PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35510237-0	2022	Nitroglycerin-induced downregulation of AKT- and ERK1/2-mediated radiation-sensitive 52 expression to enhance pemetrexed-induced cytotoxicity in human lung cancer cells.	Nitroglycerin	0-13	AKT serine/threonine kinase 1	Homo sapiens	40-43	
35510237-6	2022	In 2 NSCLC cell lines (i.e. lung squamous cell carcinoma H520 and lung adenocarcinoma H1975 cells), NTG reduced Rad52 expression; in addition, decreased phospho-AKT and phospho-ERK1/2 protein levels were observed.	Nitroglycerin	100-103	AKT serine/threonine kinase 1	Homo sapiens	161-164	
35510237-7	2022	Enhancement of AKT or ERK1/2 activity through transfection with a constitutively active AKT (AKT-CA) vector or constitutively active mitogen-activated protein kinase kinase 1 (MKK1-CA) vector increased the Rad52 protein level and cell survival, which were suppressed by NTG.	Nitroglycerin	270-273	AKT serine/threonine kinase 1	Homo sapiens	15-18	
35510237-7	2022	Enhancement of AKT or ERK1/2 activity through transfection with a constitutively active AKT (AKT-CA) vector or constitutively active mitogen-activated protein kinase kinase 1 (MKK1-CA) vector increased the Rad52 protein level and cell survival, which were suppressed by NTG.	Nitroglycerin	270-273	AKT serine/threonine kinase 1	Homo sapiens	88-91	
35510237-8	2022	The knockdown of Rad52 expression by using small interfering RNA or by inhibiting AKT and ERK1/2 activity enhanced the cytotoxicity and cell growth inhibition induced by NTG.	Nitroglycerin	170-173	AKT serine/threonine kinase 1	Homo sapiens	82-85	
35510237-9	2022	Moreover, NTG synergistically enhanced the cytotoxicity and cell growth inhibition induced by pemetrexed in NSCLC cells; these effects were associated with AKT and ERK1/2 inactivation and, consequently, Rad52 downregulation in H520 and H1975 cells.	Nitroglycerin	10-13	AKT serine/threonine kinase 1	Homo sapiens	156-159	
31630149-4	2020	In this study, NTG decreased TS expression in an AKT, also known as Protein kinase B (PKB) inactivation dependent manner in human lung adenocarcinoma A549 and squamous cell carcinoma H1703 cells.	Nitroglycerin	15-18	AKT serine/threonine kinase 1	Homo sapiens	49-52	
31630149-5	2020	Enhancement of AKT activity by transfection with constitutive active AKT vectors increased the TS expression level as well as the cell survival pretreated by NTG.	Nitroglycerin	158-161	AKT serine/threonine kinase 1	Homo sapiens	15-18	
31630149-5	2020	Enhancement of AKT activity by transfection with constitutive active AKT vectors increased the TS expression level as well as the cell survival pretreated by NTG.	Nitroglycerin	158-161	AKT serine/threonine kinase 1	Homo sapiens	69-72	
31630149-6	2020	Moreover, NTG synergistically enhanced cytotoxicity and cell growth inhibition by cisplatin treatment in NSCLC cells, which were associated with downregulation of TS expression and inactivation of AKT in A549 and H1703 cells.	Nitroglycerin	10-13	AKT serine/threonine kinase 1	Homo sapiens	197-200	
26839558-0	2016	Endothelium-Independent Hypoxic Contraction Is Prevented Specifically by Nitroglycerin via Inhibition of Akt Kinase in Porcine Coronary Artery.	Nitroglycerin	73-86	AKT serine/threonine kinase 1	Homo sapiens	105-108	
26839558-11	2016	The reduction of Akt-p at Ser-473 by NTG, DETA NONOate, and 8-Br-cGMP was significantly inhibited by ODQ, PKG-I.	Nitroglycerin	37-40	AKT serine/threonine kinase 1	Homo sapiens	17-20	
26839558-12	2016	The decrease in Akt-p level by NTG and 8-Br-cGMP was prevented by calyculin A but not by okadaic acid.	Nitroglycerin	31-34	AKT serine/threonine kinase 1	Homo sapiens	16-19	
26839558-14	2016	These results demonstrated that the endothelium-independent sustained hypoxic vasoconstriction can be prevented by NTG and that the inhibition of PI3K/Akt signaling pathway may be involved.	Nitroglycerin	115-118	AKT serine/threonine kinase 1	Homo sapiens	151-154	
22037515-4	2012	Here, we demonstrate that at such concentrations the pharmacologic effects of nitroglycerin are largely dependent on the phosphatidylinositol 3-kinase, Akt/PKB, and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signal transduction axis.	Nitroglycerin	78-91	AKT serine/threonine kinase 1	Homo sapiens	152-176