PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2592559-5 1989 Exogenous EGF administration produced increases in renal thymidine incorporation compared with non-treated animals at 24, 48, and 72 h after ischemic injury. Thymidine 57-66 epidermal growth factor like 1 Rattus norvegicus 10-13 2483973-4 1989 Maximal 3H-thymidine incorporation occurred 48 hours after addition of EGF. Thymidine 11-20 epidermal growth factor like 1 Rattus norvegicus 71-74 3049121-3 1988 Hepatocyte cultures electroporated with the c-myc gene showed a potentiation of this EGF effect exhibiting rates of DNA synthesis up to 50% greater than those of control electroporated cultures, as determined by [3H]thymidine labeling of cell nuclei. Thymidine 216-225 epidermal growth factor like 1 Rattus norvegicus 85-88 2808537-9 1989 Epidermal growth factor promoted the incorporation of [3H]-thymidine into DNA by quiescent cells, and this was also markedly stimulated when cells were plated onto ECM-coated plasticware rather than onto plastic substratum. Thymidine 59-68 epidermal growth factor like 1 Rattus norvegicus 0-23 2786746-8 1989 Similarly, the EGF concentration required for half-maximum prostate cancer or normal rat kidney fibroblast cell thymidine incorporation was comparable to that known to effect half-maximum fibroblast thymidine incorporation or granulosa cell proliferation. Thymidine 112-121 epidermal growth factor like 1 Rattus norvegicus 15-18 2786746-8 1989 Similarly, the EGF concentration required for half-maximum prostate cancer or normal rat kidney fibroblast cell thymidine incorporation was comparable to that known to effect half-maximum fibroblast thymidine incorporation or granulosa cell proliferation. Thymidine 199-208 epidermal growth factor like 1 Rattus norvegicus 15-18 2470581-10 1989 Conversely, caerulein reversed the inhibitory effect of EGF on thymidine incorporation. Thymidine 63-72 epidermal growth factor like 1 Rattus norvegicus 56-59 2783308-9 1989 The addition of EGF to glial cultures produced a dose-dependent stimulation of [3H]thymidine incorporation as well as the multiplication of cells over a 6-day period. Thymidine 83-92 epidermal growth factor like 1 Rattus norvegicus 16-19 14644778-1 2004 Endothelin-1 (ET-1), platelet-derived growth factor (PDGF), and epidermal growth factor (EGF) stimulated thymidine incorporation with different efficiency (PDGF >> EGF = ET-1) in rat myometrial cells. Thymidine 105-114 epidermal growth factor like 1 Rattus norvegicus 64-87 3121411-9 1987 EGF treatment did not alter cell number but slightly increased [3H]thymidine incorporation into cellular DNA. Thymidine 67-76 epidermal growth factor like 1 Rattus norvegicus 0-3 3499217-1 1987 Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine. Thymidine 225-234 epidermal growth factor like 1 Rattus norvegicus 146-149 3548718-2 1987 Incorporation of [3H]-thymidine was stimulated 1.4-2.4 fold by insulin, insulin like growth factor (IGF), platelet derived growth factor (PDGF), epidermal growth factor (EGF) and 2% fetal calf serum (FCS) respectively. Thymidine 22-31 epidermal growth factor like 1 Rattus norvegicus 145-168 3548718-2 1987 Incorporation of [3H]-thymidine was stimulated 1.4-2.4 fold by insulin, insulin like growth factor (IGF), platelet derived growth factor (PDGF), epidermal growth factor (EGF) and 2% fetal calf serum (FCS) respectively. Thymidine 22-31 epidermal growth factor like 1 Rattus norvegicus 170-173 6307497-9 1983 In both the normal and malignant cell strains, EGF was found to increase incorporation of 3H-labeled thymidine into acid-precipitable macromolecules. Thymidine 101-110 epidermal growth factor like 1 Rattus norvegicus 47-50 93054-1 1979 Epidermal growth factor stimulated both [3H]thymidine uptake and proliferation of rat AH66 hepatoma cells. Thymidine 44-53 epidermal growth factor like 1 Rattus norvegicus 0-23 14644778-1 2004 Endothelin-1 (ET-1), platelet-derived growth factor (PDGF), and epidermal growth factor (EGF) stimulated thymidine incorporation with different efficiency (PDGF >> EGF = ET-1) in rat myometrial cells. Thymidine 105-114 epidermal growth factor like 1 Rattus norvegicus 89-92 14644778-1 2004 Endothelin-1 (ET-1), platelet-derived growth factor (PDGF), and epidermal growth factor (EGF) stimulated thymidine incorporation with different efficiency (PDGF >> EGF = ET-1) in rat myometrial cells. Thymidine 105-114 epidermal growth factor like 1 Rattus norvegicus 170-173 12668975-5 2003 In epidermal growth factor (EGF)-treated primary cultures of rat hepatocytes, SP600125 decreased (3)H-thymidine uptake, cyclin D1 mRNA and protein expression, and inhibited the EGF-induced transcription of a cyclin D1 promoter-driven reporter gene. Thymidine 102-111 epidermal growth factor like 1 Rattus norvegicus 28-31 11263267-5 2000 In contrary, 65% or 75% EGF- or tetradecanoylphorbol acetate (TDPA, formally called PMA)--stimulated CCDPK activity and 38% or 42% [3H]thymidine incorporation treated by PDBU were inhibited, respectively. Thymidine 135-144 epidermal growth factor like 1 Rattus norvegicus 24-27 11916914-2 2002 TGF-alpha/EGF transiently (<20 min) induced phosphorylation of extracellular-regulated kinase (Erk)-1/2 (>20-fold), glycogen synthase kinase (GSK)-3 (>10-fold), and protein kinase B (PKB) (Ser(473) and Thr(308)), but did not increase [(3)H]thymidine incorporation. Thymidine 249-258 epidermal growth factor like 1 Rattus norvegicus 10-13 10579326-2 1999 In subconfluent cultures, wortmannin, LY294002, and rapamycin reversed insulin- and EGF-induced [3H]thymidine incorporation into DNA. Thymidine 100-109 epidermal growth factor like 1 Rattus norvegicus 84-87 10639200-10 2000 Addition of EGF increased the thymidine incorporation only in cells grown in 3 mM glucose. Thymidine 30-39 epidermal growth factor like 1 Rattus norvegicus 12-15 7908802-5 1994 In contrast to phenylephrine, oxymetazoline caused an elevation of the PDGF-BB- and EGF-induced [3H]thymidine incorporation to 1561 +/- 143 and 2086 +/- 235 (means S.D., n = 3), respectively. Thymidine 100-109 epidermal growth factor like 1 Rattus norvegicus 84-87 9124580-2 1997 PGs in the order 16,16-dimethyl PGE2 > PGE2 > PGF2alpha >> PGD2 augmented epidermal growth factor (EGF)/insulin-induced DNA synthesis, assessed by [(3)H]thymidine incorporation, in a concentration-dependent manner, whereas PGs alone did not stimulate basal DNA synthesis without EGF and insulin. Thymidine 165-174 epidermal growth factor like 1 Rattus norvegicus 86-109 9058010-3 1996 In contrast, thymidine incorporation into FHs cells was increased only by insulin, IGF-I, and the combination of IGF-I and EGF. Thymidine 13-22 epidermal growth factor like 1 Rattus norvegicus 123-126 8550051-6 1996 Infusion of EGF, HGF, uPA, or any combination thereof for up to 7 days resulted in increased numbers of [3H]thymidine-labeled ductal and periductal cells expanding into the liver acinus. Thymidine 108-117 epidermal growth factor like 1 Rattus norvegicus 12-15 8603597-3 1996 Thymidine incorporation in hepatocytes in the presence of EGF and IGF-II was inhibited by soluble receptor (50% inhibition at 212 +/- 45 ng/ml). Thymidine 0-9 epidermal growth factor like 1 Rattus norvegicus 58-61 8603597-4 1996 However, thymidine incorporation in the presence of EGF alone was also inhibited with similar potency. Thymidine 9-18 epidermal growth factor like 1 Rattus norvegicus 52-55 8591854-4 1996 Activin A, at a concentration of 10(-9) mol/L, blocked the effect of epidermal growth factor (EGF) on DNA synthesis, that was assessed by measuring [3H] thymidine incorporation and nuclear labeling, almost completely, and NE reversed the inhibitory effect of activin A on DNA synthesis. Thymidine 153-162 epidermal growth factor like 1 Rattus norvegicus 69-92 8591854-4 1996 Activin A, at a concentration of 10(-9) mol/L, blocked the effect of epidermal growth factor (EGF) on DNA synthesis, that was assessed by measuring [3H] thymidine incorporation and nuclear labeling, almost completely, and NE reversed the inhibitory effect of activin A on DNA synthesis. Thymidine 153-162 epidermal growth factor like 1 Rattus norvegicus 94-97 9058010-2 1996 Thymidine incorporation into IEC-6 cells was significantly increased by insulin, IGF-I, des-IGF-I, IGF-II, and IGF-I+EGF, but not by EGF alone. Thymidine 0-9 epidermal growth factor like 1 Rattus norvegicus 117-120 9058010-2 1996 Thymidine incorporation into IEC-6 cells was significantly increased by insulin, IGF-I, des-IGF-I, IGF-II, and IGF-I+EGF, but not by EGF alone. Thymidine 0-9 epidermal growth factor like 1 Rattus norvegicus 133-136 8206647-3 1994 Epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) added singly caused significant increases relative to control in both the uptake of [3H]thymidine into the cellular DNA of subconfluent monolayers and of [3H]proline into collagenase-sensitive protein. Thymidine 160-169 epidermal growth factor like 1 Rattus norvegicus 0-23 8206647-3 1994 Epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) added singly caused significant increases relative to control in both the uptake of [3H]thymidine into the cellular DNA of subconfluent monolayers and of [3H]proline into collagenase-sensitive protein. Thymidine 160-169 epidermal growth factor like 1 Rattus norvegicus 25-28 1476919-6 1992 On maintenance, fetal calf serum (FCS), epidermal growth factor (EGF) and 12-o-tetradecanoyl phorbol 13-acetate (TPA) all significantly stimulated [methyl-3H] thymidine and [U-14C] leucine uptake, but inhibited hair follicle elongation. Thymidine 159-168 epidermal growth factor like 1 Rattus norvegicus 40-63 1476919-6 1992 On maintenance, fetal calf serum (FCS), epidermal growth factor (EGF) and 12-o-tetradecanoyl phorbol 13-acetate (TPA) all significantly stimulated [methyl-3H] thymidine and [U-14C] leucine uptake, but inhibited hair follicle elongation. Thymidine 159-168 epidermal growth factor like 1 Rattus norvegicus 65-68 1444891-5 1992 Inhibitory effects of insulin on the [3H]-thymidine incorporation were potentiated by EGF, though EGF alone strongly increased the effect; whereas the addition of TGF-beta had no significant effect on the insulin action. Thymidine 42-51 epidermal growth factor like 1 Rattus norvegicus 86-89 1757491-3 1991 Analysis at the single-cell level by [3H]thymidine autoradiography indicated that in 40-50% of the EGF-treated cell population the entry into S phase is delayed. Thymidine 41-50 epidermal growth factor like 1 Rattus norvegicus 99-102 1347714-5 1992 Stimulation of [3H]thymidine incorporation into the DNA by CPA was only observed in the presence of epidermal growth factor (EGF) (10 ng/ml) and insulin (10 mU/ml). Thymidine 19-28 epidermal growth factor like 1 Rattus norvegicus 100-123 1347714-5 1992 Stimulation of [3H]thymidine incorporation into the DNA by CPA was only observed in the presence of epidermal growth factor (EGF) (10 ng/ml) and insulin (10 mU/ml). Thymidine 19-28 epidermal growth factor like 1 Rattus norvegicus 125-128 1734037-3 1992 Overexpression of c-myc did not initiate significant DNA synthesis in rat hepatocyte cultures alone, although it cooperated with added EGF to super-induce thymidine incorporation into DNA. Thymidine 155-164 epidermal growth factor like 1 Rattus norvegicus 135-138 1370376-3 1992 Epidermal Growth Factor (EGF) stimulated thymidine incorporation and DNA accumulation in both cell types. Thymidine 41-50 epidermal growth factor like 1 Rattus norvegicus 0-23 1370376-3 1992 Epidermal Growth Factor (EGF) stimulated thymidine incorporation and DNA accumulation in both cell types. Thymidine 41-50 epidermal growth factor like 1 Rattus norvegicus 25-28 2158429-10 1990 [3H]Thymidine incorporation in the presence of epidermal growth factor (50 ng/ml) was stimulated 66% by IGF-II (300 ng/ml) in control cells compared with 220% in cells from hepatectomized animals. Thymidine 4-13 epidermal growth factor like 1 Rattus norvegicus 47-70 1652217-7 1991 Epidermal growth factor (10(-9) M) produced an 87% increase in thymidine incorporation, which was not significantly inhibited by either form of ANP. Thymidine 63-72 epidermal growth factor like 1 Rattus norvegicus 0-23 2011856-3 1991 EGF at a concentration of 10 ng/ml was found to stimulate DNA synthesis (as judged by [3H]thymidine incorporation) in growth-arrested NRK-49F cells. Thymidine 90-99 epidermal growth factor like 1 Rattus norvegicus 0-3 1705563-3 1991 Thyrotropin-releasing hormone (TRH), tetradecanoylphorbol acetate (TPA), and epidermal growth factor (EGF), each known to enhance calcium entry in GH4 cells, decrease GH4 cell number and incorporation of [3H]-thymidine. Thymidine 209-218 epidermal growth factor like 1 Rattus norvegicus 77-100 1705563-3 1991 Thyrotropin-releasing hormone (TRH), tetradecanoylphorbol acetate (TPA), and epidermal growth factor (EGF), each known to enhance calcium entry in GH4 cells, decrease GH4 cell number and incorporation of [3H]-thymidine. Thymidine 209-218 epidermal growth factor like 1 Rattus norvegicus 102-105 2396670-5 1990 Exogenous EGF resulted in greater levels of renal [3H]thymidine incorporation into renal proximal tubule cells compared with those observed in nontreated animals at several time points in the first 48 h after toxic injury. Thymidine 54-63 epidermal growth factor like 1 Rattus norvegicus 10-13 2306559-2 1990 Maximal effect of aFGF and EGF on DNA synthesis measured by [3H]thymidine incorporation was observed after 18 h. aFGF stimulated DNA synthesis by 3.5-fold with an ED50 of 0.75 ng/ml while a 2.3-fold EGF stimulation was recorded with an ED50 of 0.067 ng/ml. Thymidine 64-73 epidermal growth factor like 1 Rattus norvegicus 27-30