids 0-8 cytokine like 1 Homo sapiens 38-42 16081050-2 2005 INCICH-D7 has a heterocyclic ketoester type fusion between positions C14 and C17 of the steroid nucleus, which confers this molecule stronger electronegativity than that of digitoxigenin. Steroids 88-95 cytokine like 1 Homo sapiens 77-80 14658657-3 2003 The selectivity towards acylation of the alpha- over the beta-position at C-17 makes the method adaptable to screening for anabolic steroids. Steroids 132-140 cytokine like 1 Homo sapiens 74-78 15876406-12 2005 The origins of some naturally occurring steroids hydroxylated at C-17, C-18 and C-19 are examined in the light of the suggestions made in this essay. Steroids 40-48 cytokine like 1 Homo sapiens 65-69 14614213-5 2003 From these findings, we hypothesized that the substance had the structure of a C-19 steroid with two hydroxyl groups at positions C-3 and C-11, one keto-group at C-17 and a double bond between C-4 and C-5 of the A ring. Steroids 84-91 cytokine like 1 Homo sapiens 162-166 9452426-1 1998 In the biosynthesis of steroid hormones, P450c17 is the single enzyme that catalyzes both the 17alpha-hydroxylation of 21-carbon steroids and the 17,20-lyase activity that cleaves the C17-C20 bond to produce C19 sex steroids. Steroids 23-30 cytokine like 1 Homo sapiens 184-187 11948019-5 2002 The optimal side-chain length for the inhibition of steroid sulfatase activity was found to be six carbons, which corresponds to the number of carbons that mimic the B, C and D steroid rings, between C6 and C17. Steroids 52-59 cytokine like 1 Homo sapiens 207-210 11145739-1 2001 Cytochrome P450 17alpha-hydroxylase/17-20 lyase (P450(C17)) is a critical branchpoint enzyme for steroid hormone biosynthesis. Steroids 97-112 cytokine like 1 Homo sapiens 49-58 11956172-4 2002 Our data revealed that many of the C17, C19, and C21 circulating steroids, at concentrations that are found in vivo, functioned as effective activators of the AR(ccr) but had little or no activity via the wild-type AR or GRalpha. Steroids 65-73 cytokine like 1 Homo sapiens 35-38 9656123-8 1998 However, steroidogenic enzymes, 17 alpha-hydroxylase (C17) and 3 beta-hydroxysteroid dehydrogenase (3 beta SD), were expressed only in 10 of 15 cases of histologically identified steroid cells. Steroids 9-16 cytokine like 1 Homo sapiens 54-57 9452426-1 1998 In the biosynthesis of steroid hormones, P450c17 is the single enzyme that catalyzes both the 17alpha-hydroxylation of 21-carbon steroids and the 17,20-lyase activity that cleaves the C17-C20 bond to produce C19 sex steroids. Steroids 129-137 cytokine like 1 Homo sapiens 184-187 8894099-0 1996 Inhibition of steroid C17(20) lyase with C-17-heteroaryl steroids. Steroids 14-21 cytokine like 1 Homo sapiens 41-45 11667606-2 1996 Steroids have been prepared that bear a dimethylphenylsiloxy (DPSO) group and additional C3 and/or C17 ketone functionalities. Steroids 0-8 cytokine like 1 Homo sapiens 99-102 8894099-1 1996 Steroids bearing a heteroaromatic substituent at C-17 were designed as inhibitors of C17(20) lyase. Steroids 0-8 cytokine like 1 Homo sapiens 49-53 8894099-3 1996 The position of the heterocycle with respect to the steroid skeleton was determined to be important for optimum affinity and, in general, compounds with the heterocycle attached to a trigonal center at C-17, had the best affinity for C17(20) lyase. Steroids 52-59 cytokine like 1 Homo sapiens 202-206 8071992-8 1994 In all cases, the steroid D ring is inserted into a hydrophobic cavity formed mainly by TrpH50, TyrH97, TrpH100 and PheH100b; a hydrogen bond interaction with AsnH35 to the keto group at position C17 or C20 orients the steroid in the pocket. Steroids 18-25 cytokine like 1 Homo sapiens 196-199 2268551-4 1990 A nearly linear correlation between the O3...O (substituted at C17) distance and the binding affinity of the tested steroids is observed; explanations for the lack of linear correlation of some steroids are given. Steroids 116-124 cytokine like 1 Homo sapiens 63-66 8262974-1 1993 Certain steroids having an oxo group at the C-17 or C-20 position such as pregnenolone and dehydroisoandrosterone inhibit the cholesterol transport from lysosomes to other cellular sites. Steroids 8-16 cytokine like 1 Homo sapiens 44-48 8217882-2 1993 The inhibition constants for 17 alpha-hydroxylase and C17,20-lyase with 5-ene-precursors of C21-steroids were 96 and 12.4 mumol/l, respectively. Steroids 96-104 cytokine like 1 Homo sapiens 54-57 2268551-4 1990 A nearly linear correlation between the O3...O (substituted at C17) distance and the binding affinity of the tested steroids is observed; explanations for the lack of linear correlation of some steroids are given. Steroids 194-202 cytokine like 1 Homo sapiens 63-66 3021166-2 1986 The changes of potency, resulting from systematic variations of the geometry of steroid skeleton and the character as well as the structure of side chains at C3 or/and C17 of steroid backbone, allowed the following major conclusions. Steroids 175-182 cytokine like 1 Homo sapiens 168-171 3021166-10 1986 Essentially, the geometries of the steroid nucleus determined the differential contributions of the side chains at C3 and C17 to the integral inhibitory potency on the two enzyme variants. Steroids 35-42 cytokine like 1 Homo sapiens 122-125 3795028-6 1986 The elongation of the ester chain from acetate to valerate in both position C-17 and C-21 leads to the increase in both the binding affinity for the receptor and the lipophilicity of steroids. Steroids 183-191 cytokine like 1 Homo sapiens 76-80 2268551-3 1990 Three major factors are implicated in the ability of the steroid to bind to the membrane sites: (1) the separation between the terminal oxygen atoms substituted at atoms C3 and C17, or attached to the substituent at C17, is found to be longer than 10 A for the medium and high affinity steroids; (2) the beta-orientation of the oxygen atom in the C17-substituent to the D-ring is favored over alpha-orientation; and (3) bulky substituents and nontypical configurations are not accepted by the binding sites. Steroids 57-64 cytokine like 1 Homo sapiens 177-180 2268551-3 1990 Three major factors are implicated in the ability of the steroid to bind to the membrane sites: (1) the separation between the terminal oxygen atoms substituted at atoms C3 and C17, or attached to the substituent at C17, is found to be longer than 10 A for the medium and high affinity steroids; (2) the beta-orientation of the oxygen atom in the C17-substituent to the D-ring is favored over alpha-orientation; and (3) bulky substituents and nontypical configurations are not accepted by the binding sites. Steroids 57-64 cytokine like 1 Homo sapiens 216-219 2268551-3 1990 Three major factors are implicated in the ability of the steroid to bind to the membrane sites: (1) the separation between the terminal oxygen atoms substituted at atoms C3 and C17, or attached to the substituent at C17, is found to be longer than 10 A for the medium and high affinity steroids; (2) the beta-orientation of the oxygen atom in the C17-substituent to the D-ring is favored over alpha-orientation; and (3) bulky substituents and nontypical configurations are not accepted by the binding sites. Steroids 57-64 cytokine like 1 Homo sapiens 216-219 2268551-3 1990 Three major factors are implicated in the ability of the steroid to bind to the membrane sites: (1) the separation between the terminal oxygen atoms substituted at atoms C3 and C17, or attached to the substituent at C17, is found to be longer than 10 A for the medium and high affinity steroids; (2) the beta-orientation of the oxygen atom in the C17-substituent to the D-ring is favored over alpha-orientation; and (3) bulky substituents and nontypical configurations are not accepted by the binding sites. Steroids 286-294 cytokine like 1 Homo sapiens 177-180