PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31807868-6 2020 Addition of thymidine to the treatment regimen led to a significant reversal of antifilarial effect of 4H that confirmed inhibition of thymidylate synthase as pharmacological rationale. Thymidine 12-21 thymidylate synthetase Homo sapiens 135-155 30142195-0 2018 Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer. Thymidine 89-98 thymidylate synthetase Homo sapiens 39-59 30142195-1 2018 INTRODUCTION: Successful inhibition of thymidylate synthase (TS) by pemetrexed, a TS inhibitor, results in a reproducible transient burst or "flare" in thymidine salvage pathway activity at 2 hrs. Thymidine 152-161 thymidylate synthetase Homo sapiens 39-59 28927061-7 2017 The addition of dU and thymidine dT to 5FU promoted the formation of ternary complexes and reversed 5FU resistance in MKN45/F2R cells, although dT inhibited the efficacy of raltitrexed (another TS inhibitor). Thymidine 33-35 thymidylate synthetase Homo sapiens 194-196 29137296-1 2017 Introduction: Inhibition of thymidylate synthase (TS) results in a transient compensatory "flare" in thymidine salvage pathway activity measureable with 18F-thymidine (FLT)- positron emission tomography (PET) at 2hrs. Thymidine 101-110 thymidylate synthetase Homo sapiens 28-48 26242737-3 2015 MTX inhibits thymidine synthesis by targeting dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS). Thymidine 13-22 thymidylate synthetase Homo sapiens 81-101 29324220-2 2017 The main mechanisms of 5-FU action are thymidylate synthase (TS) inhibition which can be abrogated by thymidine and strengthened by calciumfolinate (CF) and incorporation of fluorouridinetriphosphate into RNA which can be abrogated by uridine. Thymidine 102-111 thymidylate synthetase Homo sapiens 39-59 27655645-1 2017 Inhibition of thymidylate synthase (TS) results in a transient "flare" in DNA thymidine salvage pathway activity measurable with FLT ([18F]thymidine)-positron emission tomography (PET). Thymidine 78-87 thymidylate synthetase Homo sapiens 14-34 27655645-1 2017 Inhibition of thymidylate synthase (TS) results in a transient "flare" in DNA thymidine salvage pathway activity measurable with FLT ([18F]thymidine)-positron emission tomography (PET). Thymidine 139-148 thymidylate synthetase Homo sapiens 14-34 27391433-1 2016 BACKGROUND: Thymidylate synthase (TS), one of the key enzymes for thymidine synthesis, is a target of pemetrexed (PEM), a key agent for the systemic therapy of malignant pleural mesothelioma (MPM) and its overexpression has been correlated to PEM-resistance. Thymidine 66-75 thymidylate synthetase Homo sapiens 12-32 27391433-1 2016 BACKGROUND: Thymidylate synthase (TS), one of the key enzymes for thymidine synthesis, is a target of pemetrexed (PEM), a key agent for the systemic therapy of malignant pleural mesothelioma (MPM) and its overexpression has been correlated to PEM-resistance. Thymidine 66-75 thymidylate synthetase Homo sapiens 34-36 26242737-3 2015 MTX inhibits thymidine synthesis by targeting dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS). Thymidine 13-22 thymidylate synthetase Homo sapiens 103-107 23611499-1 2013 Thymidylate synthase (TSase) produces the sole intracellular de novo source of thymidine (i.e., the DNA base T) and thus is a common target for antibiotic and anticancer drugs. Thymidine 79-88 thymidylate synthetase Homo sapiens 0-20 25423174-1 2014 Expression of hTS (human thymidylate synthase), a key enzyme in thymidine biosynthesis, is regulated on the translational level through a feedback mechanism that is rarely found in eukaryotes. Thymidine 64-73 thymidylate synthetase Homo sapiens 25-45 23611499-1 2013 Thymidylate synthase (TSase) produces the sole intracellular de novo source of thymidine (i.e., the DNA base T) and thus is a common target for antibiotic and anticancer drugs. Thymidine 79-88 thymidylate synthetase Homo sapiens 22-27 23449220-3 2013 Previously, we demonstrated that deoxythymidine release from degraded siRNAs reversed the cytotoxicity of thymidylate synthase (TS)-targeted siRNAs and other TS inhibitor compounds. Thymidine 33-47 thymidylate synthetase Homo sapiens 106-126 23449220-3 2013 Previously, we demonstrated that deoxythymidine release from degraded siRNAs reversed the cytotoxicity of thymidylate synthase (TS)-targeted siRNAs and other TS inhibitor compounds. Thymidine 33-47 thymidylate synthetase Homo sapiens 128-130 23449220-3 2013 Previously, we demonstrated that deoxythymidine release from degraded siRNAs reversed the cytotoxicity of thymidylate synthase (TS)-targeted siRNAs and other TS inhibitor compounds. Thymidine 33-47 thymidylate synthetase Homo sapiens 158-160 21222488-1 2011 Human thymidine phosphorylase (hTP) is responsible for thymidine (dT) homeostasis, promotes angiogenesis, and is involved in metabolic inactivation of antiproliferative agents that inhibit thymidylate synthase. Thymidine 6-15 thymidylate synthetase Homo sapiens 189-209 23143777-1 2012 Thymidylate synthase (TS) is a key enzyme in the biosynthesis of thymidine. Thymidine 65-74 thymidylate synthetase Homo sapiens 0-20 23143777-1 2012 Thymidylate synthase (TS) is a key enzyme in the biosynthesis of thymidine. Thymidine 65-74 thymidylate synthetase Homo sapiens 22-24 21673071-3 2011 Cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2) contribute to an alternative dTMP-producing pathway, by salvaging thymidine from the tumor milieu, and may modulate resistance to TS-targeting drugs. Thymidine 10-19 thymidylate synthetase Homo sapiens 204-206 21269855-4 2011 Thymidine synthesis, catalyzed by the crucial enzyme thymidylate synthase (TS), competes with methionine metabolism for a common substrate. Thymidine 0-9 thymidylate synthetase Homo sapiens 53-73 21269855-4 2011 Thymidine synthesis, catalyzed by the crucial enzyme thymidylate synthase (TS), competes with methionine metabolism for a common substrate. Thymidine 0-9 thymidylate synthetase Homo sapiens 75-77 21222488-1 2011 Human thymidine phosphorylase (hTP) is responsible for thymidine (dT) homeostasis, promotes angiogenesis, and is involved in metabolic inactivation of antiproliferative agents that inhibit thymidylate synthase. Thymidine 66-68 thymidylate synthetase Homo sapiens 189-209 21247442-8 2011 We further demonstrated that dT-containing siRNAs prevented the cytotoxic effects of thymidylate synthase (TS) inhibitor compounds, such as ZD1694 and 5"-fluoro-deoxyuridine, while having no deleterious effect on cisplatin toxicity. Thymidine 29-31 thymidylate synthetase Homo sapiens 85-105 21247442-8 2011 We further demonstrated that dT-containing siRNAs prevented the cytotoxic effects of thymidylate synthase (TS) inhibitor compounds, such as ZD1694 and 5"-fluoro-deoxyuridine, while having no deleterious effect on cisplatin toxicity. Thymidine 29-31 thymidylate synthetase Homo sapiens 107-109 18442042-1 2008 BACKGROUND: Thymidylate synthase (TS) is important for maintenance of the intracellular thymidine pool, which is crucial for DNA synthesis and repair. Thymidine 88-97 thymidylate synthetase Homo sapiens 12-32 21498882-13 2011 5) CO dehydrogenase and thymidylate synthase and the glycine cleavage genes mutually exclude each other in archaea; this may represent an alternative route for generation of methyl donors for thymidine synthesis. Thymidine 192-201 thymidylate synthetase Homo sapiens 24-44 19839928-1 2010 Pemetrexed is a multi-targeted anti metabolite that inhibits several key folate-dependent enzymes in the thymidine and purine biosynthetic pathways, including thymidylate synthase. Thymidine 105-114 thymidylate synthetase Homo sapiens 159-179 20628382-1 2010 BACKGROUND: Thymidylate synthase (TS), a key enzyme in the de novo synthesis of thymidine, is an important chemotherapeutic target for malignant tumours including lung cancer. Thymidine 80-89 thymidylate synthetase Homo sapiens 12-32 20628382-1 2010 BACKGROUND: Thymidylate synthase (TS), a key enzyme in the de novo synthesis of thymidine, is an important chemotherapeutic target for malignant tumours including lung cancer. Thymidine 80-89 thymidylate synthetase Homo sapiens 34-36 19006382-5 2008 However, their activity was dependent on the administration of thymidine to overcome the potent inhibition of thymidylate synthase (TS) and deoxycytidine monophosphate (dCMP) deaminase by dZMP, which deprives cells of essential levels of thymidine. Thymidine 63-72 thymidylate synthetase Homo sapiens 110-130 19006382-5 2008 However, their activity was dependent on the administration of thymidine to overcome the potent inhibition of thymidylate synthase (TS) and deoxycytidine monophosphate (dCMP) deaminase by dZMP, which deprives cells of essential levels of thymidine. Thymidine 238-247 thymidylate synthetase Homo sapiens 110-130 18442042-1 2008 BACKGROUND: Thymidylate synthase (TS) is important for maintenance of the intracellular thymidine pool, which is crucial for DNA synthesis and repair. Thymidine 88-97 thymidylate synthetase Homo sapiens 34-36 16568206-0 2006 Elevation of radiolabelled thymidine uptake in RIF-1 fibrosarcoma and HT29 colon adenocarcinoma cells after treatment with thymidylate synthase inhibitors. Thymidine 27-36 thymidylate synthetase Homo sapiens 123-143 16721548-0 2007 An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed. Thymidine 17-26 thymidylate synthetase Homo sapiens 92-112 16721548-1 2007 The antitumour effect of thymidylate synthase inhibitors such as raltitrexed (RTX) may be reversed by salvage of thymidine (Thd). Thymidine 113-122 thymidylate synthetase Homo sapiens 25-45 16721548-1 2007 The antitumour effect of thymidylate synthase inhibitors such as raltitrexed (RTX) may be reversed by salvage of thymidine (Thd). Thymidine 124-127 thymidylate synthetase Homo sapiens 25-45 12467230-9 2001 Besides, whereas thymidine failed to inhibit FUra cytotoxicity in LS174T wild-type cells, the potentiation of the antitumor activity observed in the modulating regimen was partly reversed by thymidine, indicative of thymidylate synthase as the main drug target. Thymidine 191-200 thymidylate synthetase Homo sapiens 216-236 15711180-1 2005 Trifluorothymidine (TFT) is a fluorinated thymidine analog that after conversion to its monophosphate derivative can inhibit thymidylate synthase (TS) and be incorporated into DNA. Thymidine 9-18 thymidylate synthetase Homo sapiens 125-145 15207728-5 2004 This phenomenon was also observed in cervical cancer cells and was independent of thymidylate synthase, a target of thymine and thymidine analogues. Thymidine 128-137 thymidylate synthetase Homo sapiens 82-102 12102601-1 2002 Thymidylate synthase (TS) is an essential enzyme in de novo synthesis of thymidylate, and is required for DNA synthesis and cell proliferation in the absence of exogenous thymidine. Thymidine 171-180 thymidylate synthetase Homo sapiens 0-20 12102601-1 2002 Thymidylate synthase (TS) is an essential enzyme in de novo synthesis of thymidylate, and is required for DNA synthesis and cell proliferation in the absence of exogenous thymidine. Thymidine 171-180 thymidylate synthetase Homo sapiens 22-24 11862424-9 2002 The cytotoxicity of FUra alone or in combination with MCLR, but not that of PPIs alone, was abrogated almost completely by exogenous thymidine (dThd), suggesting that inhibition of thymidylate synthetase (TS) is the growth-limiting event in the cytotoxic action of FUra even in combination with MCLR. Thymidine 144-148 thymidylate synthetase Homo sapiens 181-203 15342418-5 2004 ZD9331 induced p21Cip1 up-regulation in all of the cell lines examined, as did thymidine deprivation in thymidylate synthase-deficient (thymidylate synthase-) cells. Thymidine 79-88 thymidylate synthetase Homo sapiens 104-124 11862424-9 2002 The cytotoxicity of FUra alone or in combination with MCLR, but not that of PPIs alone, was abrogated almost completely by exogenous thymidine (dThd), suggesting that inhibition of thymidylate synthetase (TS) is the growth-limiting event in the cytotoxic action of FUra even in combination with MCLR. Thymidine 133-142 thymidylate synthetase Homo sapiens 181-203 11727827-0 2001 Interaction of thymidylate synthase with the 5"-thiophosphates, 5"-dithiophosphates, 5"-H-phosphonates and 5"-S-thiosulfates of 2"-deoxyuridine, thymidine and 5-fluoro-2"-deoxyuridine. Thymidine 145-154 thymidylate synthetase Homo sapiens 15-35 11325838-1 2001 Plasma levels of folates and thymidine in mice are about 10-fold higher than in humans and may influence the therapeutic efficacy of thymidylate synthase (TS) inhibitors, such as 5-fluorouracil (5FU) and the antifolates pemetrexed (MTA) and raltitrexed (RTX). Thymidine 29-38 thymidylate synthetase Homo sapiens 133-153 10535743-11 1999 The transformed strain exhibited thymidine auxotrophy, indicating that the mutant TS (Leu216) is nonfunctional. Thymidine 33-42 thymidylate synthetase Homo sapiens 82-84 11216535-1 2001 UNLABELLED: We report improved incorporation of the radiolabeled-thymidine analog [125I/131I]5-iodo-2"-deoxyuridine ([125I/131I]IdUrd) into DNA by the addition of Thymitaq, a thymidylate synthase inhibitor, as a strategy of molecular radiotherapy for hepatoma treatment. Thymidine 65-74 thymidylate synthetase Homo sapiens 175-195 10663629-1 2000 PURPOSE: The cytotoxicity of the thymidylate synthase (TS) inhibitor raltitrexed (RTX) is reversed by supraphysiologic thymidine concentrations. Thymidine 119-128 thymidylate synthetase Homo sapiens 33-53 10482907-2 1999 Thymidylate synthase (TS), the key enzyme in de novo synthesis of thymidine, is an important target for antitumour chemotherapy. Thymidine 66-75 thymidylate synthetase Homo sapiens 0-20 10509749-0 1999 Genetic complementation and resistance to 5-fluoro-2"-deoxyuridine in thymidine auxotrophs expressing a highly defective mutant of human thymidylate synthase. Thymidine 70-79 thymidylate synthetase Homo sapiens 137-157 10509749-3 1999 Although the kcat/Km of the mutant protein for the substrate, dUMP, is 10(3) lower than that of wild-type TS, the mutant TS confers thymidine prototrophy on a TS-deficient bacterial strain when expressed at high levels. Thymidine 132-141 thymidylate synthetase Homo sapiens 106-108 10509749-3 1999 Although the kcat/Km of the mutant protein for the substrate, dUMP, is 10(3) lower than that of wild-type TS, the mutant TS confers thymidine prototrophy on a TS-deficient bacterial strain when expressed at high levels. Thymidine 132-141 thymidylate synthetase Homo sapiens 121-123 10509749-3 1999 Although the kcat/Km of the mutant protein for the substrate, dUMP, is 10(3) lower than that of wild-type TS, the mutant TS confers thymidine prototrophy on a TS-deficient bacterial strain when expressed at high levels. Thymidine 132-141 thymidylate synthetase Homo sapiens 121-123 10509749-7 1999 At similar levels of TS expression, thymidine prototrophs expressing Glu214 TS were 8-fold more resistant to 5-fluoro-2"-deoxyuridine (FdUrd) cytotoxicity than are prototrophs expressing Gln214 TS. Thymidine 36-45 thymidylate synthetase Homo sapiens 76-78 10509749-7 1999 At similar levels of TS expression, thymidine prototrophs expressing Glu214 TS were 8-fold more resistant to 5-fluoro-2"-deoxyuridine (FdUrd) cytotoxicity than are prototrophs expressing Gln214 TS. Thymidine 36-45 thymidylate synthetase Homo sapiens 76-78 10473074-2 1999 Instead of inhibiting TS, we hypothesized that it was possible to use this enzyme to activate suicide prodrugs (deoxyuridine analogues) to more toxic species (thymidine analogues). Thymidine 159-168 thymidylate synthetase Homo sapiens 22-24 10482907-2 1999 Thymidylate synthase (TS), the key enzyme in de novo synthesis of thymidine, is an important target for antitumour chemotherapy. Thymidine 66-75 thymidylate synthetase Homo sapiens 22-24 9661884-0 1998 Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro. Thymidine 34-43 thymidylate synthetase Homo sapiens 83-103 10598557-4 1999 Dipyridamole inhibits nucleoside transport and in vitro studies have demonstrated that dipyridamole can prevent thymidine salvage rescue from antifolate thymidylate synthase inhibitors. Thymidine 112-121 thymidylate synthetase Homo sapiens 153-173 9661884-1 1998 The inhibition of de novo thymidine (dThd) synthesis by the novel folate-based thymidylate synthase (TS) inhibitor ZD1694 (Tomudex) can achieve tumor cell-specific cytotoxicity in vivo. Thymidine 37-41 thymidylate synthetase Homo sapiens 79-99 7605345-1 1995 Inhibition of thymidylate synthase (TS) may increase incorporation of thymidine analogues into DNA, leading to increased inhibition of colony formation in tumor cells. Thymidine 70-79 thymidylate synthetase Homo sapiens 14-34 7575641-8 1995 Nevertheless, reversal of cytotoxicity studies with thymidine, hypoxanthine and folinic acid using the HL-60 cell line suggested that TS is the primary target for these analogues. Thymidine 52-61 thymidylate synthetase Homo sapiens 134-136 7605345-1 1995 Inhibition of thymidylate synthase (TS) may increase incorporation of thymidine analogues into DNA, leading to increased inhibition of colony formation in tumor cells. Thymidine 70-79 thymidylate synthetase Homo sapiens 36-38 7942285-6 1994 Thymidine, however, exerts its competitive effect primarily at the level of thymidylate synthase. Thymidine 0-9 thymidylate synthetase Homo sapiens 76-96 8203840-10 1994 Overall, it is clear that even with an inhibitor of malarial thymidylate synthase that is not particularly effective in itself, one can obtain selective inhibition of parasites if the antimalarial agent is used in combination with thymidine. Thymidine 231-240 thymidylate synthetase Homo sapiens 61-81 2917346-1 1989 The behavior of the activities of thymidine metabolizing enzymes, dihydrothymine dehydrogenase (EC 1.3.1.2) and thymidine phosphorylase (EC 2.4.2.4) for thymidine degradation, thymidine kinase (EC 2.7.1.75) and thymidylate synthase (EC 2.1.1.45) for DNA synthesis, was elucidated in cytosolic extracts from normal human lymphocytes and 13 human leukemia-lymphoma cell lines. Thymidine 34-43 thymidylate synthetase Homo sapiens 211-231 8398696-7 1993 Effects on thymidylate synthase (TS), the possible target of these analogues, were evaluated by thymidine rescue of growth inhibition and incorporation of tritiated deoxyuridine (3H-UdR) into DNA. Thymidine 96-105 thymidylate synthetase Homo sapiens 11-31 8398696-7 1993 Effects on thymidylate synthase (TS), the possible target of these analogues, were evaluated by thymidine rescue of growth inhibition and incorporation of tritiated deoxyuridine (3H-UdR) into DNA. Thymidine 96-105 thymidylate synthetase Homo sapiens 33-35 8246876-1 1993 Thymidine kinase (TK) and thymidylate synthetase (TS) are known to catalyse the phosphorylation of thymidine for the salvage synthesis of dTMP and the methylation of dUMP for the de novo synthesis of dTMP, respectively. Thymidine 99-108 thymidylate synthetase Homo sapiens 26-48 8325888-3 1993 Its growth inhibitory activity was completely reversed by the addition of thymidine, confirming that TS is its sole target in these cells. Thymidine 74-83 thymidylate synthetase Homo sapiens 101-103 2818627-2 1989 Dipyridamole potentiates the cytotoxicity of N10-propargyl-5,8-dideazafolic acid (CB3717), an antifolate inhibitor of thymidylate synthase, by inhibiting both thymidine (TdR) salvage and deoxyuridine (UdR) efflux. Thymidine 159-168 thymidylate synthetase Homo sapiens 118-138 8385896-4 1993 Theoretically, agents which inhibit thymidylate synthase or dihydrofolate reductase should reduce intracellular pools of thymidine, resulting in the potentiation of the antiviral effects of acyclovir. Thymidine 121-130 thymidylate synthetase Homo sapiens 36-56 8428362-8 1993 Growth inhibition was reversed by thymidine alone, indicating that thymidylate synthase was the only site of action of this compound. Thymidine 34-43 thymidylate synthetase Homo sapiens 67-87 1390771-1 1992 Thymidylate synthase (TS) catalyzes the final step in the de novo synthesis of thymidine. Thymidine 79-88 thymidylate synthetase Homo sapiens 0-20 1390771-1 1992 Thymidylate synthase (TS) catalyzes the final step in the de novo synthesis of thymidine. Thymidine 79-88 thymidylate synthetase Homo sapiens 22-24 34502300-12 2021 In addition, shMTHFR promoted the expression and translocation of nuclei thymidine synthetic enzyme complex SHMT1/DHFR/TYMS and assisted folate-dependent de novo nucleotide biosynthesis under folate restriction. Thymidine 73-82 thymidylate synthetase Homo sapiens 119-123 2917346-1 1989 The behavior of the activities of thymidine metabolizing enzymes, dihydrothymine dehydrogenase (EC 1.3.1.2) and thymidine phosphorylase (EC 2.4.2.4) for thymidine degradation, thymidine kinase (EC 2.7.1.75) and thymidylate synthase (EC 2.1.1.45) for DNA synthesis, was elucidated in cytosolic extracts from normal human lymphocytes and 13 human leukemia-lymphoma cell lines. Thymidine 112-121 thymidylate synthetase Homo sapiens 211-231 2700913-7 1989 Thymidine (10 microM) completely blocked both the cytotoxicity and induction of differentiation produced by the specific inhibitor of thymidylate synthase (TS), N10-propargyl-5,8-dideazafolic acid (CB-3717). Thymidine 0-9 thymidylate synthetase Homo sapiens 134-154 2700913-7 1989 Thymidine (10 microM) completely blocked both the cytotoxicity and induction of differentiation produced by the specific inhibitor of thymidylate synthase (TS), N10-propargyl-5,8-dideazafolic acid (CB-3717). Thymidine 0-9 thymidylate synthetase Homo sapiens 156-158 3167836-2 1988 Thymidylate synthase, which catalyzes the synthesis of thymidine precursors, has been shown to be amplified in response to a variety of chemotherapeutic agents. Thymidine 55-64 thymidylate synthetase Homo sapiens 0-20 3510622-5 1986 Time course experiments suggested that the inhibition of thymidylate synthase in situ by the dihydroxybenzene derivatives occurs after the inhibition of thymidine incorporation, indicating that an earlier event was critical to the inhibition of DNA synthesis. Thymidine 153-162 thymidylate synthetase Homo sapiens 57-77 3377815-2 1988 The toxic effects of thymidylate synthase inhibition may be prevented by salvage of exogenous thymidine. Thymidine 94-103 thymidylate synthetase Homo sapiens 21-41