PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9841495-7	1998	Accordingly, although IGF-I was not proliferative in NG, it increased [3H]thymidine incorporation and cell number in HG to an extent proportional to the decrease in IGFBP-2.	Thymidine	74-83	insulin-like growth factor 1	Mus musculus	22-27	
11340640-6	2001	IGF1 null dentate cell proliferation, assessed by thymidine analogue incorporation, was actually increased at P10 (33%, P < 0.05) and P50 (167%, P = 0.001).	Thymidine	50-59	insulin-like growth factor 1	Mus musculus	0-4	
10383152-7	1999	Parallel binding experiments using IGF-I missing the first 3 amino acids revealed a 47% increase in binding sites for IGF-I and an increase of at least 335% in DNA synthesis, as measured by labeled thymidine incorporation into DNA.	Thymidine	198-207	insulin-like growth factor 1	Mus musculus	35-40	
11564700-8	2001	GHRH antagonist JV-1-38 inhibited the autonomous growth of MXT cells and the proliferation induced by IGF-I or GH and diminished (3)H-thymidine-incorporation stimulated by IGF-I and GH.	Thymidine	134-143	insulin-like growth factor 1	Mus musculus	172-177	
11090910-5	2000	Combined treatment of TGF-beta and IGF-1 resulted in elevated 3H-thymidine incorporation and DNA and protein contents, reduction of 35S-sulfate incorporation and alkaline phosphatase activity, with no significant change in the activity of acid phosphatase.	Thymidine	65-74	insulin-like growth factor 1	Mus musculus	35-40	
11090910-9	2000	It is concluded that although 3H-thymidine incorporation and alkaline phosphatase activity appeared to be induced by TGF-beta and IGF-1, the overall responsiveness of cartilage from aged mice to these growth factors appeared to be inhibitory.	Thymidine	33-42	insulin-like growth factor 1	Mus musculus	130-135	
9741830-2	1998	Bioactivity of recombinant IGF-1 in transgenic mouse milk extracts was demonstrated by a concentration-dependent increase in [3H]thymidine incorporation in clonal bovine mammary epithelial cells (MAC-T) compared with control mouse milk extracts; moreover, addition of excess recombinant human insulin-like growth factor binding protein-3 (rhlGFBP-3) abolished the increase in [3H]thymidine incorporation attributed to recombinant IGF-1 in transgenic mouse milk.	Thymidine	129-138	insulin-like growth factor 1	Mus musculus	27-32	
9600271-3	1998	IGF-1 was able to stimulate glucose uptake, glucose incorporation into glycogen and thymidine incorporation in such cells.	Thymidine	84-93	insulin-like growth factor 1	Mus musculus	0-5	
7686165-4	1993	Overexpression of IGF-I receptors in NIH-3T3 cells resulted in increased sensitivity and maximal responsiveness of thymidine incorporation, 2-deoxyglucose uptake, and phosphatidylinositol-3 (PI3) kinase activation to IGF-I stimulation.	Thymidine	115-124	insulin-like growth factor 1	Mus musculus	18-23	
8621590-10	1996	Overexpression of Crk also enhanced IGF-I-induced mitogenesis of NIH-3T3 cells, as measured by [3H]thymidine incorporation.	Thymidine	99-108	insulin-like growth factor 1	Mus musculus	36-41	
7693688-4	1993	A mutant IGF-I receptor, in which 3 tyrosines (Tyr1131, Tyr1135, and Tyr1136) analogous to the three major autophosphorylation sites in the insulin receptor kinase were replaced by phenylalanines, was devoid of kinase activity in vivo and in vitro and inactive with respect to IGF-I internalization and stimulation of thymidine incorporation.	Thymidine	318-327	insulin-like growth factor 1	Mus musculus	9-14	
8708541-11	1996	In studies on IGFBP-6 actions, IGFBP-6 completely inhibited IGF-II-induced [3H]thymidine incorporation in MC3T3-E1 mouse osteoblast cells while it had only minimal inhibitory effects on IGF-I-induced [3H]thymidine incorporation.	Thymidine	79-88	insulin-like growth factor 1	Mus musculus	60-65	
7588225-6	1995	Despite the reduction in autophosphorylation and receptor internalization, IGF-I-induced thymidine incorporation and cellular proliferation were unaffected.	Thymidine	89-98	insulin-like growth factor 1	Mus musculus	75-80	
8440329-8	1993	CDGF together with small concentrations of bFGF (3.5 pM), higher concentrations of PDGF (300 pM), or IGF-I (1 nM) increased synergistically thymidine incorporation in the 2-h pulse, exceeding in the case of PDGF and bFGF the values obtained with 10% serum.	Thymidine	140-149	insulin-like growth factor 1	Mus musculus	101-106	
8492073-6	1993	Immunoinhibition of IGF-I resulted in an almost complete inhibition (-91%) of thymidine incorporation into DNA, as well as in marked degenerative changes in the morphological appearance of the condyle.	Thymidine	78-87	insulin-like growth factor 1	Mus musculus	20-25	
8492081-2	1993	When activin A was added together with IGF-I to competent cells primed with epidermal growth factor (primed competent cells), both [3H]thymidine incorporation and nuclear labelling induced by IGF-I were inhibited.	Thymidine	135-144	insulin-like growth factor 1	Mus musculus	39-44	
8492081-2	1993	When activin A was added together with IGF-I to competent cells primed with epidermal growth factor (primed competent cells), both [3H]thymidine incorporation and nuclear labelling induced by IGF-I were inhibited.	Thymidine	135-144	insulin-like growth factor 1	Mus musculus	192-197	
8472869-4	1993	Thus, the tumor contents of IGF-I and the rate of IGF-I-positive cells were inversely correlated to the tumor growth and the [3H]thymidine-labeled cell rate in this in vivo study, although IGF-I is known to be a mitogen for breast cancer cells in vitro.	Thymidine	129-138	insulin-like growth factor 1	Mus musculus	28-33	
8472869-4	1993	Thus, the tumor contents of IGF-I and the rate of IGF-I-positive cells were inversely correlated to the tumor growth and the [3H]thymidine-labeled cell rate in this in vivo study, although IGF-I is known to be a mitogen for breast cancer cells in vitro.	Thymidine	129-138	insulin-like growth factor 1	Mus musculus	50-55	
8472869-4	1993	Thus, the tumor contents of IGF-I and the rate of IGF-I-positive cells were inversely correlated to the tumor growth and the [3H]thymidine-labeled cell rate in this in vivo study, although IGF-I is known to be a mitogen for breast cancer cells in vitro.	Thymidine	129-138	insulin-like growth factor 1	Mus musculus	50-55	
2205200-4	1990	In contrast, in undifferentiated cells insulin and IGF-I stimulated a large increase of [3H]thymidine incorporation into DNA via IGF-I receptors, indicating that undifferentiated 3T3-L1 cells are equipped with fully functioning hormone (IGF-I) receptors.	Thymidine	92-101	insulin-like growth factor 1	Mus musculus	51-56	
1321252-5	1992	In vitro proliferative response of MGH-OGS cells to IGF-I and other pituitary-dependent factors was determined by thymidine-incorporation experiments.	Thymidine	114-123	insulin-like growth factor 1	Mus musculus	52-57	
1310625-5	1992	Both insulin and IGF1 stimulate thymidine incorporation in a dose-dependent manner with similar increases above the basal level.	Thymidine	32-41	insulin-like growth factor 1	Mus musculus	17-21	
19912810-2	1991	IGF-1 and insulin increased thymidine incorporation and cell number, but Bt(2)cAMP inhibited incorporation and FGF did not change thymidine incorporation after 24 h of treatment.	Thymidine	28-37	insulin-like growth factor 1	Mus musculus	0-5	
2205200-4	1990	In contrast, in undifferentiated cells insulin and IGF-I stimulated a large increase of [3H]thymidine incorporation into DNA via IGF-I receptors, indicating that undifferentiated 3T3-L1 cells are equipped with fully functioning hormone (IGF-I) receptors.	Thymidine	92-101	insulin-like growth factor 1	Mus musculus	129-134	
2205200-4	1990	In contrast, in undifferentiated cells insulin and IGF-I stimulated a large increase of [3H]thymidine incorporation into DNA via IGF-I receptors, indicating that undifferentiated 3T3-L1 cells are equipped with fully functioning hormone (IGF-I) receptors.	Thymidine	92-101	insulin-like growth factor 1	Mus musculus	129-134	
2162851-4	1990	In contrast, IGF-I increased calcium entry, radioactivity in [3H]diacylglycerol, and [3H]thymidine incorporation in primed competent cells while these reactions were not induced by IGF-I in quiescent cells.	Thymidine	89-98	insulin-like growth factor 1	Mus musculus	13-18	
2785831-5	1989	[3H]Thymidine incorporation into acid insoluble radioactivity was stimulated by IGF-1 in all populations but the greatest increase was in intermediate populations.	Thymidine	4-13	insulin-like growth factor 1	Mus musculus	80-85	
2720200-2	1989	IGF-I stimulated [3H]thymidine incorporation into the DNA of the cells at concentrations of 1.3-130 X 10(-9) M. The alkaline phosphatase (ALP) activity in cultures was also raised by the hormone at the same concentrations.	Thymidine	21-30	insulin-like growth factor 1	Mus musculus	0-5	
25356638-9	2015	Consistently, IGF-1 promoted the G2/M progression of thymidine-treated mSSCs, which were arrested at G1/S boundary synchronously; while GDNF and/or FGF2 stimulated their entry into the S phase.	Thymidine	53-62	insulin-like growth factor 1	Mus musculus	14-19	
2460452-9	1988	In primed competent cells, IGF-I-stimulated [3H]thymidine incorporation was dependent on extracellular calcium and was attenuated by cobalt and tetramethrin.	Thymidine	48-57	insulin-like growth factor 1	Mus musculus	27-32	
21266309-9	2012	Compared with wild-type control, recovery of pressure development and relaxation indices relative to baseline performance were significantly reduced in transgenic alphaMHC-IGF-1 Ea after 60-min reperfusion (34+-7% vs. 62+-7% recovery of +dP/dt; 35+-11% vs. 57+-8% recovery of -dP/dt).	Thymidine	241-243	insulin-like growth factor 1	Mus musculus	172-177	
21266309-9	2012	Compared with wild-type control, recovery of pressure development and relaxation indices relative to baseline performance were significantly reduced in transgenic alphaMHC-IGF-1 Ea after 60-min reperfusion (34+-7% vs. 62+-7% recovery of +dP/dt; 35+-11% vs. 57+-8% recovery of -dP/dt).	Thymidine	280-282	insulin-like growth factor 1	Mus musculus	172-177	
16293644-5	2006	IGF-1-TTC retains IGF-1 activity as indicated by [(3)H]thymidine incorporation into L6 myoblasts.	Thymidine	55-64	insulin-like growth factor 1	Mus musculus	0-5	
15329054-6	2004	RESULTS: The stimulatory effect of IGF-I on thymidine incorporation seen in WT animals was absent in eNOSKO mice.	Thymidine	44-53	insulin-like growth factor 1	Mus musculus	35-40