PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26435741-4 2015 Moreover NTG can reduce HIF-1alpha levels in hypoxic tumour tissues and this may have anti-angiogenic, pro-apoptotic and anti-efflux effects. Nitroglycerin 9-12 hypoxia inducible factor 1 subunit alpha Homo sapiens 24-34 31912870-0 2020 Inhibition of Hypoxia-Inducible Factor 1 Alpha Accumulation by Glyceryl Trinitrate and Cyclic Guanosine Monophosphate. Nitroglycerin 63-82 hypoxia inducible factor 1 subunit alpha Homo sapiens 14-46 31912870-5 2020 Using human DU145 prostate cancer cells, we assessed the effect of the NO mimetic glyceryl trinitrate (GTN) and the cGMP analogue 8-Bromo-cGMP on hypoxic accumulation of HIF-1alpha. Nitroglycerin 82-101 hypoxia inducible factor 1 subunit alpha Homo sapiens 170-180 26347109-1 2015 BACKGROUND: Nitroglycerin (NTG) increases tumor blood flow and oxygenation by inhibiting hypoxia-inducible-factor (HIF)-1. Nitroglycerin 12-25 hypoxia inducible factor 1 subunit alpha Homo sapiens 89-121 26347109-1 2015 BACKGROUND: Nitroglycerin (NTG) increases tumor blood flow and oxygenation by inhibiting hypoxia-inducible-factor (HIF)-1. Nitroglycerin 27-30 hypoxia inducible factor 1 subunit alpha Homo sapiens 89-121 31912870-6 2020 Concentrations of GTN known to primarily activate the NO/cGMP pathway (100 nM-1 microM) inhibited hypoxia-induced HIF-1alpha protein accumulation in a time-dependent manner. Nitroglycerin 18-21 hypoxia inducible factor 1 subunit alpha Homo sapiens 114-124 31912870-8 2020 Furthermore, treatment of cells with the calpain (Ca2+-activated proteinase) inhibitor calpastatin attenuated the effects of GTN and 8-Bromo-cGMP on HIF-1alpha accumulation. Nitroglycerin 125-128 hypoxia inducible factor 1 subunit alpha Homo sapiens 149-159 24336068-6 2014 Using glyceryl trinitrate (GTN), an agonist of nitric oxide (NO) signaling known to block HIF-1alpha accumulation in hypoxic cells, we prevented hypoxia-induced PD-L1 expression and diminished resistance to CTL-mediated lysis. Nitroglycerin 6-25 hypoxia inducible factor 1 subunit alpha Homo sapiens 90-100 24836861-2 2014 BACKGROUND: Nitroglycerin, a nitric oxide donor agent, reduces the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and could be a normalizer of the tumor microenvironment. Nitroglycerin 12-25 hypoxia inducible factor 1 subunit alpha Homo sapiens 81-112 24836861-2 2014 BACKGROUND: Nitroglycerin, a nitric oxide donor agent, reduces the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and could be a normalizer of the tumor microenvironment. Nitroglycerin 12-25 hypoxia inducible factor 1 subunit alpha Homo sapiens 114-124 24336068-6 2014 Using glyceryl trinitrate (GTN), an agonist of nitric oxide (NO) signaling known to block HIF-1alpha accumulation in hypoxic cells, we prevented hypoxia-induced PD-L1 expression and diminished resistance to CTL-mediated lysis. Nitroglycerin 27-30 hypoxia inducible factor 1 subunit alpha Homo sapiens 90-100 21641407-6 2011 Treatment of explants with GTN also prevented the hypoxia-induced accumulation of hypoxia-inducible factor-1alpha, a key mediator of cellular adaptations to hypoxia. Nitroglycerin 27-30 hypoxia inducible factor 1 subunit alpha Homo sapiens 82-113 15465035-4 2004 We investigated the effect of the clinically used nitrates nitroglycerin (NTG), isosorbide dinitrate (ISDN), and sodium nitroprusside (SNP) on HIF-1-mediated transcriptional responses to hypoxia. Nitroglycerin 59-72 hypoxia inducible factor 1 subunit alpha Homo sapiens 143-148 17121895-3 2006 EXPERIMENTAL DESIGN: Seventeen patients with operable lung adenocarcinoma and stable angina pectoris were selected to investigate the effects of nitroglycerin on immunoreactivity for hypoxia-inducible factor 1alpha (HIF-1alpha), vascular endothelial growth factor (VEGF), P-glycoprotein (P-gp), the production of which is regulated by HIF-1, and p53 proteins in their resected tumor by semiquantitative immunohistochemical analyses. Nitroglycerin 145-158 hypoxia inducible factor 1 subunit alpha Homo sapiens 183-214 17121895-6 2006 RESULTS: The rates of immunoreactive cells for HIF-1alpha, VEGF, and P-gp in tumor tissues treated with nitroglycerin were lower than those without nitroglycerin, but those for p53 were not different between those treated with and without nitroglycerin. Nitroglycerin 104-117 hypoxia inducible factor 1 subunit alpha Homo sapiens 47-57 17121895-9 2006 CONCLUSIONS: Nitroglycerin treatment may improve response to DCb in patients with lung adenocarcinoma, partly through decreasing VEGF and P-gp production via reduction of HIF-1alpha. Nitroglycerin 13-26 hypoxia inducible factor 1 subunit alpha Homo sapiens 171-181 15465035-4 2004 We investigated the effect of the clinically used nitrates nitroglycerin (NTG), isosorbide dinitrate (ISDN), and sodium nitroprusside (SNP) on HIF-1-mediated transcriptional responses to hypoxia. Nitroglycerin 74-77 hypoxia inducible factor 1 subunit alpha Homo sapiens 143-148 35157994-2 2022 Nitroglycerin (NTG) can reduce HIF-1 in tissues, and this may have anti-angiogenic, pro-apoptotic, and anti-efflux effects. Nitroglycerin 0-13 hypoxia inducible factor 1 subunit alpha Homo sapiens 31-36 35157994-2 2022 Nitroglycerin (NTG) can reduce HIF-1 in tissues, and this may have anti-angiogenic, pro-apoptotic, and anti-efflux effects. Nitroglycerin 15-18 hypoxia inducible factor 1 subunit alpha Homo sapiens 31-36