PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16244377-7	2005	GTN (1 microM) inhibited ALDH2 activity (55 +/- 6% of control) and ablated ALDH3 activity.	Nitroglycerin	0-3	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	75-80	
21506955-4	2011	KEY RESULTS: A decrease was observed in both ALDH2 protein expression (80% in tolerant veins and 30% in tolerant arteries after 48 h exposure to GTN) and aortic ALDH activity, concomitant with decreased vasodilator responses to GTN and decreased aortic GTN biotransformation.	Nitroglycerin	145-148	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	45-49	
21506955-5	2011	However, after a 24 h drug-free period following 48 h of GTN exposure, vasodilator responses to GTN and aortic GTN biotransformation activity had returned to control values, whereas vascular ALDH2 expression and aortic ALDH activity were still significantly depressed, and remained so for 3-5 days following cessation of GTN exposure.	Nitroglycerin	57-60	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	191-195	
21506955-6	2011	CONCLUSIONS AND IMPLICATIONS: The dissociation of reduced ALDH activity and ALDH2 expression from the duration of the impaired vasodilator and biotransformation responses to GTN in nitrate-tolerant blood vessels, suggests that factors other than changes in ALDH2-mediated GTN bioactivation contribute to nitrate tolerance.	Nitroglycerin	174-177	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	58-62	
15288585-1	2004	The role of aldehyde dehydrogenase (ALDH) in ex vivo tolerance to transdermal glyceryl trinitrate was explored in rat aorta.	Nitroglycerin	78-97	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	12-34	
15288585-1	2004	The role of aldehyde dehydrogenase (ALDH) in ex vivo tolerance to transdermal glyceryl trinitrate was explored in rat aorta.	Nitroglycerin	78-97	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	36-40	
15288585-3	2004	ALDH inhibitors, chloral hydrate (0.3 mM) and cyanamide (0.1-1 mM) inhibited relaxation to glyceryl trinitrate in non-tolerant and tolerant arteries.	Nitroglycerin	91-110	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	0-4	
15288585-9	2004	The discrepancies are consistent with evidence that (a) organic nitrates, unlike chloral and cyanamide, irreversibly inactivate ALDH (hence reduced enzyme saturability can explain the biphasic curve) and (b) eNOS contributes to tolerance by a mechanism independent of glyceryl trinitrate metabolism.	Nitroglycerin	268-287	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	128-132	
31883320-0	2019	Is the mechanism of nitroglycerin tolerance associated with aldehyde dehydrogenase activity?	Nitroglycerin	20-33	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	60-82	
31883320-2	2019	The aim of the study presented here was an attempt to answer the question posed in the title: Is the mechanism of nitroglycerin tolerance associated with aldehyde dehydrogenase (ALDH) activity?	Nitroglycerin	114-127	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	154-176	
31883320-2	2019	The aim of the study presented here was an attempt to answer the question posed in the title: Is the mechanism of nitroglycerin tolerance associated with aldehyde dehydrogenase (ALDH) activity?	Nitroglycerin	114-127	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	178-182	
31883320-5	2019	Our data revealed that not only DSF and GTN inhibited the total ALDH activity in the rat liver, but LA also proved to be an inhibitor of this enzyme.	Nitroglycerin	40-43	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	64-68	
29634107-3	2016	In this study, we investigated in viti the inactivation of yeast aldehyde dehydrogenase (ALDH) by nitroglycerin (GTN) in the presence and absence of LA and DHLA.	Nitroglycerin	98-111	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	89-93	
29634107-3	2016	In this study, we investigated in viti the inactivation of yeast aldehyde dehydrogenase (ALDH) by nitroglycerin (GTN) in the presence and absence of LA and DHLA.	Nitroglycerin	113-116	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	89-93	
29634107-5	2016	The results indicated that in vito both LA and DHLA restored and protected ALDH activity against GTN-induced inactivation, while treatment of rats with LA and GTN in combination did not provide any protection against GTN-induced ALDH inhibition.	Nitroglycerin	97-100	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	75-79