PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26408814-2 2015 In this work, we describe the discovery of diethylstilbestrol-based PXR modulators, which were designed from marine sulfated steroids with PXR agonistic activity, solomonsterols A and B, and our recently reported bazedoxifene scaffold-derived PXR antagonists. Steroids 125-133 nuclear receptor subfamily 1 group I member 2 Homo sapiens 68-71 31008491-6 2019 Recent studies have shown that PXR activation can regulate glucose metabolism, lipid metabolism, steroid endocrine homeostasis, detoxification of cholic acid and bilirubin, bone mineral balance, and immune inflammation in vivo. Steroids 97-104 nuclear receptor subfamily 1 group I member 2 Homo sapiens 31-34 29733390-0 2018 Increase in tacrolimus exposure after steroid tapering is influenced by CYP3A5 and pregnane X receptor genetic polymorphisms in renal transplant recipients. Steroids 38-45 nuclear receptor subfamily 1 group I member 2 Homo sapiens 83-102 27799961-0 2016 Heterozygous Inactivation of the Nuclear Receptor PXR/NR1I2 in a Patient With Anabolic Steroid-Induced Intrahepatic Cholestasis. Steroids 87-94 nuclear receptor subfamily 1 group I member 2 Homo sapiens 50-53 27799961-0 2016 Heterozygous Inactivation of the Nuclear Receptor PXR/NR1I2 in a Patient With Anabolic Steroid-Induced Intrahepatic Cholestasis. Steroids 87-94 nuclear receptor subfamily 1 group I member 2 Homo sapiens 54-59 27799961-6 2016 CONCLUSIONS: This case of PXR haploinsufficiency reveals transcriptional regulatory functions activated in the liver under xenobiotic stress by steroids, which appear to require two functional copies of the nuclear receptor gene. Steroids 144-152 nuclear receptor subfamily 1 group I member 2 Homo sapiens 26-29 27377607-0 2016 SXR rs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome. Steroids 39-46 nuclear receptor subfamily 1 group I member 2 Homo sapiens 0-3 27377607-4 2016 CONCLUSION: The analysis of SXR polymorphism is a promising tool to predict both the favourable response to corticosteroids and the risk of developing steroid resistance. Steroids 115-122 nuclear receptor subfamily 1 group I member 2 Homo sapiens 28-31 26408814-2 2015 In this work, we describe the discovery of diethylstilbestrol-based PXR modulators, which were designed from marine sulfated steroids with PXR agonistic activity, solomonsterols A and B, and our recently reported bazedoxifene scaffold-derived PXR antagonists. Steroids 125-133 nuclear receptor subfamily 1 group I member 2 Homo sapiens 139-142 26408814-2 2015 In this work, we describe the discovery of diethylstilbestrol-based PXR modulators, which were designed from marine sulfated steroids with PXR agonistic activity, solomonsterols A and B, and our recently reported bazedoxifene scaffold-derived PXR antagonists. Steroids 125-133 nuclear receptor subfamily 1 group I member 2 Homo sapiens 139-142 24828006-3 2014 We describe the discovery of novel bazedoxifene-scaffold-based PXR antagonists inspired by the marine sulfated steroids solomonsterol A and B as natural leads. Steroids 111-119 nuclear receptor subfamily 1 group I member 2 Homo sapiens 63-66 25294580-2 2015 In addition to its role in xenobiotic metabolism, PXR has pleiotropic functions in regulating immune/inflammatory responses, cell proliferation, bile acid/cholesterol metabolism, glucose and lipid metabolism, steroid/endocrine homeostasis, and bone metabolism. Steroids 209-216 nuclear receptor subfamily 1 group I member 2 Homo sapiens 50-53 24182399-1 2014 The nuclear receptor member human pregnane X receptor (hPXR) regulates enzymes and transporters involved in xenobiotic detoxification as well as maintains homeostatic balance of bile acids, thyroid and steroid hormones. Steroids 202-218 nuclear receptor subfamily 1 group I member 2 Homo sapiens 34-53 24182399-1 2014 The nuclear receptor member human pregnane X receptor (hPXR) regulates enzymes and transporters involved in xenobiotic detoxification as well as maintains homeostatic balance of bile acids, thyroid and steroid hormones. Steroids 202-218 nuclear receptor subfamily 1 group I member 2 Homo sapiens 55-59 23384967-2 2013 CYP3A4 enzyme is essential in the hydroxylation of steroid hormones and is regulated by PXR. Steroids 51-67 nuclear receptor subfamily 1 group I member 2 Homo sapiens 88-91 24025090-3 2013 In addition to xenobiotics, endogenous compounds such as steroid hormones and bile acids can also activate PXR and/or CAR. Steroids 57-73 nuclear receptor subfamily 1 group I member 2 Homo sapiens 107-110 23919967-7 2013 C81 cells also show decreased expression of the SXR nuclear hormone receptor and a panel of directly regulated SXR target genes that govern cholesterol efflux and steroid catabolism. Steroids 163-170 nuclear receptor subfamily 1 group I member 2 Homo sapiens 111-114 22223399-2 2014 The human pregnane X receptor (hPXR), for instance, is activated by a variety of environmental ligands such as steroids, pharmaceutical drugs, pesticides, alkylphenols, polychlorinated biphenyls and polybromo diethylethers. Steroids 111-119 nuclear receptor subfamily 1 group I member 2 Homo sapiens 10-29 22223399-2 2014 The human pregnane X receptor (hPXR), for instance, is activated by a variety of environmental ligands such as steroids, pharmaceutical drugs, pesticides, alkylphenols, polychlorinated biphenyls and polybromo diethylethers. Steroids 111-119 nuclear receptor subfamily 1 group I member 2 Homo sapiens 31-35 23320515-0 2013 Global metabolomics and targeted steroid profiling reveal that rifampin, a strong human PXR activator, alters endogenous urinary steroid markers. Steroids 129-136 nuclear receptor subfamily 1 group I member 2 Homo sapiens 88-91 23320515-6 2013 The analysis of the metabolic pathway and the metabolic ratio of steroids enabled the estimation of the induction of CYP1A/3A/7B/11B/2C and the inhibition of CYP17A/19A in response to PXR activation. Steroids 65-73 nuclear receptor subfamily 1 group I member 2 Homo sapiens 184-187 23007437-1 2012 The human pregnane X receptor (PXR) is a ligand dependent transcription factor that can be activated by structurally diverse agonists including steroid hormones, bile acids, herbal drugs, and prescription medications. Steroids 144-160 nuclear receptor subfamily 1 group I member 2 Homo sapiens 10-29 23000093-4 2012 Chemical, structural, and pharmacological characterization of sponge steroid libraries has allowed the identification of steroids that regulate FXR and PXR: selective FXR antagonists, FXR modulators, FXR antagonists endowed with PXR agonism, and selective PXR agonists. Steroids 121-129 nuclear receptor subfamily 1 group I member 2 Homo sapiens 152-155 23000093-7 2012 Identification of marine steroids endowed with dual FXR and PXR agonism-antagonism probably reflects the common identity of the unique ancestral precursor of these NRs. Steroids 25-33 nuclear receptor subfamily 1 group I member 2 Homo sapiens 60-63 22285937-2 2012 Decodification of interactions of these family with nuclear receptors shows that these steroids are potent agonists of human pregnane-X-receptor (PXR) and antagonists of human farnesoid-X-receptor (FXR) with the putative binding mode to nuclear receptors (NRs) obtained through docking experiments. Steroids 87-95 nuclear receptor subfamily 1 group I member 2 Homo sapiens 125-144 22285937-2 2012 Decodification of interactions of these family with nuclear receptors shows that these steroids are potent agonists of human pregnane-X-receptor (PXR) and antagonists of human farnesoid-X-receptor (FXR) with the putative binding mode to nuclear receptors (NRs) obtained through docking experiments. Steroids 87-95 nuclear receptor subfamily 1 group I member 2 Homo sapiens 146-149 23007437-1 2012 The human pregnane X receptor (PXR) is a ligand dependent transcription factor that can be activated by structurally diverse agonists including steroid hormones, bile acids, herbal drugs, and prescription medications. Steroids 144-160 nuclear receptor subfamily 1 group I member 2 Homo sapiens 31-34 21764778-1 2011 Pregnane X receptor (PXR), acting as a xenobiotic-activated transcription factor, regulates the hepatic metabolism of therapeutics as well as endobiotics such as steroid hormones. Steroids 162-178 nuclear receptor subfamily 1 group I member 2 Homo sapiens 0-19 22074953-5 2012 This role is fulfilled in Xenopus by CAR, which exhibits low basal activity and pronounced responsiveness to activators such as drugs and steroids, altogether resembling mammalian PXR. Steroids 138-146 nuclear receptor subfamily 1 group I member 2 Homo sapiens 180-183 21764778-1 2011 Pregnane X receptor (PXR), acting as a xenobiotic-activated transcription factor, regulates the hepatic metabolism of therapeutics as well as endobiotics such as steroid hormones. Steroids 162-178 nuclear receptor subfamily 1 group I member 2 Homo sapiens 21-24 21742782-1 2011 Steroid and xenobiotic receptor (SXR) is activated by endogenous and exogenous chemicals including steroids, bile acids, and prescription drugs. Steroids 99-107 nuclear receptor subfamily 1 group I member 2 Homo sapiens 0-31 21742782-1 2011 Steroid and xenobiotic receptor (SXR) is activated by endogenous and exogenous chemicals including steroids, bile acids, and prescription drugs. Steroids 99-107 nuclear receptor subfamily 1 group I member 2 Homo sapiens 33-36 21742782-2 2011 SXR is highly expressed in the liver and intestine, where it regulates cytochrome P450 3A4 (CYP3A4), which in turn controls xenobiotic and endogenous steroid hormone metabolism. Steroids 150-165 nuclear receptor subfamily 1 group I member 2 Homo sapiens 0-3 21428459-4 2011 Pharmacological and structure-activity relationship analysis demonstrate that these natural polyhydroxylated steroids are potent ligands of human nuclear pregnane receptor (PXR) and modulator of farnesoid-X-receptor (FXR). Steroids 109-117 nuclear receptor subfamily 1 group I member 2 Homo sapiens 173-176 21295138-5 2011 The biological and physiological implications of PXR activation are broad, ranging from drug metabolism and drug-drug interactions to the homeostasis of numerous endobiotics, such as glucose, lipids, steroids, bile acids, bilirubin, retinoic acid, and bone minerals. Steroids 200-208 nuclear receptor subfamily 1 group I member 2 Homo sapiens 49-52 20011107-1 2009 Transcriptional regulation of some genes involved in xenobiotic detoxification and apoptosis is performed via the human pregnane X receptor (PXR) which in turn is activated by structurally diverse agonists including steroid hormones. Steroids 216-232 nuclear receptor subfamily 1 group I member 2 Homo sapiens 120-139 21291553-8 2011 Tetraodon PXR was activated by a variety of bile acids and steroids, although not by the larger synthetic ligands that activate human PXR such as rifampicin. Steroids 59-67 nuclear receptor subfamily 1 group I member 2 Homo sapiens 10-13 20024649-2 2010 Among these receptors, the human pregnane X receptor (hPXR) is well described as a xenobiotic sensor to various classes of chemicals, including pharmaceuticals, pesticides, and steroids. Steroids 177-185 nuclear receptor subfamily 1 group I member 2 Homo sapiens 33-52 20024649-2 2010 Among these receptors, the human pregnane X receptor (hPXR) is well described as a xenobiotic sensor to various classes of chemicals, including pharmaceuticals, pesticides, and steroids. Steroids 177-185 nuclear receptor subfamily 1 group I member 2 Homo sapiens 54-58 19856963-1 2009 The steroid and xenobiotic-responsive human pregnane X receptor (PXR) binds a broad range of structurally diverse compounds. Steroids 4-11 nuclear receptor subfamily 1 group I member 2 Homo sapiens 44-63 19856963-1 2009 The steroid and xenobiotic-responsive human pregnane X receptor (PXR) binds a broad range of structurally diverse compounds. Steroids 4-11 nuclear receptor subfamily 1 group I member 2 Homo sapiens 65-68 20011107-1 2009 Transcriptional regulation of some genes involved in xenobiotic detoxification and apoptosis is performed via the human pregnane X receptor (PXR) which in turn is activated by structurally diverse agonists including steroid hormones. Steroids 216-232 nuclear receptor subfamily 1 group I member 2 Homo sapiens 141-144 20011107-6 2009 In this study, we present a comprehensive analysis focused on prediction of 115 steroids for ligand binding activity towards human PXR. Steroids 80-88 nuclear receptor subfamily 1 group I member 2 Homo sapiens 131-134 19702536-5 2009 Several drug-activated nuclear receptors including CAR, PXR, VDR, and GR recognize drug responsive elements within the 5" flanking promoter region of CYP2C genes to mediate the transcriptional upregulation of these genes in response to xenobiotics and steroids. Steroids 252-260 nuclear receptor subfamily 1 group I member 2 Homo sapiens 56-59 18565212-1 2008 BACKGROUND: The human pregnane X receptor (hPXR) is an orphan nuclear receptor that induces transcription of response elements present in steroid-inducible cytochrome P-450 gene promoters. Steroids 138-145 nuclear receptor subfamily 1 group I member 2 Homo sapiens 22-41 20871735-1 2009 The constitutive androstane receptor (CAR) and the pregnane x receptor (PXR) are activated by a variety of endogenous and exogenous ligands, such as steroid hormones, bile acids, pharmaceuticals, and environmental, dietary, and occupational chemicals. Steroids 149-165 nuclear receptor subfamily 1 group I member 2 Homo sapiens 51-70 20871735-1 2009 The constitutive androstane receptor (CAR) and the pregnane x receptor (PXR) are activated by a variety of endogenous and exogenous ligands, such as steroid hormones, bile acids, pharmaceuticals, and environmental, dietary, and occupational chemicals. Steroids 149-165 nuclear receptor subfamily 1 group I member 2 Homo sapiens 72-75 19297428-2 2009 PXR activation by endogenous and exogenous chemicals, including steroids, antibiotics, bile acids, and herbal compounds, results in induction of drug metabolism. Steroids 64-72 nuclear receptor subfamily 1 group I member 2 Homo sapiens 0-3 19240808-1 2009 The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary steroids, pharmaceutical agents, and xenobiotic compounds. Steroids 176-184 nuclear receptor subfamily 1 group I member 2 Homo sapiens 4-35 19240808-1 2009 The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary steroids, pharmaceutical agents, and xenobiotic compounds. Steroids 176-184 nuclear receptor subfamily 1 group I member 2 Homo sapiens 37-40 19240808-1 2009 The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary steroids, pharmaceutical agents, and xenobiotic compounds. Steroids 176-184 nuclear receptor subfamily 1 group I member 2 Homo sapiens 57-76 19240808-1 2009 The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary steroids, pharmaceutical agents, and xenobiotic compounds. Steroids 176-184 nuclear receptor subfamily 1 group I member 2 Homo sapiens 80-83 19240808-3 2009 The broad response profile of SXR has led to the development of "the steroid and xenobiotic sensor hypothesis". Steroids 69-76 nuclear receptor subfamily 1 group I member 2 Homo sapiens 30-33 19018724-3 2008 The regulatory function of PXR is implicated in normal physiology and diseases, such as drug-drug interactions, hepatic steatosis, vitamin D homeostasis, bile acids homeostasis, steroid hormones homeostasis and inflammatory bowel diseases. Steroids 178-194 nuclear receptor subfamily 1 group I member 2 Homo sapiens 27-30 18629309-1 2008 BACKGROUND: Nuclear receptor subfamily 1, group I, member 2 (NR1I2), commonly known as steroid and xenobiotic receptor (SXR) in humans, is a key ligand-dependent transcription factor responsible for the regulation of xenobiotic, steroid, and bile acid metabolism. Steroids 87-94 nuclear receptor subfamily 1 group I member 2 Homo sapiens 12-59 18629309-1 2008 BACKGROUND: Nuclear receptor subfamily 1, group I, member 2 (NR1I2), commonly known as steroid and xenobiotic receptor (SXR) in humans, is a key ligand-dependent transcription factor responsible for the regulation of xenobiotic, steroid, and bile acid metabolism. Steroids 87-94 nuclear receptor subfamily 1 group I member 2 Homo sapiens 61-66 18629309-1 2008 BACKGROUND: Nuclear receptor subfamily 1, group I, member 2 (NR1I2), commonly known as steroid and xenobiotic receptor (SXR) in humans, is a key ligand-dependent transcription factor responsible for the regulation of xenobiotic, steroid, and bile acid metabolism. Steroids 87-94 nuclear receptor subfamily 1 group I member 2 Homo sapiens 120-123 18565212-1 2008 BACKGROUND: The human pregnane X receptor (hPXR) is an orphan nuclear receptor that induces transcription of response elements present in steroid-inducible cytochrome P-450 gene promoters. Steroids 138-145 nuclear receptor subfamily 1 group I member 2 Homo sapiens 43-47 17576789-5 2007 In the present study, we have derived novel computational models for PXR agonists using different series of imidazoles, steroids, and a set of diverse molecules with experimental PXR agonist binding data. Steroids 120-128 nuclear receptor subfamily 1 group I member 2 Homo sapiens 69-72 17636047-2 2007 We demonstrated previously that steroid/xenobiotic metabolism by tumor tissue through the PXR-CYP3A pathway might play an important role in endometrial cancer and that PXR ligands enhance PXR-mediated transcription in a ligand- and promoter-dependent fashion, leading to differential regulation of individual PXR targets, especially CYP3A4 and MDR1. Steroids 32-39 nuclear receptor subfamily 1 group I member 2 Homo sapiens 90-93 17636047-2 2007 We demonstrated previously that steroid/xenobiotic metabolism by tumor tissue through the PXR-CYP3A pathway might play an important role in endometrial cancer and that PXR ligands enhance PXR-mediated transcription in a ligand- and promoter-dependent fashion, leading to differential regulation of individual PXR targets, especially CYP3A4 and MDR1. Steroids 32-39 nuclear receptor subfamily 1 group I member 2 Homo sapiens 168-171 17636047-2 2007 We demonstrated previously that steroid/xenobiotic metabolism by tumor tissue through the PXR-CYP3A pathway might play an important role in endometrial cancer and that PXR ligands enhance PXR-mediated transcription in a ligand- and promoter-dependent fashion, leading to differential regulation of individual PXR targets, especially CYP3A4 and MDR1. Steroids 32-39 nuclear receptor subfamily 1 group I member 2 Homo sapiens 168-171 17636047-2 2007 We demonstrated previously that steroid/xenobiotic metabolism by tumor tissue through the PXR-CYP3A pathway might play an important role in endometrial cancer and that PXR ligands enhance PXR-mediated transcription in a ligand- and promoter-dependent fashion, leading to differential regulation of individual PXR targets, especially CYP3A4 and MDR1. Steroids 32-39 nuclear receptor subfamily 1 group I member 2 Homo sapiens 168-171 15885729-1 2005 The pregnane X receptor (PXR) mediates the induction of enzymes involved in steroid metabolism and xenobiotic detoxification. Steroids 76-83 nuclear receptor subfamily 1 group I member 2 Homo sapiens 4-23 17088262-3 2007 The steroid- and bile acid-activated pregnane X receptor (PXR) plays critical roles in the detoxification of bile acids, cholesterol metabolites, and xenobiotics. Steroids 4-11 nuclear receptor subfamily 1 group I member 2 Homo sapiens 37-56 17088262-3 2007 The steroid- and bile acid-activated pregnane X receptor (PXR) plays critical roles in the detoxification of bile acids, cholesterol metabolites, and xenobiotics. Steroids 4-11 nuclear receptor subfamily 1 group I member 2 Homo sapiens 58-61 17298222-7 2006 The expressions of the genes for CAR and PXR are thus augmented by binding glucocorticoid receptor (GR) activated by a steroid hormone, e.g, cortisol generated in fasting, infection or different forms of stress. Steroids 119-134 nuclear receptor subfamily 1 group I member 2 Homo sapiens 41-44 17327420-4 2007 We report the crystal structure of the human PXR ligand-binding domain (LBD) in complex with 17beta-estradiol, a representative steroid ligand, at 2.65 A resolution. Steroids 128-135 nuclear receptor subfamily 1 group I member 2 Homo sapiens 45-48 17327420-8 2007 It was found that PXR"s placement of the steroid is remarkably distinct relative to other members of the nuclear receptor superfamily. Steroids 41-48 nuclear receptor subfamily 1 group I member 2 Homo sapiens 18-21 17526937-3 2006 Various endogenous steroids and drugs function as ligands of SXR. Steroids 19-27 nuclear receptor subfamily 1 group I member 2 Homo sapiens 61-64 16297466-1 2005 Pregnane and Xenobiotic Receptor (PXR) is a transcription factor that is activated by a diverse range of xenobiotics and endogenous metabolites including steroids, bile acids and about 50% of the prescription drugs. Steroids 154-162 nuclear receptor subfamily 1 group I member 2 Homo sapiens 34-37 15885729-1 2005 The pregnane X receptor (PXR) mediates the induction of enzymes involved in steroid metabolism and xenobiotic detoxification. Steroids 76-83 nuclear receptor subfamily 1 group I member 2 Homo sapiens 25-28 15885729-11 2005 Additionally, the evidence that organochlorine chemicals, particularly the ubiquitous triclosan, activate hPXR suggests that these environmental chemicals may, in part, exhibit their endocrine disruptor activities by altering PXR-regulated steroid hormone metabolism with potential adverse health effects in exposed individuals. Steroids 240-255 nuclear receptor subfamily 1 group I member 2 Homo sapiens 106-110 15885729-11 2005 Additionally, the evidence that organochlorine chemicals, particularly the ubiquitous triclosan, activate hPXR suggests that these environmental chemicals may, in part, exhibit their endocrine disruptor activities by altering PXR-regulated steroid hormone metabolism with potential adverse health effects in exposed individuals. Steroids 240-255 nuclear receptor subfamily 1 group I member 2 Homo sapiens 107-110 15650019-4 2005 Some steroids/EDCs strongly activated PXR-mediated transcription through the CYP3A4-responsive element compared with the MDR1-responsive element, whereas these steroids/EDCs also enhanced the CYP3A4 expression compared with the MDR1 expression. Steroids 5-13 nuclear receptor subfamily 1 group I member 2 Homo sapiens 38-41 16054614-5 2005 PXR and CAR received their names because of steroid ligands that activate and inhibit their transcriptional activity, respectively. Steroids 44-51 nuclear receptor subfamily 1 group I member 2 Homo sapiens 0-3 16054614-8 2005 Because PXR and CAR are activated by numerous steroids and endocrine disrupters, it appears that these receptors protect the integrity of the endocrine system. Steroids 46-54 nuclear receptor subfamily 1 group I member 2 Homo sapiens 8-11 16054614-10 2005 Furthermore, PXR and CAR induce enzymes, such as the CYP2B and CYP3A family members, responsible for the metabolism of steroid and thyroid hormones and this may alter their normal physiological function. Steroids 119-126 nuclear receptor subfamily 1 group I member 2 Homo sapiens 13-16 15650019-4 2005 Some steroids/EDCs strongly activated PXR-mediated transcription through the CYP3A4-responsive element compared with the MDR1-responsive element, whereas these steroids/EDCs also enhanced the CYP3A4 expression compared with the MDR1 expression. Steroids 160-168 nuclear receptor subfamily 1 group I member 2 Homo sapiens 38-41 15541768-6 2004 PXR is a xenosensing nuclear receptor that is activated by endobiotic (natural steroids) and xenobiotic (therapeutic drugs and environmental chemicals) molecules. Steroids 79-87 nuclear receptor subfamily 1 group I member 2 Homo sapiens 0-3 15832810-6 2005 Similarly, the steroid family of orphan nuclear receptors, the constitutive androstane receptor (CAR) and pregnane X receptor (PXR), both heterodimerize with the retinoid X receptor (RXR), are shown to transcriptionally activate the promoters of CYP2B and CYP3A gene expression by xenobiotics such as phenobarbital-like compounds (CAR) and dexamethasone and rifampin-type of agents (PXR). Steroids 15-22 nuclear receptor subfamily 1 group I member 2 Homo sapiens 106-125 15832810-6 2005 Similarly, the steroid family of orphan nuclear receptors, the constitutive androstane receptor (CAR) and pregnane X receptor (PXR), both heterodimerize with the retinoid X receptor (RXR), are shown to transcriptionally activate the promoters of CYP2B and CYP3A gene expression by xenobiotics such as phenobarbital-like compounds (CAR) and dexamethasone and rifampin-type of agents (PXR). Steroids 15-22 nuclear receptor subfamily 1 group I member 2 Homo sapiens 127-130 15832810-6 2005 Similarly, the steroid family of orphan nuclear receptors, the constitutive androstane receptor (CAR) and pregnane X receptor (PXR), both heterodimerize with the retinoid X receptor (RXR), are shown to transcriptionally activate the promoters of CYP2B and CYP3A gene expression by xenobiotics such as phenobarbital-like compounds (CAR) and dexamethasone and rifampin-type of agents (PXR). Steroids 15-22 nuclear receptor subfamily 1 group I member 2 Homo sapiens 383-386 15713537-9 2005 These findings demonstrated age-related differences in the body"s capacity to metabolize steroids and xenobiotic compounds and suggest an important role for SXR and its target genes, CYP3A4 and MDR1 in this process. Steroids 89-97 nuclear receptor subfamily 1 group I member 2 Homo sapiens 157-160 16399372-1 2005 The pregnane X receptor (PXR, receptor NR1I2) is a ligand-activated transcription factor that is activated by structurally diverse endogenous steroids and foreign chemicals and serves as an important steroid and xenobiotic sensor. Steroids 142-150 nuclear receptor subfamily 1 group I member 2 Homo sapiens 4-23 16399372-1 2005 The pregnane X receptor (PXR, receptor NR1I2) is a ligand-activated transcription factor that is activated by structurally diverse endogenous steroids and foreign chemicals and serves as an important steroid and xenobiotic sensor. Steroids 142-150 nuclear receptor subfamily 1 group I member 2 Homo sapiens 25-28 16399372-1 2005 The pregnane X receptor (PXR, receptor NR1I2) is a ligand-activated transcription factor that is activated by structurally diverse endogenous steroids and foreign chemicals and serves as an important steroid and xenobiotic sensor. Steroids 142-150 nuclear receptor subfamily 1 group I member 2 Homo sapiens 39-44 16399372-1 2005 The pregnane X receptor (PXR, receptor NR1I2) is a ligand-activated transcription factor that is activated by structurally diverse endogenous steroids and foreign chemicals and serves as an important steroid and xenobiotic sensor. Steroids 142-149 nuclear receptor subfamily 1 group I member 2 Homo sapiens 4-23 16399372-1 2005 The pregnane X receptor (PXR, receptor NR1I2) is a ligand-activated transcription factor that is activated by structurally diverse endogenous steroids and foreign chemicals and serves as an important steroid and xenobiotic sensor. Steroids 142-149 nuclear receptor subfamily 1 group I member 2 Homo sapiens 25-28 16399372-1 2005 The pregnane X receptor (PXR, receptor NR1I2) is a ligand-activated transcription factor that is activated by structurally diverse endogenous steroids and foreign chemicals and serves as an important steroid and xenobiotic sensor. Steroids 142-149 nuclear receptor subfamily 1 group I member 2 Homo sapiens 39-44 15331348-1 2005 Bile acids, steroids, and drugs activate steroid and xenobiotic receptor pregnane X receptor (PXR; NR1I2), which induces human cytochrome P4503A4 (CYP3A4) in drug metabolism and cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis in the liver. Steroids 12-20 nuclear receptor subfamily 1 group I member 2 Homo sapiens 73-92 15331348-1 2005 Bile acids, steroids, and drugs activate steroid and xenobiotic receptor pregnane X receptor (PXR; NR1I2), which induces human cytochrome P4503A4 (CYP3A4) in drug metabolism and cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis in the liver. Steroids 12-20 nuclear receptor subfamily 1 group I member 2 Homo sapiens 94-97 15331348-1 2005 Bile acids, steroids, and drugs activate steroid and xenobiotic receptor pregnane X receptor (PXR; NR1I2), which induces human cytochrome P4503A4 (CYP3A4) in drug metabolism and cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis in the liver. Steroids 12-20 nuclear receptor subfamily 1 group I member 2 Homo sapiens 99-104 15331348-1 2005 Bile acids, steroids, and drugs activate steroid and xenobiotic receptor pregnane X receptor (PXR; NR1I2), which induces human cytochrome P4503A4 (CYP3A4) in drug metabolism and cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis in the liver. Steroids 12-19 nuclear receptor subfamily 1 group I member 2 Homo sapiens 73-92 15331348-1 2005 Bile acids, steroids, and drugs activate steroid and xenobiotic receptor pregnane X receptor (PXR; NR1I2), which induces human cytochrome P4503A4 (CYP3A4) in drug metabolism and cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis in the liver. Steroids 12-19 nuclear receptor subfamily 1 group I member 2 Homo sapiens 94-97 15331348-1 2005 Bile acids, steroids, and drugs activate steroid and xenobiotic receptor pregnane X receptor (PXR; NR1I2), which induces human cytochrome P4503A4 (CYP3A4) in drug metabolism and cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis in the liver. Steroids 12-19 nuclear receptor subfamily 1 group I member 2 Homo sapiens 99-104 15548381-8 2004 These results suggest that CYP3A4 and CYP2B6 regulation through PXR activation by persistent pesticides may have an impact on the metabolism of xenobiotic agents and endogenous steroid hormones. Steroids 177-193 nuclear receptor subfamily 1 group I member 2 Homo sapiens 64-67 12970323-3 2003 On the other hand, pregnane X receptor (PXR), a new member of nuclear receptors, has been shown to mediate the genomic effects of steroid hormones, including estrogen and xenobiotics. Steroids 130-146 nuclear receptor subfamily 1 group I member 2 Homo sapiens 19-38 15364542-10 2004 The responsiveness of PXR to activation by phthalate monoesters demonstrated here suggests that these ubiquitous environmental chemicals may, in part, exhibit their endocrine disruptor activities by altering PXR-regulated steroid hormone metabolism with potential adverse health effects in exposed individuals. Steroids 222-237 nuclear receptor subfamily 1 group I member 2 Homo sapiens 22-25 15364542-10 2004 The responsiveness of PXR to activation by phthalate monoesters demonstrated here suggests that these ubiquitous environmental chemicals may, in part, exhibit their endocrine disruptor activities by altering PXR-regulated steroid hormone metabolism with potential adverse health effects in exposed individuals. Steroids 222-237 nuclear receptor subfamily 1 group I member 2 Homo sapiens 208-211 15135080-8 2004 The induction of the steroid biotransformation enzymes is partly mediated through the activation of a group of nuclear receptors including the glucocorticoid receptor, the constitutive androstane receptor (CAR), the pregnane X receptor (PXR), and the peroxisome proliferator activated receptors (PPAR). Steroids 21-28 nuclear receptor subfamily 1 group I member 2 Homo sapiens 216-235 15135080-8 2004 The induction of the steroid biotransformation enzymes is partly mediated through the activation of a group of nuclear receptors including the glucocorticoid receptor, the constitutive androstane receptor (CAR), the pregnane X receptor (PXR), and the peroxisome proliferator activated receptors (PPAR). Steroids 21-28 nuclear receptor subfamily 1 group I member 2 Homo sapiens 237-240 14754570-4 2004 Thus, exposure to PCBs may blunt the human xenobiotic response, inhibiting the detoxification of steroids, bioactive dietary compounds, and xenobiotics normally mediated by SXR. Steroids 97-105 nuclear receptor subfamily 1 group I member 2 Homo sapiens 173-176 15350151-8 2004 The St John"s wort constituent hyperforin is probably responsible for CYP3A4 induction via activation of a nuclear steroid/pregnane and xenobiotic receptor (SXR/PXR) and hypericin may be assumed to be the P-glycoprotein inducing compound, although the available evidence is less convincing. Steroids 115-122 nuclear receptor subfamily 1 group I member 2 Homo sapiens 161-164 15364542-3 2004 The present study investigates the effects of phthalates on the pregnane X receptor (PXR), which mediates the induction of enzymes involved in steroid metabolism and xenobiotic detoxification. Steroids 143-150 nuclear receptor subfamily 1 group I member 2 Homo sapiens 64-83 15364542-3 2004 The present study investigates the effects of phthalates on the pregnane X receptor (PXR), which mediates the induction of enzymes involved in steroid metabolism and xenobiotic detoxification. Steroids 143-150 nuclear receptor subfamily 1 group I member 2 Homo sapiens 85-88 12970323-3 2003 On the other hand, pregnane X receptor (PXR), a new member of nuclear receptors, has been shown to mediate the genomic effects of steroid hormones, including estrogen and xenobiotics. Steroids 130-146 nuclear receptor subfamily 1 group I member 2 Homo sapiens 40-43 12970323-8 2003 These data suggest that the steroid/xenobiotics metabolism in the tumor tissue through PXR-CYP3A pathway might play an important role, especially in alternative pathway for gonadal hormone and endocrine-disrupting chemical effects on endometrial cancer expressing low ER alpha. Steroids 28-35 nuclear receptor subfamily 1 group I member 2 Homo sapiens 87-90 12644700-4 2003 Transgenic mice expressing a constitutively active form of human PXR show markedly increased UGT activity toward steroid, heme, and carcinogens, enhanced bilirubin clearance, as well as massively increased steroid clearance. Steroids 113-120 nuclear receptor subfamily 1 group I member 2 Homo sapiens 65-68 12644700-4 2003 Transgenic mice expressing a constitutively active form of human PXR show markedly increased UGT activity toward steroid, heme, and carcinogens, enhanced bilirubin clearance, as well as massively increased steroid clearance. Steroids 206-213 nuclear receptor subfamily 1 group I member 2 Homo sapiens 65-68 9489701-2 1998 We describe a novel orphan nuclear receptor, termed the pregnane X receptor (PXR), that is activated by naturally occurring steroids such as pregnenolone and progesterone, and synthetic glucocorticoids and antiglucocorticoids. Steroids 124-132 nuclear receptor subfamily 1 group I member 2 Homo sapiens 56-75 12372848-2 2002 PXR is activated by a large number of endogenous and exogenous chemicals including steroids, antibiotics, antimycotics, bile acids, and the herbal antidepressant St. John"s wort. Steroids 83-91 nuclear receptor subfamily 1 group I member 2 Homo sapiens 0-3 11807162-3 2002 Various lipophilic compounds produced by the body, such as bile acids and steroids, also activate PXR. Steroids 74-82 nuclear receptor subfamily 1 group I member 2 Homo sapiens 98-101 11891851-2 2002 CAR and PXR have a rather broad, overlapping set of ligands that range from natural steroids to xenobiotics and also recognize similar DNA binding sites, referred to as response elements (REs), primarily in promoter regions of cytochrome P450 (CYP) genes. Steroids 84-92 nuclear receptor subfamily 1 group I member 2 Homo sapiens 8-11 11891851-8 2002 Since an iNOS-induced production of NO is known to influence inflammation and apoptosis, a CAR- and PXR-regulated iNOS activity may explain a modulatory effect of steroids and xenobiotics on these cellular processes. Steroids 163-171 nuclear receptor subfamily 1 group I member 2 Homo sapiens 100-103 11248085-1 2001 The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals. Steroids 68-76 nuclear receptor subfamily 1 group I member 2 Homo sapiens 4-23 11248085-1 2001 The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals. Steroids 68-76 nuclear receptor subfamily 1 group I member 2 Homo sapiens 25-28 10748001-0 2000 Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. Steroids 103-110 nuclear receptor subfamily 1 group I member 2 Homo sapiens 62-81 10748001-2 2000 In this report, we have systematically compared a series of xenobiotics and natural steroids for their effects on mouse and human CAR and PXR. Steroids 84-92 nuclear receptor subfamily 1 group I member 2 Homo sapiens 138-141 10403778-1 1999 Pregnane X Receptor (PXR) has been recently shown to regulate the inducible expression of CYP3A genes in response to xenobiotics and steroids. Steroids 133-141 nuclear receptor subfamily 1 group I member 2 Homo sapiens 0-25 11457660-8 2001 We thus provided evidence that androstenol, the ligand for CAR and PXR, is produced by the biosynthetic pathway of sex steroids. Steroids 119-127 nuclear receptor subfamily 1 group I member 2 Homo sapiens 67-70 9784494-0 1998 SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Steroids 13-20 nuclear receptor subfamily 1 group I member 2 Homo sapiens 0-3 9784494-6 1998 SXR forms a heterodimer with RXR that can bind to and induce transcription from response elements present in steroid-inducible cytochrome P-450 genes and is expressed in tissues in which these catabolic enzymes are expressed. Steroids 109-116 nuclear receptor subfamily 1 group I member 2 Homo sapiens 0-3 9489701-2 1998 We describe a novel orphan nuclear receptor, termed the pregnane X receptor (PXR), that is activated by naturally occurring steroids such as pregnenolone and progesterone, and synthetic glucocorticoids and antiglucocorticoids. Steroids 124-132 nuclear receptor subfamily 1 group I member 2 Homo sapiens 77-80 9489701-3 1998 PXR exists as two isoforms, PXR.1 and PXR.2, that are differentially activated by steroids. Steroids 82-90 nuclear receptor subfamily 1 group I member 2 Homo sapiens 0-3 34524495-10 2021 The mechanism studies showed that megestrol activated hPXR by binding to the ligand binding domain (LBD) of hPXR and increasing the recruitment of the cofactors such as steroid receptor cofactor (SRC-1). Steroids 169-176 nuclear receptor subfamily 1 group I member 2 Homo sapiens 54-58 33812052-2 2021 Aside from its toxic actions, CS may alter expression of the drug- and steroid-binding pregnane X receptor (PXR), which when activated upregulates expression of cytochrome P450 (CYP) enzymes, glutathione transferases (GSTs), and multidrug resistance protein 1 (MDR1), an adaptive metabolic array that mediates clearance of CS component toxins. Steroids 71-78 nuclear receptor subfamily 1 group I member 2 Homo sapiens 87-106 33812052-2 2021 Aside from its toxic actions, CS may alter expression of the drug- and steroid-binding pregnane X receptor (PXR), which when activated upregulates expression of cytochrome P450 (CYP) enzymes, glutathione transferases (GSTs), and multidrug resistance protein 1 (MDR1), an adaptive metabolic array that mediates clearance of CS component toxins. Steroids 71-78 nuclear receptor subfamily 1 group I member 2 Homo sapiens 108-111 33076284-3 2020 PXR is involved in pivotal cellular detoxification processes to include the regulation of genes that encode key drug-metabolizing cytochrome-P450 enzymes, oxidative stress response, as well as enzymes that drive steroid and bile acid metabolism. Steroids 212-219 nuclear receptor subfamily 1 group I member 2 Homo sapiens 0-3 34084152-6 2021 Using these cellular models, we tested the hPXR and zfPXR activity of various steroids and pesticides. Steroids 78-86 nuclear receptor subfamily 1 group I member 2 Homo sapiens 43-47 32352317-3 2020 The steroid and xenobiotic receptor [SXR; also known as the pregnane X receptor (PXR) and formally known as NR1I2] is a nuclear hormone receptor that regulates inducible metabolism of drugs and xenobiotics and is activated or inhibited by various PCB congeners. Steroids 4-11 nuclear receptor subfamily 1 group I member 2 Homo sapiens 37-40 32848756-11 2020 Steroids induce the metabolism of tacrolimus via pregnane X receptor mediated increased CYP3A4 expression, resulting in lower tacrolimus C0/D ratio in high risk patients. Steroids 0-8 nuclear receptor subfamily 1 group I member 2 Homo sapiens 49-68