PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6930181-0 1980 Photosensitive steroids as probes of estrogen receptor sites. Steroids 15-23 estrogen receptor 1 Homo sapiens 37-54 574598-0 1979 Factors that may influence the estradiol receptor assay in human tissues:sex hormone binding globulin and endogenous steroids. Steroids 117-125 estrogen receptor 1 Homo sapiens 31-49 397197-3 1979 Since the affinity constant for estradiol of antiestradiol antibodies is about 10(8) M-1 while those for breast estrogen-receptor complexes are about 10(9) to 10(10) M-1, it is possible to remove the free steroid from a reaction mixture containing tissue cytosol, radio-labelled estradiol, and the antiestradiol bacterial adsorbent by pelleting the bacteria at low-speed centrifugation. Steroids 205-212 estrogen receptor 1 Homo sapiens 112-129 4366805-0 1974 The steroid specificity of the estrogen-receptor of human breast carcinoma. Steroids 4-11 estrogen receptor 1 Homo sapiens 31-48 598398-0 1977 Correlation between urinary steroids and estrogen receptor content in women with early breast cancer. Steroids 28-36 estrogen receptor 1 Homo sapiens 41-58 870192-6 1977 All three steroids bind to a high-affinity estrogen receptor found in these cells. Steroids 10-18 estrogen receptor 1 Homo sapiens 43-60 168960-1 1975 In estrogen target tissues and hormone-dependent tumors, the steroid enters the cells and binds to a cytoplasmic protein called the estrogen receptor (ER). Steroids 61-68 estrogen receptor 1 Homo sapiens 132-149 168960-1 1975 In estrogen target tissues and hormone-dependent tumors, the steroid enters the cells and binds to a cytoplasmic protein called the estrogen receptor (ER). Steroids 61-68 estrogen receptor 1 Homo sapiens 151-153 33593922-2 2021 Among them, steroid nuclear receptors, such as the estrogen receptor alpha (ERalpha), are central to the etiology of hormone-dependent cancers which are accordingly treated with corresponding endocrine therapies. Steroids 12-19 estrogen receptor 1 Homo sapiens 51-74 33257172-7 2021 However, because of activation/inhibition of steroid hormonal receptor ER-alpha or ER-beta, these compounds induce or inhibit steroid hormonal (estrogen) action and, therefore, have the potential to disrupt hormone (estrogen) signalling pathway. Steroids 126-133 estrogen receptor 1 Homo sapiens 83-90 34038515-3 2021 Nuclear receptors, such as estrogen receptor alpha, can also be anchored to the plasma membrane, where they respond to steroids by activating signaling pathways independent of their function as transcription factors. Steroids 119-127 estrogen receptor 1 Homo sapiens 27-50 33739385-5 2022 Sex steroids such as androgens, progestins, and estrogen and their receptors (ERalpha, ERbeta, GPER; PR-A, PR-B; AR) have been identified as important modifiers of angiogenesis, and sex differences have been reported for anti-angiogenic drugs. Steroids 4-12 estrogen receptor 1 Homo sapiens 78-85 33739385-5 2022 Sex steroids such as androgens, progestins, and estrogen and their receptors (ERalpha, ERbeta, GPER; PR-A, PR-B; AR) have been identified as important modifiers of angiogenesis, and sex differences have been reported for anti-angiogenic drugs. Steroids 4-12 estrogen receptor 1 Homo sapiens 87-93 33593922-2 2021 Among them, steroid nuclear receptors, such as the estrogen receptor alpha (ERalpha), are central to the etiology of hormone-dependent cancers which are accordingly treated with corresponding endocrine therapies. Steroids 12-19 estrogen receptor 1 Homo sapiens 76-83 33184106-0 2021 Steroid hormone receptor and infiltrating immune cell status reveals therapeutic vulnerabilities of ESR1 mutant breast cancer. Steroids 0-7 estrogen receptor 1 Homo sapiens 100-104 32593802-0 2020 The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure. Steroids 53-60 estrogen receptor 1 Homo sapiens 76-80 33194742-1 2020 Estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) belong to a superfamily of nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the transcription of a large number of genes, thus modulating critical physiologic processes. Steroids 122-129 estrogen receptor 1 Homo sapiens 0-23 33194742-1 2020 Estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) belong to a superfamily of nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the transcription of a large number of genes, thus modulating critical physiologic processes. Steroids 122-129 estrogen receptor 1 Homo sapiens 25-32 33194742-1 2020 Estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) belong to a superfamily of nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the transcription of a large number of genes, thus modulating critical physiologic processes. Steroids 122-129 estrogen receptor 1 Homo sapiens 38-60 33194742-1 2020 Estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) belong to a superfamily of nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the transcription of a large number of genes, thus modulating critical physiologic processes. Steroids 122-129 estrogen receptor 1 Homo sapiens 62-68 31899528-1 2020 Importance: Steroid hormone receptors, including estrogen receptor (ER) and progesterone receptor (PR), are crucial biomarkers in breast cancer (BC). Steroids 12-19 estrogen receptor 1 Homo sapiens 49-66 32687858-3 2020 A homolog of the vertebrate nuclear estrogen receptor has been found in mollusks, but it does not bind to estrogens or indeed to any steroid at all. Steroids 133-140 estrogen receptor 1 Homo sapiens 36-53 32630554-5 2020 Correlations were found between MSX1 expression and the expression of beta-Catenin, p21, p53, and the steroid receptors ERalpha, ERbeta, PRalpha, and PRbeta. Steroids 102-109 estrogen receptor 1 Homo sapiens 120-127 32630554-5 2020 Correlations were found between MSX1 expression and the expression of beta-Catenin, p21, p53, and the steroid receptors ERalpha, ERbeta, PRalpha, and PRbeta. Steroids 102-109 estrogen receptor 1 Homo sapiens 129-135 31879182-1 2020 17beta-Estradiol (E2) is a natural steroid ligand for the structurally and physiologically independent estrogen receptors (ERs) ERalpha and ERbeta. Steroids 35-42 estrogen receptor 1 Homo sapiens 128-135 31879182-1 2020 17beta-Estradiol (E2) is a natural steroid ligand for the structurally and physiologically independent estrogen receptors (ERs) ERalpha and ERbeta. Steroids 35-42 estrogen receptor 1 Homo sapiens 140-146 33082746-8 2020 The frequency of metastases of breast cancer overexpressing estrogen receptor can be explained biologically by the presence of estrogen receptors in hormone acting as target choroid tissue steroids for lacrimal secretion. Steroids 189-197 estrogen receptor 1 Homo sapiens 60-77 32759680-4 2020 This article summarizes and discusses available data suggesting that steroid hormone receptors, including androgen receptor, estrogen receptor-alpha, estrogen receptor-beta, glucocorticoid receptor, progesterone receptor and vitamin D receptor, as well as their related signals, contribute to modulating urothelial tumorigenesis. Steroids 69-76 estrogen receptor 1 Homo sapiens 125-148 32759680-4 2020 This article summarizes and discusses available data suggesting that steroid hormone receptors, including androgen receptor, estrogen receptor-alpha, estrogen receptor-beta, glucocorticoid receptor, progesterone receptor and vitamin D receptor, as well as their related signals, contribute to modulating urothelial tumorigenesis. Steroids 69-76 estrogen receptor 1 Homo sapiens 150-172 31899528-1 2020 Importance: Steroid hormone receptors, including estrogen receptor (ER) and progesterone receptor (PR), are crucial biomarkers in breast cancer (BC). Steroids 12-19 estrogen receptor 1 Homo sapiens 68-70 31731733-5 2019 All three steroid receptors analyzed by immunohistochemistry, namely, the estrogen receptor (ER), the progesterone receptor (PR), and the vitamin D receptor (VDR), showed a significantly positive influence on the course of the disease, but only for the unifocal breast tumor patients. Steroids 10-17 estrogen receptor 1 Homo sapiens 74-91 31617730-3 2020 Estrogen, a major female sex steroid mediates its role through estrogen receptors (ER), ERalpha and ERbeta which are shown to be expressed in human ASM and their expression is upregulated in inflammation/asthma. Steroids 29-36 estrogen receptor 1 Homo sapiens 88-95 31731733-5 2019 All three steroid receptors analyzed by immunohistochemistry, namely, the estrogen receptor (ER), the progesterone receptor (PR), and the vitamin D receptor (VDR), showed a significantly positive influence on the course of the disease, but only for the unifocal breast tumor patients. Steroids 10-17 estrogen receptor 1 Homo sapiens 93-95 31252411-2 2019 An important family of nuclear receptors comprises those members that respond to steroid hormones, and which is subdivided in turn into estrogen receptor (ER) isoforms alpha and beta (NR3A1 and A2, respectively), and a second subfamily of so called oxosteroid receptors. Steroids 81-97 estrogen receptor 1 Homo sapiens 184-189 31684907-6 2019 These effects involve the competition between AR and ERalpha for the interaction with the steroid receptor coactivator AIB1, a limiting factor in the functional coupling of the ERalpha with the cyclin D1 promoter. Steroids 90-97 estrogen receptor 1 Homo sapiens 53-60 31684907-8 2019 Co-immunoprecipitation studies indicated that the preferential interaction of AIB1 with ERalpha or AR depends on the intracellular expression levels of the two steroid receptors. Steroids 160-167 estrogen receptor 1 Homo sapiens 88-95 30919589-3 2019 Cell growth and apoptosis are analyzed in an estrogen receptor positive breast cancer cell line in the presence of serum that have been treated to remove steroids or lipids, as well-described in the literature. Steroids 154-162 estrogen receptor 1 Homo sapiens 45-62 31150682-8 2019 We also found the expression of sex steroid receptors (e.g., AR, ERalpha and ERbeta) in the hFK at GW9-12. Steroids 36-43 estrogen receptor 1 Homo sapiens 65-72 31150682-8 2019 We also found the expression of sex steroid receptors (e.g., AR, ERalpha and ERbeta) in the hFK at GW9-12. Steroids 36-43 estrogen receptor 1 Homo sapiens 77-83 31220580-2 2019 The aim of this retrospective study was to explore the possible correlation in the EC microenvironment between master regulators of complex phenomena such as steroid responsiveness through estrogen receptor alpha (ERalpha) and progesterone receptor (PR), epithelial-to-mesenchymal transition (supported by SLUG transcription factor), hypoxia (with hypoxia inducible factor-1 alpha, HIF-1alpha), and obesity that has been recognized as a EC risk factor. Steroids 158-165 estrogen receptor 1 Homo sapiens 189-212 31220580-2 2019 The aim of this retrospective study was to explore the possible correlation in the EC microenvironment between master regulators of complex phenomena such as steroid responsiveness through estrogen receptor alpha (ERalpha) and progesterone receptor (PR), epithelial-to-mesenchymal transition (supported by SLUG transcription factor), hypoxia (with hypoxia inducible factor-1 alpha, HIF-1alpha), and obesity that has been recognized as a EC risk factor. Steroids 158-165 estrogen receptor 1 Homo sapiens 214-221 30957588-10 2019 Conclusions: We found that external radiation reduces the ERalpha and AR protein expression in the vaginal mucosa, indicating that the vaginal changes in irradiated cervical cancer survivors and the lack of response to hormonal treatment could be due to the decreases in sex steroid hormone receptor expression. Steroids 275-282 estrogen receptor 1 Homo sapiens 58-65 31123801-1 2019 Recent studies suggest that the anabolic effect of ecdysterone, a naturally occurring steroid hormone claimed to enhance physical performance, is mediated by estrogen receptor (ER) binding. Steroids 86-93 estrogen receptor 1 Homo sapiens 158-175 31123801-1 2019 Recent studies suggest that the anabolic effect of ecdysterone, a naturally occurring steroid hormone claimed to enhance physical performance, is mediated by estrogen receptor (ER) binding. Steroids 86-93 estrogen receptor 1 Homo sapiens 177-179 30817989-4 2019 The identification of molecular mechanisms underlying the interaction between these types of endocrine and juxtacrine signaling are leading to a deeper understanding of physiological conditions regulated by these steroid hormones and, potentially, to novel therapeutic approaches to prevent pathologies linked to reduced levels of estrogen, such as coronary heart disease, and cardiotoxicity caused by hormone therapy for estrogen-receptor-positive breast cancer. Steroids 213-220 estrogen receptor 1 Homo sapiens 422-439 30797876-5 2019 Good yields were obtained for the intermediates and final products, and the structural variations in the steroid component will permit evaluation of ER affinity and selectivity. Steroids 105-112 estrogen receptor 1 Homo sapiens 149-151 30731397-2 2019 Structure-based drug design coupled with ring opening strategy of the steroids skeleton revealed the potential of indole-based analogs to be synthesized targeting the ligand binding domain of estrogen receptor-alpha. Steroids 70-78 estrogen receptor 1 Homo sapiens 192-215 29307843-1 2018 The steroid, estrogen has been recognized as being important for stimulating the growth of breast cancers primarily mediated via the steroidal estrogen receptor-alpha (ER-alpha). Steroids 4-11 estrogen receptor 1 Homo sapiens 143-166 29803726-11 2018 Finally, dimerization of the steroids abolished their ability to induce transactivation by estrogen receptor alpha and androgen receptors. Steroids 29-37 estrogen receptor 1 Homo sapiens 91-114 29454903-13 2019 ERalpha isoforms are functional and display specific early transcriptional effects following steroid treatment. Steroids 93-100 estrogen receptor 1 Homo sapiens 0-7 30086626-2 2018 Fulvestrant is a steroid-based, selective estrogen receptor degrader (SERD) that both antagonizes and degrades ER-alpha and shows some activity in patients who have progressed on antihormonal agents. Steroids 17-24 estrogen receptor 1 Homo sapiens 42-59 30086626-2 2018 Fulvestrant is a steroid-based, selective estrogen receptor degrader (SERD) that both antagonizes and degrades ER-alpha and shows some activity in patients who have progressed on antihormonal agents. Steroids 17-24 estrogen receptor 1 Homo sapiens 111-119 29307843-1 2018 The steroid, estrogen has been recognized as being important for stimulating the growth of breast cancers primarily mediated via the steroidal estrogen receptor-alpha (ER-alpha). Steroids 4-11 estrogen receptor 1 Homo sapiens 168-176 29894079-1 2016 Estrogen signal medicated by estrogen receptor (ER), which is involved in various diseases related to steroid hormone, such as cancer. Steroids 102-117 estrogen receptor 1 Homo sapiens 48-50 29093525-2 2017 Estrogen receptor is a common target of sex steroids and important in mediating estradiol-induced neuroprotection. Steroids 44-52 estrogen receptor 1 Homo sapiens 0-17 28334272-4 2017 In this study, treatment of steroid-starved ERalpha-positive MCF-7 and T47D mammary carcinoma cells with 17beta-estradiol resulted in increased cellular uptake of the PUFA arachidonic acid (AA) and eicosapentaenoic acid (EPA), important building blocks for cellular membranes, and increased ACSL4 protein levels. Steroids 28-35 estrogen receptor 1 Homo sapiens 44-51 27277477-7 2017 RESULTS AND LIMITATIONS: Seven SNPs located in or nearby genes implicated in steroid hormone metabolism were significantly associated with prostate volume: HSD17B2 (rs1119933), ESR2 (rs8006145), SULT2B1 (rs279451), NQO1 (rs2917670), ESR1 (rs1569788), GSTP1 (rs1138272), and CYP19A1 (rs17523880). Steroids 77-92 estrogen receptor 1 Homo sapiens 233-237 27432813-7 2016 A 3D model of lamprey Esr1b suggests that although estradiol fits into the steroid binding site, some stabilizing contacts between the ligand and side chains that are found in human Esr1 and Esr2 are missing in lamprey Esr1b. Steroids 75-82 estrogen receptor 1 Homo sapiens 22-26 29894079-1 2016 Estrogen signal medicated by estrogen receptor (ER), which is involved in various diseases related to steroid hormone, such as cancer. Steroids 102-117 estrogen receptor 1 Homo sapiens 29-46 26763249-4 2016 EXPERIMENTAL DESIGN: Global ER chromatin immuno-precipitation (ChIP)-seq analysis of AI-resistant cells identified steroid-independent ER target genes. Steroids 115-122 estrogen receptor 1 Homo sapiens 3-5 27260406-5 2016 In addition, steroid production in retina is also increased which, in conjunction with high circulating levels, impairs estrogen receptor expression and mitochondrial respiratory complex IV activity, promoting RGC apoptosis in females. Steroids 13-20 estrogen receptor 1 Homo sapiens 120-137 26763249-4 2016 EXPERIMENTAL DESIGN: Global ER chromatin immuno-precipitation (ChIP)-seq analysis of AI-resistant cells identified steroid-independent ER target genes. Steroids 115-122 estrogen receptor 1 Homo sapiens 28-30 26763249-7 2016 Genome-wide ER-DNA-binding analysis in AI-resistant cell lines identified a subset of classic ligand-dependent ER target genes that develop steroid independence. Steroids 140-147 estrogen receptor 1 Homo sapiens 12-14 26763249-7 2016 Genome-wide ER-DNA-binding analysis in AI-resistant cell lines identified a subset of classic ligand-dependent ER target genes that develop steroid independence. Steroids 140-147 estrogen receptor 1 Homo sapiens 111-113 25879485-3 2015 Fulvestrant is a steroid-based, selective estrogen receptor degrader (SERD) that both antagonizes and degrades ER-alpha and is active in patients who have progressed on antihormonal agents. Steroids 17-24 estrogen receptor 1 Homo sapiens 111-119 26646255-12 2016 Female sex steroids and vitamin-D promoted tendon-derived cell proliferation via estrogen receptor alpha and VDR, not estrogen receptor beta. Steroids 11-19 estrogen receptor 1 Homo sapiens 81-104 26585158-3 2016 Mainly these steroid hormones induce their effects by binding and activating estrogen receptors (ERalpha and ERbeta). Steroids 13-20 estrogen receptor 1 Homo sapiens 97-104 25855477-5 2015 Neural sensitivity to sex steroids may differ between the morphs because the gene for estrogen receptor alpha (ERalpha) has been captured by a chromosomal rearrangement found only in the WS birds. Steroids 26-34 estrogen receptor 1 Homo sapiens 86-109 25855477-5 2015 Neural sensitivity to sex steroids may differ between the morphs because the gene for estrogen receptor alpha (ERalpha) has been captured by a chromosomal rearrangement found only in the WS birds. Steroids 26-34 estrogen receptor 1 Homo sapiens 111-118 26240785-1 2015 BACKGROUND: We investigated in postmenopausal women with primary breast cancer prior to surgical intervention whether, serum levels of different steroid hormones and hormonal precursors associated with tumor tissue estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status. Steroids 145-161 estrogen receptor 1 Homo sapiens 215-232 26164866-7 2015 Sex steroids initiate the development of the pathway by binding to an estrogen receptor alpha located in the outer membrane of the mast cells, causing their activation. Steroids 4-12 estrogen receptor 1 Homo sapiens 70-93 25921217-1 2015 Salpichrolides are natural plant steroids that contain an unusual six-membered aromatic ring D. We recently reported that some of these compounds, and certain analogs with a simplified side chain, exhibited antagonist effects toward the human estrogen receptor (ER), a nuclear receptor whose endogenous ligand has an aromatic A ring (estradiol). Steroids 33-41 estrogen receptor 1 Homo sapiens 243-260 25921217-1 2015 Salpichrolides are natural plant steroids that contain an unusual six-membered aromatic ring D. We recently reported that some of these compounds, and certain analogs with a simplified side chain, exhibited antagonist effects toward the human estrogen receptor (ER), a nuclear receptor whose endogenous ligand has an aromatic A ring (estradiol). Steroids 33-41 estrogen receptor 1 Homo sapiens 262-264 25530026-1 2015 We have synthesized a 17-mer peptide (ERalpha17p) that is issued from the hinge region of the estrogen receptor alpha and which activates the proliferation of breast carcinoma cells in steroid-deprived conditions. Steroids 185-192 estrogen receptor 1 Homo sapiens 94-117 25305176-1 2015 BACKGROUND: The endometrium is the primary target organ for the "female" sex steroid hormone estrogen, which exerts effects in the endometrium via two main classical estrogen receptor (ER) isoforms, ERalpha and ERbeta. Steroids 77-92 estrogen receptor 1 Homo sapiens 199-206 25665553-2 2015 Historically, the oncogenic role of AR has best been described in molecular apocrine breast cancers, an estrogen receptor (ER)-/AR+ subtype which has a steroid response signature similar to that in the ER-positive breast cancer. Steroids 152-159 estrogen receptor 1 Homo sapiens 104-121 25665553-2 2015 Historically, the oncogenic role of AR has best been described in molecular apocrine breast cancers, an estrogen receptor (ER)-/AR+ subtype which has a steroid response signature similar to that in the ER-positive breast cancer. Steroids 152-159 estrogen receptor 1 Homo sapiens 123-125 25281720-9 2014 Elevated concentrations of the steroid hormones were associated with increased risk of estrogen receptor (ER)- and progesterone receptor (PR)-negative tumors in women age <40 at diagnosis. Steroids 31-38 estrogen receptor 1 Homo sapiens 87-104 26491443-0 2015 Regulation of Estrogen Receptor alpha Expression in the Hypothalamus by Sex Steroids: Implication in the Regulation of Energy Homeostasis. Steroids 76-84 estrogen receptor 1 Homo sapiens 14-37 26491443-7 2015 A fundamental question concerning how ERalpha is regulated in wild-type animals, including humans, in response to alterations in steroid hormone levels, due to experimental manipulation (i.e., castration and hormone replacement) or physiological stages (i.e., puberty, pregnancy, and menopause), lacks consistent answers. Steroids 129-144 estrogen receptor 1 Homo sapiens 38-45 25375021-4 2015 Mitochondrial RNA levels are regulated through the association of estrogen receptor-alpha with 17beta-hydroxysteroid dehydrogenase 10, a multifunctional protein involved in steroid metabolism that is also a core subunit of the mitochondrial ribonuclease P complex responsible for the cleavage of mitochondrial polycistronic transcripts. Steroids 109-116 estrogen receptor 1 Homo sapiens 66-89 25281720-9 2014 Elevated concentrations of the steroid hormones were associated with increased risk of estrogen receptor (ER)- and progesterone receptor (PR)-negative tumors in women age <40 at diagnosis. Steroids 31-38 estrogen receptor 1 Homo sapiens 106-108 25281720-11 2014 These data suggest a positive association between high concentrations of early pregnancy steroid hormones and risk of ER(-)/PR(-) breast cancer in women diagnosed age <40, and an inverse association for overall breast cancer diagnosed age >=40. Steroids 89-105 estrogen receptor 1 Homo sapiens 118-120 25138535-1 2014 The sex steroid hormone 17beta-estradiol (E2) regulates breast cancer (BC) cell proliferation and migration through the activation of a plethora of signal transduction cascades (e.g., PI3K/AKT activation) starting after E2 binding to the estrogen receptor alpha (ERalpha). Steroids 8-23 estrogen receptor 1 Homo sapiens 238-261 25138535-1 2014 The sex steroid hormone 17beta-estradiol (E2) regulates breast cancer (BC) cell proliferation and migration through the activation of a plethora of signal transduction cascades (e.g., PI3K/AKT activation) starting after E2 binding to the estrogen receptor alpha (ERalpha). Steroids 8-23 estrogen receptor 1 Homo sapiens 263-270 23923078-1 2013 The human cervix is a tissue target of sex steroid hormones as estradiol (E2) which exerts its action through of the estrogen receptors alpha and beta (ER-alpha and ER-beta). Steroids 43-59 estrogen receptor 1 Homo sapiens 152-160 24291072-1 2014 Ovarian steroid hormones contribute to breast cancer initiation and progression primarily through the actions of their nuclear transcription factors, the estrogen receptor alpha (ERalpha) and progesterone receptors (PRs). Steroids 8-24 estrogen receptor 1 Homo sapiens 154-177 24291072-1 2014 Ovarian steroid hormones contribute to breast cancer initiation and progression primarily through the actions of their nuclear transcription factors, the estrogen receptor alpha (ERalpha) and progesterone receptors (PRs). Steroids 8-24 estrogen receptor 1 Homo sapiens 179-186 24252378-7 2014 This review describes the data from the last several years and discusses the non-classical, rapid, and membrane-associated cellular responses to steroid hormones, particularly 17beta-estradiol, through the classical receptors ERalpha and ERbeta and various non-classical receptors, especially estrogen receptor-alpha36 (ERalpha36). Steroids 145-161 estrogen receptor 1 Homo sapiens 226-233 24279585-2 2013 The expression of estrogen receptor alpha (ER alpha), androgen receptor (AR), in epithelial cells of the ovary from premenopausal and postmenopausal women is interesting because sexual steroid hormones are involved in cell growth and differentiation. Steroids 185-201 estrogen receptor 1 Homo sapiens 18-41 24279585-2 2013 The expression of estrogen receptor alpha (ER alpha), androgen receptor (AR), in epithelial cells of the ovary from premenopausal and postmenopausal women is interesting because sexual steroid hormones are involved in cell growth and differentiation. Steroids 185-201 estrogen receptor 1 Homo sapiens 43-51 23867117-7 2013 The results of the present study suggest that SNPs in sex steroid related genes, known to affect gene expression (rs2747648 in ESR1) and enzymatic activity (Leu89Val in SRD5A2), seem to be associated with ALTs in a general population. Steroids 58-65 estrogen receptor 1 Homo sapiens 127-131 23200732-3 2013 These actions are mediated by the activation of estrogen receptors (ER) alpha (ERalpha) and beta (ERbeta), which regulate target gene transcription (genomic action) through two independent activation functions (AF)-1 and AF-2, but can also elicit rapid membrane initiated steroid signals (MISS). Steroids 272-279 estrogen receptor 1 Homo sapiens 48-96 23383871-8 2013 Moreover, when the ERalpha-coregulator binding profiles were hierarchically clustered using Euclidian cluster distance, the structurally related compounds were found to cluster together, whereas the steroid test compounds having an aromatic A-ring were separated from those with a cyclohexene A-ring. Steroids 199-206 estrogen receptor 1 Homo sapiens 19-26 23566615-2 2013 These actions are mediated by the activation of estrogen receptors (ER) alpha (ERalpha) and beta (ERbeta), which regulate target gene transcription (genomic action) through two independent activation functions (AF)-1 and AF-2, but can also elicit rapid membrane initiated steroid signals (MISS). Steroids 272-279 estrogen receptor 1 Homo sapiens 48-96 23500175-5 2013 It is becoming increasingly apparent that gonadal steroids play important roles in the regulation of kisspeptin expression during pubertal development, and in particular, estradiol signaling through estrogen receptor alpha appears to be necessary for these changes to occur. Steroids 50-58 estrogen receptor 1 Homo sapiens 199-222 23313336-4 2013 However, other steroids, including Delta(5)-androstenediol, 5alpha-androstanediol and 27-hydroxycholesterol, which have a saturated A ring containing a 3beta-hydroxyl and a C19 methyl group, also mediate physiological responses through binding to estrogen receptor-alpha (ERalpha) and ERbeta. Steroids 15-23 estrogen receptor 1 Homo sapiens 247-270 23313336-4 2013 However, other steroids, including Delta(5)-androstenediol, 5alpha-androstanediol and 27-hydroxycholesterol, which have a saturated A ring containing a 3beta-hydroxyl and a C19 methyl group, also mediate physiological responses through binding to estrogen receptor-alpha (ERalpha) and ERbeta. Steroids 15-23 estrogen receptor 1 Homo sapiens 272-279 23169992-1 2013 In prostate and breast cancer, the androgen receptor and estrogen receptor (ER) mediate induction of androgen- and estrogen-responsive genes respectively and stimulate cell proliferation in response to the binding of their cognate steroid hormones. Steroids 231-238 estrogen receptor 1 Homo sapiens 57-74 23169992-1 2013 In prostate and breast cancer, the androgen receptor and estrogen receptor (ER) mediate induction of androgen- and estrogen-responsive genes respectively and stimulate cell proliferation in response to the binding of their cognate steroid hormones. Steroids 231-238 estrogen receptor 1 Homo sapiens 76-78 23159625-1 2013 Steroid hormone estrogen elicits various physiological functions, many of which are mediated through two structurally and functionally distinct estrogen receptors, ERalpha and ERbeta. Steroids 0-15 estrogen receptor 1 Homo sapiens 164-171 23036054-0 2012 Targeting the estrogen receptor using steroid-therapeutic drug conjugates (hybrids). Steroids 38-45 estrogen receptor 1 Homo sapiens 14-31 23313336-7 2013 Further studies of the role of these steroids and SERMs in regulating responses mediated by ERalpha and ERbeta a variety of tissues, during different stages of development, are likely to uncover additional estrogenic activities. Steroids 37-45 estrogen receptor 1 Homo sapiens 92-99 23231090-4 2013 The aim of this review is to survey and analyze the developments in this field, which have led to the design of a number of PET steroid-based imaging agents, a few of which seem to be promising as radiopharmaceuticals for detection of ER-positive breast tumours. Steroids 128-135 estrogen receptor 1 Homo sapiens 235-237 23036054-4 2012 In this review, we describe the strategies and methods employed by those investigators in their efforts to develop steroid-drug conjugates with the goals of enhanced antiproliferative activity and ER-selectivity. Steroids 115-122 estrogen receptor 1 Homo sapiens 197-199 23036054-5 2012 In particular, the choices of steroid scaffolds and sites for drug conjugation have evolved as the understanding of role of ER in cell function has expanded. Steroids 30-37 estrogen receptor 1 Homo sapiens 124-126 22115959-3 2012 The uterus is an endocrine organ, responsive to the presence of the ovarian steroid hormones, estrogen and progesterone, which activate transcription of target genes through the binding of their cognate receptors, the estrogen receptor and the progesterone receptor. Steroids 76-92 estrogen receptor 1 Homo sapiens 218-235 22817771-1 2012 INTRODUCTION: Molecular apocrine is a subtype of estrogen receptor (ER)-negative breast cancer that is characterized by a steroid-response gene signature. Steroids 122-129 estrogen receptor 1 Homo sapiens 49-66 22817771-1 2012 INTRODUCTION: Molecular apocrine is a subtype of estrogen receptor (ER)-negative breast cancer that is characterized by a steroid-response gene signature. Steroids 122-129 estrogen receptor 1 Homo sapiens 68-70 22537818-4 2012 Most genes of interest that participate in steroid-hormone metabolism, such as estrogen receptor alpha and estrogen receptor beta, have been associated with age at menarche and menopause. Steroids 43-50 estrogen receptor 1 Homo sapiens 79-102 22998747-7 2012 Finally, we show that STR5 specifically inhibits ERalpha- and AR-dependent transactivation of target genes in steroid-sensitive cancer cells, consistent with disruption of the targeted Pus1p-SRA pathway. Steroids 110-117 estrogen receptor 1 Homo sapiens 49-56 23037602-10 2012 As estrogen receptor alpha, estrogen receptor beta, and androgen receptor are expressed in the medial amygdala, sex steroids may modulate the autonomic nervous activities. Steroids 116-124 estrogen receptor 1 Homo sapiens 3-26 20200813-0 2012 Associations of estrogen receptor alpha and beta gene polymorphisms with sex steroid levels and body fat content in men. Steroids 77-84 estrogen receptor 1 Homo sapiens 16-39 22550166-7 2012 In contrast, the recruitment of the ERalpha/AIB1 transcriptional complex to the nonclassic ER target cyclin D1 and its subsequent expression remained sensitive to steroid treatment and could be inhibited by treatment with letrozole. Steroids 163-170 estrogen receptor 1 Homo sapiens 36-43 22550166-7 2012 In contrast, the recruitment of the ERalpha/AIB1 transcriptional complex to the nonclassic ER target cyclin D1 and its subsequent expression remained sensitive to steroid treatment and could be inhibited by treatment with letrozole. Steroids 163-170 estrogen receptor 1 Homo sapiens 36-38 22366173-2 2012 Our results show that about 8% of anterior pituitary cells expressed ERalpha in the plasma membrane, with the geometrical mean fluorescence intensity being increased after steroid hormone treatment. Steroids 172-187 estrogen receptor 1 Homo sapiens 69-76 22477185-3 2012 Upon steroid hormone stimuli, their cognate steroid receptors, including androgen receptor (AR) and estrogen receptor (ER), not only mediate transcriptional activation, but also undergo ubiquitination and consequent proteasomal degradation. Steroids 5-20 estrogen receptor 1 Homo sapiens 100-117 22477185-3 2012 Upon steroid hormone stimuli, their cognate steroid receptors, including androgen receptor (AR) and estrogen receptor (ER), not only mediate transcriptional activation, but also undergo ubiquitination and consequent proteasomal degradation. Steroids 5-20 estrogen receptor 1 Homo sapiens 119-121 20200813-2 2012 We investigated the possible association of four single nucleotide polymorphisms in Estrogen Receptor alpha ( ESR1) and Estrogen Receptor beta ( ESR2) genes with circulating levels of sex steroids and Sex Hormone Binding Globulin (SHBG) in men. Steroids 188-196 estrogen receptor 1 Homo sapiens 84-107 20200813-2 2012 We investigated the possible association of four single nucleotide polymorphisms in Estrogen Receptor alpha ( ESR1) and Estrogen Receptor beta ( ESR2) genes with circulating levels of sex steroids and Sex Hormone Binding Globulin (SHBG) in men. Steroids 188-196 estrogen receptor 1 Homo sapiens 110-114 21671899-7 2012 Activation of ERalpha and ERbeta regulates target gene transcription (genomic action) through two independent activation functions, AF-1 and AF-2, but can also elicit rapid membrane-initiated steroid signals. Steroids 192-199 estrogen receptor 1 Homo sapiens 14-21 21856418-4 2011 These sex steroids mediate their effects through sex steroid receptors including estrogen receptors (ER) i.e. ERalpha and ERbeta progesterone receptors (PR) i.e. PR-A and PR-B and androgen receptors (ARs), all of which have been reported to be expressed in lung tissue. Steroids 10-18 estrogen receptor 1 Homo sapiens 110-117 22271294-1 2012 The steroid hormone estrogen and its classical estrogen receptors (ERs), ER-alpha and ER-beta, have been shown to be partly responsible for the short- and long-term uterine endothelial adaptations during pregnancy. Steroids 4-19 estrogen receptor 1 Homo sapiens 73-81 21493749-4 2011 We hypothesize that this may occur because of the sex steroid-dependent activation of estrogen receptor alpha (ERalpha) with further transactivation of the CYP2C9 gene. Steroids 54-61 estrogen receptor 1 Homo sapiens 86-109 21420388-3 2011 Here, using an analysis of crystal structures of human ERalpha with E2 and other chemicals and 3D models of human ERalpha with 27-hydroxycholesterol and 5-androsten-3beta,17beta-diol, I propose that one or more Delta5 steroids were the ancestral ligands for the ER, with E2 evolving later as the canonical estrogen. Steroids 218-226 estrogen receptor 1 Homo sapiens 55-62 21420388-3 2011 Here, using an analysis of crystal structures of human ERalpha with E2 and other chemicals and 3D models of human ERalpha with 27-hydroxycholesterol and 5-androsten-3beta,17beta-diol, I propose that one or more Delta5 steroids were the ancestral ligands for the ER, with E2 evolving later as the canonical estrogen. Steroids 218-226 estrogen receptor 1 Homo sapiens 114-121 21493749-4 2011 We hypothesize that this may occur because of the sex steroid-dependent activation of estrogen receptor alpha (ERalpha) with further transactivation of the CYP2C9 gene. Steroids 54-61 estrogen receptor 1 Homo sapiens 111-118 20680681-3 2010 Sex steroids may stimulate angiogenesis via the estrogen receptor (ER) pathway. Steroids 4-12 estrogen receptor 1 Homo sapiens 48-65 21731573-6 2011 Estrogens include endogenous steroids and nonsteroidal compounds from the environment termed endocrine disruptors, all of which can activate "classical" estrogen receptors (ERalpha and ERbeta), as well as other types of receptors. Steroids 29-37 estrogen receptor 1 Homo sapiens 173-180 20800582-4 2010 These neurons are steroid-responsive and coexpress NKB, kisspeptin, dynorphin, NK3R, and estrogen receptor alpha (ERalpha) in a variety of mammalian species. Steroids 18-25 estrogen receptor 1 Homo sapiens 114-121 20680681-3 2010 Sex steroids may stimulate angiogenesis via the estrogen receptor (ER) pathway. Steroids 4-12 estrogen receptor 1 Homo sapiens 67-69 20347019-4 2010 Results from synthetic steroid-treated cells expressing functional GFP-ERalpha or YFP-ERbeta chimeras were compared to those obtained with estradiol (E(2)) and the antiestrogen tamoxifen. Steroids 23-30 estrogen receptor 1 Homo sapiens 71-78 20334988-7 2010 The ovarian steroids stimulated both PGF(2alpha) and PGE(2) in the epithelial cells of the feline endometrium via an E(2) receptor (ESR1)- and P(4) receptor (PGR)-dependent genomic-pathway. Steroids 12-20 estrogen receptor 1 Homo sapiens 132-136 20543978-5 2010 Steroid free culture conditions commonly used to assess the effect of hormones or antiestrogens on gene expression also block MCF-7 cells in G1-phase when several ERalpha target genes are overexpressed. Steroids 0-7 estrogen receptor 1 Homo sapiens 163-170 18563553-8 2009 In vitro experiments confirmed clinical data since CDCA stimulated the proliferation of ER-positive cells only in steroid-free medium, a stimulation inhibited upon siRNA-silencing of FXR expression as well as ER blockade by antiestrogens. Steroids 114-121 estrogen receptor 1 Homo sapiens 88-90 19758455-15 2009 We found evidence of a link between COX-2, its product PGF2alpha, and expression of ERalpha and PR that sheds new light on the cross talk between steroid and PG signalling pathways in this disease. Steroids 146-153 estrogen receptor 1 Homo sapiens 84-91 19540191-5 2009 These differences between the SR and ERalpha in the steroid-binding domain are sufficient to suggest that another steroid is the physiological regulator of the SR. Steroids 52-59 estrogen receptor 1 Homo sapiens 37-44 19540191-5 2009 These differences between the SR and ERalpha in the steroid-binding domain are sufficient to suggest that another steroid is the physiological regulator of the SR. Steroids 114-121 estrogen receptor 1 Homo sapiens 37-44 19490052-0 2009 Modulation of androgen and estrogen receptor expression by antiepileptic drugs and steroids in hippocampus of patients with temporal lobe epilepsy. Steroids 83-91 estrogen receptor 1 Homo sapiens 27-44 19792970-2 2009 The observation of steroid hormone dependence has led to the successful implementation of tamoxifen, aromatase inhibitors and other estrogen receptor modulators in both the adjuvant and advanced setting. Steroids 19-34 estrogen receptor 1 Homo sapiens 132-149 19182697-1 2009 Selective estrogen receptor modulators (SERMs), which lack the estrogen steroid moiety yet retain the ability to bind the estrogen receptor (ER), are known to confer mixed ER agonist or antagonist effects depending on the target tissue. Steroids 72-79 estrogen receptor 1 Homo sapiens 10-27 19182697-1 2009 Selective estrogen receptor modulators (SERMs), which lack the estrogen steroid moiety yet retain the ability to bind the estrogen receptor (ER), are known to confer mixed ER agonist or antagonist effects depending on the target tissue. Steroids 72-79 estrogen receptor 1 Homo sapiens 41-43 19811234-7 2009 ER-alpha modulates target gene transcription through two activation functions (AF), AF-1 and AF-2, even though signalling via ER-alpha located at the plasma membrane (responsible for membrane-initiated steroid signalling (MISS)/(extra-genomic)) can also lead to an indirect effect on gene transcription. Steroids 202-209 estrogen receptor 1 Homo sapiens 0-8 19811234-7 2009 ER-alpha modulates target gene transcription through two activation functions (AF), AF-1 and AF-2, even though signalling via ER-alpha located at the plasma membrane (responsible for membrane-initiated steroid signalling (MISS)/(extra-genomic)) can also lead to an indirect effect on gene transcription. Steroids 202-209 estrogen receptor 1 Homo sapiens 126-134 18614256-7 2009 We propose that neurons expressing KiSS-1, NKB, substance P, dynorphin and ERalpha mRNA in the infundibular nucleus play an important role in sex-steroid feedback on gonadotropin secretion in the human. Steroids 146-153 estrogen receptor 1 Homo sapiens 75-82 18275596-5 2008 We also assessed p,p"-DDE-induced modifications in cell cycle entry and the expression of the sex-steroid-dependent genes ESR1, AR, CCND1, and TFF1 (pS2) (mRNA and/or protein). Steroids 98-105 estrogen receptor 1 Homo sapiens 122-126 18249430-5 2008 There are several studies speculating a classical steroid receptor involvement in the rapid effects of steroids, localized at the cytoplasmic membrane and mediating effects directly or indirectly, via interactions with specific membrane structures (estrogen receptor (ER) isoforms have been shown to localize in caveolae) and/or other membrane receptors (like growth factor receptor). Steroids 103-111 estrogen receptor 1 Homo sapiens 249-266 18249430-5 2008 There are several studies speculating a classical steroid receptor involvement in the rapid effects of steroids, localized at the cytoplasmic membrane and mediating effects directly or indirectly, via interactions with specific membrane structures (estrogen receptor (ER) isoforms have been shown to localize in caveolae) and/or other membrane receptors (like growth factor receptor). Steroids 103-111 estrogen receptor 1 Homo sapiens 268-270 17932106-4 2008 In contrast, ER displaced p65 and associated coregulators from the IL-6 promoter, demonstrating a gene-specific role for CBP in integrating inflammatory and steroid signaling. Steroids 157-164 estrogen receptor 1 Homo sapiens 13-15 18471435-7 2008 We mapped the 12 motifs onto an alignment of human, lamprey and amphioxus ERs, which depicted residues in human ERalpha that interact with estradiol, which revealed significant differences between amphioxus ER and vertebrate ERs in the steroid-binding domain. Steroids 236-243 estrogen receptor 1 Homo sapiens 112-119 18591792-1 2008 Estrogens, a group of steroid hormones, act primarily by regulating gene expression after binding with estrogen receptor (ER), a nuclear ligand-activated transcription factor, translocates to the nucleus after dimer formation, enhances the gene transcription. Steroids 22-29 estrogen receptor 1 Homo sapiens 103-120 18591792-1 2008 Estrogens, a group of steroid hormones, act primarily by regulating gene expression after binding with estrogen receptor (ER), a nuclear ligand-activated transcription factor, translocates to the nucleus after dimer formation, enhances the gene transcription. Steroids 22-29 estrogen receptor 1 Homo sapiens 122-124 17700529-7 2008 ERalpha-induced and ERbeta-repressed genes were involved in proliferation, steroid/xenobiotic metabolism and ion transport. Steroids 75-82 estrogen receptor 1 Homo sapiens 0-7 18224541-1 2008 We have studied the modulation and differential sensitivity of the estrogen receptor (ER) in breast cancer in the presence of protecting or modifying agents of disulfide bonds and sulfhydryl groups present in the ER steroid-binding domain. Steroids 216-223 estrogen receptor 1 Homo sapiens 67-84 18224541-1 2008 We have studied the modulation and differential sensitivity of the estrogen receptor (ER) in breast cancer in the presence of protecting or modifying agents of disulfide bonds and sulfhydryl groups present in the ER steroid-binding domain. Steroids 216-223 estrogen receptor 1 Homo sapiens 86-88 16690804-2 2006 In this study, we show that the UDP-glucuronosyltransferase (UGT) enzyme UGT2B15, a member of the UGT family of phase II enzymes involved in the glucuronidation of steroids and xenobiotics, is a novel, estrogen-regulated gene in estrogen receptor (ER)-positive human breast cancer cells (MCF-7, BT474, T47D, and ZR-75). Steroids 164-172 estrogen receptor 1 Homo sapiens 229-246 17447886-7 2007 In general, the results presented suggest that long-term growth of MCF-7 breast cancer cells in steroid-free medium is accompanied with the increase in the basal ER-dependent transcriptional activity as well as the maintenance of the negative regulatory loop ER-NF-kappaB. Steroids 96-103 estrogen receptor 1 Homo sapiens 162-164 17203231-11 2007 Our results suggest that the expression of ERalpha, ERbeta and GPR30 are influenced by sex steroids and might play a role in the response of cells to 17beta-estradiol and antiestrogens but are not the only factors involved in this process. Steroids 91-99 estrogen receptor 1 Homo sapiens 43-50 17276470-4 2007 Further, ERalpha in tumor nuclei was present in activated forms as assessed by detection of ER phosphorylation at serines-118 and -167, residues commonly modulated by growth factor receptor as well as steroid signaling. Steroids 201-208 estrogen receptor 1 Homo sapiens 9-16 16530259-1 2006 The presence of steroids and their receptors throughout development, specifically androgen receptor (AR), estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta), in the epididymis of a high estrogen producing species like the stallion has not been determined. Steroids 16-24 estrogen receptor 1 Homo sapiens 106-129 16530259-1 2006 The presence of steroids and their receptors throughout development, specifically androgen receptor (AR), estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta), in the epididymis of a high estrogen producing species like the stallion has not been determined. Steroids 16-24 estrogen receptor 1 Homo sapiens 131-138 18025264-1 2007 This report offers direct evidence that association of the estradiol receptor (ER) with Src triggered by steroid agonists or growth factors controls breast and prostate cancer cell growth. Steroids 105-112 estrogen receptor 1 Homo sapiens 59-77 18025264-1 2007 This report offers direct evidence that association of the estradiol receptor (ER) with Src triggered by steroid agonists or growth factors controls breast and prostate cancer cell growth. Steroids 105-112 estrogen receptor 1 Homo sapiens 79-81 17194723-8 2007 Using chromatin immunoprecipitation assay, we confirmed that ERalpha and ERbeta associated with NF-kappaB and steroid hormone coactivators at the promoter region of NF-kappaB regulated gene. Steroids 110-125 estrogen receptor 1 Homo sapiens 61-68 17266159-0 2007 Steroid conjugates of dichloro(6-aminomethylnicotinate)platinum(II): effects on DNA, sex hormone binding globulin, the estrogen receptor, and various breast cancer cell lines. Steroids 0-7 estrogen receptor 1 Homo sapiens 119-136 16690804-2 2006 In this study, we show that the UDP-glucuronosyltransferase (UGT) enzyme UGT2B15, a member of the UGT family of phase II enzymes involved in the glucuronidation of steroids and xenobiotics, is a novel, estrogen-regulated gene in estrogen receptor (ER)-positive human breast cancer cells (MCF-7, BT474, T47D, and ZR-75). Steroids 164-172 estrogen receptor 1 Homo sapiens 248-250 16806749-5 2006 Recently, we have demonstrated that some ER alpha/PR-positive epithelial cells are quiescent breast stem cells suggesting that they act as "steroid hormone sensors" that secrete paracrine factors to regulate the proliferative activity of adjacent ER alpha/PR-negative epithelial cells. Steroids 140-155 estrogen receptor 1 Homo sapiens 41-49 16806749-5 2006 Recently, we have demonstrated that some ER alpha/PR-positive epithelial cells are quiescent breast stem cells suggesting that they act as "steroid hormone sensors" that secrete paracrine factors to regulate the proliferative activity of adjacent ER alpha/PR-negative epithelial cells. Steroids 140-155 estrogen receptor 1 Homo sapiens 247-255 16697948-11 2006 CONCLUSIONS: Co-expression of GEP and ER in endometrial cancer cells, and the regulation of GEP by estrogen, suggests a role for GEP in steroid-mediated endometrial cancer cell growth. Steroids 136-143 estrogen receptor 1 Homo sapiens 38-40 15993498-5 2005 These findings support the concept of a direct action of steroid/thyroid hormones on mitochondrial functions by way of their cognate receptors and also suggest a direct involvement of ERalpha in nucleolar-related processes. Steroids 57-64 estrogen receptor 1 Homo sapiens 184-191 16322340-1 2005 Long-term culture of MCF-7 wild-type (wt) cells in steroid-depleted medium (LTED) results in hypersensitivity to oestradiol (E2) coinciding with elevated levels of ERalpha and enhanced growth factor signalling. Steroids 51-58 estrogen receptor 1 Homo sapiens 164-171 15961505-1 2005 The steroid hormone 17beta-estradiol (estrogen) plays a significant role in the normal physiology of the mammary gland and breast cancer development primarily through binding to its receptor, the estrogen receptor alpha (ERalpha). Steroids 4-19 estrogen receptor 1 Homo sapiens 196-219 15961505-1 2005 The steroid hormone 17beta-estradiol (estrogen) plays a significant role in the normal physiology of the mammary gland and breast cancer development primarily through binding to its receptor, the estrogen receptor alpha (ERalpha). Steroids 4-19 estrogen receptor 1 Homo sapiens 221-228 16244359-9 2006 Since AIB1 appears to modulate the effect of endogenous hormones via the estrogen receptor, and smoking affects circulating hormone levels, these results support evidence that steroid hormones play an important role in breast carcinogenesis in BRCA1 mutation carriers, and suggest mechanisms for developing novel cancer prevention strategies for BRCA1 mutation carriers. Steroids 176-192 estrogen receptor 1 Homo sapiens 73-90 16153823-4 2005 The molecular actions of estrogen are mediated through two nuclear sex steroid hormone receptors, estrogen receptor alpha (ERalpha) and beta (ERbeta). Steroids 71-78 estrogen receptor 1 Homo sapiens 142-148 16180994-1 2005 Estrogen receptor (ER) alpha and beta are ligand-activated nuclear transcription factors that mediate the effects of the steroid hormone 17beta-estradiol. Steroids 121-136 estrogen receptor 1 Homo sapiens 0-28 16247594-6 2005 In the classic pathway of estrogen signal transduction, the steroid hormone binds to its intracellular ER, triggering a cascade of events that ultimately leads to altered gene transcription. Steroids 60-75 estrogen receptor 1 Homo sapiens 103-105 15301869-3 2004 A possible role of steroid hormones in these sex differences via interactions between aryl hydrocarbon receptor and estrogen receptor mediated cellular effects has been suggested. Steroids 19-26 estrogen receptor 1 Homo sapiens 116-133 15692750-13 2005 The strong association of WWOX expression with ER status reinforces the suggested role of this protein as an enzyme involved in sex steroid metabolism. Steroids 132-139 estrogen receptor 1 Homo sapiens 47-49 15544494-2 2004 The biological functions of these and other steroid hormones are mediated by a family of closely related steroid hormone receptors (SHRs), with the androgen receptor (AR) mediating the effects of testosterone and related androgens, and the classical estrogen receptor (ERalpha) mediating the effects of estradiol. Steroids 44-51 estrogen receptor 1 Homo sapiens 250-267 15544494-2 2004 The biological functions of these and other steroid hormones are mediated by a family of closely related steroid hormone receptors (SHRs), with the androgen receptor (AR) mediating the effects of testosterone and related androgens, and the classical estrogen receptor (ERalpha) mediating the effects of estradiol. Steroids 44-51 estrogen receptor 1 Homo sapiens 269-276 15313422-1 2004 Estrogens are steroid hormones, which act through specific nuclear estrogen receptors (ERalpha and ERbeta) and are important regulators of breast cancer growth. Steroids 14-30 estrogen receptor 1 Homo sapiens 87-94 15381239-3 2004 The estrogen receptor (ESR) 1 gene was selected as a candidate gene because some researchers treated vitiligo successfully with the steroid-thyroid hormone mixture containing estrogen. Steroids 132-139 estrogen receptor 1 Homo sapiens 4-29 14987051-1 2004 The female steroid hormone 3,17beta-estradiol (2) was selected as an agent to target taxol (1) to estrogen receptor (ER) positive breast cancer cells. Steroids 11-26 estrogen receptor 1 Homo sapiens 98-115 15236840-2 2004 Estrogens are steroid hormones playing critical roles in several physiological processes, which bind the estrogen receptors ERalpha and ERbeta. Steroids 14-21 estrogen receptor 1 Homo sapiens 124-131 15497901-7 2004 Recent findings presented herein support the proposal that some ERalpha/PR-positive epithelial cells are quiescent breast stem cells that act as "steroid hormone sensors". Steroids 146-161 estrogen receptor 1 Homo sapiens 64-71 14987051-1 2004 The female steroid hormone 3,17beta-estradiol (2) was selected as an agent to target taxol (1) to estrogen receptor (ER) positive breast cancer cells. Steroids 11-26 estrogen receptor 1 Homo sapiens 117-119 14667969-7 2003 One interpretation supported by our recent findings is that some ERalpha/PR-positive epithelial cells are quiescent breast stem cells that act as "steroid hormone sensors". Steroids 147-162 estrogen receptor 1 Homo sapiens 65-72 14601091-9 2003 Accordingly, limited response to sex steroids in patients with endometrial carcinoma may be ascribed to the dissociation of cofactors and ER/PR. Steroids 37-45 estrogen receptor 1 Homo sapiens 138-140 12702147-12 2003 The differential expression of ERalpha, ERbeta and AR in human skin suggests that the mechanisms by which steroid hormones mediate their effects may be more complex than previously thought. Steroids 106-113 estrogen receptor 1 Homo sapiens 31-38 12970323-8 2003 These data suggest that the steroid/xenobiotics metabolism in the tumor tissue through PXR-CYP3A pathway might play an important role, especially in alternative pathway for gonadal hormone and endocrine-disrupting chemical effects on endometrial cancer expressing low ER alpha. Steroids 28-35 estrogen receptor 1 Homo sapiens 268-276 12699299-6 2003 How much of this gender cross-talk at the physiological level is caused by "promiscuous" actions of sex steroids at the molecular level, with estrogen acting by way of the androgen receptor (and androgens via the estrogen receptor) is an interesting and important question, the answer to which may well provide additional surprises. Steroids 104-112 estrogen receptor 1 Homo sapiens 213-230 12592257-6 2003 CONCLUSION: We conclude from this study that (1) the messenger RNA expression of estrogen receptor-alpha and progesterone receptor in pregnant myometrium were maintained at relatively high levels (>89%) within 48 hours incubation and that this may be useful for in vitro studies that are designed to evaluate the effects of sex steroids on the human myometrium during pregnancy and that (2) estrogen inhibits and progesterone stimulates the expression of calcitonin gene-related peptide B receptors in cultured pregnant myometrial explants. Steroids 331-339 estrogen receptor 1 Homo sapiens 81-104 12716060-4 2003 Here, we postulate that S-acylation of cysteine residue(s) present in the ligand binding domain of ERalpha and ERbeta may play a critical role in the membrane caveolar localization of the receptor and in the formation of the "steroid signalosome". Steroids 226-233 estrogen receptor 1 Homo sapiens 99-106 12114443-16 2002 This finding is associated with increased expression of functionally active estrogen receptor after steroid-deprivation of MCF-7Ca human breast cancer cells in vitro. Steroids 100-107 estrogen receptor 1 Homo sapiens 76-93 12444603-6 2002 These studies show that estrogen receptor-alpha is expressed by neurons in autonomic and sensory areas of the lumbosacral spinal cord that have connections with the female reproductive system and that the level of estrogen receptor-alpha changes over the course of pregnancy, which may follow profiles of steroid hormones. Steroids 305-321 estrogen receptor 1 Homo sapiens 24-47 12444603-6 2002 These studies show that estrogen receptor-alpha is expressed by neurons in autonomic and sensory areas of the lumbosacral spinal cord that have connections with the female reproductive system and that the level of estrogen receptor-alpha changes over the course of pregnancy, which may follow profiles of steroid hormones. Steroids 305-321 estrogen receptor 1 Homo sapiens 214-237 15775266-2 2002 ER is a member of the nuclear steroid/thyroid hormone, fat-soluble vitamin receptor gene superfamily and acts as a ligand-inducible factor. Steroids 30-37 estrogen receptor 1 Homo sapiens 0-2 12822069-5 2002 Due to their estrogen-receptor-mediated mitogenic activity, these steroids were supposed to increase the statistical probability of spontaneous mutations. Steroids 66-74 estrogen receptor 1 Homo sapiens 13-30 12239089-5 2002 As no class of gene regulation could differentiate ERalpha from ERbeta activity, we characterized a novel steroid (7alpha-thiophenyl-E2) that bound with similar affinities to ERalpha and ERbeta, but functioned as an ERalpha agonist and ERbeta antagonist for all of these endothelial responses. Steroids 106-113 estrogen receptor 1 Homo sapiens 51-58 12239089-5 2002 As no class of gene regulation could differentiate ERalpha from ERbeta activity, we characterized a novel steroid (7alpha-thiophenyl-E2) that bound with similar affinities to ERalpha and ERbeta, but functioned as an ERalpha agonist and ERbeta antagonist for all of these endothelial responses. Steroids 106-113 estrogen receptor 1 Homo sapiens 175-182 12239089-5 2002 As no class of gene regulation could differentiate ERalpha from ERbeta activity, we characterized a novel steroid (7alpha-thiophenyl-E2) that bound with similar affinities to ERalpha and ERbeta, but functioned as an ERalpha agonist and ERbeta antagonist for all of these endothelial responses. Steroids 106-113 estrogen receptor 1 Homo sapiens 175-182 12208664-2 2002 In this study, in vitro assays were developed to rapidly and specifically detect ERalpha or ERbeta activation by these steroid hormones. Steroids 119-135 estrogen receptor 1 Homo sapiens 81-88 12231116-2 2002 The purpose of this study was to assess the association between the estrogen receptor (ER) alpha gene polymorphisms XbaI and PvuII and circulating levels of androstenedione, a precursor of sex-steroids synthetized in the ovary and adrenal. Steroids 193-201 estrogen receptor 1 Homo sapiens 68-96 10537181-1 1999 The steroid 17beta-estradiol (E2) acts to modulate transcription through classical nuclear estrogen receptors (ER-alpha and ER-beta). Steroids 4-11 estrogen receptor 1 Homo sapiens 111-119 11476946-8 2001 Partial inhibition of radioligand binding by an antibody against the steroid binding domain of the ERalpha suggests that the isoform faces the extracellular media in MCF-7 cells. Steroids 69-76 estrogen receptor 1 Homo sapiens 99-106 11406328-3 2001 Estrogen is one of a family of sex steroids that exerts many of its genomic effects through the activation of the nuclear estrogen receptors, ERalpha and ERbeta. Steroids 35-43 estrogen receptor 1 Homo sapiens 142-149 11406328-3 2001 Estrogen is one of a family of sex steroids that exerts many of its genomic effects through the activation of the nuclear estrogen receptors, ERalpha and ERbeta. Steroids 35-43 estrogen receptor 1 Homo sapiens 154-160 11037623-1 2000 Estrogen, one of several sex steroid hormones, mediates its actions through the estrogen receptor. Steroids 29-36 estrogen receptor 1 Homo sapiens 80-97 12021204-0 2002 Expression of ER-alpha and ER-beta in the hamster ovary: differential regulation by gonadotropins and ovarian steroid hormones. Steroids 110-126 estrogen receptor 1 Homo sapiens 14-22 11328819-4 2001 We found that depletion of endogenous AIB1 levels reduced steroid hormone signaling via the estrogen receptor alpha or progesterone receptor beta on transiently transfected reporter templates. Steroids 58-73 estrogen receptor 1 Homo sapiens 92-115 11231990-3 2001 The steroid hormone exerts its physiological responses through the estrogen receptor (ER), of which two subtypes, ERalpha and ERbeta, are known. Steroids 4-11 estrogen receptor 1 Homo sapiens 67-84 11231990-3 2001 The steroid hormone exerts its physiological responses through the estrogen receptor (ER), of which two subtypes, ERalpha and ERbeta, are known. Steroids 4-11 estrogen receptor 1 Homo sapiens 86-88 11231990-3 2001 The steroid hormone exerts its physiological responses through the estrogen receptor (ER), of which two subtypes, ERalpha and ERbeta, are known. Steroids 4-11 estrogen receptor 1 Homo sapiens 114-121 11231990-3 2001 The steroid hormone exerts its physiological responses through the estrogen receptor (ER), of which two subtypes, ERalpha and ERbeta, are known. Steroids 4-11 estrogen receptor 1 Homo sapiens 126-132 14973393-7 2000 In contrast, steroid antagonists such as the antiestrogen tamoxifen for the estrogen receptor induce an alternate conformation in AF-2 that occludes the coactivator binding site and recruits corepressors that can actively silence steroid responsive genes. Steroids 13-20 estrogen receptor 1 Homo sapiens 76-93 14973393-7 2000 In contrast, steroid antagonists such as the antiestrogen tamoxifen for the estrogen receptor induce an alternate conformation in AF-2 that occludes the coactivator binding site and recruits corepressors that can actively silence steroid responsive genes. Steroids 230-237 estrogen receptor 1 Homo sapiens 76-93 10440242-11 1999 CONCLUSIONS: The presence of the ERalpha in the human eye suggests that the sex steroid hormone axis may play a role in the pathogenesis of certain ocular diseases. Steroids 80-95 estrogen receptor 1 Homo sapiens 33-40 10499535-6 1999 Steroid depletion reduced ER alpha mRNA 12 h after hCG, an effect partially reversible by progestin replacement, whereas ER beta mRNA was not affected by steroids. Steroids 0-7 estrogen receptor 1 Homo sapiens 26-34 10499535-8 1999 These data demonstrate hCG-initiated, steroid-dependent (PR, ER alpha) and -independent (AR, ER beta, AhR) expression of receptor mRNAs in primate granulosa cells during the periovulatory interval. Steroids 38-45 estrogen receptor 1 Homo sapiens 61-69 9892606-5 1999 In parallel, TGF-beta1 inhibited c-Myc expression in T cell hybridomas, and ectopic expression of a chimeric molecule composed of c-Myc and the steroid binding domain of the estrogen receptor (Myc-ER) blocked both the inhibition of FasL and the decrease of AICD induced by TGF-beta1, providing that 4-hydroxytamoxifen was present. Steroids 144-151 estrogen receptor 1 Homo sapiens 174-191 10231387-7 1999 The results indicate that the binding of para-alkylphenols to the estrogen receptor is due to the effect of covalent bonding of two constituents of the phenol and alkyl groups, which correspond to the A-ring and hydrophobic moiety of the steroid structure, respectively. Steroids 238-245 estrogen receptor 1 Homo sapiens 66-83 10419599-9 1999 This preliminary study indicates up-regulation of osteocyte ERalpha protein by ovarian steroids in these patients, which is accompanied by decreased osteoblast ERalpha mRNA expression, providing further evidence for the involvement of osteocytes in the regulation of skeletal structure by ovarian steroids. Steroids 87-95 estrogen receptor 1 Homo sapiens 60-67 10419599-9 1999 This preliminary study indicates up-regulation of osteocyte ERalpha protein by ovarian steroids in these patients, which is accompanied by decreased osteoblast ERalpha mRNA expression, providing further evidence for the involvement of osteocytes in the regulation of skeletal structure by ovarian steroids. Steroids 297-305 estrogen receptor 1 Homo sapiens 60-67 9371241-2 1997 These synthetic steroids would facilitate investigations on the potential biological role of catechol estrogens and also enable further examination of the structural and electronic constraints on the A ring in the interaction of estrogens with the estrogen receptor. Steroids 16-24 estrogen receptor 1 Homo sapiens 248-265 9544987-3 1998 In most instances, a steroid receptor, such as progesterone receptor (PR) or estrogen receptor (ER), is transcriptionally inactive when complexed with an antagonist and competitively inhibits transactivation of a target steroid-responsive gene by the cognate hormone-occupied receptor. Steroids 21-28 estrogen receptor 1 Homo sapiens 77-94 9544987-3 1998 In most instances, a steroid receptor, such as progesterone receptor (PR) or estrogen receptor (ER), is transcriptionally inactive when complexed with an antagonist and competitively inhibits transactivation of a target steroid-responsive gene by the cognate hormone-occupied receptor. Steroids 21-28 estrogen receptor 1 Homo sapiens 96-98 9422719-1 1998 We have been interested in understanding how the estrogen receptor (ER) binds estrogens and discriminates between different classes of steroids with closely related structures. Steroids 135-143 estrogen receptor 1 Homo sapiens 49-66 9422719-1 1998 We have been interested in understanding how the estrogen receptor (ER) binds estrogens and discriminates between different classes of steroids with closely related structures. Steroids 135-143 estrogen receptor 1 Homo sapiens 68-70 10068898-2 1998 These ultra-small, non-charged immunoreagents, combined with a size-enlargement by silver enhancement, localized estradiol receptor in both nuclear and cytoplasmic areas of non-stimulated target cells; stimulation with the steroid induced a predominantly nuclear labelling. Steroids 223-230 estrogen receptor 1 Homo sapiens 113-131 9269899-7 1997 These data support the hypothesis that the level of expression of ER specifically influences the expression of EGFR in human breast cancer cells and provides a potential link between loss of steroid sensitivity and the acquisition of autonomous growth. Steroids 191-198 estrogen receptor 1 Homo sapiens 66-68 9045869-0 1997 Vitamin D and gonadal steroid-resistant New World primate cells express an intracellular protein which competes with the estrogen receptor for binding to the estrogen response element. Steroids 22-29 estrogen receptor 1 Homo sapiens 121-138 9160720-8 1997 ER mRNA levels rose within these compartments only when estradiol followed steroid hormone treatment designed to induce an artificial estrous cycle (estradiol-progesterone-estradiol [EPE] treatment). Steroids 75-90 estrogen receptor 1 Homo sapiens 0-2 9045869-7 1997 We conclude that vitamin D-resistant and gonadal steroid-resistant NWP cells contain a protein(s) that may "silence" ER action by interacting directly with the ERE and interfering with ER binding. Steroids 49-56 estrogen receptor 1 Homo sapiens 117-119 9045869-7 1997 We conclude that vitamin D-resistant and gonadal steroid-resistant NWP cells contain a protein(s) that may "silence" ER action by interacting directly with the ERE and interfering with ER binding. Steroids 49-56 estrogen receptor 1 Homo sapiens 160-162 8651492-3 1996 In the first step, a solution containing the steroid binding domain of the human estrogen receptor is added to the LC effluent via a mixing union, and the mixture is allowed to react. Steroids 45-52 estrogen receptor 1 Homo sapiens 81-98 9001740-1 1996 Hormone-dependent sociosexual behaviors of the displaying individual regulate the abundance of estrogen receptor- and progesterone receptor-mRNA in sex steroid hormone-concentrating brain areas of the partner. Steroids 152-167 estrogen receptor 1 Homo sapiens 95-112 9009243-1 1996 Linkage of a 11beta-chloromethyl group to estradiol-17beta (E2) dramatically increases the binding affinity of the steroid for the estrogen receptor (ER) with the formation of a quasi-irreversible steroid-receptor complex. Steroids 115-122 estrogen receptor 1 Homo sapiens 131-148 9009243-1 1996 Linkage of a 11beta-chloromethyl group to estradiol-17beta (E2) dramatically increases the binding affinity of the steroid for the estrogen receptor (ER) with the formation of a quasi-irreversible steroid-receptor complex. Steroids 115-122 estrogen receptor 1 Homo sapiens 150-152 1419884-10 1992 Higher concentrations of free steroids in ER negative cells would then be available for combination with membranes and non-specific binding sites throughout the cell. Steroids 30-38 estrogen receptor 1 Homo sapiens 42-44 8200909-7 1994 The estrogen receptor-transfected cells grown in estrogenic regular medium, however, exhibited lower constitutive levels of epidermal growth factor-receptor mRNA than in steroid-stripped medium, suggesting that estrogens coupled with some factors normally present in the regular medium may indeed downmodulate epidermal growth factor-receptor mRNA. Steroids 170-177 estrogen receptor 1 Homo sapiens 4-21 1508220-1 1992 The estrogen receptor (ER) is a transcription factor involved in steroid hormone signal transduction in higher eukaryotes. Steroids 65-80 estrogen receptor 1 Homo sapiens 4-21 1730720-0 1992 DNA allosterically modulates the steroid binding domain of the estrogen receptor. Steroids 33-40 estrogen receptor 1 Homo sapiens 63-80 1730720-1 1992 The ability of DNA to allosterically alter the conformation of the estrogen receptor"s (ER) steroid binding domain was investigated. Steroids 92-99 estrogen receptor 1 Homo sapiens 67-84 34562481-1 2022 Because of their historical mode of action, endocrine-disrupting chemicals (EDCs) are associated with sex-steroid receptors, namely the two estrogen receptors (ERalpha and ERbeta) and the androgen receptor (AR). Steroids 106-113 estrogen receptor 1 Homo sapiens 160-167 34562481-1 2022 Because of their historical mode of action, endocrine-disrupting chemicals (EDCs) are associated with sex-steroid receptors, namely the two estrogen receptors (ERalpha and ERbeta) and the androgen receptor (AR). Steroids 106-113 estrogen receptor 1 Homo sapiens 172-178 34999838-13 2022 The combination of increased ERalpha and AR expression in the SI-NET microenvironment suggests a modulating role of sex steroids in the development of the characteristic SI-NET mesenteric metastasis and associated fibrosis. Steroids 120-128 estrogen receptor 1 Homo sapiens 29-36 34901495-1 2021 Estradiol is a steroid hormone that works as an agonist estrogen receptor (ER). Steroids 15-22 estrogen receptor 1 Homo sapiens 56-73 34901495-1 2021 Estradiol is a steroid hormone that works as an agonist estrogen receptor (ER). Steroids 15-22 estrogen receptor 1 Homo sapiens 75-77 34461224-2 2021 Estrogen (E2), a steroid-derived hormone, and its receptors (ERs), particularly ER-alpha, are important drivers for the development and growth of leiomyomas. Steroids 17-24 estrogen receptor 1 Homo sapiens 80-88 34502135-0 2021 Kisspeptin Neurons and Estrogen-Estrogen Receptor alpha Signaling: Unraveling the Mystery of Steroid Feedback System Regulating Mammalian Reproduction. Steroids 93-100 estrogen receptor 1 Homo sapiens 32-55 34070471-2 2021 Several sex steroid receptors other than ER-alpha: androgen receptor (AR), second ER, ER-beta, and non-nuclear receptors represented by G-protein-coupled estrogen receptor (GPER), are frequently expressed in TNBC and their biological and clinical importance has been suggested by a large number of studies. Steroids 12-19 estrogen receptor 1 Homo sapiens 41-49 34132331-1 2021 The classification and treatment of breast cancer is largely defined by the expression of steroid hormone receptors (HRs), namely estrogen receptor (ER) and progesterone receptor (PR), and gene amplification/overexpression of human epidermal growth factor receptor 2 (HER2). Steroids 90-97 estrogen receptor 1 Homo sapiens 130-147 34132331-1 2021 The classification and treatment of breast cancer is largely defined by the expression of steroid hormone receptors (HRs), namely estrogen receptor (ER) and progesterone receptor (PR), and gene amplification/overexpression of human epidermal growth factor receptor 2 (HER2). Steroids 90-97 estrogen receptor 1 Homo sapiens 149-151 34428304-7 2021 Our findings delineate the functional interplay between RING1B, RNA and ERalpha to safeguard chromatin architecture perturbations required for estrogen-mediated gene regulation and highlight the crosstalk between steroid hormones and Polycomb proteins to regulate oncogenic programs. Steroids 213-220 estrogen receptor 1 Homo sapiens 72-79 35514537-6 2022 In different sample populations, there has been replication of SNPs near genes involved in oestrogen and other steroid regulated pathways including ESR1 (oestrogen receptor alpha), GREB1, HOXA10, WNT4 and MAPK kinase signalling. Steroids 111-118 estrogen receptor 1 Homo sapiens 148-152 2683797-2 1989 The ER and PR content in cytosolic and nuclear extracts varied with steroid treatment. Steroids 68-75 estrogen receptor 1 Homo sapiens 4-6 35039106-8 2022 Steroid nuclear receptors such as the androgen receptor and estrogen receptor alpha were localized in the PEM through the urethral wall, although some epithelial labeling was also present in the urogenital sinus epithelium (UGE). Steroids 0-7 estrogen receptor 1 Homo sapiens 60-83 35229974-6 2022 Through systems biology approaches, we found surprising roles for EGFR family members, sex steroid hormone receptor ESR1 interplay with oncogenic STAT function and proposed new drug targeting approaches of oncogenic STAT pathway addiction. Steroids 91-98 estrogen receptor 1 Homo sapiens 116-120 35176205-3 2022 Estrogen actions are mediated through the steroid hormone receptors, estrogen receptor alpha and beta and through a G-protein coupled receptor. Steroids 42-49 estrogen receptor 1 Homo sapiens 69-92 35558573-13 2020 Conclusion: The positive expressions of ER and PR in endometrial carcinoma suggest that steroid receptor studies may be of potential benefit in the management of some patients with endometrial carcinoma. Steroids 88-95 estrogen receptor 1 Homo sapiens 40-42 2470535-2 1989 If breast tumors are mishandled, the relatively labile ER protein may lose its steroid-binding capacity (become inactivated) and not be measurable by the routine steroid-binding assay. Steroids 79-86 estrogen receptor 1 Homo sapiens 55-57 2470535-2 1989 If breast tumors are mishandled, the relatively labile ER protein may lose its steroid-binding capacity (become inactivated) and not be measurable by the routine steroid-binding assay. Steroids 162-169 estrogen receptor 1 Homo sapiens 55-57 2783381-9 1989 We propose that ER+ breast cancer that has changed to a paracrine growth factor-driven system (from stromal cells or ER- breast cancer cells) is less responsive to gonadal steroids. Steroids 172-180 estrogen receptor 1 Homo sapiens 16-18 2703268-1 1989 We analyzed by restriction mapping the genomic organization of the estrogen receptor gene in several primary human brain tumors in order to investigate the possible relationships between the development of these tumors and gonadal steroid hormones. Steroids 231-247 estrogen receptor 1 Homo sapiens 67-84 2725532-10 1989 This suggested that the smaller variant ER mRNAs may be missing some or all of the E/F domain which is thought to contain the steroid hormone binding domain of the receptor. Steroids 126-141 estrogen receptor 1 Homo sapiens 40-42 2626021-4 1989 The hypothesis of vicinal space positioning of an acidic and a nucleophilic group in the estradiol receptor cavity is examined in the light of the amino-acid composition of the steroid binding domain. Steroids 177-184 estrogen receptor 1 Homo sapiens 89-107 2785242-0 1989 Regulation of estrogen receptor messenger ribonucleic acid and protein levels in human breast cancer cell lines by sex steroid hormones, their antagonists, and growth factors. Steroids 119-126 estrogen receptor 1 Homo sapiens 14-31 2845868-1 1988 Steroid binding assay using the dextran coated charcoal (DCC) method was applied to human tissues including tumors of the digestive organs, and the results were compared with those of enzymeimmunoassay (EIA) and immunocytochemical assay (ICA) with monoclonal antibody against human estrogen receptor of MCF-7 breast cancer cells. Steroids 0-7 estrogen receptor 1 Homo sapiens 282-299 3196678-3 1988 The organochromium-labeled steroids are stable in aqueous methanol solution, and their relative binding affinities to estrogen receptor have been determined; these values vary from 0.4 to 28%. Steroids 27-35 estrogen receptor 1 Homo sapiens 118-135 3677099-5 1987 ER protein was estimated by the dextran-coated charcoal steroid binding method and by an ER immunocytochemical assay using a specific monoclonal antibody. Steroids 56-63 estrogen receptor 1 Homo sapiens 0-2 3795941-1 1986 16 alpha-Iodoestradiol is an estrogenic steroid with high affinity for the estrogen receptor. Steroids 40-47 estrogen receptor 1 Homo sapiens 75-92 3324022-4 1987 The results have been compared with those obtained using a standard dextran coated charcoal steroid binding assay (ER-DCC). Steroids 92-99 estrogen receptor 1 Homo sapiens 115-117 3314674-1 1987 Enzyme immuno assay (EIA) of estrogen receptor (ER) has confirmed the results of earlier investigations using steroid binding techniques, namely that ER is present at very low concentrations in samples from metastatic melanoma. Steroids 110-117 estrogen receptor 1 Homo sapiens 29-46 3314674-1 1987 Enzyme immuno assay (EIA) of estrogen receptor (ER) has confirmed the results of earlier investigations using steroid binding techniques, namely that ER is present at very low concentrations in samples from metastatic melanoma. Steroids 110-117 estrogen receptor 1 Homo sapiens 48-50 3314674-1 1987 Enzyme immuno assay (EIA) of estrogen receptor (ER) has confirmed the results of earlier investigations using steroid binding techniques, namely that ER is present at very low concentrations in samples from metastatic melanoma. Steroids 110-117 estrogen receptor 1 Homo sapiens 150-152 3300775-0 1987 The steroid binding domain of porcine estrogen receptor. Steroids 4-11 estrogen receptor 1 Homo sapiens 38-55 3428713-6 1987 The presence of estrogen receptor in the nuclear fraction and its absence in the cytoplasm may warrant modification of the classical two-step model for steroid hormone action. Steroids 152-167 estrogen receptor 1 Homo sapiens 16-33 3795941-2 1986 When labelled with a gamma emitting isotope, such as 125I, the resulting radioactive steroid is an excellent ligand for the sensitive analysis of the estrogen receptor. Steroids 85-92 estrogen receptor 1 Homo sapiens 150-167 3021126-6 1986 Others have proposed that the segment on the ER and GR that is nearest their amino terminus (e.g. residues 173-250 of the ER) is part of their DNA binding domain and that the other two similar segments on each receptor, which are closer to their carboxy terminus, are part of their steroid binding domain. Steroids 282-289 estrogen receptor 1 Homo sapiens 45-47 3021126-6 1986 Others have proposed that the segment on the ER and GR that is nearest their amino terminus (e.g. residues 173-250 of the ER) is part of their DNA binding domain and that the other two similar segments on each receptor, which are closer to their carboxy terminus, are part of their steroid binding domain. Steroids 282-289 estrogen receptor 1 Homo sapiens 122-124 2426418-1 1986 We developed an immunoperoxidase technique using a monoclonal antibody to the estradiol receptor (ER) to identify immunoreactive ER (iER) in breast carcinomas and compared this with the conventional dextran-coated charcoal (DCC) steroid binding assay. Steroids 229-236 estrogen receptor 1 Homo sapiens 98-100 2426695-7 1986 These results indicate that estradiol receptor transformation is due to the effect of a serine protease and that the receptor itself is endowed with this catalytic activity, which is triggered by the steroid. Steroids 200-207 estrogen receptor 1 Homo sapiens 28-46 7074937-2 1982 The sensitivity of the estrogen receptor radioligand assay is therefore related to the specific activity of the steroid label used for the binding assay, the amount of the receptor protein in the volume of cytosol used, and the protein concentration in the cytosol. Steroids 112-119 estrogen receptor 1 Homo sapiens 23-40 6191047-7 1983 Sucrose gradient analysis of the estrogen receptor of benign prostatic hyperplasia revealed that it sedimented in the region of 8S, and steroid specificity studies confirmed that the binding to estrogen receptor was estrogen-specific. Steroids 136-143 estrogen receptor 1 Homo sapiens 33-50 6191047-7 1983 Sucrose gradient analysis of the estrogen receptor of benign prostatic hyperplasia revealed that it sedimented in the region of 8S, and steroid specificity studies confirmed that the binding to estrogen receptor was estrogen-specific. Steroids 136-143 estrogen receptor 1 Homo sapiens 194-211 3965140-0 1985 Comparison of immunocytochemical and steroid-binding assays for estrogen receptor in human breast tumors. Steroids 37-44 estrogen receptor 1 Homo sapiens 64-81 6237915-4 1984 The measurement of these steroid ratios in the plasma of breast cancer patients thus provides an indirect estimate of ER status. Steroids 25-32 estrogen receptor 1 Homo sapiens 118-120 7472273-1 1981 The largest and smallest discrete forms of the estrogen receptor in human breast tumor cytosol were characterized by competitive steroid binding, ultracentrifugation, gel filtration, and electrophoresis in polyacrylamide gels of several concentrations. Steroids 129-136 estrogen receptor 1 Homo sapiens 47-64 7388945-2 1980 The 46K protein, which accounts for 40% of 35S-methionine incorporation into secreted proteins, is only induced by steroids able to interact with the estrogen receptor. Steroids 115-123 estrogen receptor 1 Homo sapiens 150-167