PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2503436-7 1989 The anti-CD3-induced thymidine uptake by T cells in the presence of IL-1 and IL-6 was significantly inhibited by anti-Tac antibody, suggesting that the proliferation of T cells in this system is mostly mediated by a IL-2-dependent pathway. Thymidine 21-30 interleukin 6 Homo sapiens 77-81 24913620-8 2014 RESULTS: We demonstrated that CB2 inverse agonists SR144528 and AM630, but not CB2 agonist HU308 or CB1 antagonist SR141716, effectively inhibited IL-6-induced secretion of soluble IgM without affecting cell proliferation as measured by thymidine uptake. Thymidine 237-246 interleukin 6 Homo sapiens 147-151 2784752-2 1989 The uptake of [3H]thymidine into DNA was measured on stimulation with a range of interleukins (IL-2, IL-4, and IL-6) and solid-phase anti-IgM. Thymidine 18-27 interleukin 6 Homo sapiens 111-115 25515776-6 2015 Poly(dA:dT) induced the expression of pro-inflammatory cytokine genes including IFN-beta, TNF-alpha, IL-6 and IL-8 as well, whereas the pro-inflammatory cytokine production was suppressed by RIG-I siRNA, but not by AIM2 siRNA. Thymidine 8-10 interleukin 6 Homo sapiens 101-105 8768869-4 1996 Among the various cytokines, IL-6, GH, and insulin-like growth factor I (IGF-I) also enhanced Ig production and thymidine uptake in plasma cells. Thymidine 112-121 interleukin 6 Homo sapiens 29-33 10382942-4 1999 The addition of IL-6 or both IL-6 and MGF to M-CSF containing cultures resulted in significant higher numbers of colony-forming unit-macrophage (CFU-M) as tested in clonogenic and 3H-thymidine assays. Thymidine 183-192 interleukin 6 Homo sapiens 16-20 10382942-4 1999 The addition of IL-6 or both IL-6 and MGF to M-CSF containing cultures resulted in significant higher numbers of colony-forming unit-macrophage (CFU-M) as tested in clonogenic and 3H-thymidine assays. Thymidine 183-192 interleukin 6 Homo sapiens 29-33 9891467-3 1998 However, IL-6 production is increased in proportion to the increasing thymidine labelling index in benign or malignant tissues (r = 0.94, r = 0.76). Thymidine 70-79 interleukin 6 Homo sapiens 9-13 8968107-9 1996 Exogenous IL-10, IL-6, IL-2, and TNF-alpha significantly enhanced the [3H]thymidine uptake in 13 of 13 (100%), 5 of 13 (38%), 9 of 13 (69%), and 2 of 10 (20%) PTCPs costimulated with anti-CD40, respectively. Thymidine 74-83 interleukin 6 Homo sapiens 17-21 24415766-4 2014 Two classes of IL-6 SOMAmers were isolated from modified DNA libraries containing 40 random positions and either 5-(N-benzylcarboxamide)-2"-deoxyuridine (Bn-dU) or 5-[N-(1-naphthylmethyl)carboxamide]-2"-deoxyuridine (Nap-dU) replacing dT. Thymidine 235-237 interleukin 6 Homo sapiens 15-19 20184875-4 2010 Anti-IL-6 receptor antibody significantly (but only partially) suppressed T cell activation (as indicated by [3H]-thymidine uptake and CD25 expression) and IL-2 production in both systems, and increased the frequency of regulatory T cells among spleen cells. Thymidine 114-123 interleukin 6 Homo sapiens 5-9 7800135-7 1994 In addition, [3H]thymidine uptake was inhibited by a specific polyclonal antibody against IL-6. Thymidine 17-26 interleukin 6 Homo sapiens 90-94 7619053-3 1995 Furthermore, IFN-alpha inhibits the ability of IL-6 to induce increases in [3H]thymidine incorporation. Thymidine 79-88 interleukin 6 Homo sapiens 47-51 7949016-1 1994 To investigate the role of interleukins on the growth of human thyroid cells, the effect of IL-2, IL-4 and IL-6 was studied on EGF-induced [3H]-thymidine uptake, cell cycle by flow cytometry, and mRNA levels of cellular proto-oncogene c-fos in thyroid monolayer cells from eighteen patients with Graves" disease and sixteen with non-thyroidal disease. Thymidine 144-153 interleukin 6 Homo sapiens 107-111 1577093-3 1992 IL-6 was measured by a [3H] thymidine incorporation assay using the IL-6-dependent B9 cell line; 1 U is approximately equal to 1 pg/ml of a recombinant (r)IL-6 standard. Thymidine 28-37 interleukin 6 Homo sapiens 0-4 7949016-7 1994 IL-6 (10(-2)-10 ng/ml) stimulated the [3H]-thymidine uptake up to 218-303 % of control level, and the percentage of cells in S+G2/M phase was increased in IL-6-treated normal thyroid cells as compared to EGF-treated cells. Thymidine 43-52 interleukin 6 Homo sapiens 0-4 7683888-2 1993 Incorporation of labelled thymidine was significantly decreased by IL-6, IL-1 and HGF but only slightly by LIF and RA. Thymidine 26-35 interleukin 6 Homo sapiens 67-71 1596939-10 1992 The growth effects of IL-6 on RCC were also investigated in two experimental systems: IL-6 was found to stimulate proliferative responses in six of six RCC tumor lines as measured by thymidine-uptake assays; however, only one of six tumor lines displayed an increase in proliferative response of greater than 21% (113%). Thymidine 183-192 interleukin 6 Homo sapiens 86-90 1940549-4 1991 IL-6, TGF-beta 1 and decidual supernatants stimulated both hPL, hCG production and 3H-thymidine uptake, especially TGF-beta 1 and decidual supernatants. Thymidine 86-95 interleukin 6 Homo sapiens 0-4 1647881-2 1991 The presence of IL6 activity in SK-v cell-conditioned media (SK-v CM) was demonstrated by tritiated thymidine incorporation into IL6-dependent B9 murine plasmacytoma cells. Thymidine 100-109 interleukin 6 Homo sapiens 129-132 1912582-5 1991 The proliferative response of each line to recombinant IL-6 was measured in a clonogenic assay providing human plasma and methylcellulose as a viscous support and by 3H-thymidine uptake in liquid suspension culture. Thymidine 169-178 interleukin 6 Homo sapiens 55-59 2129417-3 1990 Keratinocyte-growth was increased by stimulation with recombinant IL 6 (as measured by either [3H] thymidine uptake or direct cell count). Thymidine 99-108 interleukin 6 Homo sapiens 66-70 1864979-6 1991 There was a dose-dependent decrease, however, in [3H]-thymidine uptake in the presence of IL-6 antisense (and not sense) oligodeoxynucleotides; in the presence of 20 microM IL-6 antisense, an 80 and 95% inhibition of the proliferation of U 266 and RPMI 8226 cells was observed, respectively. Thymidine 54-63 interleukin 6 Homo sapiens 90-94 1864979-6 1991 There was a dose-dependent decrease, however, in [3H]-thymidine uptake in the presence of IL-6 antisense (and not sense) oligodeoxynucleotides; in the presence of 20 microM IL-6 antisense, an 80 and 95% inhibition of the proliferation of U 266 and RPMI 8226 cells was observed, respectively. Thymidine 54-63 interleukin 6 Homo sapiens 173-177 1700730-7 1990 Increase of 3H-thymidine incorporation by megakaryoblasts could be duplicated by exogenous IL-6 that could be blocked by neutralizing MoAb to IL-6. Thymidine 15-24 interleukin 6 Homo sapiens 91-95 1700730-7 1990 Increase of 3H-thymidine incorporation by megakaryoblasts could be duplicated by exogenous IL-6 that could be blocked by neutralizing MoAb to IL-6. Thymidine 15-24 interleukin 6 Homo sapiens 142-146 2029798-3 1991 Interleukin-6 (IL-6) enhanced both Ig production and thymidine uptake by AF-10 and IM-9, while other cytokines, including IL-1 beta, IL-2, IL-3, IL-4, IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon-alpha (IFN-alpha) or IFN-gamma, failed to do so. Thymidine 53-62 interleukin 6 Homo sapiens 0-13 2029798-3 1991 Interleukin-6 (IL-6) enhanced both Ig production and thymidine uptake by AF-10 and IM-9, while other cytokines, including IL-1 beta, IL-2, IL-3, IL-4, IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon-alpha (IFN-alpha) or IFN-gamma, failed to do so. Thymidine 53-62 interleukin 6 Homo sapiens 15-19 2346778-3 1990 After incubation of 2 to 5 x 10(6) cells/mL for 4 hours in 5.0 ng IL-6/mL, increased thymidine suicide rates were observed for multipotent progenitors (CFU-Mix), granulocyte-macrophage progenitors (CFU-GM), and erythroid burst-forming units (BFU-E). Thymidine 85-94 interleukin 6 Homo sapiens 66-70 1693429-5 1990 The IL-6-R was functional, as [3H]thymidine incorporation by AIDS-KS cells increased significantly after exposure to human recombinant IL-6 (hrIL-6) at greater than 10 units/ml. Thymidine 34-43 interleukin 6 Homo sapiens 4-8