PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16498393-5 2006 We conclude that thymidine-containing PS-ODN can activate CLL cells and induce apoptosis via a mechanism that is independent of BCL-2 gene interference or CpG motifs. Thymidine 17-26 BCL2 apoptosis regulator Homo sapiens 128-133 30717537-6 2018 In vitro, DT inhibited the proliferation of PC9 cell line in a concentration-dependent manner, and destroyed the structure of mitochondria in PC9 cell, promoted Bax, IRE1alpha, Bip, TRAF2 and caspase 12 protein expressions, lower Bcl-2 protein expression in a time-dependent manner. Thymidine 10-12 BCL2 apoptosis regulator Homo sapiens 230-235 15647429-10 2005 Chondrocyte [(3)H]thymidine uptake correlated positively with Bcl-2 (r(s) = 0.62, p = 0.009) and correlated inversely with p53 levels (r(s) = -0.55, p = 0.02). Thymidine 18-27 BCL2 apoptosis regulator Homo sapiens 62-67 9223329-9 1997 Fas-mediated apoptosis induced by the cytotoxic anti-Fas monoclonal antibody CH-11 was inhibited following adenoviral delivery of a Bcl-2 cDNA, and Bcl-2 also protected cells from acute apoptosis induced by dThd deprivation. Thymidine 207-211 BCL2 apoptosis regulator Homo sapiens 132-137 9223329-9 1997 Fas-mediated apoptosis induced by the cytotoxic anti-Fas monoclonal antibody CH-11 was inhibited following adenoviral delivery of a Bcl-2 cDNA, and Bcl-2 also protected cells from acute apoptosis induced by dThd deprivation. Thymidine 207-211 BCL2 apoptosis regulator Homo sapiens 148-153 18634067-10 1997 In conditions of excess thymidine, which suppressed cell proliferation, Ml cell density and specific mAb productivity were further enhanced by the overexpression of bcl-2, which suggests the possibility of accomplishing a controlled proliferation in immortalized cell lines without invoking cell death. Thymidine 24-33 BCL2 apoptosis regulator Homo sapiens 165-170 8207068-6 1994 The expression and distribution of Bcl-2 is influenced by treatment with excessive thymidine. Thymidine 83-92 BCL2 apoptosis regulator Homo sapiens 35-40 34790046-8 2021 Knockdown of CEBPA and BCL2 could alleviate the increasement of cisplatin resistance induced by CEBPA-DT overexpression. Thymidine 102-104 BCL2 apoptosis regulator Homo sapiens 23-27 9474804-2 1997 The bcl-2/bag-1 transfectant survived maintaining viability above 75% for almost 5 days when the cells were treated with excess (30 mM) thymidine for arresting cell cycle, whereas the mock transfectant survived for only 2 days, and the bcl-2 alone transfectant lived for 4 days. Thymidine 136-145 BCL2 apoptosis regulator Homo sapiens 4-9 9474804-3 1997 Owing to this extended viable culture period, the bcl-2/bag-1 transfectant produced twofold amount of antibody in comparison with the mock transfectant in non-proliferating state prepared by the excess thymidine treatment. Thymidine 202-211 BCL2 apoptosis regulator Homo sapiens 50-55 18629863-9 1996 Results presented here suggest that suppression of apoptosis by bcl-2 under the condition of excess thymidine allows the maintenance of cells in a growth-arrested state for much longer than would otherwise be possible.When cells were transferred to a range of commercial serum-free media, cell growth was, in all cases, much better for the bcl-2 transfected cell line. Thymidine 100-109 BCL2 apoptosis regulator Homo sapiens 64-69 8394449-4 1993 The expression of Bcl-2 in primary B cells infected with the B95-8 strain of EBV varied between 1 and 1.8 times that in uninfected cells when 50% of the cells were infected, expressed LMP, and incorporated 20-fold more [3H]thymidine than did uninfected cells. Thymidine 223-232 BCL2 apoptosis regulator Homo sapiens 18-23