PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21506955-6 2011 CONCLUSIONS AND IMPLICATIONS: The dissociation of reduced ALDH activity and ALDH2 expression from the duration of the impaired vasodilator and biotransformation responses to GTN in nitrate-tolerant blood vessels, suggests that factors other than changes in ALDH2-mediated GTN bioactivation contribute to nitrate tolerance. Nitroglycerin 174-177 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 58-62 31883320-0 2019 Is the mechanism of nitroglycerin tolerance associated with aldehyde dehydrogenase activity? Nitroglycerin 20-33 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 60-82 31883320-2 2019 The aim of the study presented here was an attempt to answer the question posed in the title: Is the mechanism of nitroglycerin tolerance associated with aldehyde dehydrogenase (ALDH) activity? Nitroglycerin 114-127 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 154-176 31883320-2 2019 The aim of the study presented here was an attempt to answer the question posed in the title: Is the mechanism of nitroglycerin tolerance associated with aldehyde dehydrogenase (ALDH) activity? Nitroglycerin 114-127 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 178-182 31883320-5 2019 Our data revealed that not only DSF and GTN inhibited the total ALDH activity in the rat liver, but LA also proved to be an inhibitor of this enzyme. Nitroglycerin 40-43 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 64-68 16244377-7 2005 GTN (1 microM) inhibited ALDH2 activity (55 +/- 6% of control) and ablated ALDH3 activity. Nitroglycerin 0-3 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 75-80 15288585-1 2004 The role of aldehyde dehydrogenase (ALDH) in ex vivo tolerance to transdermal glyceryl trinitrate was explored in rat aorta. Nitroglycerin 78-97 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 12-34 15288585-1 2004 The role of aldehyde dehydrogenase (ALDH) in ex vivo tolerance to transdermal glyceryl trinitrate was explored in rat aorta. Nitroglycerin 78-97 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 36-40 15288585-3 2004 ALDH inhibitors, chloral hydrate (0.3 mM) and cyanamide (0.1-1 mM) inhibited relaxation to glyceryl trinitrate in non-tolerant and tolerant arteries. Nitroglycerin 91-110 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 0-4 15288585-9 2004 The discrepancies are consistent with evidence that (a) organic nitrates, unlike chloral and cyanamide, irreversibly inactivate ALDH (hence reduced enzyme saturability can explain the biphasic curve) and (b) eNOS contributes to tolerance by a mechanism independent of glyceryl trinitrate metabolism. Nitroglycerin 268-287 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 128-132 29634107-3 2016 In this study, we investigated in viti the inactivation of yeast aldehyde dehydrogenase (ALDH) by nitroglycerin (GTN) in the presence and absence of LA and DHLA. Nitroglycerin 98-111 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 89-93 29634107-3 2016 In this study, we investigated in viti the inactivation of yeast aldehyde dehydrogenase (ALDH) by nitroglycerin (GTN) in the presence and absence of LA and DHLA. Nitroglycerin 113-116 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 89-93 29634107-5 2016 The results indicated that in vito both LA and DHLA restored and protected ALDH activity against GTN-induced inactivation, while treatment of rats with LA and GTN in combination did not provide any protection against GTN-induced ALDH inhibition. Nitroglycerin 97-100 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 75-79 21506955-4 2011 KEY RESULTS: A decrease was observed in both ALDH2 protein expression (80% in tolerant veins and 30% in tolerant arteries after 48 h exposure to GTN) and aortic ALDH activity, concomitant with decreased vasodilator responses to GTN and decreased aortic GTN biotransformation. Nitroglycerin 145-148 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 45-49 21506955-5 2011 However, after a 24 h drug-free period following 48 h of GTN exposure, vasodilator responses to GTN and aortic GTN biotransformation activity had returned to control values, whereas vascular ALDH2 expression and aortic ALDH activity were still significantly depressed, and remained so for 3-5 days following cessation of GTN exposure. Nitroglycerin 57-60 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 191-195