PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25098345-1 2014 The aim of this study was to investigate whether N-arachidonic acid ethanolamine (anandamide, AEA) transporter contributed to calcitonin gene-related peptide (CGRP) expression mediated by nitroglycerin (GTN) in peripheral blood mononuclear cells (PBMCs) of healthy volunteers and its association with the mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. Nitroglycerin 188-201 calcitonin related polypeptide alpha Homo sapiens 126-157 33605657-8 2021 In addition, a corresponding increase in CGRP expression in the trigeminal ganglia and trigeminal nucleus caudalis was observed after chronic nitroglycerin, an augmentation that was blocked by SNC80. Nitroglycerin 142-155 calcitonin related polypeptide alpha Homo sapiens 41-45 30165876-14 2018 This effect was associated with a significant inhibition of the NTG-induced increase in c-Fos protein and CGRP release in the TNC. Nitroglycerin 64-67 calcitonin related polypeptide alpha Homo sapiens 106-110 25098345-0 2014 Involvement of anandamide transporter in calcitonin gene-related peptide expression stimulated by nitroglycerin and influence of ALDH2 Glu504Lys polymorphism. Nitroglycerin 98-111 calcitonin related polypeptide alpha Homo sapiens 41-72 33179114-4 2021 The pharmacological effects of nitroglycerine and rutaecarpine have been demonstrated to be associated with an increase in the synthesis and release of CGRP. Nitroglycerin 31-45 calcitonin related polypeptide alpha Homo sapiens 152-156 28856479-7 2017 Human experimental studies have reported elevated plasma CGRP levels during both spontaneous and glyceryl trinitrate-induced cluster attacks. Nitroglycerin 97-116 calcitonin related polypeptide alpha Homo sapiens 57-61 25098345-1 2014 The aim of this study was to investigate whether N-arachidonic acid ethanolamine (anandamide, AEA) transporter contributed to calcitonin gene-related peptide (CGRP) expression mediated by nitroglycerin (GTN) in peripheral blood mononuclear cells (PBMCs) of healthy volunteers and its association with the mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. Nitroglycerin 188-201 calcitonin related polypeptide alpha Homo sapiens 159-163 25098345-1 2014 The aim of this study was to investigate whether N-arachidonic acid ethanolamine (anandamide, AEA) transporter contributed to calcitonin gene-related peptide (CGRP) expression mediated by nitroglycerin (GTN) in peripheral blood mononuclear cells (PBMCs) of healthy volunteers and its association with the mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. Nitroglycerin 203-206 calcitonin related polypeptide alpha Homo sapiens 126-157 25098345-1 2014 The aim of this study was to investigate whether N-arachidonic acid ethanolamine (anandamide, AEA) transporter contributed to calcitonin gene-related peptide (CGRP) expression mediated by nitroglycerin (GTN) in peripheral blood mononuclear cells (PBMCs) of healthy volunteers and its association with the mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. Nitroglycerin 203-206 calcitonin related polypeptide alpha Homo sapiens 159-163 25098345-2 2014 In 10 ALDH2*2-genotyped Chinese volunteers, we assessed the activity of AEA transporter and expression of CGRP messenger ribonucleic acid (mRNA) in cultured PBMCs treated with different concentration of GTN with or without pretreatment with AM404 (the AEA transporter blocker). Nitroglycerin 203-206 calcitonin related polypeptide alpha Homo sapiens 106-110 25098345-3 2014 In this study, the activity of AEA transporter and expression of CGRP mRNA elevated with the increase in the concentration of GTN. Nitroglycerin 126-129 calcitonin related polypeptide alpha Homo sapiens 65-69 25098345-4 2014 Pretreatment of the cells with AM404 (1 muM) 2 hours before GTN reduced the GTN-induced increase in both AEA transporter activity and CGRP mRNA expression significantly, and cells with the ALDH2*1/*1 homozygote genotype showed significantly higher activity of AEA transporter and CGRP mRNA expression than carriers of the ALDH2*2 allele. Nitroglycerin 76-79 calcitonin related polypeptide alpha Homo sapiens 134-138 25098345-4 2014 Pretreatment of the cells with AM404 (1 muM) 2 hours before GTN reduced the GTN-induced increase in both AEA transporter activity and CGRP mRNA expression significantly, and cells with the ALDH2*1/*1 homozygote genotype showed significantly higher activity of AEA transporter and CGRP mRNA expression than carriers of the ALDH2*2 allele. Nitroglycerin 76-79 calcitonin related polypeptide alpha Homo sapiens 280-284 25098345-5 2014 Therefore, we strongly suggested that GTN can stimulate CGRP expression by elevating the AEA transporter activity, which is affected by ALDH2 Glu504Lys polymorphism. Nitroglycerin 38-41 calcitonin related polypeptide alpha Homo sapiens 56-60 22909898-1 2012 OBJECTIVE: The aim of this study was to investigate whether the neuropeptide calcitonin gene related peptide (CGRP) contributes to nitroglycerin (GTN) response in patients with chronic heart failure (CHF) and the association with the mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. Nitroglycerin 131-144 calcitonin related polypeptide alpha Homo sapiens 77-108 22909898-1 2012 OBJECTIVE: The aim of this study was to investigate whether the neuropeptide calcitonin gene related peptide (CGRP) contributes to nitroglycerin (GTN) response in patients with chronic heart failure (CHF) and the association with the mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. Nitroglycerin 146-149 calcitonin related polypeptide alpha Homo sapiens 77-108 22909898-1 2012 OBJECTIVE: The aim of this study was to investigate whether the neuropeptide calcitonin gene related peptide (CGRP) contributes to nitroglycerin (GTN) response in patients with chronic heart failure (CHF) and the association with the mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. Nitroglycerin 146-149 calcitonin related polypeptide alpha Homo sapiens 110-114 22909898-11 2012 Mean plasma concentration of CGRP was increased after GTN infusion (p < 0.001), but not changed after saline infusion (p > 0.05). Nitroglycerin 54-57 calcitonin related polypeptide alpha Homo sapiens 29-33 22909898-13 2012 CONCLUSIONS: ALDH2*2 polymorphism is associated with contributions of CGRP to GTN response in CHF patients. Nitroglycerin 78-81 calcitonin related polypeptide alpha Homo sapiens 70-74 24997804-0 2014 Nitroglycerin-induced myocardial protection and tolerance: role for CGRP. Nitroglycerin 0-13 calcitonin related polypeptide alpha Homo sapiens 68-72 22909898-1 2012 OBJECTIVE: The aim of this study was to investigate whether the neuropeptide calcitonin gene related peptide (CGRP) contributes to nitroglycerin (GTN) response in patients with chronic heart failure (CHF) and the association with the mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. Nitroglycerin 131-144 calcitonin related polypeptide alpha Homo sapiens 110-114 22539824-9 2012 In animals pretreated intravenously with the nitric oxide donor glyceryl trinitrate (GTN, 250 mug/kg) the mechanically evoked activity decreased after injection of CGRP and increased after injection of olcegepant. Nitroglycerin 64-83 calcitonin related polypeptide alpha Homo sapiens 164-168 22539824-9 2012 In animals pretreated intravenously with the nitric oxide donor glyceryl trinitrate (GTN, 250 mug/kg) the mechanically evoked activity decreased after injection of CGRP and increased after injection of olcegepant. Nitroglycerin 85-88 calcitonin related polypeptide alpha Homo sapiens 164-168 21480950-1 2011 AIMS: To assess the effect of the calcitonin gene-related peptide (CGRP) receptor antagonist, telcagepant, on the haemodynamic response to sublingual nitroglycerin (NTG). Nitroglycerin 150-163 calcitonin related polypeptide alpha Homo sapiens 34-65 21480950-1 2011 AIMS: To assess the effect of the calcitonin gene-related peptide (CGRP) receptor antagonist, telcagepant, on the haemodynamic response to sublingual nitroglycerin (NTG). Nitroglycerin 150-163 calcitonin related polypeptide alpha Homo sapiens 67-71 21480950-1 2011 AIMS: To assess the effect of the calcitonin gene-related peptide (CGRP) receptor antagonist, telcagepant, on the haemodynamic response to sublingual nitroglycerin (NTG). Nitroglycerin 165-168 calcitonin related polypeptide alpha Homo sapiens 34-65 21059625-0 2011 Comments on "Calcitonin gene-related peptide (CGRP) levels during glyceryl trinitrate (GTN)-induced headache in healthy volunteers". Nitroglycerin 66-85 calcitonin related polypeptide alpha Homo sapiens 46-50 21059625-0 2011 Comments on "Calcitonin gene-related peptide (CGRP) levels during glyceryl trinitrate (GTN)-induced headache in healthy volunteers". Nitroglycerin 87-90 calcitonin related polypeptide alpha Homo sapiens 46-50 20959429-2 2010 We tested the hypothesis that NO releases CGRP to cause the delayed migraine attack after GTN. Nitroglycerin 90-93 calcitonin related polypeptide alpha Homo sapiens 42-46 18647185-6 2008 We hypothesized that vasodilatation induced by CGRP and the NO donor glyceryltrinitrate (GTN) is mediated via K(ATP) channels. Nitroglycerin 89-92 calcitonin related polypeptide alpha Homo sapiens 47-51 18772068-0 2008 Evidence for involvement of calcitonin gene-related peptide in nitroglycerin response and association with mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism. Nitroglycerin 63-76 calcitonin related polypeptide alpha Homo sapiens 28-59 18772068-1 2008 OBJECTIVES: This study sought to determine whether calcitonin gene-related peptide (CGRP) is involved in glyceryl trinitrate (GTN) response in humans, and its association with mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. Nitroglycerin 105-124 calcitonin related polypeptide alpha Homo sapiens 51-82 18772068-1 2008 OBJECTIVES: This study sought to determine whether calcitonin gene-related peptide (CGRP) is involved in glyceryl trinitrate (GTN) response in humans, and its association with mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. Nitroglycerin 105-124 calcitonin related polypeptide alpha Homo sapiens 84-88 18772068-1 2008 OBJECTIVES: This study sought to determine whether calcitonin gene-related peptide (CGRP) is involved in glyceryl trinitrate (GTN) response in humans, and its association with mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. Nitroglycerin 126-129 calcitonin related polypeptide alpha Homo sapiens 51-82 18772068-1 2008 OBJECTIVES: This study sought to determine whether calcitonin gene-related peptide (CGRP) is involved in glyceryl trinitrate (GTN) response in humans, and its association with mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. Nitroglycerin 126-129 calcitonin related polypeptide alpha Homo sapiens 84-88 18772068-2 2008 BACKGROUND: In animal models, CGRP contributes to the cardiovascular effects of GTN. Nitroglycerin 80-83 calcitonin related polypeptide alpha Homo sapiens 30-34 18772068-5 2008 METHODS: In 18 ALDH2*2-genotyped Chinese volunteers, we observed the changes in plasma concentrations of CGRP after sublingual GTN administration and its correlation with GTN response, and assessed the expression of CGRP messenger ribonucleic acid (mRNA) in cultured peripheral blood mononuclear cells (PBMCs) pre-treated with 10(-5) mol/l GTN. Nitroglycerin 127-130 calcitonin related polypeptide alpha Homo sapiens 105-109 18772068-5 2008 METHODS: In 18 ALDH2*2-genotyped Chinese volunteers, we observed the changes in plasma concentrations of CGRP after sublingual GTN administration and its correlation with GTN response, and assessed the expression of CGRP messenger ribonucleic acid (mRNA) in cultured peripheral blood mononuclear cells (PBMCs) pre-treated with 10(-5) mol/l GTN. Nitroglycerin 171-174 calcitonin related polypeptide alpha Homo sapiens 105-109 18772068-5 2008 METHODS: In 18 ALDH2*2-genotyped Chinese volunteers, we observed the changes in plasma concentrations of CGRP after sublingual GTN administration and its correlation with GTN response, and assessed the expression of CGRP messenger ribonucleic acid (mRNA) in cultured peripheral blood mononuclear cells (PBMCs) pre-treated with 10(-5) mol/l GTN. Nitroglycerin 171-174 calcitonin related polypeptide alpha Homo sapiens 105-109 18772068-7 2008 Plasma concentrations of CGRP were increased significantly 12 min after GTN administration, the percentage increase in plasma concentrations of CGRP correlated positively with both DeltaSBP and DeltaHR, and percentage increase in plasma concentrations of CGRP was significantly higher in ALDH2*1/*1 homozygotes. Nitroglycerin 72-75 calcitonin related polypeptide alpha Homo sapiens 25-29 18772068-8 2008 In addition, PBMCs from ALDH2*1/*1 homozygotes showed a higher-fold increase in both CGRP I and CGRP II mRNA after GTN stimulation, and the GTN-induced increase in CGRP mRNA expression in PBMCs from ALDH2*1/*1 homozygotes was inhibited by the ALDH2 inhibitor chloral hydrate. Nitroglycerin 115-118 calcitonin related polypeptide alpha Homo sapiens 85-91 18772068-8 2008 In addition, PBMCs from ALDH2*1/*1 homozygotes showed a higher-fold increase in both CGRP I and CGRP II mRNA after GTN stimulation, and the GTN-induced increase in CGRP mRNA expression in PBMCs from ALDH2*1/*1 homozygotes was inhibited by the ALDH2 inhibitor chloral hydrate. Nitroglycerin 115-118 calcitonin related polypeptide alpha Homo sapiens 85-89 18772068-9 2008 CONCLUSIONS: We found that CGRP is associated with the cardiovascular effect of GTN through an ALDH2-dependent pathway in humans. Nitroglycerin 80-83 calcitonin related polypeptide alpha Homo sapiens 27-31 19673898-0 2010 Calcitonin gene-related peptide (CGRP) levels during glyceryl trinitrate (GTN)-induced headache in healthy volunteers. Nitroglycerin 53-72 calcitonin related polypeptide alpha Homo sapiens 0-31 19673898-0 2010 Calcitonin gene-related peptide (CGRP) levels during glyceryl trinitrate (GTN)-induced headache in healthy volunteers. Nitroglycerin 53-72 calcitonin related polypeptide alpha Homo sapiens 33-37 19673898-0 2010 Calcitonin gene-related peptide (CGRP) levels during glyceryl trinitrate (GTN)-induced headache in healthy volunteers. Nitroglycerin 74-77 calcitonin related polypeptide alpha Homo sapiens 0-31 19673898-0 2010 Calcitonin gene-related peptide (CGRP) levels during glyceryl trinitrate (GTN)-induced headache in healthy volunteers. Nitroglycerin 74-77 calcitonin related polypeptide alpha Homo sapiens 33-37 19673898-2 2010 We hypothesized that GTN-induced headache may activate the trigeminovascular system and be associated with increased levels of sensory neuropeptides, including calcitonin gene-related peptide (CGRP). Nitroglycerin 21-24 calcitonin related polypeptide alpha Homo sapiens 160-191 19673898-2 2010 We hypothesized that GTN-induced headache may activate the trigeminovascular system and be associated with increased levels of sensory neuropeptides, including calcitonin gene-related peptide (CGRP). Nitroglycerin 21-24 calcitonin related polypeptide alpha Homo sapiens 193-197 19673898-7 2010 After a 20-min intravenous infusion of GTN 0.12 microg kg(-1) min(-1), median peak headache intensity was 4 (range 2-6) (P < 0.05), while jugular CGRP-LI levels were unchanged (19.0 +- 2.8 pmol/l; P > 0.05). Nitroglycerin 39-42 calcitonin related polypeptide alpha Homo sapiens 149-153 19864020-6 2009 After a two hour infusion of the NO donor glyceroltrinitrate (250microg/kg/h), however, inflammatory mediators-induced CGRP release was 80% higher compared to control animals. Nitroglycerin 42-60 calcitonin related polypeptide alpha Homo sapiens 119-123 17585900-0 2007 Decrease in endogenous CGRP release in nitroglycerin tolerance: role of ALDH-2. Nitroglycerin 39-52 calcitonin related polypeptide alpha Homo sapiens 23-27 18367169-0 2008 New insights into nitroglycerin effects and tolerance: role of calcitonin gene-related peptide. Nitroglycerin 18-31 calcitonin related polypeptide alpha Homo sapiens 63-73 18367169-2 2008 CGRP is a potent vasodilator and plays an important role in mediation of nitroglycerin-induced vascular relaxation. Nitroglycerin 73-86 calcitonin related polypeptide alpha Homo sapiens 0-4 18367169-3 2008 Recently, calcitonin gene-relate peptide is emerging as a potential player in nitroglycerin tolerance. Nitroglycerin 78-91 calcitonin related polypeptide alpha Homo sapiens 10-20 18367169-4 2008 There is increasing evidence that the decreased depressor effect of nitroglycerin in tolerant states is closely related to a decrease in calcitonin gene-relate peptide release. Nitroglycerin 68-81 calcitonin related polypeptide alpha Homo sapiens 137-147 18367169-5 2008 The reduced release of calcitonin gene-relate peptide in nitroglycerin tolerance is associated with the decreased nitroglycerin biotransformation due to the mitochondrial dysfunction. Nitroglycerin 57-70 calcitonin related polypeptide alpha Homo sapiens 23-33 18367169-5 2008 The reduced release of calcitonin gene-relate peptide in nitroglycerin tolerance is associated with the decreased nitroglycerin biotransformation due to the mitochondrial dysfunction. Nitroglycerin 114-127 calcitonin related polypeptide alpha Homo sapiens 23-33 18367169-6 2008 Recent work has been shown that the inhibited activity of mitochondrial isoform of aldehyde dehydrogenase and the upregulation of phosphodiesterase 1A1 are the key factors that lead to the decreased nitroglycerin biotransformation in nitroglycerin tolerance, with a subsequently reduced release of calcitonin gene-relate peptide. Nitroglycerin 199-212 calcitonin related polypeptide alpha Homo sapiens 298-308 18367169-6 2008 Recent work has been shown that the inhibited activity of mitochondrial isoform of aldehyde dehydrogenase and the upregulation of phosphodiesterase 1A1 are the key factors that lead to the decreased nitroglycerin biotransformation in nitroglycerin tolerance, with a subsequently reduced release of calcitonin gene-relate peptide. Nitroglycerin 234-247 calcitonin related polypeptide alpha Homo sapiens 298-308 18197882-4 2008 Following NTG administration, CGRP-ir decreased steadily in the NTC, whereas SP-ir increased transiently. Nitroglycerin 10-13 calcitonin related polypeptide alpha Homo sapiens 30-34 17585900-1 2007 In the present study, we tested whether the decreased release of calcitonin gene-related peptide (CGRP) observed in nitroglycerin tolerance is associated with the decrease in aldehyde dehydrogenase (ALDH-2) activity. Nitroglycerin 116-129 calcitonin related polypeptide alpha Homo sapiens 65-96 17585900-1 2007 In the present study, we tested whether the decreased release of calcitonin gene-related peptide (CGRP) observed in nitroglycerin tolerance is associated with the decrease in aldehyde dehydrogenase (ALDH-2) activity. Nitroglycerin 116-129 calcitonin related polypeptide alpha Homo sapiens 98-102 17585900-4 2007 Pretreatment with ALDH-2 inhibitors and nitroglycerin significantly attenuated vasodilator responses to nitroglycerin concomitantly with a decrease in the release of CGRP from the isolated thoracic aorta. Nitroglycerin 40-53 calcitonin related polypeptide alpha Homo sapiens 166-170 17585900-5 2007 Nitroglycerin produced a depressor effect concomitantly with an increase in plasma concentrations of CGRP, and the effect of nitroglycerin was attenuated after pretreatment with an inhibitor of ALDH-2 or nitroglycerin for 8 days. Nitroglycerin 0-13 calcitonin related polypeptide alpha Homo sapiens 101-105 16886948-0 2006 Sumatriptan causes parallel decrease in plasma CGRP concentration and migraine headache during nitroglycerin-induced migraine attack. Nitroglycerin 95-108 calcitonin related polypeptide alpha Homo sapiens 47-51 16106903-12 2004 Previous results of the authors supported that lower platelet serotonin concentration and higher plasma CGRP concentration, during the headache free period, are risk factors that express greater susceptibility to develop both spontaneous and nitroglycerin-induced migraine attack. Nitroglycerin 242-255 calcitonin related polypeptide alpha Homo sapiens 104-108 14653081-0 2003 [Effects of nitroglycerin on plasma calcitonin gene-related peptide and endothelin in congestive heart failure]. Nitroglycerin 12-25 calcitonin related polypeptide alpha Homo sapiens 36-67 14653081-7 2003 During the nitroglycerin treatment, the plasma concentration of CGRP significantly increased (P < 0.001), whereas the concentration of ET significantly decreased (P < 0.01). Nitroglycerin 11-24 calcitonin related polypeptide alpha Homo sapiens 64-68 14653081-9 2003 CONCLUSION: Nitroglycerin can increase the peripheral plasma CGRP level and decrease the concentration of ET when treating CHF. Nitroglycerin 12-25 calcitonin related polypeptide alpha Homo sapiens 61-65 11501035-5 2000 Drug-induced preconditioning, such as by nitroglycerin, may be related to stimulated release of CGRP. Nitroglycerin 41-54 calcitonin related polypeptide alpha Homo sapiens 96-100 7540279-0 1995 Increase in plasma calcitonin gene-related peptide from the extracerebral circulation during nitroglycerin-induced cluster headache attack. Nitroglycerin 93-106 calcitonin related polypeptide alpha Homo sapiens 19-50 7540279-1 1995 In this study, changes in plasma levels of calcitonin gene-related peptide (CGRP) and substance P (SP) during a spontaneous-like cluster headache attack provoked by nitroglycerin were evaluated. Nitroglycerin 165-178 calcitonin related polypeptide alpha Homo sapiens 43-74 7540279-1 1995 In this study, changes in plasma levels of calcitonin gene-related peptide (CGRP) and substance P (SP) during a spontaneous-like cluster headache attack provoked by nitroglycerin were evaluated. Nitroglycerin 165-178 calcitonin related polypeptide alpha Homo sapiens 76-80 7540279-8 1995 The augmented levels of CGRP-LI measured before and after nitroglycerin administration, when the provoked attack reached the maximum intensity, suggest an activation of the trigeminovascular system during the active period of cluster headache. Nitroglycerin 58-71 calcitonin related polypeptide alpha Homo sapiens 24-28 12710904-0 2003 CGRP-mediated cardiovascular effect of nitroglycerin. Nitroglycerin 39-52 calcitonin related polypeptide alpha Homo sapiens 0-4 12710904-4 2003 Nitroglycerin activates sensory nerves fibres to release CGRP by generating NO and increasing cGMP level, and that the cardiovascular effects of nitroglycerin are partly mediated by endogenous CGRP. Nitroglycerin 0-13 calcitonin related polypeptide alpha Homo sapiens 57-61 12710904-4 2003 Nitroglycerin activates sensory nerves fibres to release CGRP by generating NO and increasing cGMP level, and that the cardiovascular effects of nitroglycerin are partly mediated by endogenous CGRP. Nitroglycerin 145-158 calcitonin related polypeptide alpha Homo sapiens 193-197 11284996-2 2001 In the present study we aimed to investigate plasma levels of CGRP during headache induced by the NO donor glyceryl trinitrate (GTN) in 16 patients with chronic tension-type headache and 16 healthy controls. Nitroglycerin 107-126 calcitonin related polypeptide alpha Homo sapiens 62-66 11284996-2 2001 In the present study we aimed to investigate plasma levels of CGRP during headache induced by the NO donor glyceryl trinitrate (GTN) in 16 patients with chronic tension-type headache and 16 healthy controls. Nitroglycerin 128-131 calcitonin related polypeptide alpha Homo sapiens 62-66 11284996-8 2001 Both in patients and controls, CGRP levels changed significantly over time, on both the GTN and placebo days (P < 0.05). Nitroglycerin 88-91 calcitonin related polypeptide alpha Homo sapiens 31-35