PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1362924-8	1992	Our data provide further evidence for the role of the cytochrome P-450--cytochrome P-450 reductase system in the biotransformation of GTN to an activator (presumably nitric oxide) of guanylyl cyclase.	Nitroglycerin	134-137	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	54-70	
8448809-0	1993	Particular ability of cytochrome P-450 CYP3A to reduce glyceryl trinitrate in rat liver microsomes: subsequent formation of nitric oxide.	Nitroglycerin	55-74	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	22-38	
8448809-6	1993	In the hepatic 9000 x g supernatant containing both NADPH and cytochrome P-450 and glutathione and glutathione transferase, the cytochrome P-450-dependent reaction accounts for 30-40% of the total denitration activity observed under anaerobic conditions, using 100 microM GTN.	Nitroglycerin	272-275	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	62-78	
8448809-6	1993	In the hepatic 9000 x g supernatant containing both NADPH and cytochrome P-450 and glutathione and glutathione transferase, the cytochrome P-450-dependent reaction accounts for 30-40% of the total denitration activity observed under anaerobic conditions, using 100 microM GTN.	Nitroglycerin	272-275	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	128-144	
1362924-8	1992	Our data provide further evidence for the role of the cytochrome P-450--cytochrome P-450 reductase system in the biotransformation of GTN to an activator (presumably nitric oxide) of guanylyl cyclase.	Nitroglycerin	134-137	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	72-88	
1349646-0	1992	Hepatic cytochrome P-450-mediated activation of rat aortic guanylyl cyclase by glyceryl trinitrate.	Nitroglycerin	79-98	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	8-24	
1352550-2	1992	In cultured rat lung fibroblasts (RFL-6 cells), the inhibitor of cytochrome P-450 proadifen (0.1 mM) decreased cyclic GMP stimulation by glyceryl trinitrate (GTN, 1-100 microM) by up to 81%.	Nitroglycerin	137-156	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	65-81	
1352550-2	1992	In cultured rat lung fibroblasts (RFL-6 cells), the inhibitor of cytochrome P-450 proadifen (0.1 mM) decreased cyclic GMP stimulation by glyceryl trinitrate (GTN, 1-100 microM) by up to 81%.	Nitroglycerin	158-161	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	65-81	
1352550-6	1992	In the same cell type, a 24-hr pretreatment with the inducer of cytochrome P-450 3-methylcholanthrene (10 microM) augmented cyclic GMP stimulation by GTN or isoidide dinitrate by up to 102%.	Nitroglycerin	150-153	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	64-80	
2506859-5	1989	These data demonstrate that microsomal reductive denitration of glyceryl trinitrate is catalyzed by cytochrome P-450 and can be involved in the formation of the endothelium-derived relaxing factor (EDRF = nitric oxide).	Nitroglycerin	64-83	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	100-116	
2128204-2	1990	In the current study, we assessed the involvement of cytochrome P-450 in the denitration of glyceryl trinitrate and the enantiomers of isoidide dinitrate.	Nitroglycerin	92-111	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	53-69