PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10625313-0	2000	Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability.	Nitroglycerin	21-34	nitric oxide synthase 3	Rattus norvegicus	83-90	
10625313-3	2000	It remains to be elucidated, however, whether long-term treatment with NTG alters the activity and expression of the endothelial NO synthase (NOS III) and whether this enzyme can contribute to O(2)(.-) formation.	Nitroglycerin	71-74	nitric oxide synthase 3	Rattus norvegicus	142-149	
10625313-4	2000	We studied the influence of long-term NTG treatment on the expression of NOS III as assessed by RNase protection assay and Western blot.	Nitroglycerin	38-41	nitric oxide synthase 3	Rattus norvegicus	73-80	
10625313-14	2000	These findings suggest that NTG treatment increases the expression of a dysfunctional NOS III gene, leading to increased formation of O(2)(.-) and decreased vascular NO bioavailability.	Nitroglycerin	28-31	nitric oxide synthase 3	Rattus norvegicus	86-93	
10511130-10	1999	This effect on the cNOS pathway seems to attenuate the superoxide anion accumulation induced by nitroglycerin exposure (probably via a downregulation of oxidative enzyme).	Nitroglycerin	96-109	nitric oxide synthase 3	Rattus norvegicus	19-23	
21757654-0	2011	Nitroglycerin-induced endothelial dysfunction and tolerance involve adverse phosphorylation and S-Glutathionylation of endothelial nitric oxide synthase: beneficial effects of therapy with the AT1 receptor blocker telmisartan.	Nitroglycerin	0-13	nitric oxide synthase 3	Rattus norvegicus	119-152	
21757654-1	2011	OBJECTIVE: Continuous administration of nitroglycerin (GTN) causes tolerance and endothelial dysfunction by inducing reactive oxygen species (ROS) production from various enzymatic sources, such as mitochondria, NADPH oxidase, and an uncoupled endothelial nitric oxide synthase (eNOS).	Nitroglycerin	40-53	nitric oxide synthase 3	Rattus norvegicus	244-277	
21757654-1	2011	OBJECTIVE: Continuous administration of nitroglycerin (GTN) causes tolerance and endothelial dysfunction by inducing reactive oxygen species (ROS) production from various enzymatic sources, such as mitochondria, NADPH oxidase, and an uncoupled endothelial nitric oxide synthase (eNOS).	Nitroglycerin	40-53	nitric oxide synthase 3	Rattus norvegicus	279-283	
21757654-1	2011	OBJECTIVE: Continuous administration of nitroglycerin (GTN) causes tolerance and endothelial dysfunction by inducing reactive oxygen species (ROS) production from various enzymatic sources, such as mitochondria, NADPH oxidase, and an uncoupled endothelial nitric oxide synthase (eNOS).	Nitroglycerin	55-58	nitric oxide synthase 3	Rattus norvegicus	244-277	
21757654-1	2011	OBJECTIVE: Continuous administration of nitroglycerin (GTN) causes tolerance and endothelial dysfunction by inducing reactive oxygen species (ROS) production from various enzymatic sources, such as mitochondria, NADPH oxidase, and an uncoupled endothelial nitric oxide synthase (eNOS).	Nitroglycerin	55-58	nitric oxide synthase 3	Rattus norvegicus	279-283	
21757654-9	2011	GTN-induced decrease in Ser1177, increase in Thr495 phosphorylation or S-glutathionylation of eNOS, and decrease in mitochondrial aldehyde dehydrogenase expression were normalized by telmisartan.	Nitroglycerin	0-3	nitric oxide synthase 3	Rattus norvegicus	94-98	
21757654-10	2011	CONCLUSIONS: These data identify modification of eNOS phosphorylation as an important component of GTN-induced endothelial dysfunction.	Nitroglycerin	99-102	nitric oxide synthase 3	Rattus norvegicus	49-53	
18386218-2	2008	METHODS: We examined the reactivity of cerebral arterioles in adult and aged Fisher-344 rats to endothelial nitric oxide synthase (eNOS)-dependent (acetylcholine and adenosine diphosphate [ADP]) and-independent (nitroglycerin) agonists before and during application of tempol, apocynin, and diphenyleneiodonium chloride (DPI).	Nitroglycerin	212-225	nitric oxide synthase 3	Rattus norvegicus	131-135